Tag: M.W=200-300

Electric Literature of 2425-41-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2425-41-4, name is (2-Phenyl-1,3-dioxane-5,5-diyl)dimethanol, molecular formula is C12H16O4, molecular weight is 224.25, as common compound, the synthetic route is as follows.

Example 1Compound 204, of which structure was shown above, was synthesized from monobenzalpentaerythritol (Compound A) known from literature [described in Org. Syntheses Coll., Vol. 4, 679 (1963)] as a starting material according to the following scheme. Two hydroxy groups of Compound A were condensed with phytanic acid by using a condensing agent, EDC (l-ethyl-3-(3-dimethylamino)propylcarbodiimide hydrochloride), to obtain a diester compound, Compound B [Jikken Kagaku Koza (Lecture of Experimental Chemistry), 4th edition, edited by the Chemical Society of Japan, Maruzen, Vol. 22, p.258]. The benzylidene group of Compound B was successively removed by catalytic reduction [Hanessian et al, Synthesis, 396 (1981)], and then one of the hydroxy groups was made into an oleic acid ester (Compound C). The other hydroxy group and 8-hydroxyoctanoic acid were condensed to convert the compound into an omega -hydroxy ester compound, Compound D204.

Statistics shows that 2425-41-4 is playing an increasingly important role. we look forward to future research findings about (2-Phenyl-1,3-dioxane-5,5-diyl)dimethanol.

Reference:
Patent; FUJIFILM CORPORATION; WO2007/72983; (2007); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2215-78-3, name is (4-Phenoxyphenyl)methanol, molecular formula is C13H12O2, molecular weight is 200.2332, as common compound, the synthetic route is as follows.Application In Synthesis of (4-Phenoxyphenyl)methanol

Thionyl chloride (13.34 g) was added to 4.06 g of 4-phenoxybenzyl alcohol, and the mixture was stirred at 80 C. for 3.5 hours.. After the completion of the concentration, the reaction mixture was extracted with ethyl acetate and with water.. The organic layer was concentrated to give 4.31 g of 4-phenoxybenzyl chloride. Properties of the compound: 1H-NMR(CDCl3, delta): 4..58(2H, s), 6.96-7.03(4H, m), 7.11-7.14(1H, m), 7.32-7.37(4H, m)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2215-78-3, (4-Phenoxyphenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; Fujisawa Pharmaceutical Co., Ltd.; US6352985; (2002); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 575-03-1, name is 7-Hydroxy-4-(trifluoromethyl)coumarin, molecular formula is C10H5F3O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 7-Hydroxy-4-(trifluoromethyl)coumarin

Under an argon atmosphere, 4-Trifluoromethylumbelliferone (0.2 g, 0.869 mmol) and pyridineIt was cooled and dissolved in emissions (4.3 mL) ice.Anhydrous trifluoromethanesulfonic acid (0.16 mL, 0.956 mmol) was added dropwise.Then the mixture was stirred at room temperature for 2 hours.After completion of the reaction, and extracted with ethyl acetate, 1 TadashiIt was washed at a constant hydrochloric acid and a saturated saline solution.The organic layer was dried over anhydrous sodium sulfate and the solvent was distilled off.Purification silica gel column (SiOTwo. At 40 g), resulting white solid compound (285 mg, 90percent)

With the rapid development of chemical substances, we look forward to future research findings about 575-03-1.

Reference:
Patent; HIROSAKI UNIVERSITY; PEPTIDE INSTITUTE INCORPORATED; YAMADA, KATSUYA; SASAKI, AYAKO; TESHIMA, TADASHI; YAMAMOTO, TOSHIHIRO; OTSUKA, YUJI; (81 pag.)JP2015/205870; (2015); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 202865-66-5, Adding some certain compound to certain chemical reactions, such as: 202865-66-5, name is (2-Bromo-5-fluorophenyl)methanol,molecular formula is C7H6BrFO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 202865-66-5.

Example 1; (3’R,4’S,5S,5’S,6’R)-3-[(4-ethylphenyl)methyl]-6′-(hydroxymethyl)-3′,4′,5′,6′-tetrahydrospiro[thieno[2,3,f]isobenzofuran-5(7H),2′-[2H]pyran]-3′,4′,5′-triol; 1) Synthesis of 5-bromo-2-fluoro-4-hydroxymethylbenzaldehyde; [Show Image] Tetramethylpiperidine (0.68 g, 4.87 mmol) was dissolved in tetrahydrofuran (4.5 mL). To the resultant solution was added n-butyllithium (1.0 M n-hexane solution, 4.88 mL) at 0°C, and the solution was then stirred for 15 minutes. The solution was cooled to -78°C, and a solution of (2-bromo-5-fluorophenyl)-methanol (0.50 g, 2.43 mmol) in tetrahydrofuran (2.5 mL) was added dropwise. The temperature of the solution was raised over 2 hours to -40°C. The solution was again cooled to -78°C, and N,N-dimethylformamide (0.47 mL, 6.07 mmol)was added thereto. The temperature of the solution was raised to room temperature, and the solution was then stirred for 30 minutes. Saturated aqueous ammonium chloride was added, and the resultant mixture was extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate, and then concentrated under reduced pressure, to thereby obtain the titled compound (604.3 mg, quantitative). 1H-NMR (CDCl3) delta: 4.78 (2H, s), 7.46 (1H, d, J = 10.6 Hz), 8.01 (1H, d, J = 6.2 Hz), 10.29 (1H, s).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 202865-66-5, (2-Bromo-5-fluorophenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; CHUGAI SEIYAKU KABUSHIKI KAISHA; EP2048152; (2009); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 5391-88-8, 1-(4-Bromophenyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 5391-88-8, blongs to alcohols-buliding-blocks compound. Recommanded Product: 5391-88-8

General procedure: Bi(OTf)3 (1.0 mol%) was added to a solution of the appropriate secbenzylalcohol (1.0 equiv) and TMSN3 (1.2 equiv) in CH2Cl2 (4.0mL/mmol) at r.t. When the reaction was complete (TLC), the solventwas removed and the crude material was purified by column chromatography.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5391-88-8, its application will become more common.

Reference:
Article; Tummatorn, Jumreang; Thongsornkleeb, Charnsak; Ruchirawat, Somsak; Thongaram, Phanida; Kaewmee, Benyapa; Synthesis; vol. 47; 3; (2015); p. 323 – 329;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 32707-89-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.32707-89-4, name is (3,5-Bis(trifluoromethyl)phenyl)methanol, molecular formula is C9H6F6O, molecular weight is 244.13, as common compound, the synthetic route is as follows.

Ketones: alpha-Benzylated acetamides 19 (0.14-0.35 mmol) obtained above were dissolved in anhydrous THF (2 ml). 2 equivalents of aromatic Grignard reagents or aromatic lithium reagents (0.28-0.70 mmol) were added drop-wise. The reaction mixtures were stirred at room temperature for 10 minutes before CH2Cl2 (2 ml) and MeOH (1 ml) were added to quench the reaction. The mixtures were filtered through pads of silica gel in parallel and the silica pads were rinsed with ethyl acetate. The combined filtrates were concentrated and the residues were purified by flash chromatography on silica to give ketones 20.

Statistics shows that 32707-89-4 is playing an increasingly important role. we look forward to future research findings about (3,5-Bis(trifluoromethyl)phenyl)methanol.

Reference:
Patent; Huang, Yazhong; Hu, Shuanghua; Degnan, Andrew P.; US2006/20019; (2006); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 4654-39-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 4654-39-1 as follows.

1 -Bromo-4-(2-iodoethyl)benzeneA solution of 2-(4-bromophenyl)ethanol (40.0 g, 0.199 mol) in dichloromethane (10 mL) was added dropwise to a solution of imidazole (22.4 mg, 0.329 mmol), triphenylphosphine (66.5 g, 0.254 mol), and iodine (65.0 g, 0.26 mol) indichloromethane (50 mL) at 0C. When the addition was complete it was warmed to rt. After 1 hour the reaction was filtered through celite, the filtrate was washed with saturated aqueous sodium thiosufate (2×100 mL), brine (100 mL), dried over MgS04, filtered and concentrated in vacuo. Purification by flash column chromatography on silica gel (heptane/ethyl acetate 4: 1 ) afforded the title compound as a yellow-white solid (59.09 g, 60%). 1 HNMR (400 MHz, CHLOROFORM-d) delta ppm 3.14 (t, J=7.69 Hz, 2 H) 3.33 (t, J=7.69 Hz, 2 H) 7.08 (d, J=7.89 Hz, 2 H) 7.45 (d, J=8.31 Hz, 2 H)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4654-39-1, its application will become more common.

Reference:
Patent; PFIZER INC.; BROWN, Matthew Frank; MARFAT, Anthony; MELNICK, Michael Joseph; REILLY, Usa; WO2011/45703; (2011); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1261524-75-7, name is 3-Bromo-2-chlorobenzyl Alcohol. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 1261524-75-7

A solution of (3 -bromo-2- chlorophenyl)methanol (600 mg, 2.71 mmol), (2-chloro-3 -(4,4,5,5 -tetramethyl- 1,3 ,2-dioxaborolan-2- yl)phenyl)methanol (728 mg, 2.71 mmol), K2C03 (936 mg, 6.77 mmol) in 1,4-dioxane (9 mL) and water(2.3 mL) was purged with nitrogen for 5 mi Pd(dppf)C12.DCM (198 mg, 0.27 mmol) was added and the reaction mixture was heated at 100 C for 12 h. The reaction mixture was filtered through a pad of celite and the pad was washed with MeOH. The filtrate was concentrated to dryness and the residue was purified by silica gel column with 0-30% EtOAc in hexanes to give a product.

With the rapid development of chemical substances, we look forward to future research findings about 1261524-75-7.

Reference:
Patent; GILEAD SCIENCES, INC.; AKTOUDIANAKIS, Evangelos; APPLEBY, Todd; CHO, Aesop; DU, Zhimin; GRAUPE, Michael; GUERRERO, Juan A.; JABRI, Salman Y.; LAD, Lateshkumar Thakorlal; MACHICAO TELLO, Paulo A.; MEDLEY, Jonathan William; METOBO, Samuel E.; MUKHERJEE, Prasenjit Kumar; NADUTHAMBI, Devan; NOTTE, Gregory; PARKHILL, Eric Q.; PHILLIPS, Barton W.; SIMONOVICH, Scott Preston; SQUIRES, Neil H.; VENKATARAMANI, Chandrasekar; WANG, Peiyuan; WATKINS, William J.; XU, Jie; YANG, Kin Shing; ZIEBENHAUS, Christopher Allen; (724 pag.)WO2018/195321; (2018); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 217479-60-2, name is 2,4,6-Trichlorobenzyl alcohol, the common compound, a new synthetic route is introduced below. Recommanded Product: 217479-60-2

a) Preparation of 1 ,3,5-trichloro-2-chloromethyl-benzene:To a stirred solution of 2,4,6-trichlorobenzylalcohol (10.0g; 47.3 mmoles) in chloroform (100ml) kept under nitrogen atmosphere, thionyl chloride (6.07ml_, 85.1 mmole) was added slowly at O0C over a period of 15 minutes followed by catalytic amount of DMF The reaction mix was allowed to stir at ambient temp for 3 hours. The reaction mixture was quenched with 5OmL of water; the aqueous layer was extracted with DCM (3 X 100ml). The combined organic layer was washed with 5% sodium bicarbonate solution (2 x 50ml) followed by brine (50ml) and dried over anhydrous sodium sulphate. The solvent was evaporated under reduced pressure. 10.9g (100.0% of theory) of 1 ,3,5-trichloro-2-chloromethyl-benzene was obtained in form of a white solid.1 HNMR (CDCI3, 400MHz): delta= 7.37 (2H, s); 4.82 (2H, s) Mass: M = 229.8

The synthetic route of 217479-60-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SYNGENTA PARTICIPATIONS AG; RAJAN, Ramya; WALTER, Harald; STIERLI, Daniel; WO2010/63700; (2010); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 5333-42-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 5333-42-6, name is 2-octyldodecan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

2-Octyl-l-dodecanol (5 g, 16.7 mmol) was taken in a 100 mL round bottomed flask, pyridiniumchlorochromate (10.8 g, 50.24 mmol) was added to it and the mixture was dissolved in anhydrous CH2C12 (120 mL). The reaction mixture was stirred at room temperature (27C) for 3 h and filtered through a short pad of silica gel to provide the required aldehyde as a colourless liquid. 4.68 g, Yield: 94%.1H NMR (400 MHz, CDC13) delta: 9.54 (d, / = 3.2 Hz, 1 H), 2.26 – 2.14 (m, 1 H), 1.68 – 1.53 (m, 2 H), 1.42 (dd, / = 14.2, 5.6 Hz, 2 H), 1.25 (broad s, 28 H), 0.87 (t, / = 6.8 Hz, 6 H); 13C NMR (100 MHz, CDC13) delta: 211.9, 182.8, 161.1, 77.3, 77.2, 76.7, 74.6, 72.1, 45.5, 42.8, 37.4, 34.0, 32.2, 31.9, 31.8, 29.7, (0101) 29.6, 29.6, 29.5, 29.5, 29.3, 29.3, 29.3, 29.1, 27.4, 25.6, 25.2, 23.9, 22.7, 14.1; MALDI-TOF (m/z): [M]+ calcd for C20H40O: 296.3079; found: 296.2517.

According to the analysis of related databases, 5333-42-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH; NITHYANANDAN, Jayaraj; ALAGUMALAI, Ananthan; FAIROOS, Munavvar; VELLIMALAI, Punitharasu; (47 pag.)WO2018/20518; (2018); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts