Tag: M.W=250-300

Xiao, Shuhuan; Liu, Chen; Song, Bin; Wang, Liang; Qi, Yan; Liu, Yongjun published the artcile< Samarium-based Grignard-type addition of organohalides to carbonyl compounds under catalysis of CuI>, Synthetic Route of 76-84-6, the main research area is alc ketone aldehyde preparation chemoselective; organohalide carbonyl compound Grignard addition copper catalysis.

Grignard-type additions were readily achieved under the mediation of CuI (10 mol%) and samarium (2 equivalent) by employing various organohalides, e.g. benzyl, aryl, heterocyclic and aliphatic halides (Cl, Br or I), and diverse carbonyl compounds (e.g. carbonic esters, carboxylic esters, acid anhydrides, acyl chlorides, ketones, aldehydes, propylene epoxides and formamides) to afford alcs., ketones and aldehydes, resp., with high efficiency and chemoselectivity, in which the organosamarium intermediate might be involved.

Chemical Communications (Cambridge, United Kingdom) published new progress about Addition reaction. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Synthetic Route of 76-84-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Docherty, Jamie H.; Nicholson, Kieran; Dominey, Andrew P.; Thomas, Stephen P. published the artcile< A Boron-Boron Double Transborylation Strategy for the Synthesis of gem-Diborylalkanes>, Product Details of C12H20O6, the main research area is gem alkyl diboronate preparation terminal alkyne borylation hydroborane catalyst; diborylation transborylation mechanism alkyne hydroborane catalyst preparation gem diboronate.

1,1-Diborylalkanes RCH2CH(Bpin)2 were prepared by double borylation of α-alkynes catalyzed by 9-borabicyclononane via transborylation pathway. Olefin hydroboration reactions provide efficient access to synthetically versatile and easily handled organoboronic esters. In this study, we demonstrate that the com. available organoborane reagent 9-borabicyclo[3.3.1]nonane (H-B-9-BBN) can serve as a catalyst for the sequential double hydroboration of alkynes using pinacolborane (HBpin). This strategy, which is effective for a wide range of terminal alkynes, is predicated upon a key C(sp3)-B/B-H transborylation reaction. Transition-state thermodn. parameters and 10-boron-isotopic labeling experiments are indicative of a σ-bond metathesis exchange pathway.

ACS Catalysis published new progress about Alkynes, α- Role: RCT (Reactant), RACT (Reactant or Reagent). 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Product Details of C12H20O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhuo, Ming-Hua; Wilbur, David J.; Kwan, Eugene E.; Bennett, Clay S. published the artcile< Matching Glycosyl Donor Reactivity to Sulfonate Leaving Group Ability Permits SN2 Glycosylations>, Formula: C12H20O6, the main research area is beta glycosylation sulfonyl leaving group.

Here we demonstrate that highly β-selective glycosylation reactions can be achieved when the electronics of a sulfonyl chloride activator and the reactivity of a glycosyl donor hemiacetal are matched. While these reactions are compatible with the acid- and base-sensitive protecting groups that are commonly used in oligosaccharide synthesis, these protecting groups are not relied upon to control selectivity. Instead, β-selectivity arises from the stereoinversion of an α-glycosyl arylsulfonate in an SN2-like mechanism. Our mechanistic proposal is supported by NMR studies, kinetic isotope effect (KIE) measurements, and DFT calculations

Journal of the American Chemical Society published new progress about Arenesulfonyl chlorides Role: RCT (Reactant), RGT (Reagent), RACT (Reactant or Reagent). 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Formula: C12H20O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Barbieri, Alessia; Lanzalunga, Osvaldo; Lapi, Andrea; Di Stefano, Stefano published the artcile< N-Hydroxyphthalimide: A Hydrogen Atom Transfer Mediator in Hydrocarbon Oxidations Promoted by Nonheme Iron(IV)-Oxo Complexes>, HPLC of Formula: 76-84-6, the main research area is Hydroxyphthalimide hydrogen atom transfer mediator hydrocarbon oxidations; promotor nonheme Iron Oxo complex.

The oxidation of a series of hydrocarbons by the nonheme iron(IV)-oxo complex [(N4Py)FeIV=O]2+ is efficiently mediated by N-hydroxyphthalimide. The increase of reactivity is associated to the oxidation of the mediator to the phthalimide N-oxyl radical, which efficiently abstracts a hydrogen atom from the substrates, regenerating the mediator in its reduced form.

Journal of Organic Chemistry published new progress about Hydrogen transfer. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, HPLC of Formula: 76-84-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Dowson, George R. M.; Cooper, Joshua; Styring, Peter published the artcile< Reactive capture using metal looping: the effect of oxygen>, Application In Synthesis of 76-84-6, the main research area is oxygen Grignard reagent reactive capture metal looping flue gas.

In the effort to create a sustainable future economy, the ability to directly convert dilute gas-phase CO2 in waste gas streams into useful products would be a valuable tool, which may be achievable using Grignard reagents as both the capture and the conversion materials. The magnesium salt byproduct can be recovered, and metallic magnesium regenerated through conventional high-efficiency electrolysis. This stoichiometric approach is known as metal looping, where the magnesium acts as the energy vector for the capture and conversion, allowing both to occur at room temperature and atm. pressure. However, the process has only previously been demonstrated with 12% CO2 in nitrogen mixtures If we consider this process in a real post-combustion flue gas conversion scenario, the sensitivity of Grignard reagents to other gases (and water vapor) must be considered. While some of these gases and the water vapor are relatively easily removed, in most flue gas streams the most common other gas present, oxygen, would be far more challenging to excise, and oxygen is known to react with Grignard reagents, albeit slowly. In order to determine if higher oxygen concentrations could be tolerated, allowing the possibility of a variety of relatively inexpensive and possibly profitable direct CO2 conversion pathways to be developed, a range of industrially relevant CO2/O2 mixtures were made and carefully bubbled through phenylmagnesium bromide solutions

Faraday Discussions published new progress about Decomposition. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Application In Synthesis of 76-84-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Okuda, Yuta; Nagaoka, Masahiro; Yamamoto, Tetsuya published the artcile< Bulky N-Heterocyclic-Carbene-Coordinated Palladium Catalysts for 1,2-Addition of Arylboron Compounds to Carbonyl Compounds>, Safety of Triphenylmethanol, the main research area is nitrogen heterocyclic carbene pentanylaniline cyclometallated palladium complex preparation catalyst; primary secondary tertiary alc preparation; arylboronic acid boronate aldehyde ketone addition.

The synthesis of primary, secondary, and tertiary alcs. by the 1,2-addition of arylboronic acids or boronates to carbonyl compounds, including unactivated ketones, using novel bulky yet flexible N-heterocyclic carbene (NHC)-coordinated 2,6-di(pentan-3-yl)aniline (IPent)-based cyclometallated palladium complexes (CYPs) as catalysts is reported. The PhS-IPent-CYP-catalyzed reactions are efficient at low catalyst loadings (0.02-0.3 mol% Pd), and the exceptional catalytic activity for 1,2-addition is attributed to the steric bulk of the NHC ligand. These reactions can yield a wide range of functionalized benzylic alcs. that are difficult to synthesize by classical protocols using highly active organomagnesium or lithium reagents.

ChemCatChem published new progress about 1,2-Addition reaction. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Safety of Triphenylmethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Yunqin; Xiang, Guisheng; He, Shaojun; Hu, Yikao; Liu, Yanjun; Xu, Lili; Xiao, Guozhi published the artcile< Orthogonal One-Pot Synthesis of Oligosaccharides Based on Glycosyl ortho-Alkynylbenzoates>, Product Details of C12H20O6, the main research area is glycosylation oligosaccharide synthesis alkynylbenzoate.

One of the most popular one-pot glycosylation strategies is orthogonal one-pot synthesis, which was mainly based on thioglycosides. Despite its successful application, shortcomings of thioglycosides including aglycon transfers, interference of departing species and unpleasant odor restrict its application scope. Herein, we report a new and efficient orthogonal one-pot synthesis of oligosaccharides based on glycosyl ortho-alkynylbenzoate, which solves the issues of thioglycoside-based orthogonal one-pot synthesis. Over a dozen of oligosaccharides have been efficiently synthesized by this method.

Organic Letters published new progress about Glycosides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Product Details of C12H20O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Shi, Quan-Xi; Li, Qian; Xiao, Hang; Sun, Xiao-Li; Bao, Hongli; Wan, Wen-Ming published the artcile< Room-temperature Barbier single-atom polymerization induced emission as versatile approach for utilization of monofunctional carboxylic acid resources>, Computed Properties of 76-84-6, the main research area is phenylcarboxylic acid dibenzoyl peroxide polytriphenylmethanol Barbier single atom polymerization.

Carboxylic acids are widely available from both biomass and fossil sources on the Earth. In comparison with multifunctional carboxylic acid containing chems. that have been comprehensively used as building blocks of polymer materials, monofunctional carboxylic acid resources exhibit broader availability but are rarely utilized as monomers for polymerization, attributed to their monofunctionality. Here, we demonstrate a Barbier single-atom polymerization (SAP) as a versatile approach for the utilization of monofunctional carboxylic acid resources, where they act as a carbon source to contribute only one carbon atom for the construction of the polymer main chain. The key point for the polymerization of the monofunctional carboxylic acid resource is to difunctionalize it, which is realized through two Barbier additions between bifunctional aromatic halides and monofunctional peroxyester in the presence of Mg. Prior to the Barbier SAP, monofunctional phenylcarboxylic acid is converted into dibenzoyl peroxide (BPO) with higher reactivity. Through the Barbier SAP of BPO at room temperature, a series of nonconjugated polytriphenylmethanols (PTPMs) were prepared as polymerization-induced emission luminogens (PIEgens) with structure-specific nonconjugated luminescence including aggregation-caused quenching (ACQ) and aggregation induced emission (AIE) characteristics, where starting monomers and repeating units are nonemissive. Further applications of PIEgens were carried out for an artificial light-harvesting system with an antenna effect of over 18.5 and explosive detection at the ppm level in solution and ng level on test paper. This work therefore opens a new avenue for the design of nonconjugated luminescence by utilizing Earth’s monofunctional carboxylic acid resources sufficiently.

Polymer Chemistry published new progress about Aggregation-induced emission. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Computed Properties of 76-84-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ji, Peng; Zhang, Yueteng; Wei, Yongyi; Huang, He; Hu, Wenbo; Mariano, Patrick A.; Wang, Wei published the artcile< Visible-Light-Mediated, Chemo- and Stereoselective Radical Process for the Synthesis of C-Glyco-amino Acids>, Reference of 4064-06-6, the main research area is homolytic coupling glycoside glycopeptide preparation; stereoselective C glycosylation photoredox catalyzed imine glycopeptide; imino ester chemoselective addition nucleophilic glycosyl radical amino acid.

An approach for efficient synthesis of C-glycosyl amino acids is described. Different from typical photoredox-catalyzed reactions of imines, the new process follows a pathway in which α-imino esters serve as electrophiles in chemoselective addition reactions with nucleophilic glycosyl radicals. The process is highlighted by the mild nature of the reaction conditions, the highly stereoselectivity attending C-C bond formation, and its applicability to C-glycosylations using both armed and disarmed pentose and hexose derivatives

Organic Letters published new progress about Amino acids Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Reference of 4064-06-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Denavit, Vincent; Laine, Danny; Bouzriba, Chahrazed; Shanina, Elena; Gillon, Emilie; Fortin, Sebastien; Rademacher, Christoph; Imberty, Anne; Giguere, Denis published the artcile< Stereoselective Synthesis of Fluorinated Galactopyranosides as Potential Molecular Probes for Galactophilic Proteins: Assessment of Monofluorogalactoside-LecA Interactions>, Electric Literature of 4064-06-6, the main research area is stereoselective galactopyranoside galactophilic protein monofluorogalactoside LecA interaction; crystal structure; LecA; NMR spectroscopy; TROSY NMR; carbohydrates; fluorinated glycoside.

The replacement of hydroxyl groups by fluorine atoms on hexopyranoside scaffolds may allow access to invaluable tools for studying various biochem. processes. As part of ongoing activities toward the preparation of fluorinated carbohydrates, a systematic investigation involving the synthesis and biol. evaluation of a series of mono- and polyfluorinated galactopyranosides is described. Various monofluorogalactopyranosides, a trifluorinated, and a tetrafluorinated galactopyranoside have been prepared using a Chiron approach. Given the scarcity of these compounds in the literature, in addition to their synthesis, their biol. profiles were evaluated. Firstly, the fluorinated compounds were investigated as antiproliferative agents using normal human and mouse cells in comparison with cancerous cells. Most of the fluorinated compounds showed no antiproliferative activity. Secondly, these carbohydrate probes were used as potential inhibitors of galactophilic lectins. The first transverse relaxation-optimized spectroscopy (TROSY) NMR experiments were performed on these interactions, examining chem. shift perturbations of the backbone resonances of LecA, a virulence factor from Pseudomonas aeruginosa. Moreover, taking advantage of the fluorine atom, the 19F NMR resonances of the monofluorogalactopyranosides were directly monitored in the presence and absence of LecA to assess ligand binding. Lastly, these results were corroborated with the binding potencies of the monofluorinated galactopyranoside derivatives by isothermal titration calorimetry experiments Analogs with fluorine atoms at C-3 and C-4 showed weaker affinities with LecA as compared to those with the fluorine atom at C-2 or C-6. This research has focused on the chem. synthesis of “”drug-like”” low-mol.-weight inhibitors that circumvent drawbacks typically associated with natural oligosaccharides.

Chemistry – A European Journal published new progress about Antitumor agents. 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Electric Literature of 4064-06-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts