Tag: M.W=200-350

Gostner, A. published the artcileEffects of isomalt consumption on gastrointestinal and metabolic parameters in healthy volunteers, Quality Control of 64519-82-0, the main research area is isomalt gastrointestine lipid metabolism cholesterol calcium phosphate obesity diabetes.

The polyol isomalt (Palatinit) is a well established sugar replacer. The impact of regular isomalt consumption on metabolism and parameters of gut function in nineteen healthy volunteers was examined in a randomized, double-blind, cross-over trial with two 4-wk test periods. Volunteers received 30 g isomalt or 30 g sucrose daily as part of a controlled diet. In addition to clin. standard diagnostics, biomarkers and parameters currently discussed as risk factors for CHD, diabetes or obesity were analyzed. Urine and stool Ca and phosphate excretions were measured. In addition, mean transit time, defecation frequency, stool consistency and weight were determined Consumption of test products was affirmed by the urinary excretion of mannitol. Blood lipids were comparable in both phases, especially in volunteers with hyperlipidemia, apart from lower apo A-1 (P = 0·03) for all subjects. Remnant-like particles, oxidized LDL, NEFA, fructosamine and leptin were comparable and not influenced by isomalt. Ca and phosphate homeostasis was not affected. Stool frequency was moderately increased in the isomalt phase (P = 0·006) without changes in stool consistency and stool water. This suggests that isomalt is well tolerated and that consumption of isomalt does not impair metabolic function or induce hypercalciuria. In addition, the study data indicate that isomalt could be useful in improving bowel function.

British Journal of Nutrition published new progress about Apolipoprotein A-I Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Quality Control of 64519-82-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Holub, I. published the artcileImproved metabolic control after 12-week dietary intervention with low glycaemic isomalt in patients with type 2 diabetes mellitus, COA of Formula: C12H24O11, the main research area is diet polyol isomalt glycemic index diabetes; Palatinit diet glycemic index diabetes carbohydrate metabolism.

The polyol isomalt (Palatinit) is a very low glycemic sugar replacer. The effect of food supplemented with isomalt instead of higher glycemic ingredients like sucrose and/or starch hydrolyzates on metabolic control in patients with type 2 diabetes was examined in this open study. Thirty-three patients with type 2 diabetes received a diet with foods containing 30 g/d isomalt instead of higher-glycemic carbohydrates for 12 wk. Metformin and/or thiazolidindiones were the only concomitant oral antidiabetics allowed during the study. Otherwise, the participants maintained their usual diet during the test phase, but were instructed to refrain from addnl. sweetened foods. Before start, after 6 wk and 12 wk (completion of the study), blood samples were taken and analyzed for clin. routine parameters, metabolic, and risk markers. Thirty-one patients completed the study. The test diet was well accepted and tolerated. After 12 wk, significant reductions were observed for: glycosylated Hb, fructosamine, fasting blood glucose, insulin, proinsulin, C-peptide, insulin resistance (HOMA-IR), and oxidized LDL (an atherosclerosis risk factor). In addition, significant lower nonesterified fatty acid concentrations were found in female participants. Routine blood measurements and blood lipids remained unchanged. The substitution of glycemic ingredients by isomalt and the consequent on reduction of the glycemic load within otherwise unchanged diet was accompanied by significant improvement in the metabolic control of diabetes. The present study is in agreement with findings of previous reported studies in human subjects demonstrating beneficial effects of low glycemic diets on glucose metabolism in patients with diabetes mellitus type 2.

Hormone and Metabolic Research published new progress about Apolipoprotein A-I Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, COA of Formula: C12H24O11.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Palomo Del Barrio, Elena published the artcileNew sugar alcohols mixtures for long-term thermal energy storage applications at temperatures between 70 °C and 100 °C, Product Details of C12H24O11, the main research area is sugar alc mixture temperature thermal energy storage.

Sugar alcs. (SA) are attractive phase change materials for long-term thermal energy storage (TES) applications at low-to-medium temperatures, as i.e. solar seasonal energy storage. Most of them undergo severe undercooling, thus allowing energy storage at temperatures far below the m.p. with thermal losses reduction Besides, some of them could provide very high volumetric energy d. at affordable cost. However, sugar alcs. with high latent heat of fusion often exhibit melting temperatures above 100 °C. The objective of this work was to found out new sugar alc. eutectic mixtures that display lower temperatures without significant reduction of the latent heat. A comprehensive anal. of SA relevant properties for TES has been carried out in order to select the most appropriate single SA for mixtures anal. Sixteen SA-based binary systems have been investigated. Their corresponding phase diagrams have been exptl. and theor. established. Four eutectic mixtures with potential for long-term TES at temperature around 80 °C have been identified. They are: (1) adonitol-erythritol at 30 mol% of erythritol, with melting temperature of 87 °C and latent heat of fusion of 254 J/g; (2) arabitol-erythritol at 40 mol% of erythritol, with melting temperature of 86 °C and latent heat of fusion of 225 J/g; (3) xylitol-erythritol at 36 mol% of erythritol, with melting temperature of 82 °C and latent heat of fusion of 270 J/g; and (4) arabitol-xylitol at 56 mol% of xylitol, with melting temperature of 77 °C and latent heat of fusion of 243 J/g.

Solar Energy Materials & Solar Cells published new progress about Binary systems. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Product Details of C12H24O11.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sole, Aran published the artcileStability of sugar alcohols as PCM for thermal energy storage, Recommanded Product: (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, the main research area is sugar alc phase change material thermal energy storage stability.

Sugar alcs. as phase change materials (PCM) are very promising due to their high storage capacity, safety and economic reasons. Their phase change temperatures make them suitable for medium temperature storage, which is needed for solar process heat or waste heat recovery applications. To guarantee a long PCM working lifetime they should be tested under a repeated number of freezing/melting cycles to check whether the thermophys. properties remain constant or not. The cycling stability of D-mannitol, myo-inositol and galactitol has been studied with DSC and the chem. stability with FT-IR. Myo-inositol shows a good cycling stability under the chosen measuring parameters. The cycling and chem. stability of D-mannitol up to 20 cycles can be achieved by controlling some parameters. The variable affecting it the most is the amount of oxygen in contact with it. Hence, in the storage unit this could be prevented with an inert or vacuum atm.

Solar Energy Materials & Solar Cells published new progress about Fusion enthalpy. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Recommanded Product: (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Isik, U. published the artcileFrozen yogurt with added inulin and isomalt, Synthetic Route of 64519-82-0, the main research area is freezing yogurt food formulation inulin isomalt.

The objective of this study was to produce a frozen yogurt containing low fat and no added sugar. Samples containing 5% polydextrose, 0.065% aspartame and acesulfame-K mixture, and different levels of inulin and isomalt (5.0, 6.5, and 8.0%) were produced at pilot scale and analyzed for their phys. and chem. properties including proximate composition, viscosity, acidity, overrun, melting rate, heat shock stability, as well as sensory characteristics, and viability of lactic acid bacteria. With the addition of inulin and isomalt, viscosity increased by 19 to 52% compared with that of sample B (reduced-fat control). The average calorie values of samples substituted with sweeteners were about 43% lower than that of original sample. Low-calorie frozen yogurt samples melted about 33 to 48% slower than the reduced-fat control sample at 45 min. Based on quant. descriptive profile test results, statistically significant differences among products were observed for hardness, iciness, foamy melting, whey separation, and sweetness characteristics. The results of principal component anal. showed that the sensory properties of the sample containing 6.5% inulin and 6.5% isomalt were similar to those of control. Lactic acid bacteria counts of frozen yogurt were found to be between 8.12 and 8.49 log values, 3 mo after the production The overall results showed that it is possible to produce an attractive frozen yogurt product with the incorporation of inulin and isomalt with no added sugar and reduced fat.

Journal of Dairy Science published new progress about Flavor. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Synthetic Route of 64519-82-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zyzelewicz, Dorota published the artcileEffect of milk chocolate supplementation with lyophilised Lactobacillus cells on its attributes, Category: alcohols-buliding-blocks, the main research area is milk chocolate probiotic Lactobacillus sweetener functional food.

Manufacturing of novel foodstuffs supplemented with live probiotic bacteria has recently been intensively investigated. The supplementation of confectionery with probiotics is troublesome since some unit technol. processes are conducted at high temperatures and the products are usually stored at ambient temperature Our group has developed a method of the production of milk chocolate, sweetened with either sucrose or isomalt and aspartame, containing 32, 36, or 40 g/100 g fat, and supplemented with live cells of probiotic bacterial strains: Lactobacillus casei and paracasei. This new milk chocolate displayed the same sensory properties as the reference, probiotic-free chocolate. The number of live bacterial cells was maintained at the functional level of 106 ÷ 108 CFU/g after keeping for 12 mo irresp. of the temperature The highest number of live probiotic bacteria survived in the chocolate kept at 4°C. Thus the product can be regarded as functional food.

Czech Journal of Food Sciences published new progress about Food firmness. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Heshmati, Javad published the artcileA systematic review and meta-analysis of the probiotics and synbiotics effects on oxidative stress, Application of (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, the main research area is meta analysis probiotics synbiotics effect oxidative stress.

We performed a comprehensive search of medical bibliog. databases to identify interventional studies reporting the effect of probiotics (or synbiotics) supplementation on biomarkers of oxidative stress. Twenty seven articles that included 1363 subjects (709 cases and 699 controls) were included to our analyses. Oxidative stress parameters levels, including total antioxidant capacity (TAC) (0.31 mmol/L, 95% CI: 0.13-0.50, P < 0.001), glutathione (GSH) (SMD: 0.44 μmol/L, 95% CI: 0.26-0.62, P < 0.001), superoxide dismutase (SOD) (SMD: 0.48 U/mg, 95% CI: 0.16-0.81, P = 0.004) and nitric oxide (NO) (SMD: 0.57 μmol/L, 95% CI: 0.19-0.94, P = 0.003) were higher in probiotics (or synbiotics) group compared to controls. Moreover, malondialdehyde (MDA) (SMD = -0.45 μmol/L, 95%CI = -0.63 to -0.26, P < 0.001) level was lower than controls. Probiotics and synbiotic supplementation improve antioxidant resistance and increase the amount of antioxidant enzymes in the body. Journal of Functional Foods published new progress about Bifidobacterium bifidum Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Application of (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Di Maio, Ernesto published the artcileScaffolds with tubular/isotropic Bi-modal pore structures by gas foaming and fiber templating, Recommanded Product: (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, the main research area is tissue scaffold polycaprolactone gas foaming and fiber templating pore.

The aim of this study was to engineer a scaffold for tissue engineering with double shape pore architecture, with tubular and isotropic pores. A novel method is herein proposed, based on the combination of gas foaming and fiber templating. In particular, the tubular pores have been obtained by leaching of melt-spun saccharide fibers (cotton candy) within CO2-foamed poly(ε-caprolactone). The optimization of the scaffold has been conducted via the selection of the proper saccharide, its thermal treatment to stabilize the spun fiber (crystallization), the formation of the polymer-fiber composite, the selection of the proper gas-foaming processing parameter and the final leaching in water.

Materials Letters published new progress about Composites. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Recommanded Product: (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gonnissen, Y. published the artcileDevelopment of directly compressible powders via co-spray drying, Application of (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, the main research area is carbohydrate excipient compression spray drying tablet.

Continuous production of directly compressible powders was achieved by coprocessing acetaminophen and carbohydrates via spray drying. Binary and ternary powder mixtures containing drug substance and carbohydrates were prepared by co-spray drying and evaluated on spray drying processibility, powder hygroscopicity, flowability, and compactability. The influence of process parameters during spray drying on the compaction behavior of drug/excipient mixtures was investigated via Heckel anal. Erythritol, lactose, maltodextrin, and mannitol were efficient in co-spray drying with acetaminophen. However, lactose mixtures showed poor flowability. Spray dried mixtures containing mannitol and erythritol were characterized as non-hygroscopic, highly dense, and good flowing powders. Mannitol increased tablet tensile strength in contrast with the poor compactability of erythritol. Maltodextrin was selected for further experiments because it provided excellent tablet tensile strength. The use of erythritol, maltodextrin and mannitol in binary drug/excipient mixtures resulted in high process yields. Compacts of erythritol, mannitol, and maltodextrin were characterized by higher tablet tensile strength at higher spray drying temperatures due to the increased particle fragmentation of erythritol and mannitol mixtures and to the increased plastic deformation of maltodextrin formulations. A combination of erythritol, maltodextrin, and mannitol was selected for further formulation and process optimization of co-spray dried powders for direct compression.

European Journal of Pharmaceutics and Biopharmaceutics published new progress about Compaction. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Application of (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wagner, Karl G. published the artcileFrom hot stage microscopy to hot melt extrusion – approaches to predict product performance, stability and processability, Formula: C12H24O11, the main research area is drug formulation hot melt extrusion stage microscopy computational model.

There are many drug delivery technologies that may enhance the bioavailability of a poorly water soluble drug. The ranking of the solubilization technologies is a balance between performance (both in vitro and in vivo) and efforts/costs necessary to implement the technol. In order to minimize front loading, i.e. resources expenditure prior to the selection of a front runner technol., an effective and predictive selection process needs to be in place. For hot melt extrusion (HME) this selection process can start with a micro scale performance evaluation on a hot stage microscope (HSM). A batch size of 400 mg can provide sufficient materials to assess drug product attributes like solid state properties, solubility enhancement and phys. stability as well as process related attributes such as processing temperature in a twin screw extruder (TSE). Prototype formulations will then be fed into a 5 mm TSE (apparatus 1-2 g) to confirm performance from the h SM under addnl. shear stress. Small stress stability testing might be performed with these samples or a larger batch (20-40 g) made by the 9 or 12 mm TSE. Simultaneously, numeric process simulations are performed using process data and rheol. and thermal properties of the formulations. Further scale up work to 16 mm and 18 mm TSE confirmed and refined the simulation model. Thus at the end of lab scale development, not only the clin. trial supply is manufactured but also one can form a sound risk assessment to support further scale up even without decades of process experience.

Bulletin Technique Gattefosse published new progress about Dissolution. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Formula: C12H24O11.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts