Tag: M.W=200-300

Reference of 1013031-65-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1013031-65-6 as follows.

To a solution of (2,6-dibromophenyl)methanol (5 g, 18.8 mmol) in dichloromethane (50 mL) was added te^butylchlorodimethylsilane (4.25 g, 28.2 mmol) and lH-imidazole (1.91 g, 28.2 mmol) at 0 C. The reaction was stirred at ambient temperature for 16 h. Upon completion, the mixture was washed with water (3 x 100 mL), the organic layer was dried over Na2S04. The organic layer was filtered and concentrated to dryness. Purification by column chromatography (PE) gave the product (7 g, yield: 95%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1013031-65-6, its application will become more common.

Reference:
Patent; SUNOVION PHARMACEUTICALS INC.; BOWEN, Carrie, A.; BURDI, Douglas, F.; HEFFERNAN, Michele, L., R.; HERMAN, Lee, W.; XIE, Linghong; (266 pag.)WO2019/28165; (2019); A1;,
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Related Products of 72995-94-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 72995-94-9, name is 14-Bromotetradecan-1-ol, molecular formula is C14H29BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A mixture of 14-bromotetradecan-1-ol (700 mg, 2.38 mmol) and DAST (0.63 ml_, 4.76 mmol) was heated at 35 C for 4h. The reaction mixture was poured into water and extracted with DCM (x3). The combined organic extracts were washed with brine, dried over magnesium sulfate, filtered and the solvent was removed under reduced pressure. The residue was purified by flash chromatography (hexanes/diethyl ether) to yield the title compound (422 mg, 60%) as a colourless oil. 1 H NMR d (400 MHz, CDCI3): 1.21-1.34 (m, 16H), 1.35-1.47 (m, 4H), 1.60-1 .78 (m, 2H), 1.80-1 .92 (m, 2H), 3.41 (t, J=6.9 Hz, 2H), 4.38 (t, J=6.2 Hz, 1 H), 4.50 (t, J=6.2 Hz, 1 H).

According to the analysis of related databases, 72995-94-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ALMIRALL, S.A.; BACH TANA, Jordi; ESTEVE TRIAS, Cristina; MIR CEPEDA, Marta; (187 pag.)WO2019/115405; (2019); A1;,
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Reference of 1013031-65-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1013031-65-6, name is (2,6-Dibromophenyl)methanol, molecular formula is C7H6Br2O, molecular weight is 265.93, as common compound, the synthetic route is as follows.

To a solution of (2,6-dibromophenyl)methanol i-Sa (9.6 g, 36.1 mmol) in DMF (100 mL) at 0 C was added NaH (60%, 2.2 g, 54 mmol) portionwise. The mixture was kept stirring at room temperature for additional 30 mins, followed by the additional of PMBC1 (8.8 g, 54 mmol). The mixture was stirred at room temperature for 2 h, quenched with sat NH4C1, and extracted with EtOAc. The combined organics were washed with brine, dried over Na2504, andconcentrated. The crude residue was purified by flash chromatography (0-10% EtOAc/hexanes)to give the title compound. ?H NMR (400 MHz, CDC13) oe 7.54 (d, J 7.9 Hz, 1H), 7.35 (d, J8.4 Hz, 1H), 7.01 (t, J= 7.9 Hz, 1H), 6.89 (d, J= 8.4 Hz, 2H), 4.81 (s, 2H), 4.58 (s, 2H), 3.81(s, 3H).

The chemical industry reduces the impact on the environment during synthesis 1013031-65-6, I believe this compound will play a more active role in future production and life.

Reference:
Patent; MERCK SHARP & DOHME CORP.; ZHANG, Hongjun; BARR, Kenneth, Jay; LAPOINTE, Blair, T.; GUNAYDIN, Hakan; LIU, Kun; TROTTER, B., Wesley; (67 pag.)WO2017/75185; (2017); A1;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 59012-91-8, name is 4-(Hydroxymethyl)phenyl pivalate. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 59012-91-8

Preparation of 5: A 100 G reactor containing the solution of compound 4 is charged with N-methylpyrrolidine (9.5 kg; 2.0 eq dissolved in 23 kg of dichloromethane). After 10 minutes, compound 4a (14.0 kg; 1.2 eq) is added, followed by 1,8-diazabicyclo[5.4.0]undec-7-ene (10.2 kg; 1.2 eq in 23 kg dichloromethane). The batch is warmed to 20 C. Upon reaction completion (1-9 hours), the solution is diluted with 327 kg of dichloromethane and charged to a 200 G reactor containing pH 4.5 phosphate buffer (334 kg of 1 M KH2PO4). The batch is agitated for 30 minutes, and the layers are separated. The lower organic layer is washed once more with pH 4.5 phosphate buffer (111 kg of 1 M KH2PO4), then once with brine (212 kg of 2.5% NaCl/water (w:w)). The resulting organic solution is distilled at <35 C. until Karl Fischer analysis of the batch shows <0.05% water. This solution is used directly in the preparation of compound 1f. With the rapid development of chemical substances, we look forward to future research findings about 59012-91-8. Reference:
Patent; AVI BIOPHARMA, INC.; US2009/131624; (2009); A1;,
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Application of 123206-83-7, Adding some certain compound to certain chemical reactions, such as: 123206-83-7, name is 4-(2-Bromophenyl)butan-1-ol,molecular formula is C10H13BrO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 123206-83-7.

Step C: To a solution of 4-(o-bromophenyl)-1-butanol (1.222 g, ca 0.0053 mol) and tetrakis(triphenylphosphine) palladium (0) (650 mg, 0.562 mmol) in 1,2-dimethoxyethane (55 mL) was added thiophene-2-boronic acid (2.057 g, 0.016 mol) and 1 N aqueous NaHCO3 (15 mL). The resulting mixture was heated at reflux under nitrogen atmosphere for 3 days. The dark reaction mixture was diluted with water (50 mL) and extracted with EtOAc (100 mL). The organic layer was dried over Na2SO4, filtered through a bed of Celite and concentrated to yield a crude which was purified by flash chromatography (30% EtOAc in hexane) to yield 4-(2-thien-2-yl-phenyl)-butan-1-ol as a light brown oil. 1H NMR (300 MHz, DMSO d6) delta ??1.37-1.56 (m, 4H), 2.66-2.71 (m, 2H), 3.31-3.35 (m, 2H), 4.33 (br s, 1 H), 7.10-7.15 (m, 2H), 7.21-7.26 (m, 1 H), 7.31-7.34 (m, 3H), 7.59-7.61 (m, 1 H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 123206-83-7, 4-(2-Bromophenyl)butan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Janssen Pharmaceuticals, Inc.; JORDAN, Alfonzo; PAN, Kevin; REITZ, Allen, B.; (71 pag.)EP1392687; (2017); B1;,
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Adding a certain compound to certain chemical reactions, such as: 666747-06-4, (2,4-Dibromophenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C7H6Br2O, blongs to alcohols-buliding-blocks compound. Formula: C7H6Br2O

To a stirred solution of commercially available 2,4-dibromobenzyl alcohol SI-i(500 mg, 1.88 mmol) in DMF (4 mL), under inert atmosphere, were added imidazole(153 mg, 2.25 mmol, i.2 eq.) and TBSC1 (340 mg, 2.25 mmol, 1.2 eq.). The resultingmixture was stirred for 12 h, then hydrolyzed with water and extracted with a mixture9:1 cyclohexane/CH2C12 (three times). The combined organic extracts were washed withwater, brine, dried over Mg504, filtered and concentrated under reduced pressure. The cmde product was then purified by chromatography (100percent petroleum ether) to afford the title compound SI-2 (638 mg, 1.68 mmol, 89percent) as a colorless oil.?H NMR (CDC13, 300 MHz): 7.66 (d, J = 1.8 Hz, 1H), 7.49-7.42 (m, 2H), 4.67 (s, 2H), 0.97 (s, 9H), 0.14 (s, 6H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,666747-06-4, (2,4-Dibromophenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM); UNIVERSITE DE BORDEAUX; UNIVERSITE DE RENNES 1; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; WODRICH, Harald; CHEVET, Eric; VAN DE WEGHE, Pierre; (73 pag.)WO2018/178167; (2018); A1;,
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Application of 18385-82-5, Adding some certain compound to certain chemical reactions, such as: 18385-82-5, name is 7-Bromochroman-4-ol,molecular formula is C9H9BrO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 18385-82-5.

To a solution of 7-Bromochroman-4-ol (Prepared as described in U52013/18055)(0.64g, 2.78 mmol), tert-Butyl 4-(2-hydroxy-5-(trifluoromethyl)phenyl)piperidine- 1 -carboxylate (Intermediate-iS) (0.80g, 2.3 16 mmol) and triphenylphosphine (0.91g, 3.47 mmol) in THF (25 ml) was added DIAD (0.901 ml, 4.63 mmol) stined at room temperature for 16h. Reaction mixture was diluted with ethyl actate and washed with aqueous NaOH solution, brine, dried over Na2SO4 and evaporated. The crude product was purified by flash column chromatography( 10% ethyl acetate/Petroleum ether) to obtain title compound(0.5g, 39 %). LCMS(ESI):m/z 578.12 (M+Na).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 18385-82-5, 7-Bromochroman-4-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; LUPIN LIMITED; RAMDAS, Vidya; LORIYA, Rajeshkumar, Maganlal; WALKE, Deepak, Sahebrao; DAS, Amit, Kumar; KHAN, Talha, Hussain; BANERJEE, Moloy; PALLE, Venkata, P.; KAMBOJ, Rajender, Kumar; (187 pag.)WO2015/151001; (2015); A1;,
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Related Products of 41570-61-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 41570-61-0, name is 2-(tert-Butylamino)-1-(2-chlorophenyl)ethanol, molecular formula is C12H18ClNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Compound 1, 1.8 g (7.9 mmol), was dissolved in 30 mL of diethyl ether, 0.9 mL (7.9 mmol) of a 8.5 M solution of HCl in propan-2-ol was added, and the precipitate was filtered off, washed with diethyl ether, and dried over phosphoric anhydride. Yield 1.9 g (91%), white crystals, mp 165-167C. 1H NMR spectrum (DMSO-d6), delta, ppm: 1.31 s (9H, t-Bu), 2.70 d (1H, CH2, J = 12.3 Hz), 3.07 d (1H,CH2, J = 12.4 Hz), 5.31 d (1H, CH, J = 10.1 Hz), 6.37 s(1H, OH), 7.37 d.d (1H, Harom, J = 7.3, 1.5 Hz), 7.41-7.49 m (2H, Harom), 7.69 d (1H, Harom, J = 8.8 Hz),8.64 br.s (1H, NH), 9.20 br.s (1H, NH). 13C NMR spectrum(DMSO-d6), deltaC, ppm: 25.4 [(CH3)3C], 47.1[C(CH3)3], 57.0 (CH2), 66.3 (CHOH), 128.0 (C4?, C5?),128.5 (C3?), 129.7 (C6?), 131.4 (C2?), 139.5 (C1?). Lowresolutionmass spectrum: m/z: 228.23 [M + H]+. Highresolutionmass spectrum: m/z 228.11490 [M + H]+.Mass spectrum (EI), m/z: 141 [M – CH2=NHC(CH3)3]+,86 [CH2=NHC(CH3)3]+.f

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 41570-61-0, 2-(tert-Butylamino)-1-(2-chlorophenyl)ethanol.

Reference:
Article; Burdeinyi, M. L.; Glushkova, M. A.; Popkov, S. V.; Russian Journal of Organic Chemistry; vol. 56; 3; (2020); p. 390 – 394; Zh. Org. Khim.; vol. 56; 3; (2020); p. 379 – 383,5;,
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Reference of 666747-06-4, Adding some certain compound to certain chemical reactions, such as: 666747-06-4, name is (2,4-Dibromophenyl)methanol,molecular formula is C7H6Br2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 666747-06-4.

Step 2:Synthesis of 2,4-dibromo-1-(1-methoxy-1-methylethoxymethyl)benzeneUnder a nitrogen atmosphere, to a solution of 2,4-dibromobenzyl alcohol (40 g, 0.15 mol) in tetrahydrofuran (300 ml) was added 2-methoxypropene (144 ml, 1.5 mol) at room temperature, and then the mixture was cooled to 0°C.At the same temperature, pyridinium p-toluenesulfonic acid (75 mg, 0.30 mmol) was added and the mixture was stirred for 1 hour.The reaction mixture was poured into a saturated aqueous solution of sodium hydrogen carbonate cooled to 0°C, and extracted with toluene.The organic layer was washed with a saturated aqueous solution of sodium chloride, dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to give the titled compound as an oil in quantitative yield.The product was used in the next step without further purification.1H-NMR (CDCl3) delta: 1.44 (6H, s), 3.22 (3H, s), 4.48 (2H, s), 7.42 (1H, d, J=8.0Hz), 7.44 (1H, dd, J=1.5, 8.0Hz), 7.68 (1H, d, J=1.5Hz).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 666747-06-4, (2,4-Dibromophenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Chugai Seiyaku Kabushiki Kaisha; EP2308886; (2011); A1;,
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Adding a certain compound to certain chemical reactions, such as: 666747-06-4, (2,4-Dibromophenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of (2,4-Dibromophenyl)methanol, blongs to alcohols-buliding-blocks compound. Safety of (2,4-Dibromophenyl)methanol

To the solution of (2,4-dibromophenyl)methanol (10.0 g, 37.6 mmol) was added TBSC1 (6.8 g, 45.1 mmol), imidazole (5.1 g, 75.2 mmol). The mixture was stirred at 40 °C overnight. After the reaction completed, the mixture was washed by water and DCM was removed under vacuo. The residue was purified by column chromatography on silica gel by elution with petroleum ether : ethyl acetate =50: 1 to give tert-butyl(2,4-dibromobenzyloxy)dimethylsilane (14 g, yield 98percent) as a light yellow liquid. XH NMR (400 MHz, CDC13) delta 7.68 (d, 1 H), 7.47 (m, 2H), 4.69 (s, 2H), 0.94 (s, 9 H), 0.15 (s, 6 H).

The synthetic route of 666747-06-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ANACOR PHARMACEUTICALS, INC.; BILL AND MELINDA GATES FOUNDATION; LI, Xianfeng; LUNDE, Christopher, S.; JACOBS, Robert, T.; HERNANDEZ, Vincent, S.; XIA, Yi; PLATTNER, Jacob, J.; CAO, Kathy, Jingyuan; ZHANG, Yong-kang; Perry, Matthew; (268 pag.)WO2017/151489; (2017); A1;,
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