Tag: M.W=200-350

Byl, Eline published the artcileElastic recovery of filler-binders to safeguard viability of Lactobacillus rhamnosus GG during direct compression, Product Details of C12H24O11, the main research area is Lactobacillus elastic recovery filler binders direct compression probiotic tablets; Compression; Flow cytometry; Lactobacillus rhamnosus; Probiotic; Respiratory infections; Storage; Tablet; Viability.

Tablets are increasingly explored as dosage form for oral probiotics, especially for applications such as pharyngitis and dental health. In such tablets, the dry form increases the stability and the shelf life of the product. In addition, the probiotic cells are entrapped in the tablet matrix, which protects them against the environmental factors in the human body. However, the development of a probiotic tablet with an adequate number of viable cells remains a challenge due to the stress of the compression process. The adverse conditions during production can damage the cells, which leads to a loss of viability and a failure of the therapy. This study aimed to investigate the effect of the compression behavior of filler-binders on the survival of Lactobacillus rhamnosus GG during tablet production The probiotic tablets were manufactured by direct compression of a freeze-dried mixture of the model L. rhamnosus GG, a filler-binder and a suitable amount of lubricant. The compression behavior was determined by analyzing Heckel and force-displacement plots. The results demonstrated that the elastic recovery of the filler-binder during decompression played a protective role in bacterial survival, reducing the compression stress during manufacturing Consequently, the bacterial cells were less damaged, which resulted in a higher survival rate and a better stability during long-term storage. In conclusion, the elastic recovery of a filler-binder showed to be an important key in safeguarding probiotic cells during direct compression and storage.

European Journal of Pharmaceutics and Biopharmaceutics published new progress about Binders. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Product Details of C12H24O11.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bredenberg, Susanne published the artcileEvaluation of a sieve classification method for characterization of low-dose interactive mixtures, Related Products of alcohols-buliding-blocks, the main research area is sodium salicylate carrier demixing sieving particle size.

This study investigated a sieve classification method for evaluating carrier materials and particle size fractions, which could be a valuable tool in the early development of pharmaceutical dosage forms containing low-dose interactive mixtures When developing new products based on interactive mixtures, it is essential to ensure that the drug particles are successfully deagglomerated and have adhered to the carrier particles. In this study, the effect on the demixing potential (DP) of low-dose interactive mixtures was assessed for various carrier particle sizes and surface textures. The model drug used was sodium salicylate and the tested carriers were lactose, mannitol, and isomalt. The results showed that the lowest DPs, i.e. the most mech. stable mixtures, were obtained with lactose. Furthermore, for interactive mixtures, small carrier particles and/or a narrow carrier particle size range are essential for obtaining a low DP and high homogeneity. Calculation of the DP provided a reliable estimate of the quality of the low-dose interactive mixtures used in this study.

Pharmaceutical Development and Technology published new progress about Demixing. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hadjikinova, Raina published the artcileDevelopment and validation of HPLC-RID method for determination of sugars and polyols, SDS of cas: 64519-82-0, the main research area is dessert food sugar polyol HPLC RID analysis.

The aim of the current study was to develop and validate a rapid, sensitive and accurate method for simultaneous determination of sugars (glucose, fructose, sucrose and lactose) and polyols (erythritol, mannitol, sorbitol, isomalt and xylitol) in low-calorie and no-sugar added desserts by high pressure liquid chromatog. coupled with refractive index detector (RID). The best chromatog. separation was performed on Pb2+ Shodex Sugars SP0810 operating at 80°C and mobile phase distilled water with flow rate 0.5 mL/min. Validation procedure includes for linearity, precision and accuracy of the method. The developed method offers excellent linearity in wide concentration range (0.1-5 mg/mL) for all tested carbohydrates with R2>0.997. Limit of detection (LOD) and limit of quantification (LOQ) for nine analytes were in the range of 0.01-0.17 mg/mL and 0.03-0.56 mg/mL, resp. HPLC-RID method showed very good repeatability (RSD >5 %) and reproducibility. The developed method was successfully applied for quantification of sugars and sugar alcs. in dessert foods. The results obtained from the analyzed real samples showed the possibility of the proposed method to be used for routine anal. of sugars and sugar alcs. in low-calorie, no-sugar added dessert foods and pharmaceutical formula only with one injection of the sample.

Journal of Pharmaceutical Sciences and Research published new progress about Desserts. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, SDS of cas: 64519-82-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Martinez-Cervera, Sandra published the artcileComparison of different polyols as total sucrose replacers in muffins: Thermal, rheological, texture and acceptability properties, Product Details of C12H24O11, the main research area is sucrose replacer polyol muffin quality.

The aim of this work was to compare the suitability of different polyols (sorbitol, maltitol, isomalt and erythritol) as total sucrose replacers in muffins. Thermal and rheol. properties of the batters and muffin texture, height and consumer acceptability were evaluated. As sucrose, all the polyols increased the starch gelatinization temperature, although differences were found among them, being erythritol the less effective. The batter rheol. properties also revealed that erythritol showed the highest differences with sucrose, in comparison to the other polyols. All the polyol muffins showed lower height than the sucrose muffins. The effect in muffin texture parameters was dependent on the type of polyol. In comparison to sucrose, erythritol increased the hardness and sorbitol and maltitol decreased it. Isomalt conferred similar texture parameters than sucrose. No differences were found in sensory acceptance among sucrose, sorbitol and maltitol muffins.

Food Hydrocolloids published new progress about Enthalpy. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Product Details of C12H24O11.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Billy, Yin Sing O. published the artcileThe use of non-nutritive and low-calorie sweeteners in 19,915 local and imported pre-packaged foods in Hong Kong, Product Details of C12H24O11, the main research area is nonnutritive lowcalorie sweetener prepackaged food Hong Kong; Hong Kong; intense sweeteners; low-calorie sweeteners; non-nutritive sweeteners; pre-packaged foods; sugar substitutes.

This study aims to examine the use of non-nutritive (NNSs) and low-calorie sweeteners (LCSs) in pre-packaged foods in Hong Kong and the differences in the number of NNSs/LCSs used between products from different regions. In a cross-sectional audit, the types of NNSs/LCSs used in 19,915 pre-packaged foods in Hong Kong were examined by searching the ingredients list of the included products for keywords related to 20 common NNSs/LCSs and their resp. E-numbers Prevalence of use of NNSs and LCSs, the co-presence of NNSs/LCSs and free sugar ingredients (FSI), and the number of NNSs/LCSs used in the included foods were computed. Pearson’s χ2 test was used to compare the total number of NNSs and/or LCSs used in food items from different regions. Sucralose (E955) was the most commonly used NNS (1.9%), followed by acesulfame K (E950, 1.6%). Sorbitol was the most commonly used LCS (2.9%). Overall, the use of LCSs was less common compared with NNSs (3.7% vs. 4.5%). The use of different types of NNSs varied substantially between food types. Notably, 20.2% of potato crisps and 15.2% of other crisps or extruded snacks contained at least one NNS and/or LCS. Co-presence of FSIs and NNSs/LCSs were most common in confectionery (15.7%) and snack foods (15.5%). Asian prepackaged foods were more likely to contain NNSs/LCSs (10.1%) compared with those from other regions. To conclude, NNSs/LCSs were used in a wide range of non-diet pre-packaged products which could be a public health concern due to their higher consumption frequencies than “”diet”” products.

Nutrients published new progress about Biscuits. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Product Details of C12H24O11.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nadian, Narges published the artcileTextural and sensory characteristics of sugar-free biscuit formulated with quinoa flour, isomalt, and maltodextrin, Application In Synthesis of 64519-82-0, the main research area is optimization quinoa response surface method sugar free biscuit; optimization; quinoa; response surface method; sugar ‐free biscuit.

A low-calorie biscuit formulation containing quinoa flour (cultivars TTKK), isomalt, and maltodextrin was optimized using response surface methodol. Optimized samples were evaluated in terms of total phenolic compounds (TPC), sensory properties, and nutritional value while samples containing only wheat flour (Pishgam var.) and sucrose were used as control. Morphol. of isolated starch from quinoa was also investigated. The results showed that with increasing amounts of quinoa, isomalt, and maltodextrin Δ E and Browning index increased, whereas hardness and L values decreased. The formulation containing 25% quinoa flour, 3.5% maltodextrin, and 10% isomalt was found to be optimal with an overall desirability value of 0.95. The sensory evaluation showed that replacement of wheat flour with 25 g/100 g quinoa flour in biscuits was acceptable. TPC of the optimal biscuit (1,180.34 ± 0.02 μg GAE/g) was higher than that of the control sample (729.95 ± 0.007 μg GAE/g). In addition, the optimized biscuit had more protein (8.36 ± 0.035%) and dietary fiber (2.14± 0.035%) content compared with the control sample (7.01 ± 0.007% and 1.66 ± 0.028%, resp.). The consumption of 100 g of optimized quinoa biscuits supplies the daily requirement of Fe, Mg, Ca, and Zn at 2.43%, 44.81%, 19.46% and 1.12%, resp.

Food Science & Nutrition (Hoboken, NJ, United States) published new progress about Biscuits. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Application In Synthesis of 64519-82-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Quodbach, Julian published the artcileCompaction behavior of isomalt after roll compaction, Name: (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, the main research area is galenIQ 801 tablet roll compaction dry granulation flowability friability.

The suitability of the new isomalt grade galenIQ 801 for dry granulation and following tableting is evaluated in this study. Isomalt alone, as well as a blend of equal parts with dibasic calcium phosphate, is roll compacted and tableted. Particle size distribution and flowability of the granules and friability and disintegration time of the tablets are determined Tensile strength of tablets is related to the specific compaction force during roll compaction and the tableting force. In all cases, the tensile strength increases with raising tableting forces. The specific compaction force has a different influence. For isomalt alone the tensile strength is highest for tablets made from granules prepared at 2 kN/cm and 6 kN/cm and decreases at higher values, i.e., >10 kN/cm. Tensile strength of the blend tablets is almost one third lower compared to the strongest tablets of pure isomalt. Friability of pure isomalt tablets is above the limit. Disintegration time is longest when the tensile strength is at its maximum and decreases with higher porosity and lower tensile strengths. Isomalt proves to be suitable for tableting after roll compaction. Even though the capacity as a binder might not be as high as of other excipients, it is a further alternative for the formulation scientist.

Pharmaceutics published new progress about Cohesion. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Name: (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Stojanovic, Goran M. published the artcileRapid selective detection of ascorbic acid using graphene-based microfluidic platform, Application of (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, the main research area is ascorbic acid graphene microfluidic platform selective detection.

In this paper, we present a compact microfluidic platform for selective detection of ascorbic acid. The microfluidic chip was fabricated by xurog. technique with microfluidic channel placed between the silver electrodes. To increase the conductivity of the platform and enhance electron transfer process, a graphene sheet was deposited in the gap between the electrodes. The suspension of tablets with ascorbic acid and a mixture of ascorbic acid and isomalt, a sugar substitute, were injected in the microfluidic channel. Measuring elec. parameters at the silver contacts, it was possible to successfully differentiate ascorbic acid from isomalt. The sensing mechanism of the developed microfluidic platform is based on the increase of the overall conductivity with the increase of the concentration of ascorbic acid, resulting in the decrease of the resistive parameters and increase of the capacitive parameters of the proposed equivalent elec. circuit. The addition of graphene was found to improve the response linearity by 5.28% and lower the limit of detection and quantification by 12%, compared to the reference structure without graphene.

IEEE Sensors Journal published new progress about Analysis. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Application of (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wu, Tongzhi published the artcileEffects of different sweet preloads on incretin hormone secretion, gastric emptying, and postprandial glycemia in healthy humans, Formula: C12H24O11, the main research area is glucose methylglucose Tagatesse sucralose incretin glycemia gastric emptying.

Background: Macronutrient “”preloads”” can stimulate glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), slow gastric emptying, and reduce postprandial glycemic excursions. After sweet preloads, these effects may be signaled by sodium-glucose cotransporter-1 (SGLT1), sweet taste receptors, or both. Objective: We determined the effects of 4 sweet preloads on GIP and GLP-1 release, gastric emptying, and postprandial glycemia. Design: Ten healthy subjects were studied on 4 sep. occasions each. A preload drink containing 40 g glucose, 40 g tagatose/isomalt mixture (TIM), 40 g 3-O-methylglucose (3OMG; a nonmetabolized substrate of SGLT1), or 60 mg sucralose was consumed 15 min before a 13C-octanoic acid-labeled mashed potato meal. Blood glucose, plasma total GLP-1 and GIP, serum insulin, and gastric emptying were determined Results: Both glucose and 3OMG stimulated GLP-1 and GIP release in advance of the meal (each P < 0.05), whereas TIM and sucralose did not. The overall postprandial GLP-1 response was greater after glucose, 3OMG, and TIM than after sucralose (P < 0.05), albeit later after TIM than the other preloads. The blood glucose and insulin responses in the first 30 min after the meal were greatest after glucose (each P < 0.05). Gastric emptying was slower after both 3OMG and TIM than after sucralose (each P < 0.05). Conclusions: In healthy humans, SGLT1 substrates stimulate GLP-1 and GIP and slow gastric emptying, regardless of whether they are metabolized, whereas the artificial sweetener sucralose does not. Poorly absorbed sweet tastants (TIM), which probably expose a greater length of gut to nutrients, result in delayed GLP-1 secretion but not in delayed GIP release. These observations have the potential to optimize the use of preloads for glycemic control. American Journal of Clinical Nutrition published new progress about Appetite. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Formula: C12H24O11.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lee, J.-H. published the artcileSecond-phase validation study of an alternative developmental toxicity test using mouse embryonic stem cell-derived embryoid bodies, Related Products of alcohols-buliding-blocks, the main research area is toxicity mouse embryonic stem cell embryoid body.

The embryoid body test (EBT) is a developmental toxicity test method that measures the size of embryoid bodies (EBs) and the viability of mouse embryonic stem cells (mESCs) and fibroblasts (3T3 cells). The previous pre-validation study confirmed the high accuracy (above 80%) of EBT using 26 coded test chems. This second-phase validation study assessed the inter-laboratory reproducibility (5 chems. in common) and predictive capacity (10 chems. in each laboratory) test using the coded test chems. at three laboratories For the prediction model, the accuracy is increased when more data is accumulated. Therefore, we updated the prediction model and analyzed the results of the second year with the newly created-prediction model. Statistical anal. of the inter-laboratory reproducibility test results indicated that accuracy, sensitivity, and specificity were 87%, 78%, and 100%, resp. The results of the statistical anal. of the predictive capacity test showed an accuracy of 80%, sensitivity of 78%, and specificity of 81%. In conclusion, the EBT can accurately classify various embryotoxicants within a short period and with relatively little effort. Therefore, EBT can be used as a good way to test developmental toxicity.

Journal of Physiology and Pharmacology published new progress about Chemicals. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts