Tag: M.W=250-300

Li, Xiaowei published the artcileNickel-Catalyzed Arylation of C(sp³)-O Bonds in Allylic Alkyl Ethers with Organoboron Compounds, Recommanded Product: ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, the publication is Organic Letters (2021), 23(17), 6612-6616, database is CAplus and MEDLINE.

A nickel-catalyzed cross-coupling of allylic alkyl ethers with organoboron compounds through the cleavage of the inert C(sp³)-O(alkyl) bonds is described. Several types of allylic alkyl ethers can be coupled with various boronic acids or their derivatives to give the corresponding products in good to excellent yields with wide functional group tolerance and excellent regioselectivity. The gram-scale reaction and late-stage modification of biol. active compounds further prove the practicality of this synthetic method.

Organic Letters published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, Recommanded Product: ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Nikitin, Sergei published the artcileLignin-Inspired Polybenzylethersulfone Synthesis via S_NAr Reaction, Related Products of alcohols-buliding-blocks, the publication is Macromolecular Chemistry and Physics (2022), 223(13), 2100484, database is CAplus.

A new type of lignin-inspired polybenzylethersulfone (PBES) is synthesized by S_NAr reaction in 75% yield. Success of the polymerization is confirmed by ATR-IR, ¹H, ¹³C NMR spectroscopy and MALDI-TOF MS. The obtained polysulfone is solvent casted into a film which displays high thermal and chem. stability. Treatment with 33% HBr in acetic acid leads to degradation of the material. The isolated degradation products are identified and repolymd. back into PBES demonstrating the opportunity for chem. recycling of this new polymer.

Macromolecular Chemistry and Physics published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Shiyi published the artcileThe effect of solvents on the thermal degradation products of two Amadori derivatives, Application of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, the publication is RSC Advances (2020), 10(16), 9309-9317, database is CAplus and MEDLINE.

To enrich the flavor additives of the Maillard reaction, two Amadori analogs, N-(1-deoxy-D-fructosyl-1-yl)-L-phenylalanine ester (Derivative 1) and di-O-isopropylidene-2,3:4,5-β-D-fructopyranosyl phenylalanine ester (Derivative 2), were chem. synthesized starting from D-fructose. The samples were reacted at 120 and 180°C for 2 h, and the effects of solvents (water and ethanol) on their degradation products were studied. The analyses of thermogravimetry (TG), derivative thermogravimetry (DTG), differential scanning calorimetry (DSC), and gas chromatog.-mass spectrometry (GC/MS) were used to investigate the thermal behavior and degradation products of the samples. TG-DTG curves show that the T_p values of the samples corresponding to the largest mass-loss rates are 132 and 275°C, resp. The degradation products of Derivative 1 are mainly Ph acetaldehyde and phenylalanine Et ester in water and Et benzoate and benzaldehyde di-Et acetal in ethanol. For Derivative 2, the major degradation products both in water and ethanol are phenylalanine Et ester and diacetonefructose, but the products have different relative contents affected by solvent media. The products of the pyrolysis of the samples at 350°C were analyzed and compared with the degradation compounds obtained in solvent. These results show that organic solvents can greatly influence the degradation pathway and products. Finally, possible mechanisms of the degradation processes are proposed.

RSC Advances published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C8H10S, Application of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Niu, Lijun published the artcileTuning the reactivity of permanganate by naturally occurring DNA bases: Enhanced efficiency of micropollutant abatement, Application In Synthesis of 80-09-1, the publication is Separation and Purification Technology (2022), 120654, database is CAplus.

The transformation of extracellular DNA (e.g., antibiotic resistance genes) in water has attracted increasing attention over the last decades. To date, the effect of the resulting byproducts (e.g., DNA bases) on the degradation of micropollutants by oxidants remains largely unknown. In this study, four DNA bases (i.e., deoxyadenosine (dA), deoxythymidine (dT), deoxycytidine (dC), and deoxyguanosine (dG)) were investigated as potential permanganate (Mn(VII)) activators for the oxidation of tetracycline (TC) in water. The dC exhibited the best performance, e.g., the first-order rate constant of TC increased from 0.082 min-1 in the absence of dC (i.e., Mn(VII) alone) to 0.290 min^-1 in the presence of 500μM dC (i.e., Mn(VII)/dC system). The degradation of three other emerging micopollutants (i.e., bisphenol F (BPF), bisphenol S (BPS), and methotrexate (MTX)) by Mn(VII)/dC was also greater than Mn(VII) alone. Multiple lines of evidence suggested that the synergistic effect of in-situ formed MnO2 colloids and Mn(VII) had a major role in the observed enhancement compared to radicals, Mn(VI), Mn(V) or Mn(III). The transformation products (TPs) of TC by Mn(VII) with and without dC were tentatively identified, from which the reaction pathways were proposed. Despite the high degradation of micropollutants by Mn(VII)/dC system, the majority of TPs were recalcitrant to biodegradation with multi-endpoint adverse health effects on different aquatic organisms, as indicated by in silico prediction software. Overall, this study unveiled the free DNA bases as in-situ Mn(VII) activators for removing emerging contaminants of global concern from water. However, the secondary environmental risks related to the TPs need to be considered in terms of water safety assessment.

Separation and Purification Technology published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Application In Synthesis of 80-09-1.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wu, Rui published the artcileCopper-catalyzed aerobic oxidative dehydrogenative ring-opening reaction of glycine esters with α’-angelicalactone: Approach to construct α-amino-γ-ketopimelates, HPLC of Formula: 20880-92-6, the publication is Advanced Synthesis & Catalysis (2019), 361(14), 3436-3440, database is CAplus.

A copper-catalyzed aerobic oxidative dehydrogenative reaction of glycine derivatives with α’-angelicalactone is achieved under mild and simple reaction conditions. This strategy can be applicable to a wide range of glycine esters, including complex substrates derived from (+)-dehydroisoandrosterone or menthol, thus enabling the oxidative dehydrogenative ring-opening reaction for producing diverse functionalized α-amino-γ-ketopimelate derivatives in an atom-economic manner.

Advanced Synthesis & Catalysis published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C20H18BrN3, HPLC of Formula: 20880-92-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gao, Xiaozhong published the artcilePassive sampling hydrophilic and hydrophobic bisphenol analogues using hydrophilic-lipophilic balance sorbent-embedded cellulose acetate membrane in surface waters, SDS of cas: 80-09-1, the publication is Science of the Total Environment (2022), 156239, database is CAplus and MEDLINE.

Bisphenol analogs (BPs) are ubiquitous emerging contaminants in water environments and have wide polarity ranges (1.65 < log K_OW< 7.2). Integrated passive sampling strategy rarely contains hydrophilic and hydrophobic organics simultaneously, while the method has good application perspective in monitoring organic contaminants. This work evaluated passive sampling performance for fifteen BPs in a newly developed passive sampler, i.e., hydrophilic-lipophilic balance sorbent-embedded cellulose acetate membrane (HECAM). In the dynamic accumulation experiments, both hydrophilic and hydrophobic BPs (including moderately hydrophilic BPs) well followed first-order kinetic uptake in the HECAMs. The estimated uptake rate constants, elimination rate constants, and equilibrium partition coefficients for BPs ranged from 4.4 L g^-1 d^-1 to 14.7 L g^-1 d^-1, 0.22 d^-1 to 0.72 d^-1, and 3.99 to 4.64, resp. The kinetic parameters for BPs in HECAM show limited correlations to log K_OW values, which the rule differs from traditional passive sampler. In the study of elimination kinetics, three deuterium labeled compounds showed incomplete elimination in HECAM and did not follow first-order isotropic exchange kinetics. Dual sorption mechanisms including both adsorption and partition were found for chems. in HECAM, which the partitioned part could release to water and the adsorbed part could not easily release to water from HECAM. As a result, performance reference compounds (PRCs) calibration may be inapplicable to HLB sorbent-based passive sampler. The field deployment of HECAM in coastal waters of Guangdong, China resulted in the detection of eleven BPs, which indicated that the waters have been polluted by various BPs. Finally, monitoring strategy of simultaneous passive sampling hydrophobic and hydrophilic organic contaminants in surface waters was recommended.

Science of the Total Environment published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, SDS of cas: 80-09-1.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Park, Seung Koo published the artcileHighly fluorinated and photocrosslinkable liquid prepolymers for flexible optical waveguides, Quality Control of 129301-42-4, the publication is Journal of Materials Chemistry (2011), 21(6), 1755-1761, database is CAplus.

We evaluate highly fluorinated liquid prepolymers and their UV-cured films for flexible optical waveguide applications. Two liquid prepolymers, 2,3,5,6,2′,3′,5′,6′-octafluoro-4,4′-bis-[2-{2-[1,1-difluoro-2-(2,3,5,6-tetrafluoro-4-vinyl-phenoxy)-ethoxy]-1,1,2,2-tetrafluoro-ethoxy}-2,2-difluoro-ethoxy]-biphenyl (7) and 2,3,5,6,2′,3′,5′,6′-octafluoro-4,4′-bis-[2-(2-{2-[1,1-difluoro-2-(2,3,5,6-tetrafluoro-4-vinyl-phenoxy)-ethoxy]-1,1,2,2-tetrafluoro-ethoxy}-1,1,2,2-tetrafluoro-ethoxy)-2,2-difluoro-ethoxy]-biphenyl (8), are synthesized with decafluorobiphenyl, 2,3,4,5,6-pentafluoro styrene, and fluorinated triethylene glycol or fluorinated tetraethylene glycol. The prepolymers are photocurable to give flexible and transparent films. The refractive indexes of the films made from the prepolymers are controlled with their blending composition, 1.417-1.437 at a wavelength of 1.31 μm. The optical losses of the films prepared from prepolymers 7 and 8 are 0.25 and 0.23 dB cm^-1 at a wavelength of 1.31 μm, resp. The films are thermostable at temperatures over 400°. The ultimate stress, initial modulus, and elongation of the films prepared from prepolymers 7 and 8 are 17.1 MPa, 1.25 GPa, and 1.5% and 12.3 MPa, 0.44 GPa, and 6.9%, resp. Optical waveguides fabricated from the prepolymers are flexible without any substrate film and the optical losses at a bending radius of 1.5 mm are under 0.2 dB. We identify the liquid prepolymers as possible good candidate materials for flexible optical waveguide applications by studying the optical transmission in flexible optical waveguides fabricated from them.

Journal of Materials Chemistry published new progress about 129301-42-4. 129301-42-4 belongs to alcohols-buliding-blocks, auxiliary class Fluoride,Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2,2′-((Perfluoroethane-1,2-diyl)bis(oxy))bis(2,2-difluoroethanol), and the molecular formula is C6H6F8O4, Quality Control of 129301-42-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Boyd, Mary K. published the artcileWater quenching behavior of excited 9-xanthylium cations in aqueous sulfuric acid solutions, SDS of cas: 596-38-3, the publication is Journal of the American Chemical Society (1991), 113(19), 7294-300, database is CAplus.

A series of 9-alkyl- and 9-aryl-substituted xanthylium cations (I; R = H, Me, Me₂CHr, cyclo-Pr, tert-Bu; II; R¹ = H, p-CF₃, p– and m-Me, p– and m-OMe) were generated from the corresponding 9-xanthenols in strongly acidic aqueous MeCH (2:1) solutions (39-78% H₂SO₄). Steady-state irradiation at 370 nm produced the excited cations, all of which were fluorescent in the 520-nm region. Fluorescence lifetimes varied considerably with acid concentration, from subnanosecond values at low acidity to 20-35 ns at high acidity. Stern-Volmer plots of Φ_F°/Φ_F vs. the free water concentration in these acid solutions gave linear plots in all cases, yielding k_q values in the 10⁶-10⁹ M^-1 s^-1 range, depending on substituents. For the 9-aryl systems, a plot of log k_q vs. a recently determined σ^hν scale was reasonably linear (r = 0.974) with a ρ value of -1.5, which is opposite in sign to that recently determined for H₂O quenching of the same cations in their ground states. Possible explanations for this surprising result are considered.

Journal of the American Chemical Society published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, SDS of cas: 596-38-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kazmierczak, Andrzej published the artcileMechanism of kinetin-induced death of Vicia faba ssp. minor root cortex cells, Safety of 2-(((9H-Purin-6-yl)amino)methyl)-6-methylphenol, the publication is Scientific Reports (2021), 11(1), 23746, database is CAplus and MEDLINE.

Cell death (CD) may be induced by endogenous or exogenous factors and contributes to all the steps of plant development. This paper presents results related to the mechanism of CD regulation induced by kinetin (Kin) in the root cortex of Vicia faba ssp. minor. To explain the process, 6-(2-hydroxy-3-methylbenzylamino)purine (PI-55), adenine (Ad), 5′-amine-5′-deoxyadenosine (Ado) and N-(2-chloro-4-piridylo)-N′-phenylurea (CPPU) were applied to (i) block cytokinin receptors (CKs) and inhibit the activities of enzymes of CK metabolism, i.e., (ii) phosphoribosyltransferase, (iii) kinases, and (iv) oxidases, resp. Moreover, ethylene glycol-bis(β-aminoethyl ether)-N,N,N′,N′-tetraacetic acid (EGTA), lanthanum chloride (LaCl3), ruthenium red (RRed) and cyclosporine A (CS-A) were applied to (i) chelate extracellular calcium ions (Ca2+) as well as blocks of (ii) plasma-, (iii) endoplasmic reticulum- (ER) membrane Ca2+ ion channels and (iv) mitochondria- (MIT) Ca2+ ions release by permeability transition por (PTP), resp. The measured physiol. effectiveness of these factors was the number of living and dying cortex cells estimated with orange acridine (OA) and ethidium bromide (EB), the amounts of cytosolic Ca2+ ions with chlortetracycline (CTC) staining and the intensity of chromatin and Ca2+-CTC complex fluorescence, resp. Moreover, the role of sorafenib, an inhibitor of RAF kinase, on the vitality of cortex cells and ethylene levels as well as the activities of RAF-like kinase and MEK2 with Syntide-2 and Mek2 as substrates were studied. The results clarified the previously presented suggestion that Kin is converted to appropriate ribotides (5′-monophosphate ribonucleotides), which cooperate with the ethylene and Ca2+ ion signalling pathways to transduce the signal of kinetin-programmed cell death (Kin-PCD). Based on the present and previously published results related to Kin-PCD, the crosstalk between ethylene and MAP kinase signalling, as well as inhibitors of CK receptors and enzymes of their metabolism, is proposed.

Scientific Reports published new progress about 1122579-42-3. 1122579-42-3 belongs to alcohols-buliding-blocks, auxiliary class 5.6_Aromatics,Purines, name is 2-(((9H-Purin-6-yl)amino)methyl)-6-methylphenol, and the molecular formula is C13H13N5O, Safety of 2-(((9H-Purin-6-yl)amino)methyl)-6-methylphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kazmierczak, Andrzej published the artcileMechanism of kinetin-induced death of Vicia faba ssp. minor root cortex cells, Safety of 2-(((9H-Purin-6-yl)amino)methyl)-6-methylphenol, the publication is Scientific Reports (2021), 11(1), 23746, database is CAplus and MEDLINE.

Cell death (CD) may be induced by endogenous or exogenous factors and contributes to all the steps of plant development. This paper presents results related to the mechanism of CD regulation induced by kinetin (Kin) in the root cortex of Vicia faba ssp. minor. To explain the process, 6-(2-hydroxy-3-methylbenzylamino)purine (PI-55), adenine (Ad), 5′-amine-5′-deoxyadenosine (Ado) and N-(2-chloro-4-piridylo)-N′-phenylurea (CPPU) were applied to (i) block cytokinin receptors (CKs) and inhibit the activities of enzymes of CK metabolism, i.e., (ii) phosphoribosyltransferase, (iii) kinases, and (iv) oxidases, resp. Moreover, ethylene glycol-bis(β-aminoethyl ether)-N,N,N′,N′-tetraacetic acid (EGTA), lanthanum chloride (LaCl3), ruthenium red (RRed) and cyclosporine A (CS-A) were applied to (i) chelate extracellular calcium ions (Ca2+) as well as blocks of (ii) plasma-, (iii) endoplasmic reticulum- (ER) membrane Ca2+ ion channels and (iv) mitochondria- (MIT) Ca2+ ions release by permeability transition por (PTP), resp. The measured physiol. effectiveness of these factors was the number of living and dying cortex cells estimated with orange acridine (OA) and ethidium bromide (EB), the amounts of cytosolic Ca2+ ions with chlortetracycline (CTC) staining and the intensity of chromatin and Ca2+-CTC complex fluorescence, resp. Moreover, the role of sorafenib, an inhibitor of RAF kinase, on the vitality of cortex cells and ethylene levels as well as the activities of RAF-like kinase and MEK2 with Syntide-2 and Mek2 as substrates were studied. The results clarified the previously presented suggestion that Kin is converted to appropriate ribotides (5′-monophosphate ribonucleotides), which cooperate with the ethylene and Ca2+ ion signalling pathways to transduce the signal of kinetin-programmed cell death (Kin-PCD). Based on the present and previously published results related to Kin-PCD, the crosstalk between ethylene and MAP kinase signalling, as well as inhibitors of CK receptors and enzymes of their metabolism, is proposed.

Scientific Reports published new progress about 1122579-42-3. 1122579-42-3 belongs to alcohols-buliding-blocks, auxiliary class 5.6_Aromatics,Purines, name is 2-(((9H-Purin-6-yl)amino)methyl)-6-methylphenol, and the molecular formula is C13H13N5O, Safety of 2-(((9H-Purin-6-yl)amino)methyl)-6-methylphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts