Tag: M.W=200-300

575-03-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 575-03-1 as follows.

2-(Trimethylsilyl) ethylhydrogen phthalate (1, 1.29 g, 4.83 mmol) [14,15], 7-hydroxy-4-(trifluoromethyl)-coumarin (2, 1.11 g, 4.83 mmol) [16], and4-dimethylaminopyridine (0.65 g, 5.3 mmol) were dissolved in amixture of anhydrous methylene chloride (15 mL) and anhydrous DMF (9 mL). N,N-Dicyclohexylcarbodiimide was quickly added tothe reaction mixture, which was stirred under N2 overnight. Dicyclohexyl urea was filtered off, and the filtrate was diluted in10 mL of methylene chloride. The solution was washed with brineand then dried over anhydrous Na2SO4. The crude product wascollected by evaporation under reduced pressure and then purifiedby flash chromatography on silica gel (PE/EA = 30:1) to yield 3(0.92 g, 45percent) as a white solid. Compounds 3 were characterized by1H NMR, 13C NMR and ESI-HRMS analyses (Figs. S3?S5 inSupporting information). 1H NMR (500 MHz, CDCl3): d 7.93?7.87(m, 1H), 7.87?7.78 (m, 2H), 7.69?7.62 (m, 2H), 7.45 (d, 1H,J = 2.5 Hz), 7.38 (dd, 1H, J = 9.0, 2.5 Hz), 6.80 (s, 1H), 4.46?4.37 (m,2H), 1.12?1.08 (m, 2H), 0.05 (s, 9H); 13C NMR (100 MHz, CDCl3): d166.71, 165.75, 158.51, 155.11, 154.29, 131.84, 131.69, 131.56,131.39, 129.37, 128.96, 126.35, 118.99, 111.10, 64.40, 17.37,1.53; ESI-HRMS (m/z): Calcd. for [C23H21F3O6Si + Na] 501.09572([M + Na]+), found 501.09485.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,575-03-1, its application will become more common.

Reference:
Article; Wang, Xin-Yu; Guan, Feng-Jie; Li, Bin; Zhang, Hua; Wu, Hong-Wei; Ji, Kai; Liu, Chuan-Xiang; Chinese Chemical Letters; vol. 27; 2; (2016); p. 211 – 214;,
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575-03-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 575-03-1, name is 7-Hydroxy-4-(trifluoromethyl)coumarin. This compound has unique chemical properties. The synthetic route is as follows.

1. 2.3 g (0.0100 mol) of 4-trifluoromethyl-7-hydroxycoumarin (a-1) was taken in a round bottom flask, followed by the addition of 3.5g (0.025mol) of K2CO3, 0.33g (0 ? 001mol) of tetrabutylammonium br omide, and 30mL of acetone, the mixture is mixed under magnetic stirring, then 0.02 g KI was added as a catalyst;2. The mixed solution was heated at 60¡ãC under stirring, after 15 min 1.3 mL (0,015 mol) allyl bromide was added, then stirred and refluxed for 6h, TCL monitered the progress of the reaction3. After the reaction is completed, the insoluble matter such as potassium carbonate is removed by filtration and concentrated by rotary evaporation to obtain a crude product b-1, which is recrystallized from ethanol / water to give compound b-1,4-trifluoromethyl-7-allyloxy Lutein

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 575-03-1, 7-Hydroxy-4-(trifluoromethyl)coumarin.

Reference:
Patent; (19 pag.)CN107674055; (2018); A;,
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In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 517-21-5 as follows., 517-21-5

Glyoxal sodium bisulphite hydrate (10.0 g) in water (80 ml) was warmed to 60 C. then a solution of 2,3-diaminoanisole (3.40 g) in ethanol (40 ml) was added. The stirred mixture was then heated to 80 C. for 1 h before addition of concentrated hydrochloric acid (6 drops). Heating was continued for 1 h. It was allowed to cool overnight, concentrated in vacuo and poured into aqueous potassium carbonate (40 ml). Ethyl acetate (3¡Á100 ml) extracts were washed with water (100 ml) and saturated brine (50 ml) then dried over anhydrous magnesium sulphate, filtered and evaporated in vacuo to afford the title compound as a yellow solid (3.07 g). TLC Rf 0.40 (ethyl acetate)

The chemical industry reduces the impact on the environment during synthesis 517-21-5, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Darwin Discovery, Ltd.; US6353010; (2002); B1;,
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24034-73-9, Adding a certain compound to certain chemical reactions, such as: 24034-73-9, (2E,6E,10E)-3,7,11,15-Tetramethylhexadeca-2,6,10,14-tetraen-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 24034-73-9, blongs to alcohols-buliding-blocks compound.

Error Objects cannot be created from editing field codes. [0306] Ethyl 2E,6E,10E-geranylgeranyl carbamate (7a) (R= Ethyl-): A dry reaction flask equipped with a stir bar, 2 inlet was charged with alcohol 1 (0.060 g, 0.2 mmol), pyridine (0.032 mL, 0.4 m mol) and DCM (2 m L). After cooling it to 0 C, ethyl isocyanate was added dropwise and the resulting reaction mixture was allowed to stir for 24 h. The reaction was monitored by TLC. After completion of the reaction, it was quenched with H20 (5 mL), acidified, extracted with n-hexanes (3 x 15 mL) and the combined n-hexanes were washed with H20 (10 mL). After drying the organic solution over anhydrous a2S04, the solvent was evaporated and the resulting residue was purified by silica gel column chromatography using 1-2% EtOAc in n-hexanes to afford the desired carbamate 7a. Yield: 0.039g (54%); TLC f: 0.30 (10% EtOAc/n-Hexanes); LCMS: MS (m/z): 384 (M + IMa); ret. time: 14.39 min. [0307] The following carbamates 7b to 7z were prepared according to the procedu re that was used to prepare carbamate 7a.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,24034-73-9, its application will become more common.

Reference:
Patent; COYOTE PHARMACEUTICALS, INC.; SERIZAWA, Hiroaki; ARGADE, Ankush B.; DATWANI, Akash; SPENCER, Natalie; PAN, Yonghua; ERMINI, Florian; WO2013/130654; (2013); A1;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 162358-05-6, name is 2-(4-Octylphenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows. 162358-05-6

4-Octylphenethyl Methanesulfonate (Scheme 4). To a solution of 4-octylphenethyl alcohol (200 mg, 0.853 mmol) and triethylamine (1.19 mL, 8.53 mmol) in CH2C12 (8 mL) at 0 C was added methanesulfonyl chloride (0.33 mL, 4.27 mmol). After being stirred at rt for 5 h, the reaction mixture was evaporated, diluted with water, and the product was extracted with EtOAc. The extract was washed with brine, dried, and evaporated. Purification by silica gel chromatography, eluting with hexanes/EtOAc (5: 1), gave 253 mg (95%) of the mesylate as a yellow liquid; 1H NMR (400 MHz, CDC13) delta 0.87 (t, J = 6.9 Hz, 3H), 1.26- 1.30 (m, 10H), 1.58 (m, 2H), 2.57 (t, = 7.7 Hz, 2H), 2.83 (s, 3H), 3.02 (t, = 7.0 Hz, 2H), 4.40 (t, = 7.0 Hz, 2H), 7.14 (s, 4H); 13C NMR (100 MHz, CDC13) delta 14.1, 22.7, 29.3 (2C), 29.5, 31.6, 31.9, 35.3, 35.6, 37.3, 70.6, 128.8, 128.9, 133.4, 141.9; ESI-HRMS (M + Na)+ mlz calcd for Ci7H28Na03S 335.1657, found 335.1655.

Statistics shows that 162358-05-6 is playing an increasingly important role. we look forward to future research findings about 2-(4-Octylphenyl)ethanol.

Reference:
Patent; RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK; UNIVERSITY OF STRATHCLYDE; BITTMAN, Robert; PYNE, Nigel J.; PYNE, Susan; BAEK, Dong Jae; LIU, Zheng; BYUN, Hoe Sup; WO2014/118556; (2014); A2;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 112-70-9, name is 1-Tridecanol. A new synthetic method of this compound is introduced below., 112-70-9

General procedure: To a soln. of peracetyl beta-D-O-galactopyranoside 1 (1 equiv.) and the fatty alcohol (2-8, 2 equiv.) in dry MeCN (10 mL), was added BF3*Et2O (1 equiv.). This mixture was transferred into the microwave oven with rigorous stirring for 12 min at 120 C (ramp time: 10 min). Solvent was removed in vacuum, and the resulting residue was diluted with EtOAC and washed successively with sat. NaHCO3 and brine. The combined organic layer was dried over NaSO4, filtered, concentrated in vacuum to give a crude mixture residue which was separated by column chromatography.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,112-70-9, 1-Tridecanol, and friends who are interested can also refer to it.

Reference:
Article; Song, Shao-Xing; Wu, Ming-Li; He, Xiao-Peng; Zhou, Yu-Bo; Sheng, Li; Li, Jia; Chen, Guo-Rong; Bioorganic and Medicinal Chemistry Letters; vol. 22; 5; (2012); p. 2030 – 2032;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 722-92-9, name is 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol. This compound has unique chemical properties. The synthetic route is as follows. 722-92-9

Step A: 2-(4-bromophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol To a stirred solution of copper(II) bromide (1.293 g, 5.79 mmol) in acetonitrile (15 mL) was added tert-butyl nitrite (0.764 mL, 5.79 mmol) in one portion at 60¡ã C. A solution of 2-(4-aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol (1 g, 3.86 mmol) in acetonitrile (3 mL) was then added dropwise at 60¡ã C. After stirring for 15 min at 60¡ã C., the mixture was concentrated. The residue was diluted with water (20 mL) and extracted with EtOAc (10 mL, 2*4 mL). The combined organic solutions were dried over anhydrous sodium sulfate and concentrated. Flash chromatography purification using (24 g silica gel column, gradient elution from 0 to 30percent of ethyl acetate in hexanes) afforded 2-(4-bromophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol (1.3 g, 4.02 mmol, 104percent yield) as a liquid.

Statistics shows that 722-92-9 is playing an increasingly important role. we look forward to future research findings about 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol.

Reference:
Patent; Duan, Jingwu; Dhar, T. G. Murali; Jiang, Bin; Lu, Zhonghui; Xiao, Hai-Yun; US2015/191483; (2015); A1;,
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307353-32-8 ,Some common heterocyclic compound, 307353-32-8, molecular formula is C9H9BrO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

2-(Trifluoromethyl)phenyl)boronic acid (114 mg, 0.60 mmol), PdCl2(dppf) (12 mg, 0.016 mmol), Et3N (167 muL, 1.2 mmol) were added to a solution of methyl 3-bromo-5-(hydroxymethyl)benzoate (97.5 mg, 0.40 mmol) in EtOH (4 mL). The reaction mixture was stirred at 85 C. overnight, diluted with EtOAc and washed with water. The organic layer was dried (Na2SO4) and concentrated. The residue was purified by flash chromatography (Combi-flash Rf, Hex/EtOAc=0-60% gradient) to afford the title compound (100 mg, 80%). 1H NMR (400 MHz, CDCl3) delta 8.09 (s, 1H), 7.95 (s, 1H), 7.77 (d, J=8.0 Hz, 1H), 7.56 (m, 3H), 7.33 (d, J=7.6 Hz, 1H), 4.81 (d, J=6.0 Hz, 2H), 3.94 (s, 3H), 1.79 (t, J=6.0 Hz, 1H).

According to the analysis of related databases, 307353-32-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Vanderbilt University; Alvarado, Joseph R.; Stauffer, Shaun R.; Gogliotti, Rocco D.; Han, Changho; Meyers, Kenneth M.; Tian, Jianhua; Macdonald, Jonathan D.; Fesik, Stephen W.; Lee, Taekyu; US2020/102288; (2020); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.722-92-9, name is 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol, molecular formula is C9H7F6NO, molecular weight is 259.15, as common compound, the synthetic route is as follows.722-92-9

A suspension of 2-(4-aminophenyl)-1 ,1 ,1 ,3,3,3-hexafluoro-2-propanol (1.0g), his-(2- chloroethyl)amine hydrochloride (0.69g) and potassium carbonate (0.53g) in 2- butoxyethanol (5ml), was heated at 180¡ã for 24 hours. Diluted with ethyl acetate and washed with saturated NaHCO3 solution and brine. Organic layer dried and evaporated to give crude product. Chromatography on silica gel gave, after elution with 0-20percent methanol in DCM, the desired product as a brown solid (0.54g). LC/MS (ESI) found 329 (M+H).

Statistics shows that 722-92-9 is playing an increasingly important role. we look forward to future research findings about 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol.

Reference:
Patent; GLAXO GROUP LIMITED; WO2006/94842; (2006); A1;,
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4654-39-1, Adding some certain compound to certain chemical reactions, such as: 4654-39-1, name is 2-(4-Bromophenyl)ethanol,molecular formula is C8H9BrO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4654-39-1.

EXAMPLE 10 This example demonstrates the preparation of 2-AMINO-2- [2- (2 , 3′, 4′- trimethoxybiphenyl-4-yl) ETHYL]-1, 3-propanediol hydrochloride. (10-1) PREPARATION OF 2- (4-BROMOPHENYL) ETHYL IODIDE Methanesulfonylchloride (11.5 ml) was added to a solution of 2- (4- BROMOPHENYL) ethylalcohol (25.0 G) and triethylamine (22.6 ml) in dichloromethane (250 ml) at 0 C. The resulting suspension was stirred at room temperature for 2 hours. The reaction mixture was washed with brine and dried over sodium sulfate and concentrated in vacuo to yield a red oil (39. 1 g). Sodium iodide (18.6 g) was added to a solution of methanesulfonate in 2-butanone (400 ml), and the resulting suspension was heated under reflux for 4.5 hours. The reaction mixture was diluted with ethyl acetate and washed with water, 10% aqueous sodium thiosulfate, and brine. The organic layer was dried over sodium sulfate and concentrated in vacuo. Purification by silica-gel column chromatography using hexane/ethyl acetate 30: 1 gave the title compound (34.2 g) as a colorless oil.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 4654-39-1.

Reference:
Patent; Mitsubishi Pharma Corporation; WO2005/14525; (2005); A2;,
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