Tag: M.W=200-350

Matsuo, Teruko published the artcileIntegrated Strategy for Unknown EI-MS Identification Using Quality Control Calibration Curve, Multivariate Analysis, EI-MS Spectral Database, and Retention Index Prediction, HPLC of Formula: 64519-82-0, the main research area is EI mass spectra identification.

Compound identification using unknown electron ionization (EI) mass spectra in gas chromatog. coupled with mass spectrometry (GC-MS) is challenging in untargeted metabolomics, natural product chem., or exposome research. While the total count of EI-MS records included in publicly or com. available databases is over 900 000, efficient use of this huge database has not been achieved in metabolomics. Therefore, we proposed a “”four-step”” strategy for the identification of biol. significant metabolites using an integrated cheminformatics approach: (i) quality control calibration curve to reduce background noise, (ii) variable selection by hypothesis testing in principal component anal. for the efficient selection of target peaks, (iii) searching the EI-MS spectral database, and (iv) retention index (RI) filtering in combination with RI predictions. In this study, the new MS-FINDER spectral search engine was developed and utilized for searching EI-MS databases using mass spectral similarity with the evaluation of false discovery rate. Moreover, in silico derivatization software, MetaboloDerivatizer, was developed to calculate the chem. properties of derivative compounds, and all retention indexes in EI-MS databases were predicted using a simple math. model. The strategy was showcased in the identification of three novel metabolites (butane-1,2,3-triol, 3-deoxyglucosone, and palatinitol) in Chinese medicine Senkyu for quality assessment, as validated using authentic standard compounds All tools and curated public EI-MS databases are freely available in the ‘Computational MS-based metabolomics’ section of the RIKEN PRIMe Web site (http://prime.psc.riken.jp).

Analytical Chemistry (Washington, DC, United States) published new progress about Calibration. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, HPLC of Formula: 64519-82-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Malhi, Ravneet published the artcileIs chewing gum good for your health: myth or truth, Recommanded Product: (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, the main research area is review chewing gum cariogenicity.

In the field of health there is a paradigm shift from treatment to prevention and now in today′s world to promotion of health including oral health. For the maintenance of oral health natural resource i.e. saliva which is the inherent protective factor, can be stimulated by mastication. Even the chewing gum also increases the production of saliva by a factor of 102, which can help to neutralize plaque acid, wash away food particles and remineralize the tooth enamel and strengthen our teeth. Chewing gums though can be assumed to have protective and promotive effect on oral health; but they have cariogenic effect too due to their high sugar content. Therefore, now in the market a variety of sugar free chewing gums are available where sucrose in the chewing gum is substituted with sorbitol, mannitol, xylitol, malitol, lactilol, hydrogenated starch hydrolyzate and isomalt, poorly fermented sweeteners which do not contribute to the carcinogenicity of the diet. The detrimental effect of chewing gum was eliminated while maintaining the beneficial effect; thus can be used as one of the supplementary agent in maintaining oral health.

World Journal of Pharmacy and Pharmaceutical Sciences published new progress about Chewing gum. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Recommanded Product: (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gabrielsson, Jon published the artcileMultivariate Methods in the Development of a New Tablet Formulation, Application of (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, the main research area is excipient tablet disintegration.

The overall objective of this article is to use an efficient approach to find a suitable tablet formulation for direct compression. By using traditional approaches to statistical exptl. design in tablet formulation, the number of experiments quickly grows when many descriptive variables or many excipients are included. To facilitate the screening process, a multivariate design, which allows a systematical evaluation of a large number of excipients with a limited number of experiments, was implemented. Formulations with acceptable values for disintegration time and crushing strength were obtained with some of the formulations in the present study. The multivariate exptl. design strategy yielded PLS models that will be used to identify a region of interest for the optimization. The strategy is general and can be applied in many different areas of pharmaceutical research and development.

Drug Development and Industrial Pharmacy published new progress about Compression. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Application of (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ndindayino, F. published the artcileDirect compression and molding properties of co-extruded isomalt/drug mixtures, Related Products of alcohols-buliding-blocks, the main research area is direct compression property isomalt drug mixture extrusion.

Isomalt, a disaccharide alc. was co-extruded with paracetamol or hydrochlorothiazide (HCT) in order to improve its tabletting properties. After extrusion, isomalt was transformed into an amorphous form, while paracetamol remained crystalline Hot stage microscopy showed that HCT was amorphous in the isomalt carrier up to a concentration of 1%. Direct compression of mixtures formulated with co-extruded isomalt/paracetamol powders yielded harder tablets compared with phys. mixtures and no powder agglomeration was observed Direct molding of isomalt co-extruded with either paracetamol or HCT was feasible, yielding hard tablets. A fast dissolution rate was seen for both the compressed and the molded tablets (>80% paracetamol and 60% HCT released within 20 min). The compressed tablets showed a dramatic decrease in tensile strength during storage at 85% RH, while the tensile strength of the molded tablets remained above 0.80 MPa after a 6-mo storage at the same conditions. Co-extrusion of isomalt with paracetamol and HCT dramatically improved the tabletting properties of the mixtures (compared with phys. mixtures of drug and isomalt). Direct molding proved to be a suitable technique to produce isomalt-based tablets.

International Journal of Pharmaceutics published new progress about Compression. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Khorramzadeh, Dorreh published the artcileProduction of drinking powder containing soy milk powder and low calorie sweeteners, Name: (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, the main research area is drinking soy milk powder sweetener.

In recent decades, consuming low calorie foods containing sugar substitutes has enhanced to reduce energy intake, decline of blood sugar and body weight control. By increasing tendency to reduce food energy intake through consuming lower sucrose foods and increasing demand for healthy, functional and nutritious soft drinks in the shape of ready to drink beverages, squash and drinking powder; in this study, by removing sugar from some usual drinking powders and replacing it with three other sweeteners, Stevia rebaudioside-A, erythritol and isomalt, five formulations of a drinking powder containing different combinations of the three sweeteners along with soymilk powder and apple-juice powder were evaluated. In the samples, 80 percent of the required sweetness was coming from Stevia, and remaining 20 percent of the sweetness from 5 ratios of Erythritol: Isomalt (100:0, 75:25, 50:50, 25:75, 0:100). In all five samples, there was a constant measure of soymilk powder and apple-juice powder. The samples examined in terms of physicochem. and organoleptic characteristics.Results showed that all samples were physicochemicaly in standard range and they had acceptable organoleptic quality, but the one with a 75:25 erythritolisomalt ratio was more desirable.

Advances in Environmental Biology published new progress about Apple juice. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Name: (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Karl, Corinna M. published the artcileStructure-dependent effects of sweet and sweet taste affecting compounds on their sensorial properties, Recommanded Product: (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, the main research area is sweet taste affecting compound sensorial properties; Lingering; Molecular structure of tastants; Onset; Physicochemical descriptors; Side-tastes; Sweet taste; Temporal sensory profile.

A reduction in sugar consumption is desirable from a health point of view. However, the sensory profiles of alternative sweet tasting compounds differ from sucrose regarding their temporal profile and undesired side tastes, reducing consumers acceptance. The present study describes a sensory characterization of a variety of sweet and sweet taste affecting compounds followed by a comparison of similarity to sucrose and a multivariate regression anal. to investigate structural determinants and possible interactions for the temporal profile of the sweetness and side-tastes. The results of the present study suggest a pivotal role for the number of ketones, aromatic rings, double bonds and the M LogP in the temporal profile of sweet and sweet taste affecting compounds Furthermore, interactions between aggregated physicochem. descriptors demonstrate the complexity of the sensory response, which should be considered in future models to predict a comprehensive sensory profile of sweet and sweet taste affecting compounds

Food Chemistry: X published new progress about Astringents. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Recommanded Product: (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sun, Hui-Zeng published the artcileLactation-related metabolic mechanism investigated based on mammary gland metabolomics and 4 biofluids’ metabolomics relationships in dairy cows, SDS of cas: 64519-82-0, the main research area is lactation mammary gland metabolomics dairy cow; Biofluids relationship; Dairy cow; Lactation; Mammary gland; Metabolic function; Metabolomics.

Background: Lactation is extremely important for dairy cows; however, the understanding of the underlying metabolic mechanisms is very limited. This study was conducted to investigate the inherent metabolic patterns during lactation using the overall biofluid metabolomics and the metabolic differences from non-lactation periods, as determined using partial tissue-metabolomics. We analyzed the metabolomic profiles of four biofluids (rumen fluid, serum, milk and urine) and their relationships in six mid-lactation Holstein cows and compared their mammary gland (MG) metabolomic profiles with those of six non-lactating cows by using gas chromatog.- time of flight/mass spectrometry. Results: In total, 33 metabolites were shared among the four biofluids, and 274 metabolites were identified in the MG tissues. The sub-clusters of the hierarchical clustering anal. revealed that the rumen fluid and serum metabolomics profiles were grouped together and highly correlated but were sep. from those for milk. Urine had the most different profile compared to the other three biofluids. Creatine was identified as the most different metabolite among the four biofluids (VIP = 1.537). Five metabolic pathways, including gluconeogenesis, pyruvate metabolism, the tricarboxylic acid cycle (TCA cycle), glycerolipid metabolism, and aspartate metabolism, showed the most functional enrichment among the four biofluids (false discovery rate < 0.05, fold enrichment >2). Clear discriminations were observed in the MG metabolomics profiles between the lactating and non-lactating cows, with 54 metabolites having a significantly higher abundance (P < 0.05, VIP > 1) in the lactation group. Lactobionic acid, citric acid, orotic acid and oxamide were extracted by the S-plot as potential biomarkers of the metabolic difference between lactation and non-lactation. The TCA cycle, glyoxylate and dicarboxylate metabolism, glutamate metabolism and glycine metabolism were determined to be pathways that were significantly impacted (P < 0.01, impact value >0.1) in the lactation group. Among them, the TCA cycle was the most up-regulated pathway (P < 0.0001), with 7 of the 10 related metabolites increased in the MG tissues of the lactating cows. Conclusions: The overall biofluid and MG tissue metabolic mechanisms in the lactating cows were interpreted in this study. Our findings are the first to provide an integrated insight and a better understanding of the metabolic mechanism of lactation, which is beneficial for developing regulated strategies to improve the metabolic status of lactating dairy cows. BMC Genomics published new progress about Blood serum. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, SDS of cas: 64519-82-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rose, Thomas published the artcileProduction of isomalt, Computed Properties of 64519-82-0, the main research area is review isomalt isomaltulose sucrose mutase Protaminobacter immobilization.

Sucrose is not only an important raw material in food industry and nutrition, but also an excellent starting material for the synthesis of special oligo- and polysaccharides. Modification of disaccharides. e.g., sucrose, is possible by reorganizing or conserving the carbohydrate structure. Production of isomaltulose is an example for the enzymic modification of sucrose by reorganization of the carbohydrate structure. Isomaltulose is used as a precursor for the production of the sugar replacer isomalt. Isomalt is manufactured in a two-stage process: first, sucrose is enzymically transformed into isomaltulose. The reaction can be carried out by the enzyme glycosyltransferase (sucrose mutase) for example from Protaminobacter rubrum. Isomaltulose yield is about 80 to 85 %. For the industrial process it is advantageous to use immobilized non viable cells of P. rubrum in a packed bed reactor. Isomaltulose is hydrogenated in a second step to produce isomalt, an equimolar mixture of GPM (1-O-alpha-D-glucopyranosyl-D-mannitol) and GPS (6-O-alpha-D-glucopyranosyl-D-sorbitol). Isomalt is an odorless, white, crystalline substance containing about 5 % water of crystallization It tastes just as natural as sugar, is not sticky, tooth-friendly, suitable for diabetics and has only about half as many calories as sugar because it cannot be completely metabolized. Because it is similar to sucrose, isomalt is particularly suitable for making products such as candies, chewing gum, chocolate, compressed tablets or lozenges, baked goods, baking mixtures, and pharmaceutical products using conventional equipment.

Landbauforschung Voelkenrode, Sonderheft published new progress about Fermentation. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Computed Properties of 64519-82-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lura, Ard published the artcileNew orodispersible mini-tablets for paediatric use – A comparison of isomalt with a mannitol based co-processed excipient, Synthetic Route of 64519-82-0, the main research area is minitablet isomalt mannitol excipient pediatrics; Functionalized excipients; Isomalt; Ludiflash®; Orodispersible mini-tablet; Paediatrics; Stability.

The development of orodispersible mini-tablets (ODMTs) for paediatric use has gained importance within recent years as European authorities set up regulations for developing suitable and palatable dosage forms for paediatric patients. Polyols like mannitol and isomalt are frequently used in the manufacture of tablets where sensory properties have to be taken into account. In literature, ODTMs based on a commercialized co-processed excipient based on mannitol (Ludiflash) have been already described. Isomalt is known for its pleasant sensory properties and therefore appears to be a good candidate for ODMTs. The feasibility of the direct compression grade of isomalt for the manufacture of ODMTs was assessed and compared to Ludiflash. Hydrochlorothiazide and enalapril maleate were chosen as model drugs and compressed to 2 mm mini-tablets. ODMTs could be obtained fulfilling the criteria of Ph.Eur. with disintegration times of 180 s or even the FDA limit of 30 s. Dissolution studies and mass variation were fulfilled for all mini-tablets. Acceptance values (AV) �15 were achieved for formulations based on both isomalt and Ludiflash. Stability data showed the change of disintegration time and tensile strength as a function of storing time, condition and excipient. Both excipients showed their potential for ODMTs for paediatric use.

International Journal of Pharmaceutics (Amsterdam, Netherlands) published new progress about Homo sapiens. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Synthetic Route of 64519-82-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lengyel, M. published the artcileStudy on process parameters and optimization of microencapsulation based on phase separation, Quality Control of 64519-82-0, the main research area is microencapsulation phase separation nonionic surfactant; Calcium alginate; Freeze-drying; Isomalt; Microcomputer tomography; Microparticle structure analysis; Reconstitution.

As surfactants are capable of influencing the droplet formation, our study primarily aims the investigation of the effect of a nonionic surfactant e.g. Polysorbate 80 on the formation of microspheres on the course of vibrating nozzle method with coacervation. The experiments also concern the impact of the different process parameters (e.g. vibration frequency, feed rate and voltage) on the shape and size distribution of microspheres characterized by laser diffraction size determination completed with particle image anal. The calcium-alginate microspheres were processed using freeze-drying to ensure solid state with better drug carrier capability. Addition of isomalt was advantageous in the formation of freeze-dried microspheres at low alginate concentration, which was explained by micro-CT anal. of the constructed particle structure. The internal three-dimensional network of calcium alginate demonstrated a more cancellous architecture ameliorating the roundness of microparticles.

European Journal of Pharmaceutical Sciences published new progress about Coacervation. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Quality Control of 64519-82-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts