Tag: M.W=200-350

Sahoo, Manas Ranjan published the artcileDevelopment and evaluation of polyherbal based medicated candy from Ayurveda herbs reported for cough and cold and evaluation of their anti-viral and anti-bacterial properties, Product Details of C12H24O11, the main research area is Ayurveda polyherbal cough cold antiviral antibacterial property evaluation.

Emergence and spread of new viral and bacterial originated infectious diseases along with mutated new strains posing enormous global challenges. Respiratory infection is one of the major concerns in the current and past situation. With the lack of a safe and effective vaccine and small mols. drugs for effective treatments there is a need of efficacious herbal medicine to tackle infectious diseases. The herbal treatments mentioned in the Ayurveda can be excellent source for an effective treatment. In the present study a hard-boiled candy formulation was from promising herbs recommended herbs from Ayurveda for respiratory health and immunmodulatory actions. The herbs selected were Ocimum sanctum-OS (leafs), Terminalia chebula-TC (fruit), Glycyrrhiza glabra-GG (roots), Curcuma longa-CL (rhizomes), Zingiber officinale-ZO (rhizomes), Piper longum-PL (fruits). The herbs were evaluated for antiviral and antibacterial activity. The results indicated that most of the extracts exhibited antimicrobial activity against pathogens B. subtilis, S.aureus, S.pyogens and S.pneumoniae and showed significant antiviral activity against DENV virus in vitro. The formulated hard-boiled candy was found to be having satisfactory quality parameters of hardness, friability, and dissolving time. The HPTLC profile was developed for the candy formulation as an effective quality control tool. This study indicates that the hard-boiled candy (HBC) could be an ideal solid oral dosage form for herbal drug delivery at local region of oropharyngeal region.

International Journal of Research in Pharmaceutical Sciences (Madurai, India) published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Product Details of C12H24O11.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Martinez-Cervera, S. published the artcileFunctionality of polyols as sucrose replacers in Spanish muffins, Recommanded Product: (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, the main research area is polyol sucrose replacer Spanish muffin texture starch gelatinization.

The influence of polyols sorbitol, maltitol, isomalt and erythritol as sucrose replacers on the starch gelatinization process and on the Spanish muffin batter rheol. properties was studied. The different polyols affected the muffin texture properties differently. Erythritol provided the most neg. effect in texture with a high significant increase in hardness and chewiness and a decrease in springiness. Contrary to erythritol, the other polyols showed a small decrease in hardness and no difference in springiness in comparison with the control. The effect of polyols in the flour starch gelatinization properties and in the batter linear viscoelastic behavior can not explained the texture differences observed among polyols.

Special Publication – Royal Society of Chemistry published new progress about Food batters. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Recommanded Product: (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Marcus, Julien published the artcileInfluence of high intensity sweeteners and sugar alcohols on a beverage microemulsion, Application of (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, the main research area is sweetener sugar alc beverage microemulsion; Apparent pK(A); Clearing temperature; Microemulsion; Sweeteners.

The present paper shows the effects of added sugars and sweeteners on the clearing temperature of a highly water dilutable fatty acid salt microemulsion used as a model of a beverage concentrate There is a twofold interest in this work. The first one is practical and relates to the fact that many fatty acid salt surfactants can be used in food without major regulatory restrictions. As is shown here, they allow making highly stable microemulsions even at neutral and acidic pH. The second one is more of scientific interest. The model system can be used to study the effect of sugars and sweeteners on the formulation stability depending on their charges, amphiphilic properties, and localization in the microemulsion interfacial film. An important practical result is the discovery of the possibility to formulate highly dilutable microemulsions at neutral or slightly acid pH with a good taste in presence of sucralose. Further, a significant decrease of the pKA of the fatty acid is observed in presence of stevia, thus allowing transparent, fairly stable systems at neutral pH.

Journal of Colloid and Interface Science published new progress about Beverages. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Application of (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kim, Jungyeon published the artcileSystematic re-evaluation of the long-used standard protocol of urease-dependent metabolome sample preparation, SDS of cas: 64519-82-0, the main research area is urease urea urinary metabolite metabolomic human mass spectrometry.

In the urinary metabolomics for finding biomarkers in urine, owing to high concentrations of urea, for chromatog.-based metabolomic anal., urea needed to be degraded by urease. This urease pretreatment has been the key step of sample preparation for standard urinary metabolomics until today even for mass spectrometry-based anal. The urease pretreatment involving incubation of urine with urease contradicts the concept of metabolome sampling, which should immediately arrest metabolic reactions to prevent alterations of a metabolite profile. Nonetheless, the impact of urease pretreatment has not been clearly elucidated yet. We found that activities of urease and endogenous urinary enzymes and metabolite contaminants from the urease preparations introduce artifacts into metabolite profiles, thus leading to misinterpretation.

PLoS One published new progress about Amines Role: ANT (Analyte), BSU (Biological Study, Unclassified), ANST (Analytical Study), BIOL (Biological Study). 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, SDS of cas: 64519-82-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Archana published the artcilePhysicochemical characterization and evaluation of disintegrating property of Lepidium sativum seed mucilage, Computed Properties of 64519-82-0, the main research area is Lepidium seed mucilage disintegration tablet metformin hydrochloride dissolution.

The present work was carried out to study the physicochem. characteristics and to explore the disintegration property of the mucilage extracted from the seeds of Lepidium sativum by formulating orally disintegrating tablets of Metformin HCl by the direct compression method. Mucilage extracted from the seeds was subjected to preformulation studies for its suitability as a disintegrating agent. The mucilage extracted was evaluated for various parameters as per Indian Pharmacopoeia 1996. Several formulations with different proportions of mucilage were prepared and evaluated for phys. parameters such as thickness, hardness, friability, weight variation, drug content, disintegration time and drug dissolution The study revealed that Lepidium sativum seed mucilage (Ls M) is a good pharmaceutical adjuvant and is effective as a disintegrant at low concentration as 2.5%.

Journal of Pharmacy Research published new progress about Compressibility. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Computed Properties of 64519-82-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Vicosa, Alessandra L. published the artcileBioequivalence studies and sugar-based excipients effects on the properties of new generic ketoconazole tablets formulations and stability evaluation by using direct compression method, Safety of (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, the main research area is sugar polyol excipient disintegrant ketoconazole tablet bioequivalence dissolution stability.

In this work we described the development of a new solid oral formulation of ketoconazole, a broad-spectrum antifungal agent that belongs to the class II of Biopharmaceutics Classification System (BCS). The ketoconazole raw material supplier was selected to present a best flow and compaction. In addition we used direct compression and superdisintegrants associated to polyols to enhance the dissolution of the ketoconazole tablets. The dissolution was evaluated based in level C in vivo/in vitro correlation established. The best formulation was obtained with croscarmellose/maltose association that in the accelerated stability assays presented no differences on quality specifications and no drug-excipients interaction by DSC analyses. In this work it was possible to confirm the use of sugar-based excipients as suitable dissolution enhancers in pharmaceutical technol. and real processes conditions.

Pharmaceutical Development and Technology published new progress about Dissolution (enhancers). 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Safety of (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

McFetridge, Janet published the artcileInfluence of hydrogenated starch hydrolysates on the glass transition and crystallisation of sugar alcohols, SDS of cas: 64519-82-0, the main research area is isomalt lactitol starch glass transition crystallization.

Low and high mol. weight hydrogenated starch hydrolyzates (HSH) were added to amorphous isomalt and lactitol, and the glass transition temperature (Tg) and crystallization behavior was monitored during storage at 80% relative humidity. Prior to storage, only one Tg was detected in all the binary mixtures when scanned in the differential scanning calorimetry and the Tg was in the temperature range between the Tg of the individual components. When the amorphous samples were stored in humid conditions, more than one Tg were detected. The Tg at the lowest temperature rapidly decreased during storage as the moisture uptake increased but then stabilized at approx. -40°. The maximum moisture uptake of the samples was 40% (weight/weight) and resulted in the formation of a transparent viscous solution Eventually crystallization was observed It was found that both the low and the high mol. weight HSH reduced the crystallization of isomalt, but the low mol. HSH was the most effective.

Food Research International published new progress about Crystallization. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, SDS of cas: 64519-82-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fujii, Kahori published the artcilePhysical characterization of meso-erythritol as a crystalline bulking agent for freeze-dried formulations, HPLC of Formula: 64519-82-0, the main research area is meso erythritol crystal filler freeze drying cooling crystallization.

The purpose of this study was to identify and characterize new crystalline bulking agents applicable to freeze-dried pharmaceuticals. Thermal anal. of heat-melt sugar and sugar alc. solids as well as their frozen aqueous solutions showed high crystallization propensity of meso-erythritol and d-mannitol. Exptl. freeze-drying of the aqueous meso-erythritol solutions after their cooling by two different methods (shelf-ramp cooling and immersion of vials into liquid nitrogen) resulted in cylindrical crystalline solids that varied in appearance and microscopic structure. Powder X-ray diffraction and thermal anal. indicated different crystallization processes of meso-erythritol depending on the extent of cooling. Cooling of the frozen meso-erythritol solutions at temperatures lower than their Tg’ (glass transition temperature of maximally freeze-concentrated phase, -59.7°C) induced a greater number of nuclei in the highly concentrated solute phase. Growth of multiple meso-erythritol anhydride crystals at around -40°C explains the powder-like fine surface texture of the solids dried after their immersion in liquid nitrogen. Contrarily, shelf-ramp cooling of the frozen solution down to -40°C induced an extensive growth of the solute crystal from a small number of nuclei, leading to scale-like patterns in the dried solids. An early transition of the freezing step into primary drying induced collapse of the non-crystalline region in the cakes. Appropriate process control should enable the use of meso-erythritol as an alternative crystalline bulking agent in freeze-dried formulations.

Chemical & Pharmaceutical Bulletin published new progress about Carbohydrates Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), THU (Therapeutic Use), PROC (Process), BIOL (Biological Study), USES (Uses). 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, HPLC of Formula: 64519-82-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kooij, Stefan published the artcileExplosive fragmentation of Prince Rupert’s drops leads to well-defined fragment sizes, Application In Synthesis of 64519-82-0, the main research area is explosive fragmentation glass fragment size.

Abstract: Anyone who has ever broken a dish or a glass knows that the resulting fragments range from roughly the size of the object all the way down to indiscernibly small pieces: typical fragment size distributions of broken brittle materials follow a power law, and therefore lack a characteristic length scale. The origin of this power-law behavior is still unclear, especially why it is such an universal feature. Here we study the explosive fragmentation of glass Prince Rupert’s drops, and uncover a fundamentally different breakup mechanism. The Prince Rupert’s drops explode due to their large internal stresses resulting in an exponential fragment size distribution with a well-defined fragment size. We demonstrate that generically two distinct breakup processes exist, random and hierarchical, that allows us to fully explain why fragment size distributions are power-law in most cases but exponential in others. We show exptl. that one can even break the same material in different ways to obtain either random or hierarchical breakup, giving exponential and power-law distributed fragment sizes resp. That a random breakup process leads to well-defined fragment sizes is surprising and is potentially useful to control fragmentation of brittle solids.

Nature Communications published new progress about Crack (fracture). 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Application In Synthesis of 64519-82-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts