Tag: M.W=200-300

Synthetic Route of 40571-86-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.40571-86-6, name is Trans-2-(benzylamino)cyclohexanol, molecular formula is C13H19NO, molecular weight is 205.2961, as common compound, the synthetic route is as follows.

General procedure: In a typical reaction, 90mL dry acetonitrile solution of tetrabutylammonium tetrafluoroborate(0.1 M) as the supporting electrolyte in an undivided cell fitted with a sacrificial magnesium rod as an anode and a stainless steel grid (20 cm2) as the cathode was subjected to electrolysis at a constant current density (I = 80 mA/cm?2). The cell was cooled to ?20°C by immersing in the Lauder refrigerating system. During the electrolysis, the system was maintained under an inert atmosphere by continuous bubbling of nitrogen. The electrolysis was stopped after the formationof two equivalents of cyanomethyl anion with respect to the beta-aminoalcohol derivatives(10 mmol, Q = 193 C). Then, 1.1 equivalent of carbon disulfide is added.The solution was removed from the cooling bath and was allowed to reach room temperature and kept under continuous stirring for 12 hours to ensure completion of the reaction. The excess of acetonitrile was removed using a rotatory evaporator, the residue was washed with water and the product was extracted three times with diethyl ether. The organic layer was washed with 20mL of water and dried over anhydrous magnesium sulfate. The solvent was removed and the residue was purified by column chromatography on silica gel 60 using a mixture of ethyl acetate/hexane (3:7) as the eluent. All the products were obtained as solids. They were characterized by 1H and 13C NMR spectroscopy, IR spectroscopy, EI mass spectrometry andelementary analysis.

The chemical industry reduces the impact on the environment during synthesis 40571-86-6, I believe this compound will play a more active role in future production and life.

Reference:
Article; Medini, Hayet; Mekni, Nejib Hussein; Boujlel, Khaled; Journal of Sulfur Chemistry; vol. 36; 6; (2015); p. 653 – 659;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 149965-40-2, name is (5-Bromo-2-chlorophenyl)methanol, the common compound, a new synthetic route is introduced below. Recommanded Product: (5-Bromo-2-chlorophenyl)methanol

[179.1] (5-Bromo-2-chlorophenyl)methanol (8.187 g) was dissolved in 100 ml of toluene, 12.2 g of diphenylposhorazide and 6.52 ml of diazabicycloundecene were added successively, and the mixture was stirred overnight at room temperature. After ethyl acetate was added thereto, the reaction mixture was successively washed with water and brine, dried over anhydrous magnesium sulfate, and the solvent was removed. The residue was purified by silica gel column, to give 9.75 g of the title compound in the 50:1 hexane-ethyl acetate fraction.1H-NMR(CDCl3) delta: 4.48 (s, 2H) 7.28 (d, J=8.4Hz, 1H) 7.41 (dd, J=2.4, 8.4Hz, 1H) 7.56 (d, J=2.4Hz, 1H)

The synthetic route of 149965-40-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Eisai Co., Ltd.; EP1394147; (2004); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7073-69-0, name is 2-(2-Bromophenyl)propan-2-ol, the common compound, a new synthetic route is introduced below. Computed Properties of C9H11BrO

Using 2-norborneneA 10-mL dry sealed-tube equipped with a stir bar was charged with [RhCl(C2H4)2]2 (0.0125 mmol,4.86 mg), BIPHEP (0.0125 mmol, 6.53 mg), Li2CO3 (0.5 mmol, 36.9 mg), LiCl (0.1 mmol, 4.24 mg),and 2-norbornene (1.0 mmol, 94.1 mg) under a N2 flow. Xylene (1 mL), 2a (0.25 mmol, 53.8 mg),and furfural (0.5 mmol, 48.0 mg) were then added. After degassing the reaction mixture by the freezepump-thaw method three times, the tube was filled with N2. The mixture was then placed in an oilbath that had been preheated to 130 C for 20 h. After cooling to room temperature, the resultingsolution was filtered through a celite pad, and the filtrate was concentrated in vacuo. The resultingcrude product was purified by flash column chromatography on silica-gel to afford 6.

The synthetic route of 7073-69-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Furusawa, Takuma; Tanimoto, Hiroki; Nishiyama, Yasuhiro; Morimoto, Tsumoru; Kakiuchi, Kiyomi; Chemistry Letters; vol. 46; 7; (2017); p. 926 – 929;,
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Adding a certain compound to certain chemical reactions, such as: 1074-16-4, 2-(2-Bromophenyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1074-16-4, blongs to alcohols-buliding-blocks compound. Safety of 2-(2-Bromophenyl)ethanol

2-(2-Bromophenyl)acetaldehyde A solution of 9.11 grams (0.045 mole) of 2-(2-bromophenyl)ethanol in 35 milliliters of methylene chloride was added to a stirred suspension of 14.62 grams (0.063 mole) of pyridinium chlorochromate in 75 milliliters of methylene chloride at ambient temperature whereupon a slightly exothermic reaction took place with the formation of a black reaction mixture. Stirring was continued for 15 hours at ambient temperature; then 150 milliliters of ether was added and the mixture filtered through silica gel on a pad of celite. The insoluble residue was washed with 100 milliliters of ether, filtered, the ether solutions combined and the solvents evaporated on a rotary evaporator to recover as residue, 8.0 grams (90 percent) of the desired 2-(2-bromophenyl)acetaldehyde intermediate as an oil. The oil had an Rf of 0.6 on silica gel when eluted with one percent methanol in chloroform.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1074-16-4, its application will become more common.

Reference:
Patent; Merck & Co., Inc.; US4670443; (1987); A;,
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Application of 946122-05-0, Adding some certain compound to certain chemical reactions, such as: 946122-05-0, name is (2-Amino-4-bromophenyl)methanol,molecular formula is C7H8BrNO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 946122-05-0.

Step 3. A solution of (2-amino-4-bromo-phenyl)-methanol (1.53 g, 7.57 mmol) in pyridine (15 mL) was treated with 5-chloro-2-methoxybenzenesulfonyl chloride (1.85 g, 7.57 mmol) at room temperature and stirred for 72 h, then poured upon ice-cold 2 M aq. hydrochloric acid solution and extracted with ethyl acetate. The organic layer was washed with brine, dried (MgSO4), and evaporated to produce a gummy residue, from which the product was precipitated by addition of toluene. The precipitate was collected by filtration and dried to afford N-(5-bromo-2-hydroxy-methyl-phenyl)-5-chloro-2-methoxy-benzenesulfonamide (2.51 g, 82percent). Off-white solid, MS (ISP)=404.2 (M-H)-.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 946122-05-0, (2-Amino-4-bromophenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Ackermann, Jean; Bleicher, Konrad; Ceccarelli, Simona M.; Chomienne, Odile; Mattei, Patrizio; Sander, Ulrike Obst; US2007/191603; (2007); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.107859-98-3, name is Ethyl 3-(4-(hydroxymethyl)phenyl)propanoate, molecular formula is C12H16O3, molecular weight is 208.25, as common compound, the synthetic route is as follows.name: Ethyl 3-(4-(hydroxymethyl)phenyl)propanoate

Example 3 Ethyl 3-[4-(bromomethyl)phenyl]propanoate Carbon tetrabromide (1.27 g) and triphenylphosphine (805 mg) were added to a methylene chloride solution (5 mL) of the compound (533 mg) as produced in Example 2, followed by stirring at room temperature for 30 min. An aqueous saturated sodium hydrogencarbonate solution was added to the reaction mixture, and extraction was effected with ethyl acetate. The organic layer was washed with an aqueous saturated sodium chloride solution, dried over anhydrous sodium sulfate and concentrated. The resultant residue was purified on a silica gel column chromatography (n-hexane:ethyl acetate = 9:1) to give the subject title compound (667 mg) showing the following physico-chemical values: TLC: Rf 0.61 (n-hexane:ethyl acetate = 4:1); 1H-NMR (CDCl3): d 1.23, 2.61, 2.94, 4.13, 4.48, 7.18, 7.32.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,107859-98-3, Ethyl 3-(4-(hydroxymethyl)phenyl)propanoate, and friends who are interested can also refer to it.

Reference:
Patent; ONO PHARMACEUTICAL CO., LTD.; EP1785421; (2007); A1;,
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Electric Literature of 4249-72-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 4249-72-3, name is 2-Phenoxy-1-phenylethanol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: Lignin model molecule (2-phenoxy-1-phenylethanol) wassynthesized according to the method reported by Rothenberg[9]. Catalytic hydrotreating of 2-phenoxy-1-phenylethanolwas carried out in a 100ml autoclave with Tefon liner.The catalyst (50mg) was added to a solution of 2-phenoxy-1-phenylethanol (150mg) in ethanol (2ml) and H2O(8ml).The autoclave was sealed and purged with H2several times.The reaction was performed at 170C with 2MPa hydrogenpressure for 6h. Then, the reactors were cooled down toroom temperature using an ice bath, and the organic productswere extracted with ethyl acetate (5ml × 2). The organic products mixtures were analyzed by GC and chlorobenzenewas used as an external standard. Identification of mainproducts was based on GC-MS as well as by comparisonwith authentic samples. The product distribution was shownon the mole basis. In consecutive batch tests, the catalystwas recovered by magnets and washed with EtOH for threetimes. The catalyst was recycled into the autoclave with thefeedstream.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 4249-72-3, 2-Phenoxy-1-phenylethanol.

Reference:
Article; Chen, Bingfeng; Li, Fengbo; Yuan, Guoqing; Catalysis Letters; vol. 147; 11; (2017); p. 2877 – 2885;,
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Adding a certain compound to certain chemical reactions, such as: 61367-62-2, 4-Bromo-3,5-dimethoxybenzyl alcohol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 4-Bromo-3,5-dimethoxybenzyl alcohol, blongs to alcohols-buliding-blocks compound. Safety of 4-Bromo-3,5-dimethoxybenzyl alcohol

To a mixture of 4-bromo-3,5-dimethoxybenzylalcohol (44.5 g), triethylammonium benzyl chloride (2.05 g) and 20percent aqueous sodium hydroxide solution (288 g) was added diethyl sulfate (41.7 g) under ice-cooling, and the mixture was stirred overnight at 25-30°C. After stirring for 1 hour at 70°C, the mixture was cooled and extracted with toluene. The toluene layer was washed with water and saturated aqueous NaCl solution and dried over magnesium sulfate. The solvent was removed in vacuo to yield 4-bromo-3,5-dimethoxybenzyl ethyl ether (49.5 g) as colorless oil. MS (m/z): 276 (M++2), 274 (M+)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,61367-62-2, 4-Bromo-3,5-dimethoxybenzyl alcohol, and friends who are interested can also refer to it.

Reference:
Patent; TANABE SEIYAKU CO., LTD.; WO2003/72536; (2003); A1;,
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Adding a certain compound to certain chemical reactions, such as: 722-92-9, 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol, blongs to alcohols-buliding-blocks compound. name: 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol

To a solution of [2- (4-AMINOPHENYL)-1,] 1,1, 3,3, 3-hexafluoropropan-2-ol (Oakwood, 1.5 g, 5.8 [MMOL)] in THF (25 mL) was added lithium bis (trimethyl) amide (11.6 mL of a 1.0 M solution in THF). After stirring for 10 minutes, methyl [A-BROMOPHENYLACETATE] (1.3 g, 5.8 [MMOL)] was added. The reaction mixture was stirred at room temperature for 18 h. The mixture was diluted with ethyl acetate and washed with water and brine. The organic solution was dried [(MGS04)] and concentrated in vacuo. Purification by flash chromatography (4: 1 hexanes/EtOAc) gave the free base of the title compound. A solution of the free base in CH2CI2 (20 mL) was acidified with 4N HCI in dioxane. Hexane was added and the hydrochloride salt was collected by filtration and dried to give the title compound (50 mg, 2percent). 1H NMR (DMSO-d6) [8] 7.45 (d, 2H), 7.30 (m, 5H), 6.72 (d, 2H), 5.22 (s, [1 H),] 3.62 (s, 3H). MS (ES+) [M/Z 408 (MH+).]

At the same time, in my other blogs, there are other synthetic methods of this type of compound,722-92-9, 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol, and friends who are interested can also refer to it.

Reference:
Patent; PHARMACIA CORPORATION; WO2003/99769; (2003); A1;,
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Synthetic Route of 5333-42-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5333-42-6, name is 2-octyldodecan-1-ol, molecular formula is C20H42O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 2-octyl-1-dodecanol (5.88 g, 19.7 mmol), triphenylphosphine (6.20 g, 23.6 mmol) and imidazole (1.61g, 23.6 mmol) in CH2Cl2 (40 mL) was slowly added bromine (3.78 g, 10.4 mmol) at 0 C, and the mixture was stirred at room temperature for 24 h. The reaction was then quenched with 3% Na2S2O3 aq. The product was extracted withhexane, and then the hexane layer was washed with brine. After drying the solution over MgSO4 followed by filtration,the filtrate was condensed under the reduced pressure. The crude product was purified by silica gel columnchromatography using hexane/CH2Cl2 (1/1, v/v) as an eluent to afford 1 as transparent oil (5.80 g, 82%). 1H NMR (300MHz, CDCl3, delta, ppm, 25 C): 3.44 (d, J=3.9 Hz, 2H, Br-CH2-CH), 1.64-1.53 (m, 1H, Br-CH2-CH), 1.44-1.17 (m,32H, -CH2-), 0.88 (t, J=5.1 Hz, 6H, -CH3). 13C NMR (75 MHz, CDCl3, delta, ppm, 25 C): 39.89, 39.65, 32.72-26.72(14 carbons), 22.86 (2 carbons), 14.28 (2 carbons). IR (NaCl), v (cm-1): 2924 (alkyl C-H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 5333-42-6, 2-octyldodecan-1-ol.

Reference:
Article; Aoyagi, Koutarou; Shoji, Yu; Otsubo, Saika; Kawauchi, Susumu; Ueda, Mitsuru; Matsumoto, Hidetoshi; Higashihara, Tomoya; Bulletin of the Chemical Society of Japan; vol. 87; 10; (2014); p. 1083 – 1093;,
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