Tag: M.W=250-300

Barton, Benita published the artcileSynthesis of N,N’-bis(9-phenylxanthen-9-yl)ethylenediamine and an investigation of its host-guest inclusion potential, SDS of cas: 596-38-3, the publication is Perkin 2 (2000), 865-869, database is CAplus.

The novel amine, N,N’-bis(9-phenylxanthen-9-yl)ethylenediamine (I), was synthesized by treating 9-phenylxanthen-9-ylium perchlorate with ethylenediamine. Its host potential was assessed by allowing it to crystallize from a range of organic solvents (single and binary mixtures), of which several were found to be included. The stoichiometries of these host-guest complexes were determined through ¹H-NMR anal. and their stabilities assessed through thermal anal. Single crystal x-ray crystallog. was used to elucidate the crystal structure of the 1:1 I·THF inclusion complex. It was found that only one of the two amine moieties of the host functions as a donor, forming a nearly linear hydrogen bond to the oxygen atom of the guest mol. Each THF mol. is effectively surrounded by host mols. so that the THF mols. are found to occupy discrete “cavities” within the host lattice. The activation energy associated with desolvation of the I·THF complex was determined through thermal anal. and was found to decrease as desolvation progressed.

Perkin 2 published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, SDS of cas: 596-38-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Dag, Aydan published the artcileModulating the cellular uptake of platinum drugs with glycopolymers, SDS of cas: 20880-92-6, the publication is Polymer Chemistry (2016), 7(5), 1031-1036, database is CAplus.

The therapeutic potency of platinum-based anticancer drugs can be substantially improved through the use of polymeric nanocarrier systems to target cancer cells efficiently. We synthesized a series of glyco-block copolymers with three different sugars able to self-assemble into nanoparticles when conjugated with 1,2-diamino-cyclopentane platinum(II) (DACP-Pt). The polymers are based on (2-(D-glucosyloxy)ethyl methacrylate (glucose; GlcMA), 2-(D-galactosyloxy)ethyl methacrylate (galactose; GalMA), 1-O-methacryloyl-β-D-fructopyranose (fructose; FrucMA1), and 3-O-methacryloyl-β-D-fructopyranose (fructose; FrucMA3)). They are all readily taken up intracellularly by the breast cancer cell lines MCF-7 and MDA-MB-231 and the ovarian cancer cell line A2780. All cell lines expressed a high preference for the fructose coated nanoparticles. The nanocarriers were themselves nontoxic, but exhibited high cytotoxicity and increased efficacy when conjugated with the DACP-Pt drug.

Polymer Chemistry published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, SDS of cas: 20880-92-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gerke, Christoph published the artcileDirect glucosone-based synthesis and HILIC-ESI-MS/MS characterization of N-terminal fructosylated valine and valylhistidine for validation of enzymatic HbA_1c assays in the diagnosis of diabetes mellitus, Formula: C12H20O6, the publication is Analytical and Bioanalytical Chemistry (2019), 411(30), 7967-7979, database is CAplus and MEDLINE.

Naturally occurring fructosamines are of high clin. significance due to their potential use in diabetes mellitus monitoring (quantification of fructosylated Hb, HbA_1c) or for the study of their reactivity in consecutive reactions and harmfulness towards the organism. Here the authors report the specific synthesis of the fructosylated dipeptide L-valyl-L-histidine (Fru-Val-His) and fructosylated L-valine (Fru-Val). Both are basic tools for the development and validation of enzymic HbA_1c assays. The two fructosamine derivatives were synthesized via a protected glucosone intermediate which was coupled to the primary amine of Val or Val-His, performing a reductive amination reaction. Overall yields starting from fructose were 36% and 34% for Fru-Val and Fru-Val-His, resp. Both compounds were achieved in purities and > 90%. A HILIC-ESI-MS/MS method was developed for routine anal. of the synthesized fructosamines, including starting materials and intermediates. The presented method provides a well-defined and efficient synthesis protocol with purification steps and characterization of the desired products. The functionality of the fructosylated dipeptide has been thoroughly tested in an enzymic HbA_1c assay, showing its concentration-dependent oxidative degradation by fructosyl-peptide oxidases (FPOX).

Analytical and Bioanalytical Chemistry published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, Formula: C12H20O6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Misetic, Ana published the artcileThe pixyl (Px) group: a novel photocleavable protecting group for primary alcohols, Related Products of alcohols-buliding-blocks, the publication is Tetrahedron Letters (1998), 39(13), 1653-1656, database is CAplus.

The 9-phenylxanthyl (pixyl or Px) moiety has been investigated as a potential photocleavable protecting group for primary alcs. Alcs. were protected in good yield by treatment with 9-chloro-9-phenylxanthene in dry pyridine at room temperature Irradiation of the alc. derivatives in neutral aqueous acetonitrile regenerates the alcs. and the 9-phenylxanthyl alc.

Tetrahedron Letters published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Valentino, Maria R. published the artcileQuenching behavior of singlet excited 9-arylxanthylium cations, Computed Properties of 596-38-3, the publication is Journal of Organic Chemistry (1993), 58(21), 5826-31, database is CAplus.

Several 9-arylxanthylium tetrafluoroborate salts (Ar = H, p, m-F, p, m-Me, m-OMe) were synthesized by reaction of the corresponding 9-arylxanthen-9-ol with fluoroboric acid. Spectral characteristics of the xanthyl cations were identical to those previously reported for the cations generated by alternate methods. The 9-arylxanthyl cation fluorescence was quenched by the addition of H₂O, MeOH, i-PrOH, and t-BuOH. Stern-Volmer anal. of the fluorescence quenching gave bimol. excited-state rate constants ranging from 10⁶ to 10¹⁰ M^-1 s^-1, with the larger rate constants associated with electron-donating substituents. Hammett plots of log[k_q(X)/k_q(H)] vs. σ^hv gave neg. ρ values for each quencher, opposite to the substituent dependence observed for ground-state cations reacting with nucleophiles. The relative quenching order also differs from the order observed for ground-state cation reactions. The mechanism for quenching of the singlet excited 9-arylxanthylium cations is evaluated in terms of nucleophilic attack. The possibility of an electron-transfer mechanism is considered and eliminated.

Journal of Organic Chemistry published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C6H8BNO3, Computed Properties of 596-38-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cui, Yuan-Yuan published the artcileSolvent regulation and template-free synthesis of β-cyclodextrin-based microporous organic network nanosheets for ultrafast and efficient removal of aromatic pollutants, Name: 4,4′-Sulfonyldiphenol, the publication is Chemical Engineering Journal (Amsterdam, Netherlands) (2022), 435(Part_1), 134829, database is CAplus.

Layer-stacking structures via the template-free synthesis are rare in two-dimensional microporous organic networks (2D MONs). Herein, we report a facile solvent regulation and template-free strategy by tuning the aggregation degree of 2D β-cyclodextrin (CD)-based MONs nanosheets. The 2D MON nanosheets provided larger uptake capacity and faster kinetics than the aggregated CD-MONs, revealing the significance of morphol. control for the removal of pollutants. The prepared 2D CD-MON-DMF gave ultrafast adsorption kinetics and exhibited much larger saturation sorption capacity (327.9 mg g^-1) than previous adsorbents for bisphenol AF. The developed strategy not only provides a novel way to construct 2D MON nanosheets for highly efficient removal of organic pollutants from water but also promotes the utilization of MONs in material and environmental sciences.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Name: 4,4′-Sulfonyldiphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Azarani, A. published the artcileElectron transfer reactions between excited diarylmethyl and triarylmethyl carbocations and aromatic donors, Computed Properties of 596-38-3, the publication is Journal of Photochemistry and Photobiology, A: Chemistry (1991), 57(1-3), 175-89, database is CAplus.

The excited singlet states of diarylmethyl and triarylmethyl carbocations were characterized by fluorescence. The dibenzosuberenyl, xanthenyl, and 9-phenylxanthenyl cations are strongly fluorescent and have fluorescence lifetimes in the 30-40 ns range in 2,2,2-trifluoroethanol. The fluorescence of each of these cations is efficiently quenched by a variety of substituted aromatics (e.g., cumene, anisole, toluene) with rate constants in excess of 10⁹ M^-1 s^-1. There is a correlation between the observed rate constants and the oxidation potential of the aromatic quencher which suggests that an electron transfer process occurs to generate a radical/radical cation pair. This hypothesis is confirmed by irradiation of the dibenzosuberenyl cation in the presence of benzyltrimethylsilane. This reaction produces 5-benzyldibenzocycloheptene, which is formed by addition of the benzyl radical produced via cleavage of the silane radical cation to either the dibenzosuberenyl radical or cation. Quenching studies suggest that the efficiency of product formation is controlled by the competition between cage escape and back electron transfer for the initial geminate radical/radical ion pair.

Journal of Photochemistry and Photobiology, A: Chemistry published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Computed Properties of 596-38-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Rokade, Sunil M. published the artcilePractical preparation of mono- and di-O-isopropylidene derivatives of monosaccharides and methyl 4,6-O-benzylidene glycosides from free sugars in a deep eutectic solvent, Computed Properties of 20880-92-6, the publication is Journal of Carbohydrate Chemistry (2017), 36(1), 20-30, database is CAplus.

Free sugars were rapidly converted into the corresponding di-O-isopropylidene derivatives and Me O-benzylidene glycosides in excellent yields and purity in a deep eutectic solvent made from choline chloride and malonic acid (ChCl:MA). Reaction conditions were mild; work-up was easy, and further purification was not necessary. Given the inexpensive, nontoxic, and recyclable nature of ChCl:MA, this protocol is environmental friendly.

Journal of Carbohydrate Chemistry published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, Computed Properties of 20880-92-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kumari, Aloka published the artcilePlant growth regulator interactions in physiological processes for controlling plant regeneration and in vitro development of Tulbaghia simmleri, Quality Control of 1122579-42-3, the publication is Journal of Plant Physiology (2018), 65-71, database is CAplus and MEDLINE.

The endogenous auxin and cytokinin contents of in vitro regenerated T. simmleri maintained on applied plant growth regulators in Murashige and Skoog (MS) medium were investigated using UHPLC-MS anal. The highest number of shoots (27.6 per leaf) were produced in MS medium supplemented with 2.5 μM thidiazuron. A higher number of these shoots were rooted with 10 μM 6-(2-hydroxy-3-methylbenzylamino) purine (PI-55, cytokinin antagonist). The production of somatic embryos (SEs: 16.4-4.6, globular to cotyledonary stages) improved significantly with liquid MS medium containing 2.5 μM picloram, 2.5 μM phloroglucinol (PG) and 1.5 μM gibberellic acid or 1.5 μM PI-55 and 1.0 μM trans-zeatin. SEs (torpedo and cotyledonary stages) germinated (100%) in plant growth regulator-free MS medium. The plantlets were acclimatized and all survived in the greenhouse. Higher levels of endogenous auxin, 2-oxindole-3-acetic acid (oxIAA, 371.52 pmol/g DW) and indole-3-acetylaspartate (IAAsp, 141.56 pmol/g DW) were detected in shoots from PG treatments. The roots of garden-grown mother plants possessed the highest level of indole-3-acetic acid (IAA, 630.54 pmol/g DW) and oxIAA (515.26 pmol/g DW). Cytokinins [CKs: trans-zeatin-O-glucoside (tZOG), cis-zeatin (cZ) and N⁶-isopentenyladenosine-5′-monophosphate (iPRMP)] levels were relatively high in shoots and roots of plantlets in vitro. However, PI-55 treatments influenced the development of plantlets promoting a higher biosynthesis level of iPRMP (418.06 pmol/g DW in root) and cZRMP (904.61 pmol/g DW in roots and 1427.83 pmol/g DW in shoots). Thus, the presented protocols offer organogenesis and somatic organogenesis systems for rapid plant regeneration of T. simmleri. In addition, the importance of exogenous and endogenous hormonal effects on in vitro plant growth and development as well as endogenous hormone metabolism signaling and transport related to the physiol. processes of CK metabolism and transport were illustrated for in vitro development of T. simmleri.

Journal of Plant Physiology published new progress about 1122579-42-3. 1122579-42-3 belongs to alcohols-buliding-blocks, auxiliary class 5.6_Aromatics,Purines, name is 2-(((9H-Purin-6-yl)amino)methyl)-6-methylphenol, and the molecular formula is C13H13N5O, Quality Control of 1122579-42-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kumari, Aloka published the artcileIn vitro propagation via organogenesis and embryogenesis of Cyrtanthus mackenii: a valuable threatened medicinal plant, Product Details of C13H13N5O, the publication is Plant Cell, Tissue and Organ Culture (2017), 131(3), 407-415, database is CAplus.

Efficient and simple, organogenesis (direct and indirect) and somatic embryogenesis (cell suspension) systems were developed for in vitro propagation of Cyrtanthus mackenii, a valuable economic plant from leaf explants cultured on Murashige and Skoog (MS) medium supplemented with various concentrations and combinations of sucrose, plant growth regulators (PGRs), glutamine, phloroglucinol (PG) and 6-(2-hydroxy-3-methylbenzylamino) purine (PI55). MS medium solidified with 8 g L^-1 agar (MS_S) containing 40 g L^-1 sucrose, 10 μM picloram, 2.5 μM benzyladenine (BA) and 20 μM glutamine produced a higher number of shoots from white nodular callus. This was however, not significantly different to direct shoot regeneration on media containing 10 μM picloram, 2.5 μM BA and a reduced concentration of sucrose and glutamine. The regenerated shoots were rooted best with MS_S medium incorporating 10 μM PG. The number of somatic embryos (SEs) were significantly higher using liquid MS medium containing 30 g L^-1 sucrose, 0.5 μM picloram, 1 μM thidiazuron or BA and 3 μM glutamine or gibberellic acid. The embryos were germinated in PGR-free MS_S medium. All plantlets were successfully acclimatized in the greenhouse. Histol. studies confirmed the different developmental stages and bipolar structure of SE. The organogenesis and somatic embryogenesis protocols provides a system for large scale propagation and germplasm conservation. Developed protocols can be used for clonal production and pharmacol. and genetic transformation studies.

Plant Cell, Tissue and Organ Culture published new progress about 1122579-42-3. 1122579-42-3 belongs to alcohols-buliding-blocks, auxiliary class 5.6_Aromatics,Purines, name is 2-(((9H-Purin-6-yl)amino)methyl)-6-methylphenol, and the molecular formula is C13H13N5O, Product Details of C13H13N5O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts