Tag: M.W=250-300

Tu, Jia-Lin published the artcileRadical Aza-Cyclization of α-Imino-oxy Acids for Synthesis of Alkene-Containing N-Heterocycles via Dual Cobaloxime and Photoredox Catalysis, SDS of cas: 20880-92-6, the publication is Organic Letters (2020), 22(3), 1222-1226, database is CAplus and MEDLINE.

Nitrogen-containing heterocycles are prevalent in both naturally and synthetically bioactive mols. We report herein an unprecedented protocol for radical aza-cyclization of α-imino-oxy acids with pendant alkenes via synergistic photoredox and cobaloxime catalysis. With or without alkenes as the intermol. cross-coupling partners, the transformation provides a variety of corresponding alkene-containing dihydropyrrole products in satisfactory yields. In the presence of external alkenes, the tandem reaction generates E-selective coupling products with excellent chemo- and stereoselectivity.

Organic Letters published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C9H9BO2, SDS of cas: 20880-92-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lai, Yiang published the artcilePotential application of BC₃ nanotube for removal of bisphenol from water; density functional theory study, Formula: C12H10O4S, the publication is Journal of Molecular Liquids (2022), 119147, database is CAplus.

Using d. functional theory, the current study reported stability, structures, inter-mol. forces, and the electronic characteristics in the solution of complexes which was formed between bisphenol S (BPS) and the BC₃ nanotube (BC₃NT). The potential application of BC₃NT in removing BPS was investigated. BPS had an interaction with B atom of BC₃NT with its S atom and the energy of adsorption was approx. -29.31 kcal/mol. The electronic characteristics of BC₃NT were significantly affected by BPS, which facilitated the adsorption process. Moreover, the donor-acceptor interaction mainly controlled the adsorption mechanism of BPS. In addition to promoting the development of sustainable and cheap heteroatom carbon-based materials (HCBMs), the current study systematically investigated the adsorption mechanism of HCBMs for BPS.

Journal of Molecular Liquids published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Formula: C12H10O4S.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhou, Yi published the artcileEfficient Oxidation of Paracetamol Triggered by Molecular-Oxygen Activation at β-Cyclodextrin-Modified Titanate Nanotubes, Formula: C12H10O4S, the publication is Chemistry – An Asian Journal (2022), 17(13), e202200352, database is CAplus and MEDLINE.

Titanate nanotubes (TNTs) were coated with a cyclic oligosaccharide (carboxymethyl-β-cyclodextrin, CM-β-CD) to obtain a photocatalyst (CM-β-CD-TNT) for efficiently activating mol. oxygen and removing the target contaminant. The hydrophobic cavity and the large sp. surface area of the photocatalyst provide abundant active sites for activating mol. oxygen. The free radical capture experiment and quenching experiment showed that cyclodextrin could facilitate adsorption and activation of mol. oxygen to produce O₂.-. Therefore, compared with the pristine TNT, CM-β-CD-TNT accelerated the oxidation efficiency of paracetamol (APAP) by 3.4 times. Moreover, the ring cleavage reaction induced by CM-β-CD-TNT effectively reduced the acute toxicity of wastewater containing APAP. Furthermore, 100% of bisphenol A (BPA), bisphenol S (BPS), phenol, 2,4-dichlorophen (2,4-DCP), and carbamazepine (CBZ) were degraded by CM-β-CD-TNT after 2.5 h UV light irradiation This strategy provides a new dimension for the advanced treatment of organic wastewater by organic macrocyclic mol.-modified materials.

Chemistry – An Asian Journal published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C4H5NS2, Formula: C12H10O4S.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Pengfei published the artcileA mild acetolysis procedure for the regioselective removal of isopropylidene in di-O-isopropylidene-protected pyranoside systems, Computed Properties of 20880-92-6, the publication is Carbohydrate Research (2017), 7-13, database is CAplus and MEDLINE.

A mild acetolysis method for the regioselective removal of isopropylidene group from di-O-isopropylidene-protected hexopyranosides is reported. O-Isopropylidene-protected intermediates play an important role in carbohydrate chem., as they are often found in com. available furanosyl and pyranosyl materials, and some of them contain more than one O-isopropylidene groups. Methods that permit regioselective removal of O-isopropylidene groups are extremely valuable, as the number of steps in the total synthesis of complex oligosaccharides could be significantly decreased. Here we report that trifluoroacetic acid (TFA)/acetic anhydride (Ac₂O) can be used to regioselectively convert one of the two O-isopropylidene groups to vicinal di-O-acetates in the di-O-isopropylidene-protected galacto- and fructopyranosyl systems, and the reagent is compatible with some common functionalities such as sulfonate esters, bromide, azide etc.

Carbohydrate Research published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C8H5F3O2S, Computed Properties of 20880-92-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Téteau, Ophélie published the artcileBisphenol S Alters the Steroidome in the Preovulatory Follicle, Oviduct Fluid and Plasma in Ewes With Contrasted Metabolic Status., Recommanded Product: 4,4′-Sulfonyldiphenol, the publication is Frontiers in endocrinology (2022), 892213, database is MEDLINE.

Bisphenol A (BPA), a plasticizer and endocrine disruptor, has been substituted by bisphenol S (BPS), a structural analogue that had already shown adverse effects on granulosa cell steroidogenesis. The objective of this study was to assess the effect of chronic exposure to BPS, a possible endocrine disruptor, on steroid hormones in the ovary, oviduct and plasma using the ewe as a model. Given the interaction between steroidogenesis and the metabolic status, the BPS effect was tested according to two diet groups. Eighty adult ewes were allotted to restricted (R) and well-fed (WF) groups, that were further subdivided into two subgroups. Ewes were exposed to 50 µg BPS/kg/day in their diet (R50 and WF50 groups) or were unexposed controls (R0 and WF0 groups). After at least 3 months of BPS exposure, preovulatory follicular fluid, oviduct fluid and plasma were collected and steroid hormones were analyzed by gas chromatography coupled with tandem mass spectrometry (GC-MS/MS). A deleterious effect of restricted diet on the volume of oviduct fluid and numbers of pre-ovulatory follicles was observed. Exposure to BPS impaired estradiol concentrations in both follicular and oviduct fluids of well-fed ewes and progesterone, estradiol and estrone concentrations in plasma of restricted ewes. In addition, a significant interaction between metabolic status and BPS exposure was observed for seven steroids, including estradiol. In conclusion, BPS acts in ewes as an endocrine disruptor with differential actions according to metabolic status.

Frontiers in endocrinology published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C22H18Cl2N2, Recommanded Product: 4,4′-Sulfonyldiphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Mok, Sori published the artcileWithin- and between-person variability of urinary phthalate metabolites and bisphenol analogues over seven days: Considerations of biomonitoring study design, Related Products of alcohols-buliding-blocks, the publication is Environmental Research (2022), 112885, database is CAplus and MEDLINE.

Urine was used as a part of a human biomonitoring study based on the excretion kinetics of less-persistent contaminants, such as phthalates and bisphenol A (BPA). Despite the advantages of being non-invasive and easy to collect, urine can show a large variability of concentrations of phthalate metabolites and BPA within a person depending on sampling time. Therefore, it is essential to assess the variability of urinary concentrations for comprehensive sampling design in the context of exposure and risk assessments. In this study, 18 phthalate metabolites and eight BPs were measured in all spot urine (n = 401) collected from 12 participants for seven consecutive days to evaluate within- and between-person variabilities. The intraclass correlation coefficients (ICCs) for all spot urines were poor for monomethyl phthalate (ICC: 0.002) and BPA (0.121) but were moderate for monoethyl phthalate (0.514) and monobenzyl phthalate (0.462). Based on the results of di (2-ethylhexyl) phthalate (DEHP) metabolites, the half-life and differences in metabolic capability seem to affect the ICCs. Urinary mono (2-ethylhexyl) phthalate (MEHP), a primary metabolite of DEHP, was suggested as a short-term exposure marker of DEHP in our study. Creatinine- and sp. gr.-adjusted concentrations of phthalate metabolites and BPs resulted in increased ICCs, implying requirements for randomly collected spot urine. Most analytes in the first morning voids (FMVs) were correlated significantly with those in the daily composites, suggesting the feasibility of FMVs to estimate the daily exposure dose. This study facilitates a more comprehensive sampling design and data interpretation strategy for human biomonitoring studies.

Environmental Research published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lee, Johnny W. published the artcileRedox-Neutral TEMPO Catalysis: Direct Radical (Hetero)Aryl C-H Di- and Trifluoromethoxylation, Recommanded Product: ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, the publication is Angewandte Chemie, International Edition (2020), 59(48), 21475-21480, database is CAplus and MEDLINE.

Applications of TEMPO· catalysis for the development of redox-neutral transformations are rare. Reported here is the first TEMPO·-catalyzed, redox-neutral C-H di- and trifluoromethoxylation of (hetero)arenes. The reaction exhibits a broad substrate scope, has high functional-group tolerance, and can be employed for the late-stage functionalization of complex druglike mols. Kinetic measurements, isolation and resubjection of catalytic intermediates, UV/visible studies, and DFT calculations support the proposed oxidative TEMPO·/TEMPO⁺ redox catalytic cycle. Mechanistic studies also suggest that Li₂CO₃ plays an important role in preventing catalyst deactivation. These findings will provide new insights into the design and development of novel reactions through redox-neutral TEMPO· catalysis.

Angewandte Chemie, International Edition published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, Recommanded Product: ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chung, Sheng-Hsuan published the artcileSynthesis of boron-containing primary amines, Recommanded Product: [4-Fluoro-3-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanol, the publication is Molecules (2013), 18(10), 12346-12367, database is CAplus and MEDLINE.

B-containing primary amines were synthesized for use as building blocks in the study of peptoids. In the 1st step, Gabriel synthesis conditions were modified to enable the construction of seven different aminomethylphenyl boronate esters, e.g., p-(pinB)C₆H₄CH₂NH₂ (Bpin = 4,4,5,5-tetramethyl-1,3,2-dioxaborolanyl), in good to excellent yields. These compounds were further used to build peptoid analogs via an Ugi four-component reaction (Ugi-4CR) under microwave irradiation The prepared Ugi-4CR boronate esters were then successfully converted to the corresponding boronic acids. Finally, the peptoid structures were successfully modified by cross-coupling to aryl/heteroaryl chlorides via a Pd-mediated Suzuki coupling reaction to yield the corresponding derivatives in moderate to good yields.

Molecules published new progress about 1333264-06-4. 1333264-06-4 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester,Boronic acid and ester, name is [4-Fluoro-3-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanol, and the molecular formula is C13H18BFO3, Recommanded Product: [4-Fluoro-3-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cao, Zhi published the artcileTotal Synthesis of Two Pyrrole Spiroketal Alkaloids: Pollenopyrroside A and Capparisine B, Name: ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, the publication is Synlett (2015), 26(7), 921-926, database is CAplus.

Pollenopyrroside A (I) and capparisine B (II), two diastereoisomers of pyrrole spiroketal alkaloids isolated from Brassica campestris pollen and Capparis spinosa, were synthesized by an improved microwave-assisted bishydroxymethylation of pyrrole and acid-catalyzed spirocyclization as key steps with total yields of 2.7 and 8.8%, resp.

Synlett published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, Name: ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhou, Pan published the artcileMolybdenum-Catalyzed Cross-Coupling of Benzyl Alcohols: Direct C-OH Bond Transformation via [2 + 2]-Type Addition and Elimination, Product Details of C19H14O2, the publication is Organic Letters (2022), 24(23), 4218-4223, database is CAplus and MEDLINE.

Traditional cross-couplings catalyzed by transition metal catalysts generally rely on the classic oxidative addition-transmetalation-reductive elimination process, which requires low-valent precious metals and an inert atm. and which initiates from carbon-alide or pesudo carbon-halide bonds. Herein, an unprecedented molybdenum-oxo-complex-catalyzed intermol. cross-coupling of benzyl alcs. has been reported. Various alcs. including primary, secondary, and tertiary substrates can proceed efficiently under these conditions. Several functional groups sensitive to the low-valent transition metals, such as aryl halides, can be well tolerated. The mechanistic studies and DFT calculations suggest that an intramol. concerted cyclization was involved in the reverse [2 + 2]-type elimination process.

Organic Letters published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C10H14O, Product Details of C19H14O2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts