Tag: M.W=200-350

Wang, Peng published the artcileSolubility of Isomalt in the Water + Ethanol Solvent System at (288.15, 298.15, 308.15, and 318.15) K, Synthetic Route of 64519-82-0, the main research area is solubility isomalt water ethanol solvent system.

The solubility of isomalt in the water + ethanol solvent system was measured with the mole fraction of water ranging from 0.00 to 1.00 at (288.15, 298.15, 308.15, and 318.15) K by using the laser method that is timesaving and the gravimetric method that is more reliable. The data were fitted using the simplified Jouyban-Acree model. In this study, the solubility data obtained by these two methods were compared. The mean relative deviations for isomalt solubility determined by the laser method and the gravimetric method were less than 25 % and 17 %, resp.

Journal of Chemical & Engineering Data published new progress about Crystallization. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Synthetic Route of 64519-82-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Luhn, Oliver published the artcileDissolution profile of novel composite pellet cores based on different ratios of microcrystalline cellulose and isomalt, Category: alcohols-buliding-blocks, the main research area is dissolution composite pellet microcrystalline cellulose isomalt Eudragit.

There is a growing interest towards the application of inert cores as starting materials for pharmaceutical pellet manufacturing They serve as alternatives to develop and adapt a relatively simple manufacturing technol. compared with an extrusion/spheronization process. The major objective of this study was to investigate the effect of the compositions of core materials on the drug release profile. Pure microcrystalline cellulose (MCC), isomalt and different types of novel composite MCC-isomalt cores were layered with model drug (sodium diclofenac) and were coated with acrylic polymer. The effect of the osmolality in the gastrointestinal tract was simulated using glucose as osmotically active agent during in vitro dissolution tests. The results demonstrated the dependence of drug dissolution profile on the ratio of MCC and isomalt in the core and the influence of osmotic properties of the dissolution medium. Isomalt used in the composite core was able to decrease the vulnerability of the dissolution kinetics to the changes in the osmotic environment. © 2012 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci.

Journal of Pharmaceutical Sciences published new progress about Digestive tract. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jang, Eun Ha published the artcileInvestigation of the effects of materials and dry granulation process on the mirabegron tablet by integrated QbD approach with multivariate analysis, COA of Formula: C12H24O11, the main research area is dry granulation mirabegron tablet QbD.

The purpose of this study was to evaluate the relationship among numerous variables to enhance the understanding of the effects of materials and process parameters on drug product quality. The study consisted of two stages: the first stage involved exptl. designing to optimize formulation and process parameters, and the second stage involved assessing the relationship between intermediate quality attributes (IQAs) and critical quality attributes (CQAs) by multivariate anal. (MVA). Initial risk assessment was conducted to select critical material attributes (CMAs) and critical process parameters (CPPs), which have a high effect on CQAs and IQAs. The correlation between IQAs and CQAs was confirmed via Pearson correlation anal. and principal component anal. The robustness of the correlation was verified using a wide range of variables. Therefore, the study suggests that risk in the development of drug products can be reduced via an integrated quality by design (QbD) approach employing MVA.

Powder Technology published new progress about Dry granulation. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, COA of Formula: C12H24O11.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cope, Stephen published the artcileSweeteners, SDS of cas: 64519-82-0, the main research area is sweetener solubility sweetness review.

Bulk sweeteners provide both bulk and sweetness to a food product and exhibit similar properties to sucrose and are often used as direct substitutes. Sweetness is a key element in perception of product taste and quality. It represents an obvious factor in determining the appeal of sugar free products. Consumers demand the same sweet taste associated with sugar-sweetened products, without any unpleasant after-taste. The solubility of a sweetener can greatly influence the perception of sweetness. Highly soluble sweeteners result in a finished product which exhibits a rapid sweetness onset and impact, while poorly soluble sweeteners can provide mild, prolonged background sweetness. All bulk sweeteners exhibit excellent chem. and thermal stability, are largely non-reactive and exhibit excellent heat and acid stability in comparison to sucrose. Bulk sweeteners such as lactitol and xylitol allow manufacturers the opportunity to produce healthier products with a variety of nutritional claims, while exploiting new market opportunities. The relative risk of phys. health problems associated with obesity due to sweeteners are discussed.

NutraCos published new progress about Food solubility. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, SDS of cas: 64519-82-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lopes, Diogo Gomes published the artcileImproving the granule strength of roller-compacted ibuprofen sodium for hot-melt coating processing, Synthetic Route of 64519-82-0, the main research area is ibuprofen granule coating strength excipient; Hot-melt coating; Multiparticulate system; Roller compaction; Sodium ibuprofen dihydrate; Sorbitol hydrate; Taste-masking.

Solvent-free hot-melt coating processing is a novel and cost-efficient approach to manufacturing taste-masked multiparticulate systems. However, most API powders are fine and cohesive and not processable by hot-melt coating. The aim of this study was to produce dense and abrasion-resistant granules with high drug content (>80%) via roller compaction for hot-melt coating process optimization. The selected API was ibuprofen sodium dihydrate, a salt of ibuprofen with improved bioavailability and poor intrinsic compactibility. The formulation and roller compaction process were developed for the production of granules with 94%w/w of API and low friability (∼30%), using sorbitol and isomalt as excipients. The strong bonding mechanism relied on powder jamming prior to the rollers and was investigated via SEM, differential scanning calorimetry and small and wide angle X-ray scattering. It was shown that sorbitol crystals are solubilized during roller compaction and recrystallize as sorbitol hydrate, acting as strong solid bridges. The robustness of the roller compaction process and the re-compaction of fines were investigated. A statistical design of experiments was conducted to evaluate the hot-melt coating process for taste masking of ibuprofen sodium granules. Taste masking required coating ratios higher than 40%w/w of granule batch, emphasizing the need for high-drug-content and abrasion-resistant granules.

International Journal of Pharmaceutics (Amsterdam, Netherlands) published new progress about Coating process. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Synthetic Route of 64519-82-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ilic, Ilija published the artcileDeformation properties of pharmaceutical excipients determined using an in-die and out-die method, Name: (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, the main research area is deformation pharmaceutical excipient compressibility.

This study investigated deformation mechanisms of some commonly used pharmaceutical fillers, such as microcrystalline cellulose, lactose, dicalcium phosphate, isomalt and cornstarch, using a combination of the in-die and out-die method with the Heckel and Walker models. The tableting mixtures contained of 98.5% (weight/weight) filler, the rest consisted of dry binder and an antiadhesive agent. Our results showed that plasticity and elasticity may be considered independent deformation properties as highly plastic materials (microcrystalline cellulose, cornstarch) also exhibited high elasticity. Particular emphasis was placed on explaining the differences observed between the in-die and out-die method-comparison revealed that the differences are a consequence of the material’s elastic properties. Larger error of in-die results can be expected for more elastic materials, and thus in-die Heckel should be used with some considerations. In contrast, the Walker model was found to be more robust and smaller differences were observed between the two methods. We consider the most correct results to have been obtained by the out-die approach, which excludes the elastic properties of the material evaluated. An excellent correlation between elastic determination at the single-particle level and multiple-particle scale was demonstrated, suggesting a great potential of nanoscale determination of a material’s mech. properties for better elucidation of deformation mechanisms.

International Journal of Pharmaceutics (Amsterdam, Netherlands) published new progress about Compressibility. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Name: (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sune-Negre, Josep M. published the artcileApplication of the SeDeM Diagram and a new mathematical equation in the design of direct compression tablet formulation, Name: (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, the main research area is SeDeM diagram excipient Kleptose Plasdone S630.

Application of the new SeDeM Method is proposed for the study of the galenic properties of excipients in terms of the applicability of direct-compression technol. Through exptl. studies of the parameters of the SeDeM Method and their subsequent math. treatment and graphical expression (SeDeM Diagram), six different DC diluents were analyzed to determine whether they were suitable for direct compression (DC). Based on the properties of these diluents, a math. equation was established to identify the best DC diluent and the optimum amount to be used when defining a suitable formula for direct compression, depending on the SeDeM properties of the active pharmaceutical ingredient (API) to be used. The results obtained confirm that the SeDeM Method is an appropriate system, effective tool for determining a viable formulation for tablets prepared by direct compression, and can thus be used as the basis for the relevant pharmaceutical development.

European Journal of Pharmaceutics and Biopharmaceutics published new progress about Compressibility. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Name: (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lura, Ard published the artcileTableting of mini-tablets in comparison with conventionally sized tablets: A comparison of tableting properties and tablet dimensions, COA of Formula: C12H24O11, the main research area is minitablet property tablet dimension; Compaction simulator; Direct compression; Functionalized excipients; Mini-tablets; Tablet properties; Tablets.

Mini-tablets are solid dosage forms with increasing interest for pharmaceutical industry due to clin. and biopharmaceutical benefits. But technol. aspects on mini-tableting are not fully investigated. Therefore, the impact of punch size and tableting pressure for industrially relevant excipients like microcrystalline cellulose, lactose, isomalt and Ludiflash are investigated using 8 and 11.28 mm punches for conventionally sized tablets and 1,2 and 3 mm punches for mini-tablets. For evaluation of the effect of tablet size on deformation behavior and mech. properties, compressibility, compactibility and tabletability plots are created and evaluated. Deformation behavior is analyzed by In-Die Heckel plot and modified Weibull function. Further, specific plastic energy (SPE) profiles are generated out of force-displacement plots. The effect of the adjustment of the aspect ratio towards 1 as in conventionally sized tablets on deformation behavior and tabletability is analyzed. The effect of tablet size on deformation behavior mainly showed lower yield pressures for conventionally sized tablets, whereas comparable SPEs were obtained with all tablet sizes. Furthermore, mini-tablets indicate better compactibility, as (depending on the excipient) higher tensile strengths were obtained at lower solid fractions. However, no superior tabletability properties are obtained for mini-tablets compared to conventionally sized tablets.

International Journal of Pharmaceutics: X published new progress about Compressibility. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, COA of Formula: C12H24O11.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nopianti, R. published the artcileEffect of different types of low sweetness sugar on physiocochemical properties of threadfin bream surimi (Nemipterus spp.) during frozen storage, COA of Formula: C12H24O11, the main research area is sugar cryoprotectant Nemipterus storage.

The effects of different types of low-sweetness sugar (lactitol, maltodexrin, palatinit, polydextrose, trehalose) on the physicochem. properties of threadfin bream (Nemipterus spp.) surimi during six months of frozen storage were investigated. The characteristics analyzed were moisture content, pH, water-holding capacity, whiteness, folding test, gel strength, expressible moisture, and texture profile analyses. Generally, the cryoprotective effectiveness decreased as the storage time increased. Polydextrose was able to maintain a water-holding capacity of 77.0%, 98.6% whiteness, a folding test value of 100%, and a gel strength of 53.6% compared with its initial value during six months of frozen storage. Meanwhile, sucrose was able to maintain a water-holding capacity of 80.3%, 98.6% whiteness, a folding test value of 75%, and a gel strength of 56.8% compared with its initial value. Raw surimi was able to maintain water holding capacity of 62.2%, 98.7% whiteness, a folding test value of 75%, and a gel strength of 36.0% compared with its initial value. It is suggested that, polydextrose as a potential alternative cryoprotectant to replace other low-sweetness sugars.

International Food Research Journal published new progress about Cryoprotectants. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, COA of Formula: C12H24O11.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tananuwong, Kanitha published the artcileImpact of hydrogenated starch hydrolysate on glass transition, hygroscopic behavior and crystallization of isomalt-based systems, Safety of (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, the main research area is isomalt hydrogenated starch hydrolyzate glass transition crystallization water uptake.

Glass transition behavior, adsorption isotherm and crystallization of isomalt-hydrogenated starch hydrolyzate (HSH) mixtures (0-20% HSH) and pure HSH were investigated. At similar solid content, Tg decreased as HSH concentration increased. Tg data at different solid contents were well-fitted with Gordon-Taylor equation (R2≥0.97). Adsorption isotherm showed that systems with greater HSH concentration became more hygroscopic. Accelerated storage test (30°C, 84% RH) of modeled hard candy containing 10% HSH and pure isomalt formula was done. HSH enhanced water uptake and crystallization of polyols in hard candy during aging without packaging; however, those effects were lessen for the samples aged in polyethylene terephthalate/cast polypropylene (PET/CPP) pouches, and were negligible after the application of superior moisture barrier, oriented polypropylene/metalized cast polypropylene (OPP/MCPP) film. Although HSH adversely affected storage stability of sugarless hard candies, it could be add into the formulation together with the application of packaging having a good moisture barrier.

Songklanakarin Journal of Science and Technology published new progress about Crystallization. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Safety of (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts