Tag: M.W=250-300

Duenas-Mas, Maria Jesus published the artcileSupramolecular solvent-based microextraction probe for fast detection of bisphenols by ambient mass spectrometry, Computed Properties of 80-09-1, the publication is Chemosphere (2022), 133719, database is CAplus and MEDLINE.

In this study, we investigated for the first time the suitability of supramol. solvent (SUPRAS)-based microextraction probe for the development of generic and fast sample treatment prior to qual. anal. by ambient mass spectrometry (AMS) based on ASAP (atm. solids anal. probe). SUPRAS are nanostructured liquids formed by the self-assembly of amphiphilic aggregates with multiple binding sites and microenvironments of different polarity for the efficient extraction of multiple compounds Different types of SUPRAS were evaluated as a simple and single step sample treatment for ASAP. The method was applied to the screening of bisphenol A and structural analogs in thermal paper. Optimal results were achieved with SUPRAS synthesized with 1-decanol in mixtures of ethanol:water. SUPRAS (1.1-2μL) were loaded onto glass probes and placed in contact with samples for 10 s before ASAP anal. AMS signal peaks (width: 0.2-0.5 min) were easily integrated and normalized with internal standards (RSD: 2-25%). The method was applied to 62 samples of thermal paper. BPA and BPS were the most widely used, this highlighting the progressive industrial replacement of BPA by BPS.

Chemosphere published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Computed Properties of 80-09-1.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

McClelland, Robert A. published the artcileElectrophilic reactions of xanthylium carbocations produced by flash photolysis of 9-xanthenols, Quality Control of 596-38-3, the publication is Journal of the American Chemical Society (1989), 111(8), 2929-35, database is CAplus.

The xanthylium ion and eight 9-aryl derivatives (p-MeO-, p-Me-, m-Me-, H-, p-F-, m-MeO-, p-Cl-, and p-CF₃C₆H₄) were produced in 1:4 acetonitrile/water by flash photolysis of the corresponding 9-xanthenols. The identifications of the transients as xanthylium cations were based upon their characteristic absorption spectra, as well as upon experiments with time-resolved conductivity detection. Rate constants for the reactions of these cations with solvent, with four anionic nucleophiles, and with four neutral nucleophiles (primary amines) were measured. The 9-arylxanthylium ions, which have solvent rate constants (k(solv)) at 25° ranging from 11 to 34 s^-1, follow the Ritchie equation, a plot of log k(nucleophile) vs. the nucleophile N₊ parameter being linear with a slope near unity. For the more reactive parent cation, which has k(solv) at 20° of 2.3 × 10⁴ s^-1, the rate constants k(nucleophile) are more poorly correlated with N₊ and the slope is less than unity. The failure to obey the Ritchie relationship is suggested to be associated with the rate constants becoming controlled by diffusion (azide ion) or desolvation (amines).

Journal of the American Chemical Society published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Quality Control of 596-38-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lei, Zhen published the artcileβ-Selective Aroylation of Activated Alkenes by Photoredox Catalysis, Name: ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, the publication is Angewandte Chemie, International Edition (2019), 58(22), 7318-7323, database is CAplus and MEDLINE.

Late-stage synthesis of α,β-unsaturated aryl ketones remains an unmet challenge in organic synthesis. Reported herein is a photocatalytic non-chain-radical aroyl chlorination of alkenes by a 1,3-chlorine atom shift to form β-chloroketones as masked enones that liberate the desired enones upon workup. This strategy suppresses side reactions of the enone products. The reaction tolerates a wide array of functional groups and complex mols. including derivatives of peptides, sugars, natural products, nucleosides, and marketed drugs. Notably, addition of 2,6-di-tert-butyl-4-methylpyridine enhances the quantum yield and efficiency of the cross-coupling reaction. Exptl. and computational studies suggest a mechanism involving PCET (proton-coupled electron transfer), formation and reaction of an α-chloro-α-hydroxy benzyl radical, and 1,3-chlorine atom shift. Thus, e.g., irradiation of a reaction mixture containing 4-fluorobenzoyl chloride, 1,1-diphenylethylene, fac-Ir(ppy)₃ and 2,6-di-tert-butyl-4-methylpyridine in CHCl₃ in CHCl₃ with blue LEDs afforded I (85%) upon isolation.

Angewandte Chemie, International Edition published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, Name: ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Schonberg, Alexander published the artcileAction of Grignard reagents. II. Replacement of the oxygen atoms of ketones by two hydrocarbon radicals by the action of Grignard reagents, Recommanded Product: 9-Phenyl-9H-xanthen-9-ol, the publication is Journal of the Chemical Society (1946), 609-10, database is CAplus.

cf. C.A. 39, 65.1. PhMgBr (from 15 g. PhBr) and 5 g. xanthone in 40 cc. ether and 30 cc. C₆H₆, refluxed 5 hrs., allowed to stand overnight, and the residue extracted repeatedly with petr. ether, give, in addition to the main product [phenylxanthydrol (I)], 0.5 g. of 9,9-diphenylxanthene [Ullmann and Engi, Ber. 37, 2367(1904), reported only I]. Similarly, o-MeC₆H₄MgBr yields 9,9-di-o-tolylxanthene, m. 119°. 2,3,6,5-Dithianaphtheno-1,4-thiapyrone (II)(Part I) and PhCH₂MgCl in ether-C₆H₆, refluxed 5 hrs. and the product decomposed with dilute HCl, give 4,4-dibenzyl-2,3,6,5-dithianaphtheno-1,4-thiapyran (III), m. 176°; it does not react with Ac₂O; the concentrated H₂SO₄ solution is yellow. In another experiment the product was 4-hydroxy-4-benzyl-2,3,6,5-dithianaphtheno-1,4-thiapyran, light yellow, m. 220°; refluxed with Ac₂O for 3 hrs., it yields the 4-benzylidene derivative, light yellow, m. 244°. II and PhMgBr give the 4,4-diphenyl homolog of III, yellow, m. 235°, and m-MeC₆H₄MgBr yields the 4,4-ai-m-tolyl homolog, yellow, m. 219°. (p-MeC₆H₄)₂O (10 g.), 25 g. (COCl)₂, 10 g. AlCl₃ and 75 cc. CS₂ give 80% of 2,7-tlimethylxanthone.

Journal of the Chemical Society published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Recommanded Product: 9-Phenyl-9H-xanthen-9-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ilem-Ozdemir, Derya published the artcileRadiolabeling and in vitro evaluation of a new 5-fluorouracil derivative with cell culture studies, Category: alcohols-buliding-blocks, the publication is Journal of Labelled Compounds and Radiopharmaceuticals (2019), 62(13), 874-884, database is CAplus and MEDLINE.

The clin. impact and accessibility of ^99mTc tracers for cancer diagnosis would be greatly enhanced by the availability of a new, simple, and easy labeling process and radiopharmaceuticals. 5-Fluorouracil is an antitumor drug, which has played an important role for the treatment of breast carcinoma. In the present study, a new derivative of 5-Fluorouracil was synthesized as (1-[{1′-(1”-deoxy-2”,3”:4”,5”-di-O-isopropylidene-β-D-fructopyranose-1”-yl)-1’H-1′,2′, 3′-triazol-4′-yl}methyl]-5-fluorouracil) (E) and radiolabeled with ^99mTc. It was analyzed by radio thin layer chromatog. for quality control and stability. The radiolabeled complex was subjected to in vitro cell-binding studies to determine healthy and cancer cell affinity using HaCaT and MCF-7 cells, resp. In addition, in vitro cytotoxicity studies of compound E were performed with HaCaT and MCF-5 cells. The radiochem. purity of the [^99mTc]TcE was found to be higher than 90% at room temperature up to 6 h. The radiolabeled complex showed higher specific binding to MCF-7 cells than HaCaT cells. IC₅₀ values of E were found 31.5 ± 3.4μM and 20.7 ± 2.77μM for MCF-7 and HaCaT cells, resp. The results demonstrated the potential of a new radiolabeled E with ^99mTc has selective for breast cancer cells.

Journal of Labelled Compounds and Radiopharmaceuticals published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Salahinejad, Arash published the artcileMaternal exposure to bisphenol S induces neuropeptide signaling dysfunction and oxidative stress in the brain, and abnormal social behaviors in zebrafish (Danio rerio) offspring, Quality Control of 80-09-1, the publication is Science of the Total Environment (2022), 154794, database is CAplus and MEDLINE.

Recent studies show that bisphenol S (BPS) induces multiple adverse effects in exposed organisms; however, the maternal effects of BPS exposure remain poorly understood. Here, we expose adult female zebrafish to environmentally relevant concentrations of BPS (0, 1, 10, 30μg/L) and 1μg/L of 17-β-estradiol (E2) as a pos. control for 60 days. Females were then paired with BPS-unexposed males and their offspring were raised in control water for 6 mo. Maternal exposure to BPS was found to alter social behavior and anxiety response in a dose-specific manner in male offspring. Group preferences and social cohesion were significantly reduced by maternal exposure to 1 and 10μg/L BPS, resp. Addnl., maternal exposure to 1 and 30μg/L BPS and E2 decreased offspring stress responses during the novel tank test. The impaired social behavior was associated with elevated arginine-vasotocin (AVT) level as well as with the altered expression of genes involved in AVT signaling pathway (AVT, avpr1aa) and enzymic antioxidant genes (cat and Mn-sod) in the brain. Collectively, these results suggest that maternal exposure to environmentally relevant concentrations of BPS alters social behavior in zebrafish offspring, which is likely mediated by oxidative stress and disruption of neuropeptide signaling pathways in the brain.

Science of the Total Environment published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Quality Control of 80-09-1.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Erabi, Tatsuo published the artcile9-Phenylxanthen-9-ylium and 9-phenylthioxanthen-9-ylium ions: Comparison of o- and p-substitutions in the 9-phenyl group by cyclic voltammetry and visible spectra, Recommanded Product: 9-Phenyl-9H-xanthen-9-ol, the publication is Bulletin of the Chemical Society of Japan (2002), 75(6), 1325-1332, database is CAplus.

9-Arylxanthen-9-ylium and 9-arylthioxanthen-9-ylium perchlorates I [X = O, S; R = Ph, 2,4,6-(MeO)₃C₆H₂, 2,6-(MeO)₂C₆H₃, 2-MeOC₆H₄, 4-MeOC₆H₄, etc.] were prepared by the reactions of the corresponding 9-arylxanthen-9-ols or 9-arylthioxanthen-9-ols II with HClO₄. The LUMO and HOMO levels of I were estimated from the redox potential (E₀) in cyclic voltammetry and λ_max in the UV-visible spectra measured for a 1,2-dichloroethane solution, and were compared with those of 9-aryl-1,8-dimethoxyxanthen-9-ylium ions III. The studies showed that (1) both the LUMO and HOMO levels varied almost in the same order of substituent on the 9-Ph group; (2) the MeO-group on the 9-Ph group was more effective to raise both the HOMO and LUMO levels than the Me-group; (3) the HOMO levels of I were more sensitive than the LUMO levels to the change in the 9-aryl group; (4) p-substitution by MeO- or Me-groups was more effective to raise the HOMO and LUMO levels than o-substitution; (5) the presence of two o-MeO groups was more effective to raise the HOMO and LUMO levels than one o-MeO group; (6) m-bromination of 9-aryl group in I [X = O, S; R = 2,6-(MeO)₂C₆H₃] greatly lowered both LUMO and HOMO levels; (7) both the HOMO and LUMO levels of III [R = Ph, 2,6-(MeO)₂C₆H₃] were higher than those of the resp. I [X = O; R = Ph, 2,6-(MeO)₂C₆H₃]; (8) the LUMO level of I [X = O, R = 2,6-(MeO)₂C₆H₃] was higher than that of III (R = Ph), the isomer.

Bulletin of the Chemical Society of Japan published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Recommanded Product: 9-Phenyl-9H-xanthen-9-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Memon, Almas F. published the artcileElectrochemical monitoring of bisphenol-s through nanostructured tin oxide/Nafion/GCE: A solution to environmental pollution, Formula: C12H10O4S, the publication is Chemosphere (2022), 303(Part_3), 135170, database is CAplus and MEDLINE.

Over the past few decades, phenolic compounds have been broadly exploited in the industries to be utilized in several applications including polycarbonate plastic, food containers, epoxy resins, etc. One of the major compounds in phenolics is Bisphenol-S (BPS) which has dominantly replaced Bisphenol-A in several applications. Phenolic compounds are extensively drained into the environment without proper treatment and cause several health hazards. Thus, to tackle this serious problem an electrochem. sensor based on SnO2/GCE has been successfully engineered to monitor the low-level concentration of BPS in water samples. The fabrication of SnO₂ nanoparticles (SnO₂ NPs) was confirmed through FTIR, XRD, and TEM to examine the size, crystallinity, internal texture, and functionalities of the prepared material. The fabricated material was exploited as a chem. modified sensor for the determination of BPS in water samples collected from different sources. Under optimal conditions such as scan sweep 100 mV/s, PBS electrolyte pH of 6, potential window (0.3-1.3 V), the proposed sensor manifested an excellent response for BPS. The LOD of the present method for BPS was calculated as 0.007μM, resp. Moreover, the stability and selectivity profile of SnO₂/GCE for BPS in the real matrix was examined to be outstanding.

Chemosphere published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Formula: C12H10O4S.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Capo, Xavier published the artcileQuantification of differential tissue biomarker responses to microplastic ingestion and plasticizer bioaccumulation in aquaculture reared sea bream Sparus aurata, Product Details of C12H10O4S, the publication is Environmental Research (2022), 113063, database is CAplus and MEDLINE.

Marine aquaculture is considered a potential source of microplastics (MPs). MPs can induce oxidative stress and damage in marine species. In this study we evaluated the impact of MPs intake in the com. fish, Sparus aurata, from aquaculture facilities and the antioxidant response associated to this MPs ingestion in caged specimens for 120 days. Sampling was carried out at the beginning of the study (T0), at 60 days (T60) and at 120 days (T120). At each sampling stage, gastrointestinal tract, blood, plasma, liver and muscle samples were obtained to analyze MPs intake (gastrointestinal tract), oxidative stress markers (blood, plasma and liver) and plasticizers bioaccumulation (muscle). Fish sampled at T60 presented the highest MPs intake and plasticizers accumulated in muscle over time, but with a different pattern according to type: bisphenols and phthalates. This indicates MPs ingestion induces a differential tissue response in S. aurata. Similarly, stress biomarkers presented a differential response throughout the study, depending on the analyzed tissue. In the case of oxidative damage markers, for malondialdehyde (MDA) an increase throughout the study was observed both in liver and blood cells but with a progressive decrease in plasma. In the case of phase I detoxifying enzyme activities in liver, 7-ethoxyresorufin O-deethylase (EROD), 7-benzyloxy-4-[trifluoromethyl]-coumarin-O-debenzyloxylase (BFCOD) and carboxylesterases (CE), showed a comparable decrease at T60 with a slight recovery at T120. In contrast, glutathione-S-transferase (GST) activity was significantly enhanced at T60 compared to the other sampling stages. In conclusion, MPs ingestion occurs in aquaculture reared seabream where potentially associated plasticizers accumulate in the muscle and both could be responsible for plasma and liver oxidative stress damage and alterations on detoxifying biomarkers responses.

Environmental Research published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Product Details of C12H10O4S.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Pickel, Thomas C. published the artcileEsterification by Redox Dehydration Using Diselenides as Catalytic Organooxidants, Computed Properties of 20880-92-6, the publication is Journal of Organic Chemistry (2019), 84(9), 4954-4960, database is CAplus and MEDLINE.

Ortho-functionalized aryl diselenides are catalytic (5.0 mol %) oxidants for the construction of esters from carboxylic acids and alcs. in the presence of stoichiometric tri-Et phosphite and dioxygen in air as the terminal redox reagents (redox dehydration conditions). The reaction proceeds through the intermediacy of the anhydride and requires the presence of 10% DMAP to drive the esterification.

Journal of Organic Chemistry published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, Computed Properties of 20880-92-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts