Tag: M.W=200-300

Synthetic Route of 517-21-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 517-21-5, name is Sodium 1,2-dihydroxyethane-1,2-disulfonate, molecular formula is C2H4Na2O8S2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Zinc powder (1.1 g, 19 mmol) was added to a mixture of benzo[1,2,5]thiadiazole-4-sulfonic acid [5-iodo-2-(morpholine-4-carbonyl)-phenyl]amide (1.0 g, 1.9 mmol) and AcOH (20 mL), and the resulting mixture was heated at 50 C. for 1 h with vigorous stirring. The mixture was filtered through a pad of diatomaceous earth, rinsing well with methanol, and the clear solution was concentrated to a yellow solid. This material was dissolved in methanol (20 mL) and added to a mixture of glyoxal sodium bisulfite adduct (1.5 g, 5.7 mmol), AcOH (0.85 mL), NaOAc (0.16 g, 2.0 mmol), and H2O (6 mL). The reaction was allowed to proceed under reflux for 3 h, then was diluted with EtOAc (200 mL) and filtered through a pad of diatomaceous earth, rinsing well with EtOAc. The filtrate was washed with H2O (100 mL) and brine (100 mL), then was dried and concentrated to a yellow solid. Purification by flash chromatography gave the titled compound as a light yellow solid (0.69 g, 70%).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 517-21-5, Sodium 1,2-dihydroxyethane-1,2-disulfonate.

Reference:
Patent; Allison, Brett D.; Hack, Michael D.; Phuong, Victor K.; Rabinowitz, Michael H.; Rosen, Mark D.; US2005/38032; (2005); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 61439-59-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 61439-59-6, name is 2-(4-(Benzyloxy)phenyl)ethanol. A new synthetic method of this compound is introduced below.

Take 10.0 mL ionic liquid [Emim] [OSO2OE],Add 1.0 g (4.1 mmol) 4-phenoxyphenylethanol and 2.4 g (4.9 mmol) 2,3,4,6-tetra-O-acetyl-?[-0-glucopyranose trichloroacetimidate ,Nitrogen gas three times,Cool to 0 ° C,75 muL of TMSOTf (0.4 mmol) was added dropwise using a microsyringe.Keep the temperature at around 0 °C for about 0.5 hours.Then slowly increase to room temperature for 2 h.TLC detects the disappearance of alcohol raw materials,The reaction was quenched with triethylamine.The reaction solution was extracted with anhydrous diethyl ether to give the resulting glycoside.Combine the ether phase,Use a small amount of 4percent Na2CO3,Washed with saturated saline,Then add 4percent Na2SO4 to dry,The ether was removed by rotary evaporation and recrystallized from ethanol-cyclohexane to give 2-(4-benzyloxyphenyl)ethyl-(2,3,4,6-tetra-O-acetyl)-alpha-D-pyridin Glucosinolate1.83 g, milky white solid product, yield 80.1percent.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,61439-59-6, its application will become more common.

Reference:
Patent; Zaozhuang College; Zhou Fengyan; Zhang Wenzhi; Kong Xiaoyu; Yuan Yaru; Li Suwan; (12 pag.)CN107880085; (2018); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 24006-92-6, Adding some certain compound to certain chemical reactions, such as: 24006-92-6, name is (4,5-Dichloro-1,2-phenylene)dimethanol,molecular formula is C8H8Cl2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 24006-92-6.

Into a 100-mL round-bottom flask, was placed a solution of (4,5-dichloro-1,2-phenylene)dimethanol (500 mg, 2.41 mmol, 1.00 equiv) in dichloromethane (50 mL) and tribromophosphane (1.30 g, 4.80 mmol, 2.00 equiv). The resulting solution was stirred overnight at room temperature. The mixture was poured into 50 mL of water/ice. The resulting solution was extracted with 3×100 mL of ethyl acetate, dried over anhydrous sodium sulfate and concentrated under vacuum. The residue was applied onto a silica gel column with ethyl acetate/petroleum ether (1:100). The collected fraction was concentrated under vacuum to give 1,2-bis(bromomethyl)-4,5-dichlorobenzene (400 mg, 50%) as off-white oil. 1H-NMR (CDCl3, 4001411z, ppm): delta 7.48 (s, 2H), 4.57 (s, 4H).

According to the analysis of related databases, 24006-92-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Forma Therapeutics, Inc.; Bair, Kenneth W; Barczak, Nicholas; Han, Bingsong; Lancia, JR., David R.; Liu, Cuixian; Martin, Matthew W; Ng, Pui Yee; Rudnitskaya, Aleksandra; Thomason, Jennifer R; Zablocki, Mary Margaret; Zheng, Xiaozhang; (195 pag.)US2016/264518; (2016); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 101597-25-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.101597-25-5, name is 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol, molecular formula is C17H16O3, molecular weight is 268.31, as common compound, the synthetic route is as follows.

2-Phenylthio-1,4-dihydroxynaphthalene (2 g) from Step 1 and 1,1-bis(4-methoxyphenyl)-2-propyn-1-ol (2.25 g) from Step 2 of Example 1 were added to a reaction flask containing 70 ml of toluene and stirred at room temperature. A catalytic amount of p-toluenesulfonic acid (about 100 mg) was added and stirred for 4 hours under a nitrogen atmosphere. Afterwards, the reaction mixture was poured into 50 ml of 10 weight percent aqueous sodium hydroxide solution. The organic layer was separated, washed and dried over anhydrous sodium sulfate. Evaporation of solvent resulted in an oily product which was purified using a silica gel column and a 1:1 mixture of chloroform:hexane as the eluant. The photochromic fractions were combined and the eluant was removed under vacuum. The resulting product was induced to crystallize from diethyl ether. The recovered product (2.5 g) had a melting point of 152-154C. A nuclear magnetic resonance (NMR) spectrum showed the product to have a structure consistent with 2,2-bis(4-methoxyphenyl)-5-phenylthio-6-hydroxy-2H-naphtho[1,2-b]pyran.

Statistics shows that 101597-25-5 is playing an increasingly important role. we look forward to future research findings about 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol.

Reference:
Patent; TRANSITIONS OPTICAL, INC.; EP994871; (2006); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 101597-25-5, 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol, blongs to alcohols-buliding-blocks compound. Safety of 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol

A 500 mL three-necked flask equipped with a water trap was charged with 1-hydroxypyrene (Ea0,623 mg, 2.85 mmol), a propargyl alcohol derivative (E0, 903 mg, 3.36 mmol)3.5g of acidic alumina and 300mL of toluene, under argon protection, dark reaction 90 C for 35h, the solution was dark green.After cooling to room temperature, the reaction mixture was suction filtered, the filter cake was washed with dichloromethane, the filtrate and the washings were combined, the solvent was spin dried,The crude product was separated by column chromatography, and the resulting crude product was recrystallized from absolute ethanol to give 210 mg of a light yellow solid in a yield of 22%. Yield 55%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,101597-25-5, 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; Shanghai Gantian Optical Materials Co., Ltd.; Gan Jiaan; (9 pag.)CN104016996; (2017); B;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 2043-47-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2043-47-2, name is 1H,1H,2H,2H-Nonafluoro-1-hexanol. A new synthetic method of this compound is introduced below.

Example 16 is repeated, but using the hydrofluoro alcohol CF3CF2CF2CF2CH2CH2OH from Aldrich.The NMR spectrum indicates approximately 10 mol% degradation of the hydrofluoro alcohol. The main degradation product is :CF3CF2CF2CF=CHCH2OH.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2043-47-2, its application will become more common.

Reference:
Patent; SOLVAY SOLEXIS S.P.A.; MARCHIONNI, Giuseppe; DE PATTO, Ugo; AVATANEO, Marco; WO2010/57691; (2010); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 149965-40-2 , The common heterocyclic compound, 149965-40-2, name is (5-Bromo-2-chlorophenyl)methanol, molecular formula is C7H6BrClO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

(5-bromo-2-chlorophenyl)methan-1-ol (2.00 g; 9.03 mmol; 1.00 eq.) was dissolved in DMF (30 mL), then the mixture was cooled down to 0C. Imidazole (1.54 g; 22.58 mmol; 2.50 eq.) and tert-butyldimethylsilyl chloride (1.88 mL; 10.84 mmol; 1.20 eq.) were added and the mixture was stirred 2h at 0 C, then 2h at rt. The reaction mixture was concentrated and diluted with EtOAc. The resulting organic phase was washed with saturated aqueous NH4Cl solution, dried over MgSO4, filtered and concentrated to dryness to give crude (5-bromo-2-chloro-phenyl)methoxy-tert-butyl-dimethyl-silane (3.47 g; quantitative), used in the next step without purification. 1H NMR (DMSO-d6, 300 MHz): delta 7.52 (m, 1H); 7.40 (m, 1H); 7.29 (d, J = 8.4 Hz, 1H); 4.61 (s, 2H); 0.80 (s, 9H); 0.00 (s, 6H).

The synthetic route of 149965-40-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Inventiva; BARTH, Martine; CONTAL, Sylvie; JUNIEN, Jean-Louis; MASSARDIER, Christine; MONTALBETTI, Christian; SOUDE, Anne; EP3632908; (2020); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2043-47-2, name is 1H,1H,2H,2H-Nonafluoro-1-hexanol, the common compound, a new synthetic route is introduced below. Product Details of 2043-47-2

6.00 parts of the salt represented by the formula (I-73-d) and 30 parts of chloroform were mixed and stirred at 23 C. for 30 minutes. In the obtained mixed solution,1.78 parts of the compound represented by the formula (I-1-b) are added, andAfter stirring at 50 C for 2 hours, the mixture was cooled to 23 C. The resulting mixed solution2.64 parts of a compound represented by the formula (I-1-e) are added to the solution,The mixture was further stirred at 23 C. for 18 hours. In the resulting mixture,After adding 15 parts of a 5% oxalic acid aqueous solution and stirring at 23 C. for 30 minutes, the organic layer was separated and separated. To the obtained organic layer, 15 parts of ion-exchanged water was added, and the mixture was stirred at 23 C. for 30 minutes. This washing operation was repeated five times. After the obtained organic layer was filtered, the filtrate was concentrated, 30 parts of tert-butyl methyl ether was added to the concentrated residue, the mixture was stirred at 23 C. for 30 minutes, and the supernatant was removed and concentrated.As a result, 5.29 parts of a salt represented by the formula (I-73) was obtained.

The synthetic route of 2043-47-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Sumitomo Chemical Co., Ltd.; Masuyama, Tatsuo; Yamamoto, Toshio; Ichikawa, Koji; (94 pag.)JP2019/218340; (2019); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 196811-90-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 196811-90-2, name is 2-(4-(Trifluoromethoxy)phenyl)ethanol, molecular formula is C9H9F3O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

MsCl (199 mg, 1.74 mmol) was added dropwise into a mixture of 2-[4- (trifluoromethoxy)phenyl]ethan-l-ol (300 mg, 1.46 mmol), dichloromethane (10 mL), and TEA (439 mg, 4.34 mmol) at 0C in 5 min under nitrogen. The resulting solution was stirred for 12h at room temperature and concentrated under vacuum. This resulted in the title compound (410 mg, crude) as a white solid

According to the analysis of related databases, 196811-90-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; PARAZA PHARMA, INC.; BEAUMIER, Francis; DERY, Martin; LAROUCHE-GAUTHIER, Robin; CHEN, Huifen; SHORE, Daniel; VILLEMURE, Elisia; VOLGRAF, Matthew; HU, Baihua; LU, Aijun; CRIDLAND, Andrew; WARD, Stuart; (212 pag.)WO2018/96159; (2018); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.61439-59-6, name is 2-(4-(Benzyloxy)phenyl)ethanol, molecular formula is C15H16O2, molecular weight is 228.29, as common compound, the synthetic route is as follows.Recommanded Product: 61439-59-6

Step 2: To a solution of 4-benzyloxyphenethyl alcohol (8.29 g) and carbon tetrabromide (24.1 g) in ether (150 ml) is portionwise added triphenylphosphine (19.0 g) and the resulting mixture stirred for about 3 hours. The supernatent is decanted, the solid washed with ether and the combined organic solution concentrated in vacuo. The crude product is purified by passing it through a silica plug to give 4-benzyloxyphenethyl bromide.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,61439-59-6, 2-(4-(Benzyloxy)phenyl)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; Rhone-Poulenc Rorer Pharmaceuticals, Inc.; US5674482; (1997); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts