Tag: M.W=200-350

Beck, L. G. published the artcileEvaluation of isomalt and hydrogenated starch hydrolysate in sugarless caramel popcorn, Quality Control of 64519-82-0, the main research area is caramel popcorn isomalt starch flavor texture.

Five formulations of sugarless caramel popcorn sweetened with different proportions of hydrogenated starch hydrolyzate and isomalt were developed. Control and test products were evaluated for changes in phys., chem. and sensory properties over a 3-mo storage period at 33C and 50% humidity. Moisture content and water activity values increased for all products, but color values did not change with time. Texture compressibility measurements were highly correlated with liking of texture values gathered from a consumer study. The formula with 100% isomalt was liked significantly more by consumers than the other formulas.

Journal of Food Quality published new progress about Caramel (color). 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Quality Control of 64519-82-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kim, MeeKyung published the artcileSafety assessment of 16 sweeteners for the Korean population using dietary intake monitoring and poundage method, Application of (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, the main research area is sweetener dietary intake safety assessment poundage method Korea; Food additive; dietary intake; poundage method; safety assessment; sweetener.

A sweetener is a food additive that imparts a sweet taste to food products. Sweeteners have been increasingly used in Korea since the approval of sodium saccharin and D-sorbitol in 1962. Unlike food contaminants, humans are exposed to food additives only through the consumption of processed food products. For exposure assessments of sweeteners, the dietary intakes of food products containing acesulfame-K, aspartame, saccharin-Na, and sucralose were determined, and the resulting calculated estimated daily intake (EDI) values were compared directly with each additive’s ADI. The poundage method was used to calculate the daily intake per capita for 12 addnl. sweeteners, such as lactitol, for which appropriate anal. methods for food products do not exist. The risk, as evaluated by comparing the EDI with the ADI, was determined to be 2.9% for acesulfame-K, 0.8% for aspartame, 3.6% for saccharin-Na, 4.3% for steviol glycosides, and 2.1% for sucralose. No hazardous effect was predicted for the other 11 sweeteners, including lactitol.

Food Additives & Contaminants, Part A published new progress about Carcinogenicity. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Application of (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ndindayino, F. published the artcileBioavailability of hydrochlorothiazide from isomalt-based moulded tablets, Application of (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, the main research area is hydrochlorothiazide isomalt molded tablet bioavailability.

The bioavailability of hydrochlorothiazide (HCT) from molded isomalt-based tablets was evaluated after oral administration of 50 mg HCT to healthy volunteers as an oral molded tablet and as a lozenge, in comparison with a conventional tablet formulation (Dichlotride® 50 mg). Molded tablets had a high relative bioavailability (Frel) as the pharmacokinetic parameters (Cmax, tmax, t1/2, AUC0 24 h) determined from HCT plasma concentration vs. time profiles were not significantly different (P>0.05; two-way ANOVA) in comparison with the conventional tablet. The relative bioavailability of the molded tablet administered as a lozenge and as an oral tablet was 106.2±30.9% and 89.4±25.9%, resp., in relation to the conventional tablet formulation. Direct molding of isomalt tablets proved to be a suitable technique to administer a poorly soluble drug either as a conventional tablet or as a lozenge.

International Journal of Pharmaceutics published new progress about Bioavailability. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Application of (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kalicka, Dorota published the artcilePhysical and sensory characteristics and probiotic survival in ice cream sweetened with various polyols, Safety of (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, the main research area is Bifidobacterium survival ice cream polyol sweetening agent probiotic.

The effect of polyols (xylitol, erythritol, maltitol and isomalt) on phys. and sensory properties of probiotic ice cream, as well as the survival of BifidobacteriumBB-12 during freezing over 28 days of frozen storage, was investigated. The control sample of ice cream, sweetened with sugar, showed a lower pH and higher overrun than those sweetened with polyols. The viable bifidobacteria counts remained above 8 log cfu/g in all samples. The amount of erythritol added was not enough to obtain a similar sweetness as in control, but too high to get an ice cream with good textural properties.

International Journal of Dairy Technology published new progress about Bifidobacterium. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Safety of (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Schauber, Juergen published the artcileHuman rectal mucosal gene expression after consumption of digestible and non-digestible carbohydrates, Recommanded Product: (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, the main research area is rectum mucosa gene expression profile nutrition sucrose isomalt.

The effects of regular consumption of the low-digestible and prebiotic carbohydrate isomalt (Palatinit) vs. the digestible sucrose on gene expression in the rectal mucosa were examined in 19 healthy humans. They received 30 g isomalt or sucrose daily as part of controlled diet over two 4-wk test periods with a 4-wk washout in between. At the end of each test phase, rectal biopsies were obtained. After RNA extraction, mucosal gene expression was assayed using GeneChip microarrays. The expression of cathelicidin hCap18/LL37, cellular detoxification enzymes GSTπ, UGT1A1 and CYP3A4, cyclooxygenase 2, and barrier factors MUC2 and ZO-1 were determined by real-time RT-PCR. Microbiol. analyses of fecal samples revealed a shift of the gut flora to increased bifidobacteria counts following consumption of isomalt. Isomalt did not affect the rectal mucosal gene expression in microarray analyses compared to sucrose. The expression of cathelicidin LL37, GSTπ, UGT1A1, CYP3A4, COX-2, MUC2 and ZO-1 was not changed in rectal biopsies. Thus, gene expression of the human rectal mucosa can be reliably measured in biopsy samples taken at endoscopy. Dietary intervention with the low-digestible isomalt compared to sucrose did not affect the gene expression in the rectal mucosa.

Molecular Nutrition & Food Research published new progress about Bifidobacterium. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Recommanded Product: (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mirheydari, Seyyedeh Narjes published the artcileComparison of models for correlation of drug solubility in ethanol + water binary mixtures, Synthetic Route of 64519-82-0, the main research area is ethanol water binary mixture drug solubility computational model.

The ability of a number of common models for correlating the collected solubility data of drugs in ethanol + water mixtures (the number of data sets is 43) was tested. The selected models are classified within three groups, (1) λ-h, van’t Hoff and Apelblat models with temperature dependency, and modified Wilson with solvent composition dependency, (2) Jouyban-Acree, Jouyban-Acree-van’t Hoff and Jouyban-Acree-Apelblat (linear models) and NRTL, Wilson and UNIQUAC (nonlinear models) with both temperature and solvent composition dependencies, (3) UNIFAC, Yalkowsky, log-linear model of Yalkowsky, Jouyban-Acree-Abraham and Jouyban-Acree-Hansen predictive models. Of the models in group 1, the Apelblat model has the lowest overall %ARD and Jouyban-Acree-van’t Hoff and Jouyban-Acree-Apelblat models in group 2 performed best in correlations. Moreover, predictions using Jouyban-Acree-Abraham and Jouyban-Acree-Hansen models in group 3 have the lowest %ARDs in this group.

Journal of Solution Chemistry published new progress about Binary mixtures. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Synthetic Route of 64519-82-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pierre, Ronan published the artcileCarboxymethyl glucosides and carboxymethyl glucoside lactones: A detailed study of their preparation by oxidative degradation of disaccharides, Recommanded Product: (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, the main research area is acid hydrolysis isomaltulose oxidation catalysis glucoside preparation; carboxymethyl glucoside lactone preparation oxidative degradation disaccharide synthon.

A detailed study of the access to carboxylmethyl tri-O-acetyl-α-D-glucopyranoside 2-O-lactone from isomaltulose was performed. Side products can arise from incomplete oxidation of isomaltulose by hydrogen peroxide, acidic hydrolysis, or opening of the lactone during the acylation step. Based on these observations, the optimum conditions for the preparation of this interesting synthon, as well as of its benzylated and pivaloylated analogs, was determined Also, the use of the hydrogenated analog of isomaltulose, isomalt, as the starting material was studied. In this case, during the oxidation step, the catalysis by sodium tungstate proved to be indispensable to form carboxymethyl glucoside, unlike for isomaltulose. Although giving low yields, this reaction is very direct and was performed using cheap and simple procedures from a readily available substrate.

Comptes Rendus Chimie published new progress about Acid hydrolysis. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Recommanded Product: (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ramadhan, K. published the artcileFreeze-thaw stability of duck surimi-like materials with different cryoprotectants added, Category: alcohols-buliding-blocks, the main research area is freezing thawing duck surimi stability cryoprotectant.

The effect of the addition of different cryoprotectants on the freeze-thaw stability of duck surimi-like material (DSLM) was tested. A 6% (wt/wt) low-sweetness cryoprotectant (i.e., polydextrose, trehalose, lactitol, or palatinit) was added to a 3-kg portion of DSLM, and the mixture was subjected to freeze-thaw cycles during 4 mo of frozen storage. The DSLM with no cryoprotectant added (control) and with a 6% sucrose-sorbitol blend (high-sweetness cryoprotectant) added also were tested. The polydextrose-added sample had the highest water-holding capacity among the sample types tested (P < 0.05), and it retained its higher value during frozen storage. The protein solubility of the cryoprotectant-added samples decreased significantly (P < 0.05) from 58.99 to 59.60% at initial frozen storage (0 mo) to 48.60 to 54.61% at the end of the experiment (4 mo). The gel breaking force of all samples significantly decreased (P < 0.05) at 1 mo; this breaking force then stabilized after further frozen storage for the cryoprotectant-added samples, whereas it continued to decrease in the control samples. Gel deformation fluctuated during frozen storage and was significantly lower (P < 0.05) at the end of experiment than at the beginning. The presence of cryoprotectants reduced the whiteness of DSLM. Samples containing polydextrose, trehalose, lactitol, and palatinit were able to retain the protein solubility, gel breaking force, and deformation of DSLM better than control samples after 4 mo of frozen storage and exposure to freeze-thaw cycles. The effects of these low-sweetness cryoprotectants are comparable to those of sucrose-sorbitol, thus, these sugars could be used as alternatives in protecting surimi-like materials during frozen storage. Poultry Science published new progress about Anas domesticus. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Stojanovic, Goran M. published the artcileRapid selective detection of ascorbic acid using graphene-based microfluidic platform, Application of (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, the main research area is ascorbic acid graphene microfluidic platform selective detection.

In this paper, we present a compact microfluidic platform for selective detection of ascorbic acid. The microfluidic chip was fabricated by xurog. technique with microfluidic channel placed between the silver electrodes. To increase the conductivity of the platform and enhance electron transfer process, a graphene sheet was deposited in the gap between the electrodes. The suspension of tablets with ascorbic acid and a mixture of ascorbic acid and isomalt, a sugar substitute, were injected in the microfluidic channel. Measuring elec. parameters at the silver contacts, it was possible to successfully differentiate ascorbic acid from isomalt. The sensing mechanism of the developed microfluidic platform is based on the increase of the overall conductivity with the increase of the concentration of ascorbic acid, resulting in the decrease of the resistive parameters and increase of the capacitive parameters of the proposed equivalent elec. circuit. The addition of graphene was found to improve the response linearity by 5.28% and lower the limit of detection and quantification by 12%, compared to the reference structure without graphene.

IEEE Sensors Journal published new progress about Analysis. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Application of (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wu, Tongzhi published the artcileEffects of different sweet preloads on incretin hormone secretion, gastric emptying, and postprandial glycemia in healthy humans, Formula: C12H24O11, the main research area is glucose methylglucose Tagatesse sucralose incretin glycemia gastric emptying.

Background: Macronutrient “”preloads”” can stimulate glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), slow gastric emptying, and reduce postprandial glycemic excursions. After sweet preloads, these effects may be signaled by sodium-glucose cotransporter-1 (SGLT1), sweet taste receptors, or both. Objective: We determined the effects of 4 sweet preloads on GIP and GLP-1 release, gastric emptying, and postprandial glycemia. Design: Ten healthy subjects were studied on 4 sep. occasions each. A preload drink containing 40 g glucose, 40 g tagatose/isomalt mixture (TIM), 40 g 3-O-methylglucose (3OMG; a nonmetabolized substrate of SGLT1), or 60 mg sucralose was consumed 15 min before a 13C-octanoic acid-labeled mashed potato meal. Blood glucose, plasma total GLP-1 and GIP, serum insulin, and gastric emptying were determined Results: Both glucose and 3OMG stimulated GLP-1 and GIP release in advance of the meal (each P < 0.05), whereas TIM and sucralose did not. The overall postprandial GLP-1 response was greater after glucose, 3OMG, and TIM than after sucralose (P < 0.05), albeit later after TIM than the other preloads. The blood glucose and insulin responses in the first 30 min after the meal were greatest after glucose (each P < 0.05). Gastric emptying was slower after both 3OMG and TIM than after sucralose (each P < 0.05). Conclusions: In healthy humans, SGLT1 substrates stimulate GLP-1 and GIP and slow gastric emptying, regardless of whether they are metabolized, whereas the artificial sweetener sucralose does not. Poorly absorbed sweet tastants (TIM), which probably expose a greater length of gut to nutrients, result in delayed GLP-1 secretion but not in delayed GIP release. These observations have the potential to optimize the use of preloads for glycemic control. American Journal of Clinical Nutrition published new progress about Appetite. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Formula: C12H24O11.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts