Tag: M.W=250-300

Zhu, Zhen-Yuan published the artcileEfficient synthesis and activity of beneficial intestinal flora of two lactulose-derived oligosaccharides, Recommanded Product: ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, the publication is European Journal of Medicinal Chemistry (2016), 8-13, database is CAplus and MEDLINE.

Lactulose is considered as a prebiotic because it promotes the intestinal proliferation of Lactobacillus acidophilus which is added to various milk products. Moreover, lactulose is used in pharmaceuticals as a gentle laxative and to treat hyperammonemia. This study was aimed at the total synthesis of two Lactulose-derived oligosaccharides: one is 3-O-β-D-galactopyranosyl-D-fructose, D-fructose and β-D-galactose bounded together with β-1,3-glycosidic bound, the other is 1-O-β-D-galactopyranosyl-D-fructose, D-fructose and β-D-galactose bounded together with β-1,1-glycosidic bound, which were accomplished in seven steps from D-fructose and β-D-galactose and every step of yield above 75%. This synthetic route provided a practical and effective synthetic strategy for galacto-oligosaccharides, starting from com. available monosaccharides. Then we evaluated on their prebiotic properties in the search for potential agents of regulating and improving the intestinal flora of human. The result showed that the prebiotic properties of Lactulose-derived oligosaccharides was much better than Lactulose. Among them, 3-O-β-D-galactopyranosyl-D-fructose displayed the most potent activity of proliferation of L. acidophilus.

European Journal of Medicinal Chemistry published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C7H8FNO2S, Recommanded Product: ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tkalec, Ziga published the artcileLC-HRMS based method for suspect/non-targeted screening for biomarkers of chemical exposure in human urine, Category: alcohols-buliding-blocks, the publication is Chemosphere (2022), 134550, database is CAplus and MEDLINE.

Every day we are exposed to a cocktail of anthropogenic compounds many of which are biol. active and capable of inducing neg. effects. The simplest way to monitor contaminants in a population is via human biomonitoring (HBM), however conventional targeted approaches require foreknowledge of chems. of concern, often have compound specific extractions and provide information only for those compounds This study developed an extraction process for human biomarkers of interest (BoE) in urine that is less compound specific. Combining this with an ultra-high resolution mass spectrometer capable of operating in full scan, and a suspect and non-targeted anal. (SS/NTA) approach, this method provides a more holistic characterization of human exposure. Sample preparation development was based on enzymically hydrolyzed urine spiked with 34 native standards and extracted by solid-phase extraction (SPE). HRMS data was processed by MzMine2 and 80% of standards were identified in the final data matrix using typical NTA data processing procedures.

Chemosphere published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C11H10N4, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Harris, Sean M. published the artcileA Data Mining Approach Reveals Chemicals Detected at Higher Levels in Non-Hispanic Black Women Target Preterm Birth Genes and Pathways, HPLC of Formula: 80-09-1, the publication is Reproductive Sciences (2022), 29(7), 2001-2012, database is CAplus and MEDLINE.

Preterm birth occurs disproportionately in the USA non-Hispanic Black population. Black women also face disproportionate exposure to certain environmental chems. The goal of this study was to use publicly available toxicogenomic data to identify chem. exposures that may contribute to preterm birth disparities. We tested 19 chems. observed at higher levels in the blood or urine of non-Hispanic Black women compared to non-Hispanic White women. We obtained chem.-gene interactions from the Comparative Toxicogenomics Database and a list of genes involved in preterm birth from the Preterm Birth Database. We tested chems. for enrichment with preterm birth genes using chi-squared tests. We then conducted pathway enrichment anal. for the preterm birth genes using DAVID software and identified chem. impacts on genes involved in these pathways. Genes annotated to all 19 chems. were enriched with preterm birth genes (FDR-adjusted p value < 0.05). Preterm birth enriched chems. that were detected at the highest levels in non-Hispanic Black women included Me mercury, methylparaben, propylparaben, di-Et phthalate, dichlorodiphenyldichloroethylene, and bisphenol S. The preterm birth genes were enriched for pathways including “inflammatory response” (FDR-adjusted p value = 3 x 10-19), “aging” (FDR-adjusted p value = 4 x 10-8) and “response to estradiol” (FDR-adjusted p value = 2 x 10-4). Chems. enriched with preterm birth genes impacted genes in all three pathways. This study adds to the body of knowledge suggesting that exposures to environmental chems. contribute to racial disparities in preterm birth and that multiple chems. drive these effects. These chems. affect genes involved in biol. processes relevant to preterm birth such as inflammation, aging, and estradiol pathways.

Reproductive Sciences published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, HPLC of Formula: 80-09-1.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yin, Zhenting published the artcileHierarchical Ti3C2Tx@BPA@PCL for flexible polyurethane foam capable of anti-compression, self-extinguishing and flame-retardant, Quality Control of 80-09-1, the publication is Journal of Colloid and Interface Science (2022), 208-220, database is CAplus and MEDLINE.

It is of great importance to fabricate flexible polyurethane foam (FPUF) with superior mech. properties and flame retardancy for practical applications. Herein, organosilicon and Ph phosphorus compounds were synthesized and grafted on the surface of Ti₃C₂T_x (Ti₃C₂T_x@BPA@PCL) via in-situ polymerization Then, the FPUF composites were fabricated, combining intrinsic flame retardancy (9,10-dihydro-9-oxa-10-phosphaphenanthrene 10-oxide-diethanolamine: DH-DOPO) (addition amount: 20 wt%) and Ti₃C₂T_x@BPA@PCL (addition amount: 4 wt%). Attributed to the rigid structure of Ti₃C₂T_x@BPA@PCL, the tensile strength and compression strength of FPUF showed 24.0% and 253% increase, resp. In addition, anti-fatigue properties of FPUF composites during the cyclical test were dramatically enhanced. In contrast to pure FPUF, 36.1% and 44.0% reductions in peak heat release rate (pHRR) and total heat release (THR) were achieved for the FPUF containing Ti₃C₂T_x@BPA@PCL and DH-DOPO, the production rate of carbon dioxide (CO₂) and carbon oxide (CO) also decreased by 40.3% and 52.1%, resp. FPUF4 showed self-extinguishing behavior, and passed the vertical burning test (VBT). This work provides a facile approach to preparing high-performance FPUF with enhanced mech. property and flame retardancy.

Journal of Colloid and Interface Science published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C2H4ClNO, Quality Control of 80-09-1.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Yuhuan published the artcileTailoring diameters of carbon nanofibers with optimal mesopores to remarkably promote hemin adsorption toward ultrasensitive detection of bisphenol A, Application of 4,4′-Sulfonyldiphenol, the publication is Food Chemistry (2022), 132628, database is CAplus and MEDLINE.

Bisphenol A (BPA) is a worldwide used endocrine disrupting chem. that can migration from food containers and packaging, resulting in bioaccumulation of BPA in humans and causing adverse health effects. Porous electrodes have been proved with large surface areas and high sensing abilities in electrochem. detection of BPA. However, how to tailor the pore sizes to further improve the sensing performance is still a great challenge. Here, we delicately tailored the diameters of carbon nanofibers (CNFs) by adjusting electrospinning parameters to have optimal mesopore structure for strong adsorption of hemin that has been demonstrated with high electrocatalytic activity for BPA sensing. Benefiting from the optimal mesopores structure of CNFs and the synergistic effect of hemin and CNFs, this hemin@CNFs based sensor achieves an ultrahigh sensitivity of 40.97μA cm-2μM-1, a low detection limit of 3.1 nM and satisfactory recoveries from 90.2% to 104.2% in the direct detection of BPA in liquors. This work offers a promising sensing platform for ultrasensitive monitoring of BPA.

Food Chemistry published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C5H7NO, Application of 4,4′-Sulfonyldiphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Hai-Jun published the artcileChemoselective, Scalable Nickel-Electrocatalytic O-Arylation of Alcohols, Product Details of C12H20O6, the publication is Angewandte Chemie, International Edition (2021), 60(38), 20700-20705, database is CAplus and MEDLINE.

Herein a Ni-catalyzed electrochem. driven protocol to afford aryl-alkyl ether bonds through O-arylation of alcs. was depicted. This electrochem. method did not require strong base, exogenous expensive transition metal catalysts (e.g., Ir, Ru), and could easily be scaled up in either a batch or flow setting. Interestingly, e-etherification exhibited an enhanced substrate scope over the mechanistically related photochem. variant as it tolerated tertiary amine functional groups in the alc. nucleophile. with a broad substrate scope in an operationally simple way.

Angewandte Chemie, International Edition published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C7H7IN2O, Product Details of C12H20O6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Mahale, Rajendra D. published the artcileCorey-Itsuno Reduction of Ketones: A Development of Safe and Inexpensive Process for Synthesis of Some API Intermediates, Related Products of alcohols-buliding-blocks, the publication is Organic Process Research & Development (2012), 16(4), 710-713, database is CAplus.

A safe and inexpensive procedure for asym. reduction of ketones using in situ prepared N,N-diethylaniline borane (DEANB) and oxazaborolidine catalyst from sodium borohydride, N,N-diethylaniline hydrochloride and (S)-α,α-diphenylprolinol is described. This protocol is demonstrated successfully to manufacture enantiopure dapoxetine at the plant scale.

Organic Process Research & Development published new progress about 156453-53-1. 156453-53-1 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Benzene,Naphthalene,Alcohol,Ether, name is (R)-3-(Naphthalen-1-yloxy)-1-phenylpropan-1-ol, and the molecular formula is C19H18O2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Arnett, Edward M. published the artcileMaster equations for calculating heterolysis energies in solution, Recommanded Product: 9-Phenyl-9H-xanthen-9-ol, the publication is Energy & Fuels (1987), 1(1), 17-23, database is CAplus.

The title LFER, in which carbocation stability is represented by the π-delocalization energy instead of k_R⁺, correlates. The reactions of six carbocations with twenty-one carbanions and five phenoxides with excellent statistical accuracy and self-consisting. This equation can be used to predict the bond heterolysise enthalpies when resonance stabilized ions are formed.

Energy & Fuels published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Recommanded Product: 9-Phenyl-9H-xanthen-9-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Le-Cheng published the artcileNickel-Catalyzed Four-Component Carbonylation of Ethers and Olefins: Direct Access to γ-Oxy Esters and Amides, Product Details of C12H20O6, the publication is Angewandte Chemie, International Edition (2022), 61(33), e202207970, database is CAplus and MEDLINE.

Multi-component carbonylation of olefins, a reaction that installs both a carbon-carbon(heteroatom) bond and a carbonyl group across the double bond, is an attractive strategy for alkene functionalization. Herein, a novel nickel-catalyzed four-component carbonylation of olefins with ethers under low CO gas pressure is developed. Using alcs. and amines as the reaction partner, diverse γ-oxy-substituted esters and amides were produced in good yields with excellent functional group tolerance. Notably, Naftidrofuryl, a medicine for the treatment of cerebrovascular disease (CVD), can be synthesized by this process straightforwardly.

Angewandte Chemie, International Edition published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C13H9FO, Product Details of C12H20O6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Le-Cheng published the artcileCobalt-Catalyzed Direct Aminocarbonylation of Ethers: Efficient Access to α-Amide Substituted Ether Derivatives, Category: alcohols-buliding-blocks, the publication is Angewandte Chemie, International Edition (2022), 61(23), e202203797, database is CAplus and MEDLINE.

Herein, a novel cobalt-catalyzed carbonylative coupling of ethers with amines to construct α-carbonylated ethers R¹C(O)NR²R³ [R¹ = tetrahydrofuran-2-yl, cyclopentyl, tetrahydropyran-2-yl, etc.; R² = Ph, 4-MeC₆H₄, 3-pyridyl, etc.; R³ = H, Me, Et] was repored. Remarkably, Alfuzosin, a medicine for treatment of benign prostatic hyperplasia (BPH), could be synthesized by this process straightforwardly. Notably, this protocol presented the first example on the direct carbonylative reaction of ethers.

Angewandte Chemie, International Edition published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C38H24F4O4P2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts