Tag: M.W=250-300

Maness, Peter published the artcileSubstituent Effects on Temperature Dependence of Kinetic Isotope Effects in Hydride-Transfer Reactions of NADH/NAD⁺ Analogues in Solution: Reaction Center Rigidity Is the Key, Synthetic Route of 596-38-3, the publication is Organic Letters (2020), 22(15), 5963-5967, database is CAplus and MEDLINE.

Substituent effects on the temperature dependence of primary kinetic isotope effects, characterized by ΔE_a = E_aD – E_aH, for two series of the title reactions in acetonitrile were studied. The change from ΔE_a â‰?0 for a highly rigid system to ΔE_a > 0 for systems with reduced rigidities was observed The rigidities were controlled by the electronic and steric effects. This work replicates the observations in enzymes and opens a new research direction that studies structure-ΔE_a relationship.

Organic Letters published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Synthetic Route of 596-38-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wada, Masanori published the artcileReactions of 1,8-Dimethoxy-9-phenylxanthen-9-ol in the Presence of an Acid, and Its Basicity, SDS of cas: 596-38-3, the publication is Bulletin of the Chemical Society of Japan (1999), 72(4), 779-785, database is CAplus.

In the presence of a catalytic amount of acid, the title xanthenol (1) reacted in acetone to give 1,8-dimethoxy-9-phenylxanthen-9-ylmethyl Me ketone. Analogous reactions were observed for Et Me ketone and acetophenone, but not for di-Et ketone. Propanal and butanal also reacted to give 2-(1,8-dimethoxy-9-phenylxanthen-9-yl)propanal and 2-(1,8-dimethoxy-9-phenylxanthen-9-yl)butanal, resp. In hot primary and secondary alcs.,1 was reduced to give 1,8-dimethoxy-9-phenylxanthene. 1 also reacted with methoxybenzenes, phenol, and N-alkylanilines to give 9-aryl-1,8-dimethoxy-9-phenylxanthenes. The basicity of 1, or the stability of the carbenium ion (pK_R⁺ = -0.81), was measured in hydrochloric acid and compared with those of related 9-arylxanthen-9-ols, such as 1,8-dimethoxy-9-(2,6-dimethoxyphenyl)xanthen-9-ol (1.14), 9-(2,6-dimethoxyphenyl)xanthen-9-ol (4.80) (8), and 9-phenylxanthen-9-ol (0.75). The drastic differences in the reactivities and the basicity between 1 and 8 were attributed to a steric effect rather than an electronic effect.

Bulletin of the Chemical Society of Japan published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C4H6O3, SDS of cas: 596-38-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ungnade, Herbert E. published the artcileCondensations of aromatic aldehydes and aryl carbinols with aluminum chloride and aromatic systems, Quality Control of 596-38-3, the publication is Journal of the American Chemical Society (1953), 3333-6, database is CAplus.

The reaction of aryl carbinols and aromatic aldehydes with aromatic hydrocarbons and excess AlCl₃ has been extended to include substituted benzyl alcs. as donors and mesitylene, Ph₂, and Ph₂O as acceptor mols. An unexpected reaction occurred in Ph₂O with formation of 9-phenylxanthydrol (I) from BzH, PhCH₂OH, or Ph₂CHOH. The formation of I in these reactions is unique since the oxygenated compounds apparently undergo condensation at the normally unreactive o-positions of the Ph₂O rather than cleavage. BzH (30 g.) added during 0.5 h. with stirring to 20 g. Ph₂ and 79 g. AlCl₃ at 60°, the mixture stirred 3.5 h. at 60°, decomposed, and steam-distilled, the nonvolatile fraction (32.39 g.) distilled in vacuo, and the distillate (6.02 g., 28%), b_0.001 170-210°, crystallized 3 times from ligroine gave diphenylanthracene (II), m. 202-3°, λ_maximum 230 mμ (log ε 4.65), 257.5 (4.97), 277.5 (5.09), 332.5 (3.67), 347.5 (3.91), 365 (4.01), 385 (3.89). II (1 g.) in 14 cc. glacial AcOH refluxed gently over a low flame and treated slowly during 0.5 h. with 4.0 g. CrO₃ in 4 cc. H₂O and 16 cc. AcOH, the solution cooled, diluted with 200 cc. H₂O, and filtered, and the crude green solid washed with H₂O, dilute aqueous NaOH, and again H₂O, and recrystallized from 95% EtOH and dried in vacuo at 100° gave 1.02 g. (93.5%) diphenylanthraquinone, yellow needles, m. 270-1°. BzH (25 g.) added during 0.5 h. to 67 g. AlCl₃ in 60 cc. mesitylene, the mixture stirred 3.5 h. at 60°, decomposed and steam-distilled, the distillate taken up in C₆H₆, washed with saturated aqueous NaHSO₃ [the insoluble adduct gave 7.86 g. (31%) BzH (oxime, m. 32-3°)], and the C₆H₆ solution rectified yielded 1.0 g. (2%) xylenes, b₅₉₈ 140-50°, n_D²³ 1.4970, λ_maximum^EtOH 266 mμ (log ε 2.40), 8.7 g. (17%) trimethylbenzenes, b₆₀₀ 150-60°, n_D²³ 1.5005, λ_maximum^EtOH 266 mμ (log ε 2.40) [gave nitrated 2,4,6-(O₂N)₃C₆Me₃, m. 230-2°], and 2.6 g. (4%) C₆H₂Me₄, b₆₀₀ 180-5°, n_D²³ 1.5105, λ_maximum 269 mμ (log ε 2.57); a portion (12.86 g.) of the nonvolatile residue (22.50 g.) refluxed with ligroine (b. 70-90°), the solution filtered from 2.74 g. insoluble material, the solution adsorbed on Al₂O₃, and the resulting 3 bands (blue fluorescing under UV light) eluted with ligroine gave 7.34 g. (45.7%) oily solid, m. 132-8°, which gave, after repeated recrystallization from ligroine, tetramethylanthracene, m. 148-8.7°, λ_maximum 338 mμ (log ε 3.45), 350 (3.66), 366 (3.78), 386 (3.68). BzH (25 g.), 67 g. AlCl₃, and 75 cc. Ph₂O treated in the usual manner, the steam distillate extracted with Et₂O, the extract washed with H₂O, dried, and distilled gave 1.2% unreacted BzH (b₁₉ 96-8°) and 44.3% recovered Ph₂O [identified as (p-H₂NSO₂C₆H₄)₂, m. 157-8°]; the semi-solid residue from the steam distillation taken into C₆H₆, washed, dried, and distilled gave 32.2 g. distillate; a 2.18-g. portion in C₆H₆ gave 4 distinct bands on Al₂O₃; the bulk of the product was contained in 3 bands which were eluted with C₆H₆ and gave 0.12 g. red viscous oil, 1.48 g. red-brown oil, and 0.46 g. I crystalline solid, m. 149-54° (from ligroine); distillation of the residue (9.55 g.) gave 4.15 g. red oil, b_0.001 190-210°, which solidified on standing to yield 3.02 g. I, m. 156-7° (from C₆H₆-ligroine); on distillation in vacuo of larger quantities of the residue, pyrolysis and reduction occurred to yield PhOH and 9-phenylxanthene. Similar results were obtained with PhCH₂OH and Ph₂CHOH as starting materials, the over-all yields of I being from BzH 15.5%, from PhCH₂OH 15%, and from Ph₂CHOH 27%. I, m. 157-8°, was also obtained in 76% yield from xanthone and PhMgBr. I dissolved with green-yellow color and fluorescence in concentrated H₂SO₄; it gave derivatives with semicarbazide (m. 206-7°), NH₂OH (m. 194-5°), and PhNHNH₂ (m. 127-8°); it was recovered unchanged from its reaction mixture with MeMgI, and with acylating and oxidizing agents under ordinary conditions; pyrolyzed at 282° it gave PhOH. I was reduced to 9-phenylxanthene (III), m. 142-3° (from ligroine), by a Clemmensen reduction (91.3%), by a Schmidt reaction (96.6%), and by refluxing with alc. HCl (87.7%); insoluble in concentrated H₂SO₄, gave oxidized with KMnO₄ in aqueous Me₂CO, I, m. 155-6° (from ligroine). Xanthone (IV) (5 g.) in dry C₆H₆ added to 0.025 mol PhCH₂MgCl in dry Et₂O, the complex decomposed with ice and aqueous NH₄Cl, and the resulting yellow oil triturated with petr. ether, recrystallized from ligroine, or chromatographed on Al₂O₃ yielded 89% crystalline benzalxanthene (V), yellow needles, m. 110-11°, yellow with green fluorescence in cold concentrated H₂SO₄. The reduction of 2.65 g. V with HI and Ac₂O cleaved at the 9,10 double bond to give 0.11 g. IV, m. 158-60° (recrystallized m. 173-4°), and 0.74 g. 9-benzylxanthene (VI), m. 69-70°. p-PhOC₆H₄Bz (VII), m. 69.2-9.4°, was prepared by the method of Kipper [Ber. 38, 2490(1905)]; soluble with yellow color in cold concentrated H₂SO₄; unchanged under the conditions of the cyclodehydration procedure of Bradsher (C.A. 34, 6265.4); cleaved by fusion with NaOH at 350° to give BzOH, Ph₂O, and traces of PhOH and p-HOC₆H₄Bz; and showed strong IR absorption at 6.05 and 8.02, and 10 addnl. bands common to PhBz and Ph₂O. VII (2.0 g.) in 100 cc. 95% EtOH hydrogenated at 30 mm. pressure with 3 g. Raney Ni and 1 drop 50% aqueous KOH as catalyst, the mixture filtered, the solvent removed, and the residue crystallized from petr. ether gave 1.70 g. (85%) p-PhOC₆H₄CH(OH)Ph (VIII), m. 75.8-6.9°. VII (20 g.) added to amalgamated Zn (from 100 g. Zn and 10 g. HgCl₂) and 100 cc. concentrated HCl, the mixture refluxed 12 h. while 3 fresh 50-cc. portions concentrated HCl were added, the product extracted with C₆H₆, the extract washed neutral, dried, and evaporated, the residue (19.67 g.) sublimed from a mol. still at 0.001 mm., and the colorless distillate (9.34 g.) resublimed to give 8.61 g. colorless liquid which solidified on standing to give p-PhOC₆H₄CH₂Ph (IX), m. 41-2°; the 2nd fraction from the mol. distillation, a viscous oil, which set to a glassy solid in the side arm, is believed to be the corresponding pinacol p-MeOC₆H₄CH₂OH (33 g.) added during 1 h. to 75 g. AlCl₃ in 160 cc. C₆H₆, and the mixture worked up as usual gave unreacted C₆H₆, b₆₀₆ 72-5°, n_D²⁵ 1.4952, 11.8 g. PhOMe, b₁₉ 75-8°, n_D²³ 1.5147 [redistilled 8.4 g. (43%), b₆₀₆ 144°, n_D²² 1.5157, identified as 2,4-(O₂N)₂C₆H₃OMe, m. 84-5°], and 3.2 g. anthracene (X), b₁₉ 155-60°, colorless plates, m. 212-13°; an addnl. amount X, m. 210-11°, was obtained by decolorizing the still residue with Nuchar and recrystallizing To establish the composition of the binary mixture X-H₂O, 1.0 g. pure X was steam-distilled at 97°/603 mm. to furnish 0.49 g. X in 5 l. distillate during 1 h.; the binary mixture contained thus 0.0098% X. X (1 g.) and 10 g. PhOMe steam-distilled at 98°/605 mm. yielded 5 l. distillate in 1 h. containing 0.30 g. X. 3,4-(MeO)₂C₆H₃CH₂OH (0.148 mol) gave with 0.297 mol AlCl₃, and 150 cc. thiophene-free C₆H₆, by the general procedure, 1.34 g. guaiacol (phenylurethane, m. 134°) and 1.03 g. X, m. 211-12°. To 0.20 mol o-HOC₆H₄CH₂OH and 150 cc. C₆H₆ was added 0.40 mol AlCl₃ in small portions, and the mixture worked up as usual to give 0.61 g. PhOH and 2.47 g. X. To 10 g. LiAlH₄ in 180 cc. dry Et₂O was added with stirring 34.50 g. o-PhCH₂C₆H₄CO₂H, m. 110-11°, in 100 cc. Et₂O at such a rate as to keep the mixture refluxing gently, the mixture stirred 0.5 h. and decomposed cautiously with cooling with 100 cc. H₂O, and then with 10% aqueous H₂SO₄, and the Et₂O layer washed with 10% aqueous Na₂CO₃, dried, and evaporated to give 20.47 g. (64.5%) o-PhCH₂C₆H₄CH₂OH (XI), b_0.001 130-2°. XI (10 g.) in 50 cc. C₆H₆ gave with 20 g. AlCl₃, by the general procedure, 5.00 g. X, m. 212-14° (sublimed at 160-200°/1-2 mm.). XI (10 g.) treated in exactly analogous manner with 75 cc. PhMe and 0.15 mol AlCl₃ yielded 11.08 g. non-volatile residue which gave 4.76 g. dimethylanthracene, m. 215-17° (from ligroine); the volatile fraction contained 4.02 g. (47.8%) Ph₂CH₂, b. 260-2° (identified as BzPh, m. 47-8°). The UV absorption maximum in mμ and in parentheses the log ε values in 95% EtOH are listed for: Ph₂O 225 shoulder (4.01), 271 (3.31); p-PhOC₆H₄Me, 225 (4.06), 278 (3.30); 3,4-Me₂C₆H₃OPh, 226 shoulder (4.05), 278 (3.32); VIII, 233 (4.18), 265 (3.27); IX 228 shoulder (4.21), 271 (3.47); VII, 286 (4.24); xanthene, 247 (3.88), 283 (3.36); III, 250 (3.91) 284 (3.47); VI, 243 (3.94), 283 (3.50), 338 (2.37); V, 252 shoulder (4.10), 284 (3.89), 341 (4.08); xanthydrol, 239 (4.17), 290 (3.59), 336 (2.69); I, 244 (4.10), 290 (3.61); 1-(9-phenylxanthyl)-semicarbazide, 245 (4.11), 290 (3.69); IV, 260 (4.11), 288 (3.66), 336 (3.85). The UV absorption spectra of I and III are recorded in Document 3953 ADI Auxiliary Publications Project, Photoduplication Service, Library of Congress, Washington, D.C.

Journal of the American Chemical Society published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C14H20BClO2, Quality Control of 596-38-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yilmaz, Can published the artcileIn vitro and in silico evaluation of inhibitory effects of bisphenol derivatives on acetylcholinesterase of electric eel (Electrophorus electricus L.), Recommanded Product: 4,4′-Sulfonyldiphenol, the publication is Comparative Biochemistry and Physiology, Part C: Toxicology & Pharmacology (2022), 109416, database is CAplus and MEDLINE.

The inhibitory effects of bisphenol A (BPA) and bisphenol S (BPS), which are common pollutants, especially in marine and freshwater, on the elec. eel acetylcholinesterase (AChE) activity were studied in vitro and in silico. Both produced full non-competitive inhibition, but the Ki value of BPA was half that of BPS. Mol. docking analyses revealed that both interact with residues W286, F297, Y337, F338 in the PAS and ABS regions in the middle and entrance of the active site gorge, and that BPS also has hydrogen bond with S203 of the catalytic triad. The surge at IC50 values of both compounds with an inflection point at pH: 8.2 suggested that Y124 and/or Y337 in the narrow gorge are primary structural factors in binding. Less effective inhibition of BPS, especially at 25-30°C, the temperature at which enzyme activity peaks, was attributed to the conformation of the narrow gorge. Homol. analyses for AChE initially revealed a significant degree of identity, particularly in the alpha/beta hydrolase domain, which also comprises the active site, with sequences from seven distinct teleost species of various environments. Finally, it was discovered for the first time that BPS, like BPA, is a significant inhibitor of AChE, and this was confirmed by in vitro and in silico analyses done at various pH and temperature levels. It was concluded that this effect might also apply to AChE of most other bony fish.

Comparative Biochemistry and Physiology, Part C: Toxicology & Pharmacology published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is CBF6K, Recommanded Product: 4,4′-Sulfonyldiphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ifon, Binessi Edouard published the artcileEffects of bisphenols and perfluoroalkylated substances on fluorescence properties of humic and amino acids substances of dissolved organic matter: EEM-PARAFAC and ATR-FTIR analysis, Name: 4,4′-Sulfonyldiphenol, the publication is Journal of Environmental Chemical Engineering (2022), 10(4), 108186, database is CAplus.

Abiotic, biotic, and sparingly the xenobiotic factors are considered to influence the compositional variation of dissolved organic matter (DOM) in aquatic environments. Increasing discharge of xenobiotics into water bodies necessitates the need to investigate their effects on the key components of DOM. The effects of bisphenols (BP) and perfluoroalkylated substances (PFAS) on the fluorescence characteristics of pure humic substances (HS) and amino acids (AA) of DOM were examined by using excitation-emission matrix-parallel factor anal. (EEM-PARAFAC) and the attenuated total reflection Fourier-transform IR (ATR-FTIR) spectroscopy in this work. The results showed that interactions of fulvic acid (FA), humic acid (HA), and tryptophan (Trp) with the xenobiotic compounds could generate some fluorescence components like both HS and AA components, whereas the interactions with tyrosine (Tyr) could only generate AA fluorescence components. In addition, it was revealed that the fluorescence intensity of HS decreases by 50-70% and 18-25% in the treatments of HA and FA, resp., at low concentration (2.5 x 10^-3 mg/L) of BP, while this increases by 350-425% and 18-25% at the same concentration of PFAS. However, both BP and PFAS increase the fluorescence intensity of AA. The findings suggest that the xenobiotic compounds are important factors affecting the compositional variation of DOM, especially in the anthropogenically-impacted water bodies.

Journal of Environmental Chemical Engineering published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Name: 4,4′-Sulfonyldiphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hori, Mikio published the artcileReactivities of heteroaromatic cations containing a group VIB element in nucleophilic reactions. Reactions of 9-phenyl-xanthylium, -thioxanthylium, and -selenoxanthylium salts with amines, sodium phenolate, and sodium benzenethiolate, Synthetic Route of 596-38-3, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) (1988), 2271-6, database is CAplus.

Addition of amines RH (R = morpholino, piperidino, NEt₂, 4-MeNHC₆H₄, 4-Me₂NC₆H₄) to 9-phenylchalcogenoxanthylium perchlorates I (X = O, S) gave the expected addition products II (X = O, S; R = same) in 91-98% yields. Addition of PhNH₂ or PhONa to I (X = O, S, Se) gave mixtures of I (X = O, S, Se; R = NHPh, OPh, 4-H₂NC₆H₄, 4-HOC₆H₄) and 1:2 addition products III (X¹ = NH, O). II (R = NHPh) underwent Hofmann-Martius rearrangement to II (R = 4-H₂NC₆H₄). III (X¹ = O) underwent cleavage with HCl to give II (R = OH) and II (R = 4-HOC₆H₄). Addition of PhSNa to I (X = O, S, Se) gave only II (R = SPh).

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Synthetic Route of 596-38-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hori, Mikio published the artcileDibenzothiepin derivatives and related compounds. III. Investigation of the reactivity of triphenylmethyl hexachloroantimonate and synthesis of 6,11-dihydrodibenzo[b,e]thiepin-11-ylium hexachloroantimonates, Related Products of alcohols-buliding-blocks, the publication is Yakugaku Zasshi (1978), 98(10), 1333-40, database is CAplus and MEDLINE.

In order to exam. the utility of Ph₃CSbCl₆ (I) for organic synthesis, various kinds of hexachloroantimonates of carbonium ions were prepared by the reaction of I with equimolar amounts of various kinds of appropriate cyclic compounds These products were obtained in a simple and stable manner compared to the synthesis of the corresponding perchlorates. Exptl. studies were also made on the limitation of I as an anion (H^–, OH^–, Cl^–, etc.) abstraction reagent, using various kinds of 6,11-dihydrodibenzo[b,e]thiepin derivatives

Yakugaku Zasshi published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Nishimura, Takahiro published the artcileRhodium-catalyzed aryl transfer from trisubstituted aryl methanols to α,β-unsaturated carbonyl compounds, Recommanded Product: 9-Phenyl-9H-xanthen-9-ol, the publication is Angewandte Chemie, International Edition (2007), 46(26), 4937-4939, database is CAplus and MEDLINE.

The rhodium-catalyzed arylation of α,β-unsaturated carbonyl compounds with 9-aryl-10-benzyl-9,10-dihydroacridin-9-ols as arylating reagents proceeds efficiently via β-aryl elimination of the rhodium alkoxide intermediates, to give the 1,4-addition products in high yields. E.g., reaction of MeCOCH:CHC₅H₁₁ with 9-phenyl-10-benzyl-9,10-dihydroacridin-9-ol gave 96% MeCOCH₂CHPhC₅H₁₁.

Angewandte Chemie, International Edition published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Recommanded Product: 9-Phenyl-9H-xanthen-9-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Rapolu, Rajesh Kumar published the artcileShort enantioselective routes to (S)-Dapoxetine, Formula: C19H18O2, the publication is Chemistry & Biology Interface (2013), 3(1), 50-60, database is CAplus.

Two enantioselective approaches involving a stereoselective conjugate addition of a homochiral lithium amide based on (R)-N-(1-phenylethyl)benzylamine and a stereoselective ketone reduction of a prochiral ketone were employed for a chiral synthesis of (S)-dapoxetine. Both routes employ readily and com. viable starting materials and reagents, and suitable for process synthesis of (αS)-N,N-dimethyl-α-[2-(1-naphthalenyloxy)ethyl]benzenemethanamine (Dapoxetine hydrochloride) (I). The synthesis of the target compound was achieved using 3-chloro-1-phenyl-1-propanone as a starting material.

Chemistry & Biology Interface published new progress about 156453-53-1. 156453-53-1 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Benzene,Naphthalene,Alcohol,Ether, name is (R)-3-(Naphthalen-1-yloxy)-1-phenylpropan-1-ol, and the molecular formula is C19H18O2, Formula: C19H18O2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ghiasi, Mina published the artcileConformational Analysis of Topiramate and Related Anion in the Solution and Interaction Between the Most Stable Conformer of Topiramate with Active Center of Carbonic Anhydrase Enzyme, Computed Properties of 20880-92-6, the publication is Journal of Carbohydrate Chemistry (2015), 34(2), 80-102, database is CAplus.

D. functional theory using the B3LYP/6-311++G** method was employed to calculate the details of the electronic structure and electronic energy of the carbonic anhydrase enzyme active center (CA); topiramate, a sulfamate substituted monosaccharide; and the complex between topiramate and CA. The calculated results indicate that topiramate appears to adopt a twist-boat conformation in the solution The conformational anal. around the S-N bond (H-N-S-O dihedral angle) in deprotonated topiramate shows that the conformers with a H-N-S-O torsion of 270, 0, and 180 degrees are the min., transition state, and maximum energy conformers, resp. The deprotonated form of topiramate is coordinated to the Zn²⁺ ion.

Journal of Carbohydrate Chemistry published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, Computed Properties of 20880-92-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts