Tag: M.W=200-300

Related Products of 18385-82-5, Adding some certain compound to certain chemical reactions, such as: 18385-82-5, name is 7-Bromochroman-4-ol,molecular formula is C9H9BrO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 18385-82-5.

[0332j A solution of 7-bromochroman-4-ol (200 mg, 0.88 mmol, 1.0 equiv) in toluene (5 mL) was cooled in an ice bath under N2 and treated with DPPA (532 mg, 1.93 mmol, 2.2 equiv) in one portion followed by DBU (293 mg, 1.93 mmol, 2.2 equiv). The reaction temperature was kept at 0 C for 1 h and then was warmed to room temperature for 16 h. The mixture was diluted with EtOAc (50 mL), washed with 2N HC1 (2 x 30 mL), brine and the organic layer was dried over Na2504, filtered then concentrated. The crude product was purified by silica gel column (eluted with PE). 4-azido-7-bromochroman (188 mg, yield: 90%) was obtained as a white solid. ?H NMR (400 MHz, CDC13) 5: 7.07-7.06 (m, 3H), 4.56 (t, J= 3.6 Hz, 1H), 4.30-4.17 (m, 2H), 2.19-1.99 (m, 2H).

According to the analysis of related databases, 18385-82-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BIOGEN IDEC MA INC.; SUNESIS PHARMACEUTICALS, INC.; HOPKINS, Brian, T.; MA, Bin; CHAN, Timothy, Raymond; SUN, Lihong; ZHANG, Lei; KUMARAVEL, Gnanasambandam; LYSSIKATOS, Joseph, P.; KOCH, Kevin; MIAO, Hua; WO2015/89337; (2015); A1;,
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Related Products of 18385-82-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 18385-82-5, name is 7-Bromochroman-4-ol. This compound has unique chemical properties. The synthetic route is as follows.

7-bromochaoman-4-ol (8.80 mmol, crude), TBSCl (1.64 g, 10.5 mmol), and imidazole (1.80 g, 26.4 mmol) were stirred in DCM (17 mL) at r.t. After 16h the reaction was quenched by the addition of water (100 mL) and DCM (100 mL). The organic layer was removed and the aqueous layer was extracted with DCM (2 x 100 mL). The combined organic fractions were dried with Na2SO4 and concentrated. The crude product was purified by column chromatography to provide ((7-bromochroman-4-yl)oxy)(tert-butyl)dimethylsilane (2.9 g, 96%). mlz 375.0 [M+MeOH+H]+, 1H NMR (400 MHz, Chloroform-d) 7.05 (d, J = 8.0 Hz, 1H), 7.02 – 6.94 (m, 2H), 4.74 (t, J = 4.6Hz, 1H), 4.31 (ddd, J 10.9, 9.6, 3.0 Hz, 1H), 4.20 (ddd, J = 10.9, 5.7, 3.6 Hz, 1H), 2.11 – 1.88 (m,2H), 0.90 (s, 9H), 0.15 (s, 3H), 0.13 (s, 3H).

According to the analysis of related databases, 18385-82-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GENENTECH, INC.; XENON PHARMACEUTICALS INC.; BERGERON, Phillipe; BURFORD, Kristen; CHOWDHURY, Sultan; DEHNHARDT, Christoph Martin; FOCKEN, Thilo; GRIMWOOD, Michael Edward; HASAN, Abid; LAI, Kwong Wah; LIU, Zhiguo; MCKERRALL, Steven; NGUYEN, Teresa Phuongtram; SAFINA, Brian; SUTHERLIN, Daniel; TAN, Wang Tao; (470 pag.)WO2017/58821; (2017); A1;,
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Adding a certain compound to certain chemical reactions, such as: 41570-61-0, 2-(tert-Butylamino)-1-(2-chlorophenyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 41570-61-0, blongs to alcohols-buliding-blocks compound. HPLC of Formula: C12H18ClNO

Tulobuterol (1.00 g) and Boc-beta-alanine (0.99 g) were dissolved in dichloromethane (10 mL). After cooling to 0 C., N,N-dimethylaminopyridine (161.3 mg) and water soluble carbodiimide (1.11 g) were added thereto followed by stirring for 3 hours at room temperature. After confirming the disappearance of the reacting materials by thin layer chromatography, a saturated aqueous solution of ammonium chloride was added to terminate the reaction. After dilution with ethyl acetate, the organic layer was washed with a saturated aqueous solution of ammonium chloride, a saturated aqueous solution of sodium hydrogen carbonate, and saturated brine. After drying over magnesium sulfate anhydrous, it was filtered and the solvent was distilled off under reduced pressure to obtain the desired compound 42 (1.71 g, 98%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,41570-61-0, its application will become more common.

Reference:
Patent; SEIKAGAKU CORPORATION; Sato, Tomoya; Takeuchi, Hisayuki; Zuinen, Ryoji; (39 pag.)US2016/158369; (2016); A1;,
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Application of 624-08-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 624-08-8, name is Heptadecan-9-ol, molecular formula is C17H36O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

From 0 C in a round flask was added the p- toluenesulfonyl chloride (5.5g) and the mixture was stirred and then placed in methylene chloride (150mL). Put Then, hepta-decane-9-ol followed by the addition of (5g) and slowly diluted in methylene chloride (5mL), triethylamine (7mL) and triethylamine hydrochloride (3.71g), and the mixture was stirred for 90 minutes . MC and the organic layer with brineAnd then extracted to remove the remaining water over anhydrous magnesium sulfate, and after evaporation of the solvent was recrystallized from a MC and MeOH to give the Heptadecane-9-yl 4-methlybenzenesulfornate (compound f-4) as a white solid (yield: 64% ).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 624-08-8, Heptadecan-9-ol.

Reference:
Patent; Pusan National University Industry-Academic Cooperation Foundation; Hwang, Do Hun; Kim, Ji Hun; Kim, Hee Woon; Im, Jong Min; (52 pag.)KR101495152; (2015); B1;,
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Reference of 59012-91-8, Adding some certain compound to certain chemical reactions, such as: 59012-91-8, name is 4-(Hydroxymethyl)phenyl pivalate,molecular formula is C12H16O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 59012-91-8.

Compound M2. [00202] Compound Ml (see below; 7.79 g, 37.4 mmol) was dissolved in anhydrous THF (50 mL) containing N,N-diisopropylethylamine (8.14 mL, 46.8 mmol) under argon, and the resulting solution was chilled down to 0C in an ice-water bath. Diisopropylphosphoramidous dichloride (3.46 mL, 18.8 mmol) was added drop wise via syringe over a period of 5 minutes with stirring and cooling. The reaction mixture was allowed to warm up to room temperature and stirred overnight. Precipitated salts were removed by filtration, and the filtrate was concentrated in vacuum. The residue was dissolved in ethyl acetate (-150 mL) and washed with 5% NaHC03 (3 x 50 mL) followed by brine (50 mL). The organic layer was separated, dried over Na2S04, filtered and concentrated. The product (TLC: Rf -0.6 in ethyl acetate/hexanes/triethylamine (20:80:2)) was isolated using flash chromatography on silica gel column (4 x 20 cm) loading from hexanes/ triethylamine (100:2) and eluting with acetate/hexanes/ triethylamine (20:80:2). Pure fractions were pooled and concentrated to give 8.1 g (79%) of colorless oil. XH NMR (DMSO-d6): delta 7.37 (d, 4H, J=8.6 Hz), 7.07 (d, 4H, J=8.6 Hz), 4.76 – 4.63 (m, 4H), 3.70 – 3.61 (m, 2H), 1.30 (s, 18H), 1.16 (d, 12H, J=6.8 Hz). 31P NMR (DMSO-d6): delta 147.30.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 59012-91-8, 4-(Hydroxymethyl)phenyl pivalate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; CEPHEID; GALL, Alexander A.; LOKHOV, Sergey G.; PODYMINOGIN, Mikhail A.; VIAZOVKINA, Ekaterina V.; LUND, Kevin Patrick; WO2015/153510; (2015); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 55357-38-5, name is 2-Hydroxy-N,N,N-trimethylethanaminium 4-methylbenzenesulfonate. A new synthetic method of this compound is introduced below., SDS of cas: 55357-38-5

40 mg of {2-[(4′-Hexyl-biphenyl-4-carbonyl)-amino]-benzyl}-phosphonic acid (compound of preparation example 3) are dissolved in 10 ml of pyridine and 111 mg of dry choline p- toluolsulfonate salt and 2 ml trichloroacetonitrile are added. The mixture obtained is stirred at 500C for 76 hours. From the mixture obtained solvent is evaporated and the evaporation residue is subjected to RP-18 chromatography (0,1% TFA-water/methanol gradient). [2-({2- [(4′-Hexyl-biphenyl-4-carbonyl)-amino]-be?zyl}-hydroxy-phosphinoyloxy)-ethyl]-trimethyl- ammonium, inner salt is obtained.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 55357-38-5, 2-Hydroxy-N,N,N-trimethylethanaminium 4-methylbenzenesulfonate.

Reference:
Patent; NOVARTIS AG; WO2008/22771; (2008); A1;,
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Application of 55357-38-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.55357-38-5, name is 2-Hydroxy-N,N,N-trimethylethanaminium 4-methylbenzenesulfonate, molecular formula is C12H21NO4S, molecular weight is 275.3644, as common compound, the synthetic route is as follows.

EXAMPLE 9 A solution of 2.22 g of (E)-stigmasta-5,22-dien-3beta-yl (2-hydroxyethyl)carbonate and 1.1 ml of pyridine in 10 ml of chloroform is added dropwise to a solution, cooled to 0 C., of 0.75 g of phosphorus oxychloride in 3 ml of chloroform. The mixture is reacted at room temperature for 1 hour. Then, 1.6 g of choline tosylate in 15 ml of pyridine are added. The mixture is stirred overnight, then a solution of 2 g of potassium bicarbonate is added. The mixture is evaporated to dryness and the residue is taken up in 100 ml of THF/methanol/chloroform (1/1/1). The solids are filtered off. The solution remaining behind is percolated over an ion exchanger (Amberlite MB-3). After chromatography on silica gel with chloroform/methanol/water (60/35/5 vol) and crystallization from methylene chloride/acetone there are obtained 1.6 g of O-[hydroxy-[2-[[[(E)-stigmasta-5,22-dien-3beta-yloxy]carbonyl]oxy]ethoxy]phosphinyl]choline hydroxide internal salt, MS: 666 (M+H+).

The chemical industry reduces the impact on the environment during synthesis 55357-38-5, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Hoffmann-La Roche Inc.; US5215972; (1993); A;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 57371-44-5, name is 3-(4-(Benzyloxy)-3-methoxyphenyl)propan-1-ol. A new synthetic method of this compound is introduced below., Formula: C17H20O3

General procedure: To an ice-cooled solution of 2-iodoxybenzoic acid (0.876 g, 3.129 mmol) in DMSO (1.11 mL, 15.64 mmol) was added a solution of alcohol 26a (0.59 g, 2.607 mmol) in dry CH2Cl2 (10 mL). The mixture was stirred at room temperature for 2 h and then filtered through a Celite pad and washed with ether. The combined organic filtrates were washed with water, brine, dried over anhydrous Na2SO4, and concentrated in vacuo. The residue was purified by silica gel column chromatography (EtOAc/pet-ether, 1:9) to afford the pure compound 27a (0.508 g, 87%) as a viscous liquid. The unstable aldehyde used immediately for the next reaction.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 57371-44-5, 3-(4-(Benzyloxy)-3-methoxyphenyl)propan-1-ol.

Reference:
Article; Sabitha, Gowravaram; Srinivas, Chitti; Reddy, Teega Rammohan; Yadagiri, Kurra; Yadav, Jhillu Singh; Tetrahedron Asymmetry; vol. 22; 24; (2011); p. 2124 – 2133;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 28229-69-8, name is 3-Bromophenethyl alcohol. A new synthetic method of this compound is introduced below., Formula: C8H9BrO

Intermediate 56; 3-(2-Hydroxy-ethyl)-benzoic acid methyl ester; 2-(3-Bromo-phenyl)-ethanol (5.00 g, 24.87 mmol), 1 ,1′-bis(diphenylphosphino) ferrocene-palladium dichloride (0.70 g, 0.85 mmol) and triethylamine (7.00 g, 69.18 mmol) in MeOH (30 ml.) was heated at 90 0C (internal temperature) over a period of 10 h under carbon monoxide atmosphere (5 bar). After cooling to RT the solution was concentrated in vacuo and then partitioned between ethyl acetate and water. The organic layer was washed with brine and evaporated in vacuo. The crude product was purified by flash silica chromatography eluting with ethyl acetate//-hexane (1 :1).Yield: 3.3 g (74%).1H NMR (400 MHz, CDCI3): delta 7.93 – 7.90 (m, 2H), 7.44 (d, J = 7.2 Hz, 1 H),7.39 (t, J = 8.1 Hz, 1 H), 3.92 (s, 3H), 3.89 (t, J = 6.2 Hz, 2H), 2.93 (t, J = 6.4

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 28229-69-8, 3-Bromophenethyl alcohol.

Reference:
Patent; ARGENTA DISCOVERY LIMITED; ASTRAZENECA AB; WO2008/149110; (2008); A1;,
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Application of 17102-63-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 17102-63-5, name is 4-Bromo-2-methoxybenzyl alcohol. A new synthetic method of this compound is introduced below.

A solution of anhydrous DMSO (5.1mL, 73mmol, 3.0equiv) in anhydrous dichloromethane (50mL) was cooled to ?78°C in a dry ice/i-PrOH bath. Oxalyl chloride (6.4mL, 73mmol, 3.0equiv) was added dropwise over 45min. The mixture was stirred for 15min and a solution of 4-bromo-2-methoxybenzyl alcohol (30b; 5.30g, 24mmol) in dichloromethane (10mL) was added dropwise. The resulting mixture was stirred for 30min at ?78°C. Triethylamine (12.4g, 120mmol, 5.0equiv) was then added, and the mixture was allowed to warm to rt over 16h. The mixture was quenched with water (100mL) and extracted with chloroform (3×200mL). The combined organic extracts were washed with water (1×150mL), brine (1×150mL), dried (MgSO4), filtered, and evaporated to yield the crude product as dark residue. The residue was purified by flash chromatography using chloroform to obtain an off-white solid that was recrystallized from hexanes to yield 3.73g (71percent) of the product as a white solid: Rf 0.18 (5percent EtOAc/hexane); mp 65?67°C; 1H NMR (CDCl3) delta 10.39 (s, 1H), 7.68 (d, 1H), 7.2?7.16 (m, 2H), 3.94 (s, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,17102-63-5, its application will become more common.

Reference:
Article; Williams, John D.; Khan, Atiyya R.; Cardinale, Steven C.; Butler, Michelle M.; Bowlin, Terry L.; Peet, Norton P.; Bioorganic and Medicinal Chemistry; vol. 22; 1; (2014); p. 419 – 434;,
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