Tag: M.W=200-300

Reference of 80379-31-3, Adding some certain compound to certain chemical reactions, such as: 80379-31-3, name is Ethyl 3-hydroxy-2H-chromene-4-carboxylate,molecular formula is C12H12O4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 80379-31-3.

The mixture of 2a (44 mg, 0.2 mmol) and Ph2O (400 mg) was heated to 210 C under argon for 30 min. After cooling to the room temperature, the residue was purified on silica gel (PE/EtOAc, 30:1) to get the product as a colorless oil (25 mg, 84%). 1H NMR (400 MHz, CDCl3): delta 7.26-7.22 (m, 1H), 7.14-7.12 (m, 1H), 7.06 (d, J=7.6 Hz, 2H), 4.41 (s, 2H), 3.62 (s, 2H); 13C NMR (100 MHz, CDCl3): delta 207.74, 154.65, 129.08, 128.58, 123.45, 121.63, 117.80, 73.08, 41.03 ppm. The date of the compound is identical with the described date of the reference.16

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 80379-31-3, Ethyl 3-hydroxy-2H-chromene-4-carboxylate, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Zhang, Xiaolin; Lei, Mei; Zhang, Yi-Nan; Hu, Li-Hong; Tetrahedron; vol. 70; 21; (2014); p. 3400 – 3406;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 55489-58-2, name is 2-(2-(2-(Benzyloxy)ethoxy)ethoxy)ethanol, molecular formula is C13H20O4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. category: alcohols-buliding-blocks

General procedure: Methanesulfonyl chloride (1.5 equiv.) was added drop-wise to astirred solution of alcohol (1 equiv.) and Et3N (1.5 equiv.) in anhydrousDCM (30 mL) at 0 C under nitrogen. The reaction wasallowed to warm to room temperature, and stirred for 2 h. Thereaction mixture was poured into methanol (10 mL), and concentratedin vacuo. The reaction mixture was then diluted with diethylether (20 mL), washed with water (3 20 mL) and brine(3 20 mL). The combined organic extracts were then dried overanhydrous MgSO4, filtered, and concentrated in vacuo. The residuewas dissolved in DMF (25 mL), sodium azide (3 equiv.) was added, and the mixture was stirred at 60 C for 16 h. The reaction mixturewas concentrated in vacuo, and The reaction mixture was thendiluted with diethyl ether (50 mL), washed with water (3 20 mL)and brine (3 30 mL), dried over anhydrous MgSO4, filtered, andconcentrated in vacuo, to give a residue which was purified by flashchromatography.

With the rapid development of chemical substances, we look forward to future research findings about 55489-58-2.

Reference:
Article; Suthagar, Kajitha; Watson, Andrew J.A.; Wilkinson, Brendan L.; Fairbanks, Antony J.; European Journal of Medicinal Chemistry; vol. 102; (2015); p. 153 – 166;,
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Reference of 162358-05-6, Adding some certain compound to certain chemical reactions, such as: 162358-05-6, name is 2-(4-Octylphenyl)ethanol,molecular formula is C16H26O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 162358-05-6.

(1) 2-(4-Octylphenyl)ethyl iodide To a solution of 2-(4-octylphenyl)ethanol (25 g) in ether (200 ml)-acetonitrile (100 ml), imidazole (11 g) and triphenylphosphine (36 g) were added and the mixture was stirred at 0 C. for an hour. Iodine (38 g) was added to the solution and the whole mixture was stirred at 0 C. for 2 hours. Silica gel was added to the reaction solution and the mixture was filtered off. The precipitate was washed with a mixed solution of hexane-ethyl acetate (2:1). The filtrate and the solvent employed at washing were combined and concentrated. The residue was purified by silica gel chromatography (eluent; hexane-ethyl acetate=2:1) to give the subject compound (37 g). Rf value: 0.85 (hexane-ethyl acetate=4:1) MS: 344(M+) 1 H-NMR(400 MHz, CDCl3) delta: 0.88 (3H, t, J=8 Hz), 1.10-1.40 (10H, m), 1.50-1.65 (2H, m), 2.57 (2H, t, J=8 Hz), 3.14 (2H, t, J=8 Hz), 3.33 (2H, t, J=8 Hz), 7.09 (2H, d, J=8 Hz), 7.13 (2H, d, J=8 Hz)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 162358-05-6, 2-(4-Octylphenyl)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Yoshitomi Pharmaceutical Industries, Ltd.; US5948820; (1999); A;,
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Electric Literature of 202865-66-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 202865-66-5, name is (2-Bromo-5-fluorophenyl)methanol, molecular formula is C7H6BrFO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of (2-bromo-5-fluorophenyl) methanol (5g, 0.02 mol) in 1,4-dioxane (60 mL), bis(pinacolato)diboron (5.6 g, 0.022 mol) and potassium acetate (5.6 g, 0.06 mol) were added. The resulting mixture was degassed using a stream of nitrogen and to this was added [U’-bis(diphenylphosphino) ferrocene]dichloropalladium(ll) (250 mg, 0.34 mmol). The reaction mixture was then heated at 80 °C for 10 hrs. The mixture was cooled to room temperature, diluted with H20 and extracted with EtOAc. The organic layer was dried over Na2S04 and evaporated in vacuum to yield (5-fluoro-2-(4,4,5,5-tetramethyl-l,3,2- dioxaborolan-2-yl)phenyl)methanol (5) that was used in the next reaction step without further purification. Yield-95percent; Purity-99.9percent.

According to the analysis of related databases, 202865-66-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BIOPHORE INDIA PHARMACEUTICALS PVT. LTD.; PULLAGURLA, Manik Reddy; NANDA KUMAR, Mecheril Valsan; PITTA, Bhaskar Reddy; RANGISETTY, Jagadeesh Babu; (55 pag.)WO2017/183043; (2017); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 101597-25-5, name is 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol. A new synthetic method of this compound is introduced below., Recommanded Product: 101597-25-5

10244] A propargyl alcohol compound represented by thefollowing formula was provided. 10245] 1.55 Grams (4.0 mmols) of the indenonaphthol compound obtained in Example 4 and 1.40 g (5.2 mmols) of the above propargyl alcohol compound were dissolved in 47 ml of toluene and to which was, further, added 0.03 g of camphorsulfonic acid to conduct the reaction at 100 C. for one hour.10246] After the reaction, the solvent was removed, the reaction product was refined by chromatography (solvent chloroform) using silica gel and was, thrther, recrystallized with acetonitrile to obtain 1.86 g (2.9 mmols) of a white solid material of an indenonaphthopyran represented by the following formula (ES). The yield was 73%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 101597-25-5, 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol.

Reference:
Patent; TOKUYAMA CORPORATION; IZUMI, Shinobu; TERANISHI, Kazuhiro; (26 pag.)US2016/130203; (2016); A1;,
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Reference of 13826-35-2, Adding some certain compound to certain chemical reactions, such as: 13826-35-2, name is (3-Phenoxyphenyl)methanol,molecular formula is C13H12O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 13826-35-2.

To a solution of triphenyl phosphine (4.52 g; 17.2 mmol) and 3-phenoxybenzyl alcohol (3.44 g; 17.2 mmol) in THF (20 mL) kept in an ice bath was added a solution of 1a (4.61 g; 17.2 mmol) and diisopropyl azodicarboxylate (95%, 3.66 g; 17.2 mmol) in THF (20 mL). The reaction mixture was stirred at 0 C for 2 h and monitored by TLC. The solvent was removed on the rotary evaporator, leaving a yellow oil which was purified by flash chromatography (silica gel/ethyl acetate/hexane) to yield a white solid (6.33 g; 82% yield), mp 75-77 C. 1H NMR (CDCl3): delta 1.49 (s, 9H), 3.65 (d, 2H), 3.72 (s, 3H), 4.79 (s, 2H), 4.77 (t, J = 13.6 Hz, 1H), 6.90-7.03 (m, 4H), 7.10 (d, 2H), 7.30-7.39 (m, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 13826-35-2, (3-Phenoxyphenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Dou, Dengfeng; Tiew, Kok-Chuan; Mandadapu, Sivakoteswara Rao; Gunnam, Mallikarjuna Reddy; Alliston, Kevin R.; Kim, Yunjeong; Chang, Kyeong-Ok; Groutas, William C.; Bioorganic and Medicinal Chemistry; vol. 20; 6; (2012); p. 2111 – 2118;,
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Adding a certain compound to certain chemical reactions, such as: 756520-66-8, 1-(2,6-Dichloro-3-fluorophenyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 756520-66-8, blongs to alcohols-buliding-blocks compound. Recommanded Product: 1-(2,6-Dichloro-3-fluorophenyl)ethanol

General procedure: 1-(2-chloro-5-fluorophenyl)ethan-1-ol (2.200 g, 12.6 mmol),triphenylphosphine (3.976 g, 15.1 mmol) and 5-bromo-2-nitropyridin-3-ol(2.755 g, 12.6 mmol) was dissolved in anhydrous THF(20 mL) and stirred for 30 minutes in an ice bath. The diisopropylazodiformate (3.057 g, 15.1 mmol) was added to the reaction solutionslowly at 0 oC and the mixture was stirred for4 h at room temperature. Then, the solution was concentrated with a rotaryevaporator. The crude product was purified by silica gelchromatography (petroleum ether/ethyl aceate = 100: 1, v/v) to obtain the titleproduct as white solid (4.232 g, 89.5 %).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,756520-66-8, its application will become more common.

Reference:
Article; Wang, Wanqi; Diao, Yanyan; Li, Wenjie; Luo, Yating; Yang, Tingyuan; Zhao, Yuyu; Qi, TianTian; Xu, Fangling; Ma, Xiangyu; Ge, Huan; Liang, Yingfan; Zhao, Zhenjiang; Liang, Xin; Wang, Rui; Zhu, Lili; Li, Honglin; Xu, Yufang; Bioorganic and Medicinal Chemistry Letters; vol. 29; 12; (2019); p. 1507 – 1513;,
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Synthetic Route of 83647-43-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 83647-43-2 as follows.

2-methyl-3-bromobenzyl alcohol (7 g, 34 mmol) was added to 120 mL of acetonitrile,NBS (6.8 g, 38 mmoL) was added at room temperature,The reaction was stirred at room temperature for 3 h,The solvent was removed by concentration under reduced pressure.To the residue was added 150 mL of dichloromethane,Stir,filter,The filtrate was concentrated under reduced pressure.The crude product was obtained by silica gel column chromatography (PE / EA = 85/15) to obtain 7.3 g (yield: 76.5%) of 2-methyl-3,6-dibromobenzyl alcohol;

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,83647-43-2, its application will become more common.

Reference:
Patent; Chengdu Na Sheng Technology Co., Ltd.; Yan Gexin; Zhang Hui; Zhou Lihong; (15 pag.)CN106432214; (2017); A;,
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Electric Literature of 133803-81-3 ,Some common heterocyclic compound, 133803-81-3, molecular formula is C11H22O5, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of tert- butyl 3-[2-(2-hydroxyethoxy)ethoxy]propanoate (350 mg, 1.49 mmol) in DCM (15 ml) was added TEA (0.62 ml, 4.48 mmol), then the reaction mixture was cooled to 0 C (water ice/acetone bath) and Mesyl chloride (0.14 ml, 1.79 mmol) was added dropwise. The reaction mixture was stirred for 1 h at room temperature. By TLC no starting material (Hex:AcOEt, 3:7). Reaction mixture was poured into an aqueous solution of NaHC03 (20 mL) and product extracted with DCM (20mL, 2x), the organic extracts were combined, dried (Na2S04), and evaporated under vacuum. The crude product (mesylate) was used in the next step without any further purification (>95% pure by NMR): 1H NMR (500 MHz, Chloroform-d) delta 4.44 – 4.28 (m, 2H), 3.76 (dd, J = 5.2, 3.8 Hz, 2H), 3.70 (t, J = 6.4 Hz, 2H), 3.68 – 3.57 (m, 4H), 3.07 (s, 3H), 2.49 (t, J = 6.4 Hz, 2H), 1.45 (s, 9H). [00400] Crude mixture from previous step was diluted in Acetonitrile (5 ml) and Nal (335.88 mg, 2.24 mmol) was added, the reaction mixture was stirred at 70 C for 12 h (overnight). By TLC no starting material (Hex:AcOEt, 7:3), the reaction was poured into an aqueous solution of Na2S203 (10%, 50 mL) and product was extracted with DCM (2×50 mL). Organic extracts were combined, dried (Na2S04) and evaporated under vacuum. Crude product was purified by flash chromatography (SiO2-40g, grad. Hex:AcOEt, 2 to 40% in 15 min), to give 413 mg of product as an oil (80% yield). 1H NMR (500 MHz, Chloroform-d) delta 3.73 (dt, J = 13.5, 6.6 Hz, 4H), 3.68 – 3.54 (m, 4H), 3.24 (t, J = 6.9 Hz, 2H), 2.50 (t, J = 6.5 Hz, 2H), 1.44 (s, 9H). 13C NMR (151 MHz, cdcl3) delta 171.00, 80.69, 72.11, 70.50, 70.27, 67.09, 36.39, 28.25, 3.02. LC- MS ESI); m/z: [M+Na]+ Calcd. for CnH2iI04Na, 367.0382. Found 367.0943.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 133803-81-3, tert-Butyl 3-(2-(2-hydroxyethoxy)ethoxy)propanoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ARVINAS, INC.; YALE UNIVERSITY; CREW, Andrew P.; DONG, Hanqing; WANG, Jing; CREWS, Craig M.; JAIME-FIGUEROA, Saul; (496 pag.)WO2018/226542; (2018); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 55489-58-2, name is 2-(2-(2-(Benzyloxy)ethoxy)ethoxy)ethanol, the common compound, a new synthetic route is introduced below. category: alcohols-buliding-blocks

15-Bromo-1-phenyl-2,5,8,11-tetraoxapentadecane To a suspension of sodium hydride, 60% w/w in mineral oil (0.250 g, 6.24 mmol) in DMF (2 mL) was added a solution of 2-(2-(2-(benzyloxy)ethoxy)ethoxy)ethanol (1 g, 4.16 mmol) (Fluorochem) in DMF (2 mL) at 0 C. After stirring for 25 minutes, 1,4-dibromobutane (Aldrich) (4.04 g, 18.73 mmol) dissolved in DMF (2 mL) was added dropwise to the mixture. The reaction was stirred under an atmosphere of nitrogen for 2.5 hours. A further aliquot of sodium hydride, 60% w/w in mineral oil (0.250 g, 6.24 mmol) was added and the reaction was stirred at 0 C. for 30 minutes. The reaction was warmed to room temperature and stirred for 30 minutes. A final aliquot of sodium hydride, 60% w/w in mineral oil (0.250 g, 6.24 mmol), was added and the reaction stirred at room temperature for 2 hours then left standing over the weekend. The reaction mixture was filtered through celite and the solid washed with DCM. The filtrate was partitioned between DCM (30 mL) and water (30 mL). The organic extract was washed with brine (2*30 mL), dried using a hydrophobic frit and concentrated under reduced pressure. The product was purified by chromatography on silica using a gradient elution from 0% to 100% methyl tert-butyl ether in cyclohexane to afford the title compound (711 mg, 1.89 mmol, 46% yield). LCMS RT=1.16 min, ES+ve m/z 375.2/377.1 [M+H]+.

The synthetic route of 55489-58-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Yale University; Arvinas, Inc.; Crew, Andrew; Crews, Craig; Dong, Hanqing; Ko, Eunhwa; Wang, Jing; (89 pag.)US2016/45607; (2016); A1;,
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