Huang, Yuan’s team published research in Journal of Steroid Biochemistry and Molecular Biology in 222 | CAS: 80-09-1

Journal of Steroid Biochemistry and Molecular Biology published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Synthetic Route of 80-09-1.

Huang, Yuan published the artcileRapid and reagent-free bioassay using autobioluminescent yeasts to detect agonistic and antagonistic activities of bisphenols against rat androgen receptor and progesterone receptor, Synthetic Route of 80-09-1, the publication is Journal of Steroid Biochemistry and Molecular Biology (2022), 106151, database is CAplus and MEDLINE.

Bisphenol A (BPA) and its analogs have been classified as endocrine disruptors via binding to nuclear receptors. Two novel bioassays, BLYrARS and BLYrPRS, were developed for rapid detection of agonistic and antagonistic activities of BPA and five of its analogs binding rat androgen receptor (rAR) and rat progesterone receptor (rPR). The reporter bioassay was based on two autonomously bioluminescent strains of the yeast Saccharomyces cerevisiae, recombined with a bacterial luciferase reporter gene cassette (lux) that can produce autofluorescence, regulated by the corresponding hormone response element acting as the responsive promoter. The bioluminescent signal is autonomous and continuous without cell lysis or addition of exogenous reagents. The AR agonist R1881 could be detected at 4 h with a half-maximal effective concentration (EC50) of ∼9.4 nM. The PR agonist progesterone could be determined at 4 h with an EC50 of ∼2.74 nM. None of the sixteen bisphenols presented agonistic activities against rAR and rPR. However, thirteen BPs were rAR antagonists and eleven BPs acted as rPR antagonists with different potency. The BLYrARS and BLYrPRS bioassay characterized by automated signal acquisition without addnl. manipulations or cost can be applied for simple and rapid detection of agonistic and antagonistic activities of BPs and other compounds acting as agonists or antagonists of rAR and rPR. Based on data derived by use of this bioassay endocrine-disrupting activities of some BPA analogs are more potent than BPA.

Journal of Steroid Biochemistry and Molecular Biology published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Synthetic Route of 80-09-1.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Xue, Da-quan’s team published research in Hecheng Huaxue in 18 | CAS: 156453-53-1

Hecheng Huaxue published new progress about 156453-53-1. 156453-53-1 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Benzene,Naphthalene,Alcohol,Ether, name is (R)-3-(Naphthalen-1-yloxy)-1-phenylpropan-1-ol, and the molecular formula is C10H15ClO3S, Product Details of C19H18O2.

Xue, Da-quan published the artcileSynthesis of dapoxetine hydrochloride, Product Details of C19H18O2, the publication is Hecheng Huaxue (2010), 18(5), 647-649, database is CAplus.

Dapoxetine hydrochloride was synthesized from 3-chloropropiophenone by catalytic asym. reduction, alkylation, O-methylsulfonylation, and dimethylamination, as well as salt formation in an overall yield of 39.9%.

Hecheng Huaxue published new progress about 156453-53-1. 156453-53-1 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Benzene,Naphthalene,Alcohol,Ether, name is (R)-3-(Naphthalen-1-yloxy)-1-phenylpropan-1-ol, and the molecular formula is C10H15ClO3S, Product Details of C19H18O2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sui, Rui’s team published research in Nano Research in 15 | CAS: 80-09-1

Nano Research published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C13H10F2, HPLC of Formula: 80-09-1.

Sui, Rui published the artcileSilver based single atom catalyst with heteroatom coordination environment as high performance oxygen reduction reaction catalyst, HPLC of Formula: 80-09-1, the publication is Nano Research (2022), 15(9), 7968-7975, database is CAplus.

Ag is a potential low-cost oxygen reduction reaction (ORR) catalyst in alk. condition, which is important for the zinc-air batteries. Here, we report that an Ag based single atom catalyst with heteroatom coordination. Ag1-h-NPClSC, has been synthesized and shown much improved performance towards ORR by manipulating the coordination environment of the Ag center. It shows a high half wave potential (0.896 V) and a high turnover frequency (TOF) (5.9 s-1) at 0.85 V, which are higher than the previously reported Ag based catalysts and com. Pt/C. A zinc-air battery with high peak power d. of 270 mW·cm-2 is fabricated by using the Ag1-h-NPClSC as air electrode. The high performance is attributed to (1) the hollow structure providing good mass transfer; (2) the single atom metal center structure providing high utility of the Ag; (3) heteroatom coordination environment providing the adjusted binding to the ORR intermediates. D. functional theory (DFT) calculations show that the energy barrier for the formation of OOH*, which is considered as the rate determine step for ORR on Ag nanoparticles, is lowered on Ag1-h-NPClSC, thus improving the ORR activity. This work demonstrates that the well manipulated Ag based single atom catalysts are promising in electrocatalysis.

Nano Research published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C13H10F2, HPLC of Formula: 80-09-1.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yao, Dongxue’s team published research in Journal of Environmental Chemical Engineering in 10 | CAS: 80-09-1

Journal of Environmental Chemical Engineering published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C7H6Cl2O, Computed Properties of 80-09-1.

Yao, Dongxue published the artcileHigh-flux PSF/PES-COOH hollow fiber loose nanofiltration membrane for high-efficiency dye-salt separation, Computed Properties of 80-09-1, the publication is Journal of Environmental Chemical Engineering (2022), 10(4), 108180, database is CAplus.

Loose nanofiltration membranes show great potential to realize the effective separation of dyes and salts but still show low capacity for treating textile wastewater due to low membrane flux. In this work, a high-flux hollow fiber nanofiltration membrane (HFNFM) for the separation of dyes and salts was fabricated through a simple one-step non-solvent induced phase separation (NIPS) method. A carboxylated polyethersulfone (PES-COOH) was synthesized by the polycondensation based on Williamson reaction using diallyl bisphenol sulfur as a commoner followed by the thio-ene reaction with thioglycolic acid. Then PES-COOH was blended with polysulfone (PSF) for hollow fiber spinning based on the NIPS method. The effects of the ratio of PSF to PES-COOH on the membrane structure and performance were studied with scanning electron microscope (SEM), differential scanning calorimetry (DSC), X-ray photoelectron spectrometer (XPS), water contact angle and zeta potential measurements. Upon optimization, the PSF/PES-COOH HFNFM displayed a water flux of 159.6 L m-2 h-1 bar-1, and a rejection of 99.2% for Congo red at a dye concentration of 100 mg/L and operating pressure of 0.1 MPa. With the effective dye-salt fractionation which was comparative to literature reports, the membrane showed unprecedentedly high flux, which can be attributed to the double layer finger-like structure and hydrophilic PES-COOH as additives. The membrane also presented excellent stability and antifouling property during the treatment of simulated textile wastewater.

Journal of Environmental Chemical Engineering published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C7H6Cl2O, Computed Properties of 80-09-1.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Pu, Yanchi’s team published research in European Journal of Medicinal Chemistry in 183 | CAS: 20880-92-6

European Journal of Medicinal Chemistry published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, HPLC of Formula: 20880-92-6.

Pu, Yanchi published the artcileDual-targeting liposomes with active recognition of GLUT5 and αvβ3 for triple-negative breast cancer, HPLC of Formula: 20880-92-6, the publication is European Journal of Medicinal Chemistry (2019), 111720, database is CAplus and MEDLINE.

At present, chemo- and radiotherapies remain to be the mainstream methods for treating triple-neg. breast cancer (TNBC), which is known for poor prognosis and high rate of mortality. Two types of novel dual-targeting TNBC liposomes (Fru-RGD-Lip and Fru+RGD-Lip) that actively recognize both fructose transporter GLUT5 and integrin αvβ3 were designed and prepared in this work. Firstly, a Y-shaped Fru-RGD-chol ligand, where a fructose and peptide Arg-Gly-Asp (RGD) were covalently attached to cholesterol, was designed and synthesized. Then, the Fru-RGD-Lip was constructed by inserting Fru-RGD-chol into liposomes, while Fru+RGD-Lip was obtained by inserting both Fru-chol and RGD-chol (with the molar ratio of 1:1) into liposomes. The particle size, zeta potential, encapsulation efficiency and serum stability of the paclitaxel-loaded liposomes were characterized. The results indicated that the paclitaxel-loaded Fru-RGD-Lip had the strongest growth inhibition against GLUT5 and αvβ3 overexpressed MDA-MB-231 and 4T1 cells. The cellular uptake of Fru-RGD-Lip on MDA-MB-231 cells and 4T1 cells was 3.19- and 3.23-fold more than that of the uncoated liposomes (Lip). The uptake of Fru+RGD-Lip was slightly lower, giving a 2.81- and 2.90-fold increase than that of Lip in two cell lines, resp. The mechanism study demonstrated that the cellular uptake of both dual-targeting liposomes was likely to be recognized and mediated by GLUT5 and αvβ3 firstly, then endocytosed through comprehensive pathways in an energy-dependent manner. Moreover, Fru-RGD-Lip displayed the maximum accumulation, which was 2.62-fold higher than that of Lip for instance, at the tumor sites compared to other liposomes using in vivo imaging. Collectively, the liposomes co-modified by fructose and RGD have enormous potential in the development of targeted TNBC treatment, especially the covalently modified Fru-RGD-Lip, making it a promising multifunctional liposome.

European Journal of Medicinal Chemistry published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, HPLC of Formula: 20880-92-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yu, Dan’s team published research in ACS Materials Letters in 2 | CAS: 20880-92-6

ACS Materials Letters published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C8H10O4, HPLC of Formula: 20880-92-6.

Yu, Dan published the artcileSelf-Assembled Nucleotide/Saccharide-Tethering Polycation-Based Nanoparticle for Targeted Tumor Therapy, HPLC of Formula: 20880-92-6, the publication is ACS Materials Letters (2020), 2(5), 550-556, database is CAplus.

Development of novel concepts to construct drug vehicles for efficient encapsulation of hydrophobic drugs and targeted therapy is highly desirable to biomedical science. It remains a challenge to create effective noncovalent linkage between the components within the drug vectors. In this work, we report a supramol. approach to construct multifunctional nanoparticles, which combined tumor-targeting capability via saccharide, cell penetration via pos.-charged surface, and chemotherapeutic function via drug delivery for cancer therapy. A endogenous self-associating nucleotide (guanosine monophosphate) noncovalently bonded with a hydrophobic nucleoside analog drug (clofarabine) to form nanofibrils, which were transformed to spherical nanoparticles by assembling with a fructose/ethanolamine-functionalized starlike poly(glycidyl methacrylate)-based cationic polymer. Noncovalent cavities within the nanoparticles were created, through the nucleotide self-association, and acted as linkage between the hydrophilic cationic polymer and the drug. The saccharide-tethering polycation and nucleotide components were labeled with fluorescent dyes, resp., to image the endocytosis and biodistribution. In vitro and in vivo results show that the functional nanoparticles exhibited good capabilities of the targeted accumulation of the nanoparticles and delivery of drugs in cancer cells and tumor sites, leading to a robust anticancer effect.

ACS Materials Letters published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C8H10O4, HPLC of Formula: 20880-92-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhou, Xukai’s team published research in Journal of the American Chemical Society in 144 | CAS: 20880-92-6

Journal of the American Chemical Society published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C14H12O3S, Category: alcohols-buliding-blocks.

Zhou, Xukai published the artcileSite-Specific and Degree-Controlled Alkyl Deuteration via Cu-Catalyzed Redox-Neutral Deacylation, Category: alcohols-buliding-blocks, the publication is Journal of the American Chemical Society (2022), 144(22), 9570-9575, database is CAplus and MEDLINE.

A Cu-catalyzed degree-controlled deacylative deuteration of diverse alkyl groups with the methylketone (acetyl) moiety as a traceless activating group was reported. The use of N-methylpicolino-hydrazonamide (MPHA) promotes efficient aromatization-driven C-C cleavage. Mono-, di-, and trideuteration at specific sites was selectively achieved. The reaction is redox-neutral with broad functional group tolerance. The utility of this method was demonstrated in forming a complete set of deuterated Et groups, merging with the Diels-Alder reaction, a net devinylative deuteration, and the synthesis of the d2-analog of Austedo.

Journal of the American Chemical Society published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C14H12O3S, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Amanchukwu, Chibueze V.’s team published research in Journal of the American Chemical Society in 142 | CAS: 129301-42-4

Journal of the American Chemical Society published new progress about 129301-42-4. 129301-42-4 belongs to alcohols-buliding-blocks, auxiliary class Fluoride,Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2,2′-((Perfluoroethane-1,2-diyl)bis(oxy))bis(2,2-difluoroethanol), and the molecular formula is C6H6F8O4, Product Details of C6H6F8O4.

Amanchukwu, Chibueze V. published the artcileA New Class of Ionically Conducting Fluorinated Ether Electrolytes with High Electrochemical Stability, Product Details of C6H6F8O4, the publication is Journal of the American Chemical Society (2020), 142(16), 7393-7403, database is CAplus and MEDLINE.

Increasing battery energy d. is greatly desired for applications such as portable electronics and transportation. However, many next-generation batteries are limited by electrolyte selection because high ionic conductivity and poor electrochem. stability are typically observed in most electrolytes. For example, ether-based electrolytes have high ionic conductivity but are oxidatively unstable above 4 V, which prevents the use of high-voltage cathodes that promise higher energy densities. In contrast, hydrofluoroethers (HFEs) have high oxidative stability but do not dissolve lithium salt. In this work, we synthesize a new class of fluorinated ether electrolytes that combine the oxidative stability of HFEs with the ionic conductivity of ethers in a single compound We show that conductivities of up to 2.7 x 10-4 S/cm (at 30°C) can be obtained with oxidative stability up to 5.6 V. The compounds also show higher lithium transference numbers compared to typical ethers. Furthermore, we use NMR (NMR) and mol. dynamics (MD) to study their ionic transport behavior and ion solvation environment, resp. Finally, we demonstrate that this new class of electrolytes can be used with a Ni-rich layered cathode (NMC 811) to obtain over 100 cycles at a C/5 rate. The design of new mols. with high ionic conductivity and high electrochem. stability is a novel approach for the rational design of next-generation batteries.

Journal of the American Chemical Society published new progress about 129301-42-4. 129301-42-4 belongs to alcohols-buliding-blocks, auxiliary class Fluoride,Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2,2′-((Perfluoroethane-1,2-diyl)bis(oxy))bis(2,2-difluoroethanol), and the molecular formula is C6H6F8O4, Product Details of C6H6F8O4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Rui’s team published research in Journal of Analytical and Applied Pyrolysis in 160 | CAS: 20880-92-6

Journal of Analytical and Applied Pyrolysis published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, Computed Properties of 20880-92-6.

Li, Rui published the artcilePreparation and pyrolysis of two Amadori analogues as flavor precursors, Computed Properties of 20880-92-6, the publication is Journal of Analytical and Applied Pyrolysis (2021), 105357, database is CAplus.

Amadori compounds, produced during Maillard reaction, are considered as precursors of flavor compounds On the basis of Amadori compounds, herein two Amadori analogs, di-O-isopropylidene-2,3:4,5-β-D-fructopyranosyl alanine ester (A-ARP) and di-O-isopropylidene-2,3:4,5-β-D-fructopyranosyl proline ester (P-ARP), were chem. synthesized and their possibility as flavor precursors was evaluated by thermogravimetry (TG), derivative thermogravimetry (DTG), differential scanning calorimetry (DSC), and pyrolysis gas chromatog.-mass spectrometry (Py-GC/MS). TG-DTG analyses indicated that the samples were stable at room temperature, and the largest mass-loss rates (Tp) were at 208 and 278 °C, resp. Upon thermal pyrolysis, the major flavor substances were butan-2-one, Et propionate, furfural, and DL-limonene for A-ARP, while 2,5-dimethylfuran, heptan-2-one, acetophenone, and 1H-pyrrole for P-ARP. The flavor profiles are different from that of corresponding Amadori compounds, and are influenced by pyrolytic temperatures These results provide one method to regulate the species and amounts of the degraded flavor products. Finally, the possible mechanisms of the pyrolytic processes are proposed.

Journal of Analytical and Applied Pyrolysis published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, Computed Properties of 20880-92-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wan, Peter’s team published research in Journal of Organic Chemistry in 50 | CAS: 596-38-3

Journal of Organic Chemistry published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C15H14Cl2S2, Safety of 9-Phenyl-9H-xanthen-9-ol.

Wan, Peter published the artcileAdiabatic photodehydroxylation of 9-phenylxanthen-9-ol. Observation of carbocation fluorescence in neutral aqueous solution, Safety of 9-Phenyl-9H-xanthen-9-ol, the publication is Journal of Organic Chemistry (1985), 50(16), 2881-6, database is CAplus.

The photobehavior of the title compound (I) is examined in aqueous solution and organic solvents. Aqueous I undergoes adiabatic photodehydroxylation (the first example of a new class of adiabatic photochem. reactions). The reaction is not observed in MeCN and 95% aqueous EtOH. The photogenerated carbocation is trapped by MeOH in aqueous MeOH. The photobehavior of I is due to the enhanced basicity (as measured by the ionization constant pKR+ of the mol. in S1 relative to that of the ground state (S0). The enhanced electron-donating effect of the ortho atom of I in the excited singlet state is responsible for this effect.

Journal of Organic Chemistry published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C15H14Cl2S2, Safety of 9-Phenyl-9H-xanthen-9-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts