Tag: M.W=250-300

Chen, Zhixiang published the artcileOxalic Diamides and tert-Butoxide: Two Types of Ligands Enabling Practical Access to Alkyl Aryl Ethers via Cu-Catalyzed Coupling Reaction, Category: alcohols-buliding-blocks, the publication is Journal of the American Chemical Society (2019), 141(8), 3541-3549, database is CAplus and MEDLINE.

A robust and practical protocol for preparing alkyl aryl ethers has been developed, which relies on using two types of ligands to promote Cu-catalyzed alkoxylation of (hetero)aryl halides. The reaction scope is very general for a variety of coupling partners, particularly for challenging secondary alcs. and (hetero)aryl chlorides. In case of coupling with aryl chlorides and bromides, two oxalic diamides serve as the powerful ligands. The tert-butoxide is first demonstrated as a ligand for Cu-catalyzed coupling reaction, leading to alkoxylation of aryl iodides complete at room temperature Addnl., a number of carbohydrate derivatives are applicable for this coupling reaction, affording the corresponding carbohydrate-aryl ethers in 29-98% yields.

Journal of the American Chemical Society published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Mandrah, Kapil published the artcileA study on bisphenol S induced nephrotoxicity and assessment of altered downstream kidney metabolites using gas chromatography-mass spectrometry based metabolomics, Product Details of C12H10O4S, the publication is Environmental Toxicology and Pharmacology (2022), 103883, database is CAplus and MEDLINE.

The global use of bisphenol S (BPS) has now been significantly increased for commensurate utilization as a substitute for BPA for its regulatory concerns. Though, previous reports indicated that BPS been also appeared as a toxic congener comparable to BPA. In the present study, we determined nephrotoxicity condition induced due to BPS exposure. Anal. indicated that BPS significantly promoted histopathol. disturbance in the kidney, and altered the levels of biomarkers of kidney damage in serum and urine samples of Wistar rats. It is also indicated that BPS altered the expression of kidney damage biomarkers associated with glomerular and tubular injury. Addnl., we determined the perturbation of kidney metabolites in the underlying pathophysiol. response of kidney injury due to BPS exposure. Gas chromatog.-mass spectrometry based untargeted metabolomics exhibited 20 significantly perturbed metabolites. Moreover, metabolic pathway anal. revealed significant disturbance in the TCA cycle and pyruvate metabolism pathways.

Environmental Toxicology and Pharmacology published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Product Details of C12H10O4S.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jorvekar, Sachin B. published the artcileDetermination of bisphenols and parabens in cow urine distillate from India: implication of human exposure and risk assessment, Recommanded Product: 4,4′-Sulfonyldiphenol, the publication is Environmental Science and Pollution Research (2022), 29(35), 52507-52519, database is CAplus and MEDLINE.

The exposures of a wide range of endocrine-disrupting chems. to cows have been linked to diseases and are a major concern. In Indian scripts, cow urine is believed to be a treatment for many diseases. Nonetheless, exposure of bisphenols and parabens to cow urine distillates is unknown. Hence, in this study, we determined the concentration of bisphenols and parabens in com. available cow urine distillate collected from India. The mean concentration of total bisphenols and parabens ranges from the limit of quantification (LOQ) to 149.3 ng/mL and 1479.88 ng/mL, resp. Predominant bisphenol-F and bisphenol-A were accounted for 88.6% and 6% of total bisphenol concentration, resp., in marketed cow urine distillate, whereas Me and Pr parabens were dominant and accounted for 33% and 65%, resp. The estimated mean daily intake (EDI) of bisphenol for males and females were 45.94 ng/kg-bw/day and 54.29 ng/kg-bw/day, resp., while for parabens EDI was 455.35ng/kg-bw/day and 538.14 ng/kg-bw/day for males and females, resp. Hazard quotient, to evaluate the potential risk of exposure, showed no risk in the studied samples. Even though the EDI results from the Monte-Carlo risk assessment anal. did not exceed the acceptable daily intake, their estrogenic actions cannot be ignored in general populations. The estrogenic activities contributed by parabens and bisphenol A measured by estradiol equivalency quotient (EEQ) ranged from 0.00033-42 pg/mL and 2.3 pg/mL, resp. Our results revealed higher concentrations of bisphenols and parabens in cow urine distillates; hence, special attention should be given to the quality and safety of cow urine distillates. Moreover, strict guidelines should be enforced for the quality of cow urine distillates.

Environmental Science and Pollution Research published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Recommanded Product: 4,4′-Sulfonyldiphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Heuckendorff, Mads published the artcileDIDMH in combination with triflic acid – A new promoter system for thioglycoside glycosyl donors, Product Details of C12H20O6, the publication is Carbohydrate Research (2018), 86-91, database is CAplus and MEDLINE.

We have explored the possibility of using 1,3-diiodo-5,5-dimethylhydantoin (DIDMH) as an alternative to N-iodosuccinimide (NIS) for activation of glycosyl donors of the thioglycoside type in various glycosylation reactions. DIDMH was found to match NIS when it comes to the capability to activate thioglycosides and provide glycosylation products in good yields. Notably, with the two equivalent of reactive iodonium ions per mol. of DIDMH less mass needs to be added making this activator a more atom economically alternative to NIS. Furthermore, DIDMH was found to be stable upon storage for weeks and comparably priced to NIS. With this knowledge in hand we therefore encourage the carbohydrate community to consider using DIDMH for activation of thioglycosides in glycosylation reactions.

Carbohydrate Research published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, Product Details of C12H20O6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Pestova, S. V. published the artcileSynthesis and membrane protective activity of bis-sulfides derived from monoterpenoids and monosaccharides, Product Details of C12H20O6, the publication is Russian Journal of Bioorganic Chemistry (2017), 43(3), 302-310, database is CAplus.

Hydroxyl- and chloroethyl derivatives of neomenthane- and isobornanethiol in yields of to 80% were synthesized. They served as the basis for the preparation of new bis-sulfides with diacetone-protected galacto- and fructopyranose fragments in yields up to 98%. The bis-sulfides synthesized were screened for membrane protective and antioxidant properties in a model cell system (in vitro) based on their ability to inhibit the H₂O₂-induced hemolysis of erythrocytes and retard the oxy-Hb oxidation

Russian Journal of Bioorganic Chemistry published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, Product Details of C12H20O6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Pestova, S. V. published the artcileSynthesis and membranoprotective properties of new disulfides with monoterpene and carbohydrate fragments, Computed Properties of 20880-92-6, the publication is Russian Chemical Bulletin (2015), 64(3), 723-731, database is CAplus.

A cooxidn. of carbohydrate and terpene thiols gives mixtures of disulfides containing 51-90% of the unsym. product. Membranoprotective and antioxidant properties of obtained unsym. and sym. disulfides were evaluated based on their ability to inhibit the H₂O₂-induced hemolysis of erythrocytes, as well as the accumulation of secondary products of the peroxy oxidation of lipids and the oxidation of Hb.

Russian Chemical Bulletin published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, Computed Properties of 20880-92-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Blaauwendraad, Sophia M. published the artcileAssociations of maternal urinary bisphenol and phthalate concentrations with offspring reproductive development, Synthetic Route of 80-09-1, the publication is Environmental Pollution (Oxford, United Kingdom) (2022), 119745, database is CAplus and MEDLINE.

Fetal exposure to bisphenols and phthalates may influence development of the reproductive system. In a population-based, prospective cohort study of 1059 mother-child pairs, we examined the associations of maternal gestational urinary bisphenols and phthalates concentrations with offspring reproductive development from infancy until 13 years. We measured urinary bisphenol and phthalate concentrations in each trimester. We obtained information on cryptorchidism or hypospadias after birth from medical records. At 9.7 years, we measured testicular and ovarian volume by MRI. At 13.5 years, we measured child Tanner stages and menstruation through questionnaire. We performed linear or logistic regression models for boys and girls to assess the associations of maternal urinary average and trimester-specific bisphenols and phthalates with child reproductive outcomes. Next, to further explore potential synergistic or additive effects of exposures together, we performed mixed exposure models using a quantile g computation approach. Models were adjusted for maternal age, ethnicity, body-mass index, education, parity, energy intake, smoking and alc. use, and childs gestational age at birth, birthweight and body-mass index. In boys, no associations of maternal gestational phthalate or bisphenol with offspring cryptorchidism and hypospadias were found. Higher maternal high-mol.-weight phthalate and total bisphenol, but not phthalic acid or low-mol.-weight phthalate, were associated with larger child testicular volume at 10 years. Higher maternal phthalic acid and total bisphenol were associated with earlier genital and pubic hair development at 13 years, resp. (p-values<0.05). In girls, we found no associations of maternal urinary bisphenol and phthalate with ovarian volume or menstrual age. Only higher maternal urinary high-mol.-weight phthalate was associated with earlier pubic hair development at 13 years (p-values <0.05). Higher mixture exposure was associated with earlier pubic hair development in both sexes. In conclusion, higher maternal gestational urinary bisphenol and phthalate concentrations were associated with alterations in offspring reproductive development, mainly in boys.

Environmental Pollution (Oxford, United Kingdom) published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Synthetic Route of 80-09-1.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Watanabe, Bunta published the artcileSynthesis and inhibitory activity of substrate-analog fructosyl peptide oxidase inhibitors, SDS of cas: 20880-92-6, the publication is Bioorganic & Medicinal Chemistry Letters (2015), 25(18), 3910-3913, database is CAplus and MEDLINE.

Fructosyl peptide oxidases (FPOXs) play a crucial role in the diagnosis of diabetes. Their main function is to cleave fructosyl amino acids or fructosyl peptides into glucosone and the corresponding amino acids/dipeptides. In this study, the substrate-analog FPOX inhibitors were successfully designed and synthesized. These glycosyl-amino acid inhibitors mimic N^α-fructosyl-L-valine (Fru-Val), [N^α-fructosyl-L-valyl]-L-histidine (Fru-ValHis), and N^ε-fructosyl-L-lysine (εFru-Lys), resp. The secondary nitrogen atom in the natural substrates, linking fructose and amino acid or dipeptide moieties, was substituted in glycosyl-amino acids with a sulfur atom to avoid enzymic cleavage. Kinetic studies revealed that prepared glycosyl-amino acids act as competitive inhibitors against an FPOX obtained from Coniochaeta sp., and K_i values of 11.1, 66.8, and 782 μM were obtained.

Bioorganic & Medicinal Chemistry Letters published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H15BF2O2, SDS of cas: 20880-92-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhao, Pinjing published the artcileDirect Observation of β-Aryl Eliminations from Rh(I) Alkoxides, Quality Control of 596-38-3, the publication is Journal of the American Chemical Society (2006), 128(10), 3124-3125, database is CAplus and MEDLINE.

Rhodium(I) tris-phosphine triaryl alkoxides undergo β-Ph elimination, affording phenylrhodium complexes and diaryl ketones. Ligand substitution of [(PEt₃)₂Rh[N(SiMe₃)₂]] with ROH in the presence of PEt₃ afforded either [(PEt₃)₂RhOR] (2a,c; R = CPh₃, 9-phenyl-9-xanthenyl) or [(PEt₃)₃RhOR] [3b–e; R = CMePh₂, 9-phenyl-9-xanthenyl, 9-phenyl-9H-fluoren-9-yl, CMe₂(CF₃)]. Reaction of 2a with an excess of PEt₃ gave [(PEt₃)₃RhPh] and Ph₂CO; Ph β-elimination from 3b–d gave similarly [(PEt₃)₃RhPh] and acetophenone, xanthone and 9-fluorenone, resp. Kinetic results are most consistent with irreversible β-Ph elimination from a bisphosphine-ligated rhodium alkoxide complex. Such bisphosphine complexes result from ligand dissociation from the tris-phosphine complexes and were isolated in some cases. The bisphosphine complexes are stabilized by Rh-Ph interactions, as evidenced by an x-ray structure of 2a, and this structure with a metal-aryl interaction likely illustrates the pathway for C-C bond cleavage.

Journal of the American Chemical Society published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C6H13N3O2, Quality Control of 596-38-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kato, Yuichi published the artcileDeoxygenation of tertiary and secondary alcohols with sodium borohydride, trimethylsilyl chloride, and potassium iodide in acetonitrile, Name: 9-Phenyl-9H-xanthen-9-ol, the publication is Tetrahedron Letters (2021), 153519, database is CAplus.

In this study, a deoxygenation method was developed for tertiary and secondary alcs., ROH [R = triphenylmethyl, 9-phenyl-9H-xanthen-9-yl, bis(4-methoxyphenyl)(thiophen-2-yl)methyl, etc.] using trimethylsilane and trimethylsilyl iodide generated in situ from sodium borohydride and trimethylsilyl chloride, and trimethylsilyl chloride and potassium iodide, resp. In this method, tertiary and secondary alcs., which provided stable carbocations, were converted into the corresponding alkanes RH. This paper also presents the optimization of the reaction conditions, the reaction mechanism, as well as the scope and limitations of the method.

Tetrahedron Letters published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Name: 9-Phenyl-9H-xanthen-9-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts