Tag: M.W=200-350

Vujic, Lovorka published the artcileImpact of dietetic tea biscuit formulation on starch digestibility and selected nutritional and sensory characteristics, Recommanded Product: (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, the main research area is tea biscuit formulation starch digestibility sensory property nutritional value.

In this research, the effects of replacement of 30% of wheat flour in a control biscuit formulation with different whole grain flours (barley, buckwheat, oat, amaranth or soy) or 15% of wheat flour with apple- or oat dietary fiber (DF) were investigated in terms of their impact on the nutritional quality, rates of starch digestibility and sensory characteristics of the final product. Modifications of control formulation resulted in improved macronutrient distribution ranges and increase of dietary fiber (DF) and protein content. Soy- and amaranth enriched samples contained significantly lower rapidly available glucose (RAG) and total starch (TS) content in comparison to control sample. The anal. of starch digestibility showed that the most significant increase of RAG content in the starch fraction was observed in oat- and apple dietary fiber enriched samples defining them as samples with the highest expected glycemic index (GI). All modifications of control sample resulted in formulations with acceptable sensory characteristics; addition of pure fiber can be considered as significantly less favorable in comparison to whole grain flours especially regarding the taste and texture of the final product.

LWT–Food Science and Technology published new progress about Amaranthus. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Recommanded Product: (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Homayouni Rad, Aziz published the artcileApplication of cfor optimization of sucrose-free milk chocolate produced in a ball mill, Computed Properties of 64519-82-0, the main research area is sucrose free milk chocolate simplex lattice mixture design.

The aim of this study was to define optimal conditions by using Simplex lattice mixture design for the formulation of sucrose-free chocolate produced in a ball mill. Milk chocolate mass were made using three different polyols including maltitol, xylitol and isomalt along with Stevia as high potency sweetener. The influences of polyols mixtures as sucrose substitutes on rheol. properties and main phys. quality parameters were investigated. According to the results, the fitted models demonstrated a high coefficient of determination (�3%). The optimization of the variables illustrated that utilizing 11.16% weight/weight maltitol, 8.9% weight/weight xylitol and 12.93% weight/weight isomalt produced the optimum milk chocolate with the highest desirability (1.00) without unwanted variations in the rheol. and quality characteristics. Also the optimum formulation was produced to validate the optimum model. The sensory anal. of the optimized formulation satisfied the consumer demand.

LWT–Food Science and Technology published new progress about Ball mills. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Computed Properties of 64519-82-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Matta, Eliana published the artcileIsomalt-Plasticized Methylcellulose-Based Films as Carriers of Ascorbic Acid, Application of (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, the main research area is ascorbic acid methylcellulose film physicochem property.

In the present study, isomalt-plasticized methylcellulose-based films with and without ascorbic acid (AA) addition were developed. The aims of our research were to analyze the effect of the isomalt concentration and the drying temperature upon the physicochem. properties of films, also the stability of AA during film storage. Films prepared by 1.5% w/v methylcellulose (MC) using isomalt (0.25-1.5 w/v) showed improved properties when compared to those without isomalt. Unplasticized films exhibited higher elastic modulus and lower elongation at break than films with isomalt. The AA addition increased film elongation and decreased elastic modulus. FTIR spectra indicated that addition of AA produces structural changes in films and showed the presence of AA during storage. Two drying temperatures were tested, 37°C and 45°C. The change of drying temperature to a higher temperature significantly increased film water vapor permeability (WVP) and decreased the concentration of AA present in the films compared to those dried at a lower temperature Thus, based on the WVP and AA retention results, the selected drying temperature was 37°C. Films obtained by methylcellulose (1.5%) with 0.75% of isomalt, 0.4% of ascorbic acid, and dried at 37°C can result in a good carrier of ascorbic acid. These films can be consumed through foods such as fresh or dehydrated fruits coated.

Food and Bioprocess Technology published new progress about Absorption. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Application of (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Motallae, Saeed published the artcilePreparation and characterization of solid dispersions of celecoxib obtained by spray-drying ethanolic suspensions containing PVP-K30 or isomalt, Recommanded Product: (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, the main research area is acute pain celecoxib bioavailability dispersion suspension.

Celecoxib (CLX) is an anti-inflammatory drug that is used for acute pain treatment, but it has very low oral bioavailability owing to its poor water solubility In this study, CLX solid dispersions are prepared by spray-drying using hydrophilic carriers with the aim of improving its apparent solubility and dissolution rate. Blends with different ratios of CLX, isomalt (ISO) and PVP were prepared in ethanol, and solid dispersions were obtained using a spray dryer. The saturation solubility and dissolution kinetics in 0.25% SLS and 0.04 M Na3PO4 containing media were determined Also, SEM, DSC, XRPD, and stability studies were used to characterize the systems. Physicochem. anal. demonstrated the presence of amorphous CLX in the spray dried samples. The saturation solubility and dissolution rate of CLX from these formulations were higher than those for pure celecoxib and its phys. mixtures Amorphous CLX showed a lower dissolution rate compared to its crystalline form in 0.25% SLS medium, while this tendency was reversed under alk. conditions. The CLX:PVP:ISO 3:5:2 spray dried sample showed the highest dissolution rate in both media. Exposure of samples to high moisture (75% humidity) recrystallized some of the amorphous CLX. Thus, the results showed that the dissolution rate of CLX was enhanced in 0.25% SLS, whereas a reduction in dissolution rate was observed in 0.04 M Na3PO4.

Journal of Drug Delivery Science and Technology published new progress about Acute pain. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Recommanded Product: (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mourya, Satyanand published the artcileFormulation and evaluation of Rizatriptan fast dissolving tablets utilizing different super disintegrants with special emphasis on fenugreek, Related Products of alcohols-buliding-blocks, the main research area is Rizatriptan fast tablet disintegrant formulation.

FDTs (Fast Dissolving Tablets) are intended to dissolve quickly, allowing for excellent oral delivery without the need of water. Chewing these formulations also provides improved convenience and simplicity of administration, as well as a substantial potential effectiveness in improving patient compliance, particularly in populations that have difficulty swallowing traditional solid oral dose forms. Rizatriptan was used as API and different super disintegrants were used. Fenugreek was one of the super disintegrant. Pre formulation studies were performed on the raw materials. Different formulations were prepared using different technique and they were evaluated for various parameters. The purpose of this study was to find the best combination of super disintegrants for the creation of Rizatriptan benzoate orally disintegrating tablets. Ten formulations were prepared with different super disintegrants. Formulation F8 containing fenugreek as super disintegrant was found to be more efficacious as compared to other formulations. Croscarmellose sodium, sodium starch glycolate, and Cross-povidone were used as super disintegrants. A total of ten formulations were produced using the direct compression technique & assessed for friability, in-vitro dispersion time, hardness, wetting time, and water absorption ratio. The highest percentage drug release was determined to be 99.80 in formulation FD8.

World Journal of Pharmaceutical Research published new progress about Absorption. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Suciu, Stefana published the artcileQbD approach in the development of oral lyophilisates with ibuprofen for paediatric use, SDS of cas: 64519-82-0, the main research area is oral lyophilisates mucosa ibuprofen methylcellulose drug safety xanthan gum.

Quality-by-Design (QbD) concept in drug formulation and development was introduced in order to achieve and ensure an adequate product quality through a good process understanding. By identifying the variability sources that influence the product features, the quality of the product can be built from the development phase. Applying the concept, in the current work it was intended to develop and characterize orodisperable lyophilisates (OLs) for paediatric use. The drug model used was ibuprofen and following risk assessment evaluation, twenty-five exptl. formulations were prepared With a D-optimal exptl. design with six factors and two levels, the influence of the formulation factors on the desired quality target product profile was assessed (QTPP, the quality characteristics of a product that is intended to be achieved considering the aspects related to the safety and efficacy of the product): disintegration time, wetting time, mean dissolution time, texture and bio-adhesive features of the OLs were studied. During this experiment, it was observed that the type of the matrix forming and bio-adhesive agent influenced the disintegration time. All formulation factors influenced the wetting time, while no significant influence was observed for the bio-adhesive properties of the OLs. The hardness and rigidity of the OLs was increased by gelatine, while the methylcellulose and xanthan gum conducted to opposite results. The fracturability of the OLs was influenced only by the quant. factors, resp. the percentage of the matrix forming agent and the bio-adhesive agent. The dissolution profile was slightly influenced by the type of bio-adhesive agent. The design space has been defined based on the obtained results. The QbD approach was successfully applicd within this study and OLs with ibuprofen for paediatric use with desired pharmaceutical characteristics may be successfully obtained by lyophilisation.

Farmacia (Bucharest, Romania) published new progress about Absorption. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, SDS of cas: 64519-82-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pourmohammadi, Kiana published the artcileEffects of sucrose, isomalt and maltodextrin on microstructural, thermal, pasting and textural properties of wheat and cassava starch gel, Quality Control of 64519-82-0, the main research area is wheat cassava starch gel sucrose isomalt maltodextrin microstructure; PCA; Polyol sugar; Starch; Thermal properties.

This study investigated the effect of different levels (4, 8 and 12%) of sucrose, isomalt and maltodextrin on the microstructural, water absorption, physico-chem., thermal and textural characteristics of wheat and cassava starch gels, by SEM (SEM), rapid visco anal. (RVA), differential scanning calorimetry (DSC) and texture profile anal. According to SEM anal., cassava granules were more impressed than wheat starch in the presence of isomalt > sucrose > maltodextrin. Results showed that water absorption decreased when the amount of sucrose, isomalt and maltodextrin increased. In contrast, onset (To), peak (Tp) and conclusion (Tc) temperature, and enthalpy (ΔH) of wheat and cassava starch gels, increased as the level of addition increased. With increasing the sugar concentration, To, Tp, Tc and ΔH gel enhanced significantly relative to the native starch. The polyols had more remarkable effects on the thermal properties of cassava starch than wheat starch. The texture of wheat and cassava starch gels incorporated with polyol sugars had solid-like properties. The gelatinization of starch was delayed more by isomalt than sucrose and maltodextrin. Moreover, the combination of principal component anal. and cluster anal. proved to be a suitable statistical approach to highlight the effect of adding varying levels of polyols to starch.

International Journal of Biological Macromolecules published new progress about Absorption. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Quality Control of 64519-82-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nadernezhad, Ali published the artcileMelt Electrowriting of Isomalt for High-Resolution Templating of Embedded Microchannels, Application of (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, the main research area is isomalt melt electrowriting high resolution templating microchannel.

Fabrication of microchannels using 3D printing of sugars as fugitive material is explored in different fields, including microfluidics. However, establishing reproducible methods for the controlled production of sugar structures with sub-100μm dimensions remains a challenge. This study pioneers the processing of sugars by melt electrowriting (MEW) enabling the fabrication of structures with so far unprecedented resolution from Isomalt. Based on a systematic variation of process parameters, fibers with diameters down to 20μm can be fabricated. The flexibility in the adjustment of fiber diameter by on-demand alteration of MEW parameters enables generating constructs with perfusable channels within polydimethylsiloxane molds. These channels have a diameter that can be adjusted from 30 to 200μm in a single design. Taken together, the experiments show that MEW strongly benefits from the thermal and phys. stability of Isomalt, providing a robust platform for the fabrication of small-diameter embedded microchannel systems.

Advanced Materials Technologies (Weinheim, Germany) published new progress about Dissolution. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Application of (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Casian, Tibor published the artcileQbD for pediatric oral lyophilisates development: risk assessment followed by screening and optimization, Application of (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, the main research area is oral lyophilisate tablet drug release delivery system; D-optimal design; Orodispersible tablets; failure mode effect analysis; freeze drying; pediatric formulation.

This study proposed the development of oral lyophilisates with respect to pediatric medicine development guidelines, by applying risk management strategies and DoE as an integrated QbD approach. Product critical quality attributes were overviewed by generating Ishikawa diagrams for risk assessment purposes, considering process, formulation and methodol. related parameters. Failure Mode Effect Anal. was applied to highlight critical formulation and process parameters with an increased probability of occurrence and with a high impact on the product performance. To investigate the effect of qual. and quant. formulation variables D-optimal designs were used for screening and optimization purposes. Process parameters related to suspension preparation and lyophilization were classified as significant factors, and were controlled by implementing risk mitigation strategies. Both quant. and qual. formulation variables introduced in the exptl. design influenced the product’s disintegration time, mech. resistance and dissolution properties selected as CQAs. The optimum formulation selected through Design Space presented ultra-fast disintegration time (5 s), a good dissolution rate (above 90%) combined with a high mech. resistance (above 600 g load). Combining FMEA and DoE allowed the science based development of a product with respect to the defined quality target profile by providing better insights on the relevant parameters throughout development process. The utility of risk management tools in pharmaceutical development was demonstrated.

Drug Development and Industrial Pharmacy published new progress about Dissolution. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Application of (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lenz, Elisabeth published the artcileImpact of fillers on dissolution kinetic of fenofibrate dry foams, Safety of (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, the main research area is fenofibrate tablet fast release drug delivery Maltrin Soluthin dissolution; Dissolution rate; dry foam granulation; eroding tablets; fast dissolving; starch derivatives; sugar alcohols.

Dry foam technol. reveals the opportunity to improve the dissolution behavior of poorly soluble drugs tending to agglomeration due to micronization. In this study, the impact of fillers on the manufacturability, the properties of dry foams and granules as well as the dissolution kinetics of dry foam tablets was investigated using fenofibrate as a model compound Different maltodextrins and dried glucose syrups, a maltodextrin-phosphatidylcholine complex, isomalt and a 1:1 mixture of mannitol/glucose syrup were used as filler. Within the group of maltodextrins and glucose syrups, the influences of dextrose equivalent (DE), particle morphol. and botanical source of starch were investigated. Comparable macroscopic foam structures were obtained with maltodextrins and glucose syrups whereas different foam morphologies were obtained for the other fillers tested. Regarding the maltodextrins and glucose syrups, different physicochem. and particle properties had a minor impact on granule characteristics and tablet dissolution Using the maltodextrin-phosphatidylcholine complex resulted in a low sp. surface area of the granules and a slow tablet dissolution caused by a slow disintegration. In contrast, a high sp. surface area and a fast release were obtained with isomalt and glucose syrup/mannitol mixture indicating that high soluble low mol. weight fillers enable the development of fast dissolving dry foam tablets.

Pharmaceutical Development and Technology published new progress about Dissolution. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Safety of (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts