Tag: M.W=200-300

78573-45-2, Adding a certain compound to certain chemical reactions, such as: 78573-45-2, 3-(3-(Trifluoromethyl)phenyl)propan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 78573-45-2, blongs to alcohols-buliding-blocks compound.

Example 4 Preparation of methanesulfonic acid 3-(3-trifluoromethyl-phenyl)-propyl ester To a stirred solution of 3-(3-trifluoromethyl-phenyl)-propan-1-ol (250 g, 1.224 mol) and triethylamine (148.52 g, 1.47 mol) in dichloromethane (1.25 L), methanesulfonyl chloride (161.32 g, 1.41 mol) was added at 25 C. to 40 C. and reaction mixture was stirred for 2-3 hours at 40 C. Thereafter, reaction mixture was washed with demineralized water (500 ml*3) and dried over anhydrous sodium sulfate. The dichloromethane was distilled off to give 335 g of title compound having purity 91.58% by HPLC.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,78573-45-2, its application will become more common.

Reference:
Patent; IND-SWIFT LABORATORIES LIMITED; US2011/172455; (2011); A1;,
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5391-88-8, Adding a certain compound to certain chemical reactions, such as: 5391-88-8, 1-(4-Bromophenyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 5391-88-8, blongs to alcohols-buliding-blocks compound.

l-(4-bromo-phenyl)-ethanol was stirred in aq. HCl at room temperature for 20 h. The excess acid was evaporated under vacuum to give the expected product in quantative yield.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5391-88-8, its application will become more common.

Reference:
Patent; GALAPAGOS NV; MENET, Christel, Jeanne, Marie; BLANC, Javier; HODGES, Alastair, James; BURLI, Roland, Werner; BRECCIA, Perla; BLACKABY, Wesley, Peter; VAN ROMPAEY, Luc, Juliaan, Corina; FLETCHER, Stephen, Robert; WO2010/10184; (2010); A1;,
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2615-15-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2615-15-8, name is 3,6,9,12,15-Pentaoxaheptadecane-1,17-diol. This compound has unique chemical properties. The synthetic route is as follows.

Step 1.In a 50 mL three-necked flask, add TsCl (6.05 g, 31.9 mmol),Hexaethylene glycol (3.81 g, 12.8 mmol), a catalytic amount of 4-dimethylaminopyridine (20 mg) and 20 mL of CH2Cl2,Under an ice-salt bath, triethylamine (6.55 g, 64.8 mmol) was added dropwise using a constant pressure dropping funnel.After stirring at room temperature for 12h, the reaction was stopped and washed with 1M HCl solution (30mL ¡Á 3).Wash with saturated sodium bicarbonate solution (30 mL ¡Á 3), wash with saturated brine (30 mL ¡Á 3), and dry with anhydrous sodium sulfate. Filter and spin dry.Column chromatography separation: CH2Cl2 ? CH2Cl2: EA = 1: 1, red compound A was obtained as a viscous liquid.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 2615-15-8, 3,6,9,12,15-Pentaoxaheptadecane-1,17-diol.

Reference:
Patent; Changzhou University; Xiao Tangxin; Zhou Ling; Wu Kehui; Li Zhengyi; Sun Xiaoqiang; (6 pag.)CN110372682; (2019); A;,
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355-80-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 355-80-6, name is 2,2,3,3,4,4,5,5-Octafluoro-1-pentanol. A new synthetic method of this compound is introduced below.

General rocedure: 5.5 ml of aq. solutions of KBr (0.55 mol/dm3), 20 ml MeCN, TEMPO (0.12 g, 0.00077 mol), and 2,2,3-trifluoro-3-(1,1,2,2,3,3-hexafluoro-3-trifluoromethoxy-propoxy)-propan-1-ol (2a) (10 g, 0.0275 mol) were placed in the flask. 14% aq. NaOCl (48 ml) buffered by NaHCO3 (5.2 g) were added via the dropping funnel in 3 portions during two days of stirring in a room temperature (slight exothermic effect). The progress of reaction was monitored by 19F NMR spectroscopy. Then concentrated sulfuric acid followed by water was added. After extraction with diethyl ether, the organic phases were dried over magnesium sulfate. The solvent was evaporated to give a colorless liquid, which was distilled.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,355-80-6, 2,2,3,3,4,4,5,5-Octafluoro-1-pentanol, and friends who are interested can also refer to it.

Reference:
Article; Ignatowska, Jolanta; Shyshkov, Oleg; Zipplies, Tilman; Hintzer, Klaus; Roeschenthaler, Gerd-Volker; Journal of Fluorine Chemistry; vol. 141; (2012); p. 35 – 40;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.355-80-6, name is 2,2,3,3,4,4,5,5-Octafluoro-1-pentanol, molecular formula is C5H4F8O, molecular weight is 232.0719, as common compound, the synthetic route is as follows.355-80-6

To a solution of freshly distilled pyridine (0.35 mL, 4.35 mmol) in 2,2,3,3,4,4,5,5-octafluoropentanol (8 mL, 0.06 mol) was added 9H-fluorene-2,4,7-trisulfonyl trichloride 1 (0.50 g, 1.08 mmol). The reaction mass was heated for 1 h in an oil bath maintained at 90-100 C. After cooling, the resulting solution was diluted with 2-propanol (20 mL) and treated with concentrated hydrochloric acid (1 mL). A gel-like precipitate formed throughout the reaction volume. It was allowed to settle down, then filtered off, washed twice with 2-propanol (2 x 5 mL), and finally with water to give the crude product (0.86-0.87 g). It was dissolved in boiling 2-propanol (15 mL) and crystallized on standing. Yield 0.80-0.82 g (71-72%). Mp. 177.0-177.5 C. IR (KBr),?/cm-1: 3096, 1382, 1182, 1036, 803, 592. The filtrate was distilled with steam. The organic phase was then separated, washed with water, and fractionally distilled to regenerate the excess of octafluoropentanol. 1H NMR (Acetone-d6, 300 MHz), deltaH/ppm: 4.54 (2H, s, -CH2-), 4.94 (2H, t, J = 13.5 Hz, -OCH2-), 5.02 (2H, t, J = 13.8 Hz, -OCH2-), 5.05 (2H, t, J = 13.5 Hz, -OCH2-), 6.70 (1H, tt, J1 = 51.0 Hz, J2 = 5.4 Hz, -CHF2), 6.76 (2H, tt, J1 = 51.0 Hz, J2 = 5.4 Hz, -CHF2), 8.24 (1H, d, J = 8.4 Hz, Ar-H), 8.47 (1H, s, Ar-H), 8.69 (1H, s, Ar-H), 8.81 (1H, s, Ar-H), 8.92 (1H, d, J = 8.4 Hz, Ar-H). Found: C, 31.91; H,1.48; S, 9.02%; molecular formula C28H16F24O9S3 requires C, 32.07; H, 1.54; S, 9.17%.

Statistics shows that 355-80-6 is playing an increasingly important role. we look forward to future research findings about 2,2,3,3,4,4,5,5-Octafluoro-1-pentanol.

Reference:
Article; Kurdyukova, Irina V.; Ishchenko, Alexander A.; Mysyk, Dmitriy D.; Dyes and Pigments; vol. 142; (2017); p. 201 – 211;,
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1113-21-9 , The common heterocyclic compound, 1113-21-9, name is 3,7,11,15-Tetramethylhexadeca-1,6,10,14-tetraen-3-ol, molecular formula is C20H34O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

[0307] The 5E, 9E, BE-geranyl geranyl acetone (1) can be prepared by reacting 6E-10E- geranyl linalool (23) with diketene (24) catalyzed by DMAP in ethyl ether to give the ester 25. The ester 25 in. the Carroll rearrangement using Al(OiPr)j at elevated temperature can afford the desired 5E, 9E, 13E-geranyl geranyl acetone (1). In another approach, the GGA ( ) can be prepared by treating geranyi linalool (23) with the Meldrurn’s acid 26 in the Carroll rearrangement using Al(QiPr) at 160 “C, Similar}’, the use of ,’er.f-buiyl acetoaeetate (27) with geranyi linalool (23) in the Carroll rearrangement can also give the desired SE, 9E. 1 E-gerany geranyi acetone (1 ).

The synthetic route of 1113-21-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; COYOTE PHARMACEUTICALS, INC.; SERIZAWA, Hiroaki; WO2014/107686; (2014); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.355-80-6, name is 2,2,3,3,4,4,5,5-Octafluoro-1-pentanol, molecular formula is C5H4F8O, molecular weight is 232.0719, as common compound, the synthetic route is as follows.355-80-6

EXAMPLE 4 2,2,3,3,4,4,5,5-Octafluoro-n-pentanol (11.6 g, 0.05 mol) and sodium metal (1.4 g, 0.05 mol) were added to 100 ml of dry ether and stirred at room temperature overnight. The solution obtained was added into a solution of 1,2-dichlorohexafluorocyclopentene (12.3 g, 0.05 mol) in 100 ml of dry ether. The reaction mixture was poured into 150 ml of ice water and an organic layer was separated. The aqueous layer was then extracted with 3 portions of 100 ml ether. Next, the extracts were combined with the separated organic layer and dried over sodium sulfate overnight. The desired 2-chlorohexafluorocyclopentyl 2,2,3,3,4,4,5,5-octafluoro-n-pentyl ether (38-42 C./0.3 mmHg) was obtained in 50% yield based on 1,2-dichlorohexafluorocyclopentene used by vacuum distillation.

Statistics shows that 355-80-6 is playing an increasingly important role. we look forward to future research findings about 2,2,3,3,4,4,5,5-Octafluoro-1-pentanol.

Reference:
Patent; The Green Cross Corporation; US4686024; (1987); A;,
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78573-45-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 78573-45-2, name is 3-(3-(Trifluoromethyl)phenyl)propan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

Example 2: Synthesis of 3-[3-(trifluoromethyl)phenyl]-propionaldehyde (II) A solution of compound (V) (1.0 g, 4.90 mmol) in dichloromethane (20 ml) is cooled in water / ice bath, treated in succession with DMSO (770 mg, 9.80 mmol) and P2O5 (1.39 g, 9.80 mmol) and left under stirring for 30 minutes, while temperature raises to 20C. The reaction mixture is then cooled in water / ice bath and triethylamine (2.4 ml, 17.15 mmol). The resulting solution is kept under stirring while temperature raises to 20C. After one hour the mixture is treated with 5% HCl, the phases are separated and the organic one is further washed with 5% HCl. The organic phase is then washed with brine, dried over Na2SO4, filtered and concentrated under reduced pressure, to afford 0.99 g of the aldehyde of formula (II) in quantitative yield. 1H NMR (300 MHz, CDCl3), ppm: 9.83 (t, 1H, J 0.9 Hz), 7.48-7.38 (m, 4H), 3.02 (t, 2H, J 7.2 Hz), 2.82 (m, 2H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 78573-45-2, 3-(3-(Trifluoromethyl)phenyl)propan-1-ol.

Reference:
Patent; Dipharma Francis S.r.l.; EP2327684; (2011); A1;,
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Some common heterocyclic compound, 575-03-1, molecular formula is C10H5F3O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.575-03-1

take 2.3g (O. Olmol) 4-trifluoromethyl _7_ hydroxy coumarin in a round bottom flask, followed by adding 3.5g (0 ¡¤ 025mol) K2C03, 0 ¡¤ 33g (0 ¡¤ OOlmol) Tetrabenzo Ammonium bromide, and 30mL of acetone, magnetic stirring to make it mix well, and then add 0.02g KI as a catalyst;2. The mixed solution was heated at 60¡ãC under stirring, after 15 min 1.6 mL (0.015 mol) of 1-Bromobutane was added, then stirred and refluxed for 6h, TCL monitered the progress of the reaction.3. After the reaction, the filtrate was filtered to remove insolubles such as potassium carbonate, and concentrated by rotary evaporation to give crude product d-1, which was recrystallized from ethanol / water to give compound d-1,4-trifluoromethyl-7- Lutein.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 575-03-1.

Reference:
Patent; (19 pag.)CN107674055; (2018); A;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.575-03-1, name is 7-Hydroxy-4-(trifluoromethyl)coumarin, molecular formula is C10H5F3O3, molecular weight is 230.1401, as common compound, the synthetic route is as follows.575-03-1

General procedure: To around bottomed flask equipped with a magnetic stir bar were added, the7-hydroxycoumarin substrate (1 equiv.), acetone (25 mL/mmol of substrate), and K2CO3 (3 equiv.). The solution wasstirred for 5 minutes at room temperature followed by addition of R3-X (1 equiv.; R3 = alkyl, X = Br or OTs.). The reaction mixture was placed under anArgon atmosphere (balloon) and stirred at reflux temperature for 16 hours atwhich point complete consumption of substrate was observed by TLC in all cases. The reaction was cooled to r.t., poured intowater, and extracted with EtOAc (x 3). The combined extracts were dried over MgSO4. The solvent was removed in vacuo and theremaining residue purified via flash chromatography over silica gel using gradient elution with EtOAc and Hexanes to yield Compounds 18-28.?

Statistics shows that 575-03-1 is playing an increasingly important role. we look forward to future research findings about 7-Hydroxy-4-(trifluoromethyl)coumarin.

Reference:
Article; Farley, Conner M.; Dibwe, Dya Fita; Ueda, Jun-Ya; Hall, Eric A.; Awale, Suresh; Magolan, Jakob; Bioorganic and Medicinal Chemistry Letters; vol. 26; 5; (2016); p. 1471 – 1474;,
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