Tag: M.W=200-300

Application of 59012-91-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.59012-91-8, name is 4-(Hydroxymethyl)phenyl pivalate, molecular formula is C12H16O3, molecular weight is 208.25, as common compound, the synthetic route is as follows.

Compound M2._:Compound Ml (see above; 7.79 g, 37.4 mmol) was dissolved in anhydrous THF (50 mL) containing Nu,Nu-diisopropylethylamine (8.14 mL, 46.8 mmol) under argon, and the resulting solution was chilled down to 0C in an ice-water bath. (0378) Diisopropylphosphoramidous dichloride (3.46 mL, 18.8 mmol) was added drop wise via syringe over a period of 5 minutes with stirring and cooling. The reaction mixture was allowed to warm up to room temperature and stirred overnight. Precipitated salts were removed by filtration, and the filtrate was concentrated in vacuum. The residue was dissolved in ethyl acetate (-150 mL) and washed with 5% NaHC03 (3 x 50 mL) followed by brine (50 mL). The organic layer was separated, dried over Na2S04, filtered and (0379) concentrated. The product (TLC: Rf~0.6 in ethyl acetate/hexanes/triethylamine (20:80:2)) was isolated using flash chromatography on silica gel column (4 x 20 cm) loading from hexanes/ triethylamine (100:2) and eluting with acetate/hexanes/ triethylamine (20:80:2). Pure fractions were pooled and concentrated to give 8.1 g (79%) of colorless oil. H NMR (DMSO-d6): delta 7.37 (d, 4H, J=8.6 Hz), 7.07 (d, 4H, J=8.6 Hz), 4.76 – 4.63 (m, 4H), 3.70 – 3.61 (m, 2H), 1.30 (s, 18H), 1.16 (d, 12H, J=6.8 Hz). 31P NMR (DMSO-d6): delta 147.30.

Statistics shows that 59012-91-8 is playing an increasingly important role. we look forward to future research findings about 4-(Hydroxymethyl)phenyl pivalate.

Reference:
Patent; CEPHEID; GALL, Alexander A.; LOKHOV, Sergey G.; PODYMINOGIN, Mikhail; VIAZOVKINA, Ekaterina V.; LUND, Kevin Patrick; WO2015/153496; (2015); A1;,
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Adding a certain compound to certain chemical reactions, such as: 17102-63-5, 4-Bromo-2-methoxybenzyl alcohol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C8H9BrO2, blongs to alcohols-buliding-blocks compound. Computed Properties of C8H9BrO2

Step 2:; To the benzyl alcohol prepared in step 1 (0.86 g, 4.0 mmol) in DMF (8 mL) was added CuCN (1.1 g, 12 mmol). The mixture was warmed to 15O°C and stirred for 20 h. The mixture was then cooled to room temperature and EtOAc was added, followed by a saturated NH4CI/NH4OH solution. The mixture was stirred vigorously for 10 minutes and extracted with EtOAc, then the organic layer was dried (MgSO4), filtered, and concentrated in vacuo. Purification by silica gel chromatography provided 4-hydroxymethyl-3-methoxy-benzonitrile (0.38 g, 2.3 mmol).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,17102-63-5, 4-Bromo-2-methoxybenzyl alcohol, and friends who are interested can also refer to it.

Reference:
Patent; SCHERING CORPORATION; WO2006/60461; (2006); A1;,
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Chemistry, like all the natural sciences, SDS of cas: 130198-05-9, begins with the direct observation of nature— in this case, of matter.130198-05-9, Name is 1-[2-Amino-1-(4-methoxyphenyl)ethyl]cyclohexanol Hydrochloride, SMILES is Cl[H].COC1=CC=C(C=C1)C(CN)C1(O)CCCCC1, belongs to alcohols-buliding-blocks compound. In a document, author is Antonelli, Mariangela, introduce the new discover.

Substance Use Disorder (SUD) is a chronic and relapsing disease characterized by craving, loss of control, tolerance and physical dependence. At present, the combination of pharmacotherapy and psychosocial intervention is the most effective management strategy in preventing relapse to reduce dropout rates and promote abstinence in SUD patients. However, only few effective medications are available. Transcranial Magnetic Stimulation (TMS) is a non-invasive brain stimulation technique that modulates the cellular activity of the cerebral cortex through a magnetic pulse applied on selected brain areas. Recently, the efficacy of TMS has been investigated in various categories of SUD patients. The present review analyzes the application of repetitive TMS in patients with alcohol, tobacco, and cocaine use disorder. Although the number of clinical studies is still limited, repetitive TMS yields encouraging results in these patients, suggesting a possible role of TMS in the treatment of SUD.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 130198-05-9. SDS of cas: 130198-05-9.

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Related Products of 13826-35-2, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 13826-35-2, Name is (3-Phenoxyphenyl)methanol, SMILES is OCC1=CC(OC2=CC=CC=C2)=CC=C1, belongs to alcohols-buliding-blocks compound. In a article, author is Jimenez-Murcia, Susana, introduce new discover of the category.

Objectives: Tobacco smoking and gambling disorder (GD) often co-occur. However, few studies have assessed the extent to which cigarette smoking may serve to classify and/or better define GD behaviour profiles. Methods: Among a large sample of n = 3,652 consecutive treatment-seeking patients with GD (91% men). Smokers were compared to non-smokers across different sociodemographic, clinical, psychopathological and personality variables. The effect sizes for the means and the proportion differences between the groups were estimated. An evaluation of the smoking changes over the last 15 years was also performed. Results: From the total sample, 62.4% of gamblers reported tobacco use. A decreasing linear trend in tobacco use was observed within the studied period, women having a more irregular pattern. The use of tobacco was linked to the use of alcohol and other illegal drugs. Gamblers who smoke, as compared to those who don’t, presented lower education levels, lower social position indexes and active employment. They were younger, with an earlier age of onset, shorter duration of the gambling behavior, higher GD severity, more psychological symptoms, higher scores in novelty seeking and lower scores in reward dependence, self-directedness and self-transcendence. Conclusions: Gamblers seeking treatment who smoke display particular social, clinical, psychological, temperamental and character features different from non-smoking gamblers, suggesting that the presence or absence of comorbid smoking condition in GD should always be considered when developing an optimal treatment, as gamblers who smoke might need treatment strategies different from non-smoking gamblers.

Related Products of 13826-35-2, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 13826-35-2 is helpful to your research.

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Chemistry can be defined as the study of matter and the changes it undergoes. You’ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 100442-33-9, Name is 1-(3,3-Diphenyl-N-methylpropylamino)-2-methyl-2-propanol, molecular formula is , belongs to alcohols-buliding-blocks compound. In a document, author is Zhan, Zi-Ming, Quality Control of 1-(3,3-Diphenyl-N-methylpropylamino)-2-methyl-2-propanol.

Surface modification is an efficient post-treatment method to optimize the properties of nanofiltration (NF) membranes. Here, we report a facile surface modification strategy coupling with heat curing for grafting monoethanolamine (MEA), a monomer containing both a primary amine and a primary alcohol group, onto a nascent polyamide NF membrane. With grafting 0.5 wt% MEA at 50 degrees C, the pure water permeability of the polyamide NF membranes was improved from 7.9 to 19.5 L m(-2) h(-1) bar(-1) due to their enhanced physicochemical property, such as superior hydrophilicity, rough surface morphology, and enlarged membrane pores. Meanwhile, the rejection of Na2SO4 remained above 97.5%. More importantly, the optimal membrane modified with 0.5 wt% MEA exhibited a high Na2SO4 rejection of 99.1% and a negative NaCl rejection of -20.1% when treating a mixed salt solution containing 2 g/L Na2SO4 and 2 g/L NaCl. Our study provides a novel insight for the fabrication of high permselectivity NF membranes via surface modification.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 100442-33-9, in my other articles. Quality Control of 1-(3,3-Diphenyl-N-methylpropylamino)-2-methyl-2-propanol.

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Related Products of 2615-15-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2615-15-8, name is 3,6,9,12,15-Pentaoxaheptadecane-1,17-diol, molecular formula is C12H26O7, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Preparation of Compound 29a To a solution of hexaethylene glycol (25.0 g, 88.5 mmol) in DCM (100 mL) were added triethylamine (61.7 mL, 443 mmol) and ^-toluenesulfonyl chloride (50.6 g, 266 mmol) at 0 C under N2. After 5 hours at 0 C, the reaction mixture was poured into 1 N aq. HC1 (200 mL) and extracted with DCM (2 x 200 mL). The combined organic layers were washed with saturated aq. NaHCO3 (100 mL) and brine (100 mL), and dried over anhydrous Na2SO4. After filtration and concentration, the residue was purified by column chromatography, which produced the compound 29a (45.0 g, 87 %) as brown oil. 1H- MR (400 MHz, CDC13) delta 7.79 (d, J= 7.6 Hz, 4H), 7.34 (d, J= 7.6 Hz, 4H), 4.16-4.14 (m, 4H), 3.69-3.67 (m, 4H), 3.64-3.56 (m, 16H), 2.44 (s, 6H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 2615-15-8, 3,6,9,12,15-Pentaoxaheptadecane-1,17-diol.

Reference:
Patent; LEGOCHEM BIOSCIENCES, INC.; KIM, Yong, Zu; OH, Yeong, Soo; CHAE, Jeiwook; SONG, Ho, Young; CHUNG, Chul-woong; PARK, Yun, Hee; CHOI, Hyo, Jung; PARK, Kyung, Eun; KIM, Hyoungrae; KIM, Jinyeong; MIN, Ji, Young; KIM, Sung, Min; LEE, Byung, Soo; WOO, Dong, Hyun; JUN, Ji, Eun; LEE, Su, In; (272 pag.)WO2017/89890; (2017); A1;,
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Adding a certain compound to certain chemical reactions, such as: 223251-16-9, (4-(2-(Azepan-1-yl)ethoxy)phenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C15H23NO2, blongs to alcohols-buliding-blocks compound. COA of Formula: C15H23NO2

4-Hydroxybenzyl alcohol (10 g) is added to a solution of sodium hydroxide (7.73 g) in water (150 mL). The mixture is stirred to obtain a clear solution, and then toluene (100 mL), 2-chloroethylazepan hydrochloride (20.74 g), and tetrabutylammonium bromide (0.519 g) are added. The mixture is refluxed for completion of the reaction (1 -1.5 hours), as verified using TLC. The mixture is cooled to 25-35C and the organic layer is separated and washed with 10% NaCI solution (100 mL) at 500C. The organic layer is distilled completely under vacuum, and then dichloromethane (200 mL) is added to the residue. The mixture is stirred for dissolution under a nitrogen atmosphere. Dry HCI gas is passed through the solution for 30-60 minutes at 25-35C and the mixture is stirred for 1 -1.5 hours at the same temperature. About 85-90% of the solvent is distilled from the mixture, then acetone (60 mL) is added, and 85-90% of the solvent is distilled. This addition and distillation step is repeated twice with acetone (60 mL). To the residue, acetone (60 mL) is added and mixture is cooled to 0-50C and further stirred at same temperature for 4-4.5 hours. The solid obtained is filtered under a nitrogen atmosphere, washed with chilled acetone (40 mL) under a nitrogen atmosphere, and dried under vacuum at 50-550C for 4-5 hours to afford the title compound in 61.2% yield.

The synthetic route of 223251-16-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; DR. REDDY’S LABORATORIES LTD.; DR. REDDY’S LABORATORIES, INC.; BANDICHHOR, Rakeshwar; LEKKALA, Amarnath Reddy; HALDAR, Pranab; MYLAVARAPU, Ravi Kumar; GOLLA, China Malakondaiah; VAGWALA, Raghunath; KARRI, Vijaya Kumar; AKULA, Swapna; WO2011/22596; (2011); A2;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 34598-50-0, name is 5-Bromo-2,3-dihydro-1H-inden-1-ol, molecular formula is C9H9BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Application In Synthesis of 5-Bromo-2,3-dihydro-1H-inden-1-ol

[001036] Part B. Preparation of l-azido-5-bromo-2,3-dihydro-lH-indene.; [001037] A solution of the product from Part A (l.Olg, 4.73mmol) in toluene (8.ImL) was treated with the diphenyl phosphoroyl azide (1.23mL, 1.56g, 5.67mmol) followed by cooling to O0C. The solution was treated dropwise with DBU (855muL, 863mg, 5.67mmol) followed by stirring at O0C for 2h, and then warming to room temperature for 48h. The mixture was diluted with ethyl acetate and extracted with water and 1 M citric acid solution, and then with saturated sodium chloride solution. Drying (Na2SO4) and concentration in vacuo afforded a brown oil, which was purified by flash chromatography, eluting with 5-50 % ethyl acetate in hexanes. These procedures afforded the title compound (889mg, 79%) as a light yellow oil.

With the rapid development of chemical substances, we look forward to future research findings about 34598-50-0.

Reference:
Patent; ABBOTT LABORATORIES; WO2009/39134; (2009); A1;,
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Adding a certain compound to certain chemical reactions, such as: 64431-96-5, 2,2′-(Propane-1,3-diylbis(azanediyl))bis(2-(hydroxymethyl)propane-1,3-diol), can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 2,2′-(Propane-1,3-diylbis(azanediyl))bis(2-(hydroxymethyl)propane-1,3-diol), blongs to alcohols-buliding-blocks compound. Safety of 2,2′-(Propane-1,3-diylbis(azanediyl))bis(2-(hydroxymethyl)propane-1,3-diol)

[0052]To a solution of bis-ths propane (56.5 g, 0.2 mol) in 200 ml of dry THF in a three-necked round bottom flask with mechanical stir was added trimethylamine (40.52 g, 0.4 mol) at room temperature. The resulting solution was cooled down to 0 C under N2, then a solution of acryloyl chloride (36.2 g, 0.4 mol) in 100 ml of dry THF was added dropwise at 0 C. After the addition was complete, the mixture was allowed to warm to room temperature and continued to stir at room temperature for overnight. The white solid was collected by filtration and washed with THF (3X50 ml). The combined THF filtrate and THF washing solutions were evaporated off to give a residue. The residue was dissolved into 500 ml of chloroform and washed with saturated sodium (0121) bicarbonate aqueous solution (3X100 ml) until no gas generated. The chloroform layer was then dried with sodium sulfate. Sodium sulfate was removed by filtration and the filtrate was evaporated off to give the desired BIS TRIS Propane diacrylamide (BTPDA, Photo Active Co-solvent-1 ) (50.7 g, 65%).

The synthetic route of 64431-96-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.; ZHOU, Zhang-Lin; BAR, Mazi; LANE, Gregg A.; (29 pag.)WO2018/143916; (2018); A1;,
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Reference of 24034-73-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 24034-73-9, name is (2E,6E,10E)-3,7,11,15-Tetramethylhexadeca-2,6,10,14-tetraen-1-ol. A new synthetic method of this compound is introduced below.

[0364] Methyl 2E,6E,10E-geranylgeranyl thiocarbamate (10a) (R= Methyl-): A dry reaction flask equipped with a stir bar, N2 inlet was charged with alcohol 1 (0.087 g, 0.3 mmol), pyridine (0.48 mL, 0.6 mmol) and DCM (1 mL). After cooling it to 0 C, methyl thioisocyanate (0.051 mL, 1.0 mmol) was added dropwise and the resulting reaction mixture was allowed to stir for 24 h. The reaction was monitored by TLC. After completion of the reaction, it was quenched with H20 (5 mL), acidified, extracted with n-hexanes (3 x 15 m L) and the combined n-hexanes were washed with H20 (10 mL). After drying the organic solution over anhydrous Na2S04, the solvent was evaporated and the resulting residue was purified by silica gel column chromatography using 1-2% EtOAc in n-hexanes to afford the desired thiocarbamate 10a. Yield: 0.030g (28%); LCMS: MS (m/z): 386.4 (M+Na).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,24034-73-9, its application will become more common.

Reference:
Patent; COYOTE PHARMACEUTICALS, INC.; SERIZAWA, Hiroaki; ARGADE, Ankush B.; DATWANI, Akash; SPENCER, Natalie; PAN, Yonghua; ERMINI, Florian; WO2013/130654; (2013); A1;,
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