Tag: M.W=250-300

Shen, Guang-Bin published the artcilePrediction of Kinetic Isotope Effects for Various Hydride Transfer Reactions Using a New Kinetic Model, Category: alcohols-buliding-blocks, the publication is Journal of Physical Chemistry A (2016), 120(11), 1779-1799, database is CAplus and MEDLINE.

In this work, kinetic isotope effect (KIE_self) values of 68 hydride self-exchange reactions, XH(D) + X⁺ → X⁺ + XH(D), in acetonitrile at 298 K were determined using a new exptl. method. KIE values of 4556 hydride cross transfer reactions, XH(D) + Y⁺ → X⁺ + YH(D), in acetonitrile were estimated from the 68 determined KIE_self values of hydride self-exchange reactions using a new KIE relation formula derived from Zhu’s kinetic equation and the reliability of the estimations was verified using different exptl. methods. A new KIE kinetic model to explain and predict KIE values was developed according to Zhu’s kinetic model using two different Morse free energy curves instead of one Morse free energy curve in the traditional KIE theories to describe the free energy changes of X-H bond and X-D bond dissociation in chem. reactions. The most significant contribution of this paper to KIE theory is to build a new KIE kinetic model, which can be used to not only uniformly explain the various (normal, enormous and inverse) KIE values but also safely predict KIE values of various chem. reactions.

Journal of Physical Chemistry A published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C6H10N2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lu, Xiao-Yu published the artcileDual Nickel/Ruthenium Strategy for Photoinduced Decarboxylative Cross-Coupling of α,β-Unsaturated Carboxylic Acids with Cycloketone Oxime Esters, Recommanded Product: ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, the publication is Journal of Organic Chemistry (2021), 86(13), 8829-8842, database is CAplus and MEDLINE.

Herein, a dual nickel/ruthenium strategy is developed for photoinduced decarboxylative cross-coupling between α,β-unsaturated carboxylic acids and cycloketone oxime esters. The reaction mechanism is distinct from previous photoinduced decarboxylation of α,β-unsaturated carboxylic acids. This reaction might proceed through a nickelacyclopropane intermediate. The C(sp²)-C(sp³) bond constructed by the aforementioned reaction provides an efficient approach to obtaining various cyanoalkyl alkenes, which are synthetically valuable organic skeletons in organic and medicinal chem., under mild reaction conditions. The protocol tolerates many critical functional groups and provides a route for the modification of complex organic mols.

Journal of Organic Chemistry published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, Recommanded Product: ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ou, Wei published the artcileRoom-Temperature Palladium-Catalyzed Deuterogenolysis of Carbon Oxygen Bonds towards Deuterated Pharmaceuticals, Category: alcohols-buliding-blocks, the publication is Angewandte Chemie, International Edition (2021), 60(12), 6357-6361, database is CAplus and MEDLINE.

Site-specific incorporation of deuterium into drug mols. to study and improve their biol. properties is crucial for drug discovery and development. Herein, we describe a palladium-catalyzed room-temperature deuterogenolysis of carbon-oxygen bonds in alcs. and ketones with D₂ balloon for practical synthesis of deuterated pharmaceuticals and chems. with benzyl-site (sp³ C-H) D-incorporation. The highlights of this deoxygenative deuteration strategy are mild conditions, broad scope, practicability and high chemoselectivity. To enable the direct use of D₂O, electrocatalytic D₂O-splitting is adapted to in situ supply D₂ on demand. With this system, the precise incorporation of deuterium in the metabolic position (benzyl-site) of ibuprofen is demonstrated in a sustainable and practical way with D₂O.

Angewandte Chemie, International Edition published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shen, Haigen published the artcileCopper-Catalyzed Radical Bis(trifluoromethylation) of Alkynes and 1,3-Enynes, Safety of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, the publication is Synlett (2020), 31(1), 41-44, database is CAplus.

The copper-catalyzed radical bis(trifluoromethylation) of alkynes ArCCH [Ar = 4-tert-butylphenyl, phenanthren-9-yl, 2-methyl-1,3-benzothiazol-6-yl, [4-([[(1R,2S,5R)-5-methyl-2-(propan-2- yl)cyclohexyl]oxy]carbonyl)phenyl], etc.] and 1,3-enynes R¹CCC(=CH₂)R² (R¹ = 4-bromophenyl, 9-oxo-9H-fluoren-2-yl, 3-[(benzenesulfonyl)oxy]propyl, etc.; R² = H, Me) is described. With Cu(CH₃CN)₄BF₄as the catalyst, the reaction of arylalkynes with Togni reagent II and (bpy)Zn(CF₃)₂ at room temperature affords the corresponding 1,2-bis(trifluoromethylated) alkenes ArC(CF₃)=CHCF₃ in good yields with excellent E-stereoselectivity. Under similar conditions, the reaction of 1,3-enynes provides the corresponding 1,4-bis(trifluoromethylated) allenes R¹C(CF₃)=C=C(CH₂CF₃)R² exclusively in satisfactory yields. The protocol exhibits broad substrate scope and excellent functional group compatibility.

Synlett published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H10O4S, Safety of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chen, Xing published the artcileProperties of Multiblock Sulfonated Poly(arylene ether sulfone)s Synthesized by Precise Controllable Post-sulfonation for Proton Exchange Membranes, Recommanded Product: 4,4′-Sulfonyldiphenol, the publication is Chinese Journal of Polymer Science (2022), 40(7), 754-763, database is CAplus.

A series of multiblock sulfonated poly(arylene ether sulfone)s (SPAES) with various block lengths and predictable ion exchange capacity were synthesized from 4,4′-difluorodiphenyl sulfone, 4,4′-dihydrodiphenyl sulfone and 4,4′-biphenol by one-pot and two-pot polymerization 1H-NMR and FTIR spectra confirmed the structure that sulfonic acid groups were introduced precisely on the poly(arylene ether sulfone)s by post-sulfonation which resulted in controllable sulfonation degree. The proton exchange membranes (PEMs)-based SPAES displayed excellent dimensional, thermal, antioxidant stability, proton conductivity and mech. properties (maximum tensile stress >35 MPa). Thermogravimetric anal. indicated the prepared SPAES began to degrade above 310°C. The effects of polymerization processes, those were, one-pot hydrophobic segment process, one-pot hydrophilic segment process and two-pot process, on the properties of polymers were investigated. The proton conductivity and microphase separation of SPAES PEMs increased in order of those prepared by one-pot hydrophobic segment process, two-pot process and one-pot hydrophilic segment process. The highest conductivities of SPAES synthesized by the above processes under 80°C and 100% relative humidity were 213 (MS4), 297 (MB3) and 360 mS·cm^-1 (MQ2), resp.

Chinese Journal of Polymer Science published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Recommanded Product: 4,4′-Sulfonyldiphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Xiao, Cong published the artcileLight-promoted nickel catalysis: etherification of aryl electrophiles with alcohols catalyzed by Ni (II)/aryl complex, Recommanded Product: ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, the publication is Youji Huaxue (2020), 40(9), 3004-3006, database is CAplus.

In this paper, a highly efficient photo promoted nickel catalyzed C-O bond coupling reaction was realized. The reaction uses air stable Ni (II) – aryl halide as catalyst and DBU as base without external photosensitizer.

Youji Huaxue published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H15NO, Recommanded Product: ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Pilkington-Miksa, Michael A. published the artcileTargeting lipopolyplexes using bifunctional peptides incorporating hydrophobic spacer amino acids: Synthesis, transfection, and biophysical studies, Related Products of alcohols-buliding-blocks, the publication is Bioconjugate Chemistry (2007), 18(6), 1800-1810, database is CAplus and MEDLINE.

We have developed efficient synthetic routes to two hydrophobic amino acids, suitably protected for solid-phase peptide synthesis, and have successfully synthesized peptides containing these or other hydrophobic amino acids as spacers between a Lys₁₆ moiety and an integrin-targeting motif. These peptides have in turn been used to formulate a range of lipopolyplex vectors with Lipofectin and plasmid DNA. The transfection efficiencies of these vectors and their aggregation behavior in buffers and in serum have been studied. We have shown that vectors containing peptides incorporating long linkers that are entirely hydrophobic are less efficient transfection agents. However, linkers of equivalent length that are in part hydrophobic show improved transfection properties, which is probably due to the improved accessibility of the integrin-binding motif.

Bioconjugate Chemistry published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liu, Gaoxiaozheng published the artcileConcise synthesis of xanthones by the tandem etherification-Acylation of diaryliodonium salts with salicylates, Computed Properties of 596-38-3, the publication is Chinese Chemical Letters (2018), 29(6), 985-988, database is CAplus.

An efficient synthetic method for multi-substituted xanthones, e.g., I was developed. The reaction of diaryliodonium salts (RC₆H₄)₂I⁺OTf^– (R = H, 3-Me, 4-F, etc.) and salicylates R¹C(O)₂CH₃ (R¹ = 4-Br-2-HOC₆H₃, 3-hydroxythiophen-2-yl, 3-hydroxynaphth-2-yl, etc.) was employed for the preparation of the xanthones. This method proceeded through an intermol. etherification-acylation to give target heterocycles in good yields (up to 91%). Multi-substituted xanthones I were gained by shifting the substituent of salicylates or diaryliodonium salts.

Chinese Chemical Letters published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Computed Properties of 596-38-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chen, Sheng published the artcileA high-throughput screening assay for identification of chemicals with liver tumor promoting potential using a transgenic zebrafish line, Name: 4,4′-Sulfonyldiphenol, the publication is Chemosphere (2022), 134169, database is CAplus and MEDLINE.

Traditional high-throughput methods for identification of chems. with liver tumor promotion potentials are based on established cancer cell lines, and rapid and cost-effective high-throughput screening assays in whole organisms are presently lacking. In this study, a transgenic zebrafish liver cancer model was employed to develop a method that could be used to identify chems. with liver tumor promotion effect quickly and accurately. The method consisted of three parts, including exposure preparation, exposure process and image acquisition. In brief, after chem. exposure for 7 days, 96-well plate exposure system for zebrafish larvae was assessed by microplate reader. Then, the liver cancer promoting potential chems. were evaluated by field area and field average intensity of fluorescence. The results were further validated by conducting histopathol. examination Our data demonstrated that the high-throughput screening assay developed in this study was reproducible and could be used to rapidly screen chems. with liver tumor promoting potentials by using tris-(2-chloropropyl)-phosphate (TDCIPP) as a pos. control. Furthermore, some other pos. chems. found in previous studies and environmental compounds were assessed using the established method. Results indicated that 86.7% of the pos. chems. and five environmental compounds out of seventeen compounds could enhance liver tumor progression.

Chemosphere published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Name: 4,4′-Sulfonyldiphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhu, Yuanzhao published the artcileEffect of weak intermolecular interactions in micro/nanoscale polyphosphazenes and polyethylene terephthalate composites on flame retardancy, Recommanded Product: 4,4′-Sulfonyldiphenol, the publication is Polymers for Advanced Technologies (2022), 33(7), 2231-2243, database is CAplus.

This study investigates the effects of weak intermol. interactions on the flame retardancy of a poly(ethylene terephthalate) (PET) and polyphosphazene flame retardant. Monodispersed poly-(cyclotriphosphazene-co-4,4′-sulfonyldiphenol) (PZS) microspheres with different diameters were synthesized by controlling the reactant concentration Simulation studies revealed that the weak intermol. interactions between PZS and PET predominantly include strong hydrogen bonding and π-π interactions. The weak intermol. interactions imparted high thermal stability, even in the molten state, and PZS microspheres with smaller diameters achieved stronger hydrogen bonds and π-π interactions with PET. The diameter of the PZS microspheres influenced the limiting oxygen index value and UL-94 rating. Increasing the carbon residue alone was insufficient to promote the flame retardancy, and the weak intermol. interactions played an important role. Thus, stronger weak-intermol.-interactions are beneficial for realizing a material with superior flame retardancy and anti-dropping performance.

Polymers for Advanced Technologies published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C13H9FO2, Recommanded Product: 4,4′-Sulfonyldiphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts