Tag: M.W=250-300

Yildirim, Ayhan published the artcileD-Fructose-Derived Acetonide as a Green Neutral Organocatalyst for Proficient One-Pot and Three-Component Preparation of 1,3-Benzoxazine Monomers, Product Details of C12H20O6, the publication is ChemistrySelect (2020), 5(23), 6971-6977, database is CAplus.

A series of 1,3-benzoxazine monomers were successfully synthesized by simple one-pot and three-component condensation of phenol, paraformaldehyde and varying types of primary aliphatic and aromatic amines in a molar ratio of 1 : 2 : 1 and in the presence of non-acidic 2,3;4,5-di-O-isopropylidene-β-D-fructopyranose as an effective green carbohydrate based organocatalyst obtained from renewable feedstock. This multicomponent method provided a convenient fast approach for the construction of valuable 1,3-benzoxazine monomers (8 examples) with moderate to excellent yields. The chem. structures of the synthesized benzoxazines were confirmed by FTIR, ¹H NMR, ¹³C NMR spectra and elemental anal.

ChemistrySelect published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C23H20BN, Product Details of C12H20O6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ginzburg, O. F. published the artcileProducts of condensation of arylcarbinols with 1-phenyl-3-methyl-5-pyrazolone. III, Product Details of C19H14O2, the publication is Zhurnal Obshchei Khimii (1957), 993-7, database is CAplus.

cf. C.A. 49, 1049a. Refluxing 0.3 g. 1-phenyl-3-methyl-5-pyrazolone and 0.4 g. 9-phenylxanthhydrol in dry MeOH 2 hrs. gave 95.8% 9-phenyl-9-(1-phenyl-3-methyl-4,5-dihydro-5-oxo-4-pyrazolyl)xanthene (I), m. 220-1°; also formed in AcOH solution The product can be dissolved in aqueous alc. NaOH, refluxed, and regenerated on acidification; it is also recovered readily after being refluxed in AcOH containing a little HCl. I (0.43 g.) in 10 ml. 60% EtOH containing 1 g. NaOH was treated with 0.001 mole diazosulfanilic acid and the resulting precipitate separated; the filtrate contained the azo dye from sulfanilic acid and the pyrazolone as shown by the absorption spectrum, while the precipitate was 9-phenylxanthhydrol, m. 159°. 1-Phenyl-3-methyl-4-triphenylmethyl-5-pyrazolone treated similarly gave the same azo compound in solution and a precipitate of Ph₃COH. Similar results were obtained with 1-phenyl-3-methyl-4-(9-phenyl-10-methyl-9,10-dihydro-9-acridyl)-5-pyrazolone (II), diphenyl-p-dimethylaminophenyl(1-phenyl-3-methyl-4,5-dihydro-5-oxo-4-pyrazolyl)methane, and bis(p-dimethylaminophenyl)phenyl(1-phenyl-3-methyl-4,5-dihydro-5-oxo-4-pyrazolyl)methane (III), all of which yielded the same azo compound in the solution Conductivity of II and III was determined in PhNO₂ over a period of time; a constant value is established only after 24 hrs. The results indicate that the increasing conductivity of such solutions is caused by cleavage between the 4-position of the pyrazolone and the arylcarbinyl group with formation of expected ionic charges. The process is unusually slow.

Zhurnal Obshchei Khimii published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Product Details of C19H14O2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Coutinho, Rodrigo published the artcileOptimisation of the conditions of dispersive liquid-liquid microextraction for environmentally friendly determination of bisphenols and benzophenone in complex water matrices by LC-MS/MS, HPLC of Formula: 80-09-1, the publication is Microchemical Journal (2022), 107636, database is CAplus.

Due to well-known risks to human and environmental health, the increasing presence of several micropollutants even in very low concentrations in environmental matrixes requires sustainable and advanced anal. methods to expand monitoring programs, particularly for water quality control. The objective of this study was to optimize the conditions of the dispersive liquid-liquid microextraction (DLLME) for a combined group of emerging micropollutants (bisphenol A, bisphenol S, bisphenol F, bisphenol AF and benzophenone) in complex water matrixes. Ten variables were chosen as the most important for DLLME procedure and the Design of Experiments (DoE) approach was applied to find the most relevant variables and optimize the DLLME procedure. The optimized DLLME was then, applied to real complex water samples including raw and treated wastewaters and surface water in Rio de Janeiro city, Brazil, and the extracted samples were analyzed by ultra-performance liquid chromatog.-tandem mass spectrometry (UPLC-MS/MS). The variables vortex mixing time (VMT), Dispersive Solvent Volume (DSV) and Extractor Solvent Volume (ESV) are the most important among the variables evaluated. The recovery efficiencies ranged from 60 to 120% after optimization the amounts of target compounds found in the five real aqueous matrixes varied from 0.005 to 150μg L-1. The association of optimized DLLME with the UPLC-MS/MS met the validation requirements adopted and generated anal. results of high quality. The advantages of this extraction technique include reduction of cost per anal.; low volume of samples and low volume of solvent required; no need to use cartridges; reduction of waste generation. The method is, therefore, suitable to process large numbers of samples, particularly in countries with limited budgets for environmental monitoring.

Microchemical Journal published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, HPLC of Formula: 80-09-1.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Pinto, Eduardo Costa published the artcileDevelopment and validation of a stability-indicating HPLC method for topiramate using a mixed-mode column and charged aerosol detector, Computed Properties of 20880-92-6, the publication is Journal of Separation Science (2018), 41(8), 1716-1725, database is CAplus and MEDLINE.

The anal. of topiramate in the presence of its main degradation products is challenging due to the absence of chromophore moieties and their wide range of polarity. Mixed-mode chromatog. has been used in such cases because it combines two or more modes of separation Charged aerosol detector is also an alternative since its detection is independent of optical properties and analyte ionization. This study is aimed to develop and validate two new stability-indicating methods by high-performance liquid chromatog. for the main degradation products of topiramate using mixed-mode chromatog. and a charged aerosol detector. Method 1 employed an Acclaim Trinity P1 column (3.0 mm × 150 mm, 2.7 μm) with a mobile phase comprising of 80% ammonium acetate buffer (20 mM, pH 4.0) and 20% methanol at a flow rate of 0.5 mL/min at 35°C. Method 2 utilized a C18 Acclaim 120 column (4.6 mm × 250 mm; 5 μm) with ACN/water (50:50) at a flow rate of 0.6 mL/min at 50°C. Validation of the two methods demonstrated excellent performance with respect to linearity, precision, accuracy, and selectivity. The limits of detection for topiramate, fructose, sulfate, sulfamate, and compound A were 2.97, 12.08, 4.02, 13.91, and 3.94 μg/mL, resp.

Journal of Separation Science published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, Computed Properties of 20880-92-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liu, Jiandong published the artcileNickel-catalyzed, regio- and enantioselective benzylic alkenylation of olefins with alkenyl bromide, SDS of cas: 20880-92-6, the publication is Angewandte Chemie, International Edition (2021), 60(8), 4060-4064, database is CAplus and MEDLINE.

A NiH-catalyzed migratory hydroalkenylation reaction of olefins with alkenyl bromides has been developed, affording benzylic alkenylation products with high yields and excellent chemoselectivity. The mild conditions of the reaction preclude olefinic products from undergoing further isomerization or subsequent alkenylation. Catalytic enantioselective hydroalkenylation of styrenes was achieved by using a chiral bisoxazoline ligand.

Angewandte Chemie, International Edition published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, SDS of cas: 20880-92-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cozens, F. L. published the artcileSpontaneous carbocation generation on clays, Safety of 9-Phenyl-9H-xanthen-9-ol, the publication is Langmuir (1993), 9(3), 874-6, database is CAplus.

Stable carbocations were generated from arylfluorenols I (R = R¹ = H, Me; R = H, R¹ = Me), phenylxanthenol II, and tritylamine incorporated on smectic montmorillonite. Diffuse reflectance spectra were obtained.

Langmuir published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Safety of 9-Phenyl-9H-xanthen-9-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Jia-Xin published the artcilePhotoredox-Catalyzed Allylic Defluorinative Alkoxycarbonylation of Trifluoromethyl Alkenes through Intermolecular Alkoxycarbonyl Radical Addition, Recommanded Product: ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, the publication is Organic Letters (2022), 24(7), 1471-1475, database is CAplus and MEDLINE.

Herein, a photoredox-catalyzed allylic defluorinative alkoxycarbonylation of trifluoromethyl alkenes ArC(CF₃):CH₂ (Ar = 4-BrC₆H₄, naphthalen-2-yl, 6-methoxypyridin-3-yl, etc.) enabled by intermol. alkoxycarbonyl radical addition is disclosed. A wide variety of alc. oxalate derivatives ROC(O)CO₂H (R = Me, t-Bu, cyclopentyl, L-menthyl, N-Boc-piperidin-4-yl, etc.) was amenable, affording various β-gem-difluoroalkene esters ArC(:CF₂)CH₂COOR with excellent functional group tolerance. Notably, the potential synthetic value of this method is highlighted by successful late-stage modification for bioactive mols.

Organic Letters published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C18H34N4O5S, Recommanded Product: ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Youcan published the artcilePalladium-Catalyzed Carbonylative Four-Component Synthesis of β-Perfluoroalkyl Amides, HPLC of Formula: 20880-92-6, the publication is Chemistry – A European Journal (2021), 27(70), 17682-17687, database is CAplus and MEDLINE.

Transition-metal-catalyzed multicomponent carbonylation is one of the most efficient strategies to construct carbonyl-containing compounds Herein, a palladium-catalyzed four-component perfluoroalkylation/aminocarbonylation of unactivated alkenes with perfluoroalkyl halides, and amines was developed. A wide range of substrates, including anilines, alkylamines, sulfonamides, and hydrazines are all suitable reaction partners for this catalyst system, resulting in various β-perfluoroalkyl amides with good functional-group tolerance and excellent chemoselectivity. Furthermore, not only alkyl olefins, but also aliphatic alkynes, and even alkyl allenes can all be employed. Notably, several medical and bioactive related mols. are compatible here as well.

Chemistry – A European Journal published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C19H14O2, HPLC of Formula: 20880-92-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Minguez-Alarcon, Lidia published the artcilePregnancy urinary concentrations of bisphenol A, parabens and other phenols in relation to serum levels of lipid biomarkers: Results from the EARTH study, Related Products of alcohols-buliding-blocks, the publication is Science of the Total Environment (2022), 155191, database is CAplus and MEDLINE.

The epidemiol. literature on associations between urinary phenol concentrations and lipid profiles during pregnancy is limited. We examined whether urinary concentrations of phenol and phenol replacement biomarkers were associated with serum lipid levels among pregnant women. This cross-sectional study included 175 women attending the Massachusetts General Hospital Fertility Center who enrolled in the Environment and Reproductive Health (EARTH) Study between 2005 and 2017 and had data available on urinary phenol biomarkers and serum lipids during pregnancy. We used linear regression models to assess the relationship between groups of urinary phenol and phenol replacement biomarkers and serum lipid levels [total cholesterol, high d. lipoprotein (HDL), non-HDL, low-d. lipoprotein (LDL) cholesterol, and triglycerides], while adjusting for age at sample collection, pre-pregnancy BMI, education, race, infertility diagnosis, cycle type, number of fetuses, trimester and sp. gr. In adjusted models, pregnant women with urinary propylparaben concentrations in the highest tertile had 10% [22 (95% CI = 5, 40) mg/dL], 12% [19 (95% CI = 2, 36) mg/dL] and 16% [19 (95% CI = 3, 35) mg/dL] higher mean total, non-HDL and LDL cholesterol, resp., compared to women with concentrations in the lowest tertile. Similar elevations were observed for urinary bisphenol A concentrations Urinary bisphenol S, benzophenone-3, triclosan, methylparaben, ethylparaben, and butylparaben were unrelated to serum lipids. Among pregnant women, urinary concentrations of bisphenol A and propylparaben were associated with higher serum levels of total, non-HDL and LDL cholesterol.

Science of the Total Environment published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jamnik, Thomas published the artcileNext-generation biomonitoring of the early-life chemical exposome in neonatal and infant development, Computed Properties of 80-09-1, the publication is Nature Communications (2022), 13(1), 2653, database is CAplus and MEDLINE.

Exposure to synthetic and natural chems. is a major environmental risk factor in the etiol. of many chronic diseases. Investigating complex co-exposures is necessary for a holistic assessment in exposome-wide association studies. In this work, a sensitive liquid chromatog.-tandem mass spectrometry approach was developed and validated. The assay enables the anal. of more than 80 highly-diverse xenobiotics in urine, serum/plasma, and breast milk; with detection limits generally in the pg-ng mL-1 range. In plasma of extremely-premature infants, 27 xenobiotics are identified; including contamination with plasticizers, perfluorinated alkylated substances and parabens. In breast milk samples collected longitudinally over the first 211 days post-partum, 29 analytes are detected, including pyrrolizidine- and tropane alkaloids which have not been identified in this matrix before. A preliminary estimation of daily toxicant intake via breast milk is conducted. In conclusion, we observe significant early-life co-exposure to multiple toxicants, and demonstrate the method′s applicability for large-scale exposomics-type cohort studies.

Nature Communications published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Computed Properties of 80-09-1.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts