Tag: M.W=200-300

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 106-28-5, name is (2E,6E)-3,7,11-Trimethyldodeca-2,6,10-trien-1-ol, the common compound, a new synthetic route is introduced below. 106-28-5

L-(+)-Diethyltartrate (428 muL, 2.5 mmol, 12.5 mol %) and 4A molecular sieves(2g, 0.1g/mmol) were placed in a 50 mL round bottom flask under a stream of argon.CH2Cl2 (20 mL) was added at room temperature, followed by Ti(Oi-Pr)4 (600 muL, 2mmol, 10 mol %). The mixture was stirred vigorously at room temperature for 20 min.tert-Butylhydroperoxide (4.54 mL, ~25 mmol, 125 mol%, 5-6 M in decane) was addedand the mixture was stirred 5 min at room temperature. The mixture was cooled in aCH3CN / dry ice bath. The temperature was maintained below -40 C. Farnesol (5.06mL, 20 mmol, 100 mol %) was added and stirred in the CH3CN / dry ice bath for 10 h.The mixture was placed in the freezer overnight. The next day citric acid monohydrate(420 mg, 2 mmol, 10 mol%) was dissolved in 1:1 acetone / diethylether (~5 mL) and thesolution was added to the reaction mixture. The mixture was stirred vigorously for 20min at room temperature. Celite was added to the mixture and stirred vigorously for 1min. The slurry was filtered through a thick pad of celite and the celite was washed withEt2O. The clear filtrate was washed with saturated Na2S2O3 and then dried with MgSO4.Column chromatography isolated 4.53 g of S1 (95% yield). The enantiomeric excess wasdetermined by HPLC of the benzoate to be 87%. 1H NMR (400 MHz, CDCl3):delta 5.10 (m, 2H), 3.84 (ddd, J = 4.3, 7.5, 12.0 Hz, 1H), 3.70 (ddd, J = 4.9, 6.7, 11.8 Hz,1H), 2.99 (dd, J = 4.3, 6.7 Hz, 1H), 2.16-1.94 (m, 6H), 1.71 (m, 1H), 1.69 (s, 3H), 1.614(s, 3H), 1.608 (s, 3H), 1.48 (m, 1H), 1.32 (s, 3H).13C NMR (125 MHz, CDCl3):delta 136.0, 131.6, 124.4, 123.3, 63.2, 61.6, 61.4, 39.8, 38.7, 26.8, 25.9, 23.8, 17.9, 17.0,16.2.IR (NaCl, thin film): 3422, 2919, 1456, 1384, 1033 cm-1.HR-MS (ESI) m/z calcd for C15H26O2 [M+Na]+: 261.1825, found 261.1830.[alpha]20D = -4.2 (c = 1.9, CHCl3). Chiral HPLC analysis: Analysis was performed on the corresponding benzoate (BzCl,Et3N, DMAP, CH2Cl2): (Chiralcel AD-H, hexanes:2-propanol, 99:1, 1.0 mL/min):tR(2S,3S) = 7.3 min; tR(2R,3R) = 8.1 min. The enantiomeric excess was determined to be87%.

Statistics shows that 106-28-5 is playing an increasingly important role. we look forward to future research findings about (2E,6E)-3,7,11-Trimethyldodeca-2,6,10-trien-1-ol.

Reference:
Article; Underwood, Brian S.; Tanuwidjaja, Jessica; Ng, Sze-Sze; Jamison, Timothy F.; Tetrahedron; vol. 69; 25; (2013); p. 5205 – 5220;,
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2615-15-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2615-15-8, name is 3,6,9,12,15-Pentaoxaheptadecane-1,17-diol, molecular formula is C12H26O7, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A solution of sodium hydroxide (5.48 g, 137 mmol) in water (30 mL) was added to a solution of PEG compound (904 mmol) in THF (30 mL). The resulting mixture was cooled to 0 C and a solution of p-toluenesulfonyl chloride (16.6 g, 87.4 mmol) in THF (100 mL) was slowly added under stirring for 2 hours. After stirring at 0 C for 3 hours, the reaction mixture was poured onto an ice/water mixture (500 mL). The organic layer was separated, and the aqueous layer was extracted with dichloromethane (3 ¡Á 200 mL). The combined organic layers were washed twice with water (100 mL), dried with MgSO4 and concentrated in vacuo.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2615-15-8, 3,6,9,12,15-Pentaoxaheptadecane-1,17-diol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Kachbi-Khelfallah, Souad; Monteil, Maelle; Cortes-Clerget, Margery; Migianu-Griffoni, Evelyne; Pirat, Jean-Luc; Gager, Olivier; Deschamp, Julia; Lecouvey, Marc; Beilstein Journal of Organic Chemistry; vol. 12; (2016); p. 1366 – 1370;,
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In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 575-03-1 as follows., 575-03-1

General procedure: The corresponding coumarin derivatives (4.21mmol) 5a-k and potassium carbonate (0.872 g, 6.31 mmol) were suspended in dry acetone, and then the corresponding dibromoalkyl derivative (84.12 mmol) was added. The mixture was refluxed for 6 h. After cooling to room temperature, the solid was filtered and washed with acetone. The filtrate was concentrated under reduced pressure and purified by column chromatography using petroleum ether/ethy actate (5 : 1 to 8:1) as eluent to get the intermediates of 6a-n

The chemical industry reduces the impact on the environment during synthesis 575-03-1, I believe this compound will play a more active role in future production and life.

Reference:
Article; He, Qi; Liu, Jing; Lan, Jin-Shuai; Ding, Jiaoli; Sun, Yongbing; Fang, Yuanying; Jiang, Neng; Yang, Zunhua; Sun, Liyuan; Jin, Yi; Xie, Sai-Sai; Bioorganic Chemistry; vol. 81; (2018); p. 512 – 528;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2615-15-8, name is 3,6,9,12,15-Pentaoxaheptadecane-1,17-diol. This compound has unique chemical properties. The synthetic route is as follows. 2615-15-8

j00479j A solution of 3,6,9,12,15-pentaoxaheptadecane-1,17-diol (7 g, 24.8 mmol) in DCM (50 mL) was cooled to 0 C and charged with silver oxide (8.60 g, 37.2 mmol), potassium iodide (822 mg, 4.95 mmol) and tosyl chloride (5.10 g, 27.17 mmol) and stirred at0C for 4 h. The reaction mixture was diluted with iN HC1 solution (15 mL), the organic layers was separated and dried over anhydrous Na2SO4, filtered and concentrated in vacuo resulting in a crude compound which was purified by chromatography on silica gel, eluting with 1-3% methanol in DCMto give 7.30 g, 67% yield of the title compound as colorless oil. ?H NMR (400 MHz, DMSO-d6): oe = 7.79 (d, J= 8.43 Hz, 2H), 7.48 (d, J= 7.98 Hz, 2H), 4.56 (t, J= 5.54 Hz, 1H), 4.08 -4.14 (m, 1H), 3.43 -3.59 (m, 20H), 3.41 (d, J= 5.32 Hz, 2H), 3.39 (s, 1H), 2.42 (s, 3H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2615-15-8, 3,6,9,12,15-Pentaoxaheptadecane-1,17-diol, and friends who are interested can also refer to it.

Reference:
Patent; COFERON, INC.; FOREMAN, Kenneth, W.; JIN, Meizhong; WANNER, Jutta; WERNER, Douglas, S.; WO2015/106292; (2015); A1;,
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355-80-6, Adding a certain compound to certain chemical reactions, such as: 355-80-6, 2,2,3,3,4,4,5,5-Octafluoro-1-pentanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 355-80-6, blongs to alcohols-buliding-blocks compound.

Example 8Preparation of 5-(2,2,2-trifluoroethoxy)-1,1,2,2,3,3,4,4-octafluoropentane; H(CF2CF2)2CH2OCH2CF3 2,2,3,3,4,4,5,5-Octafluoropentan-1-ol (50 g, 0.215 mol), 2,2,2-trifluoroethyl trifluoromethanesulfonate (50 g, 0.215 mol, obtained from Synquest Labs, Inc., Alachua, Fla.), potassium carbonate (29.7 g, 0.215 mol) and 175 g of acetone (solvent) were combined in a 600-mL Parr pressure reactor. After degassing, the reactor was sealed and the mixture was heated to 75 C. with vigorous stirring for 16 hours. After cooling, the reactor was opened and the contents filtered to remove the insoluble salts. The acetone was removed by rotary evaporation. To this residue was then added an excess of water and the product azeotropically distilled using a Dean Stark trap to give after phase separation and water washing 60.4 g crude product. The yield at this stage by GC analysis was 50 percent. The product was distilled at atmospheric pressure and the distillation cuts greater than 138 C. were combined with the pot and subsequently treated with LiCl (15 g) in N,N-dimethylformamide (250 mL) at 50 C. as described in Example 4 to remove the residual 2,2,2-trifluoroethyl trifluoromethanesulfonate. The product was then distilled through the concentric tube column to give the product ether, boiling point=138-143 C. in 95.9 percent purity. The structure was consistent with GC/MS and 1H NMR analysis.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,355-80-6, its application will become more common.

Reference:
Patent; Flynn, Richard M.; Bulinski, Michael J.; Costello, Michael G.; US2010/108934; (2010); A1;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 64431-96-5, name is 2,2′-(Propane-1,3-diylbis(azanediyl))bis(2-(hydroxymethyl)propane-1,3-diol). This compound has unique chemical properties. The synthetic route is as follows. 64431-96-5

1 was prepared by the self-assembly approach: Na2MoO4¡¤2H2O (1.400g, 6.394mmol) and H6bthmap (0.414g, 1.466mmol) were dissolved in water (30mL, 1665mmol) at room temperature, and then the pH was adjusted to 4.0 with 6mol¡¤L-1 HCl. CoCl2¡¤6H2O (0.237g, 0.996mmol) and Ho(NO3)3¡¤5H2O (0.250g, 0.591mmol) were added, and then the pH was adjusted to 4.0 again with 6mol¡¤L-1 HCl. The reaction solution was stirred at ambient temperature for 30min, kept in the 70C water bath for 30min, filtered and evaporated at room temperature. Colorless block crystals were obtained after three weeks. Yield: ca. 42% (based on Na2MoO4¡¤2H2O). Anal. calcd. (found %) for C22H58Mo8N4Na2O40 (1): C 14.42 (14.63), H 3.19 (3.36), N 3.06 (2.95), Na 2.70 (2.51), Mo 41.74 (41.89). The synthetic method of 2 is similar to that of 1 except that (NH4)6Mo7O24¡¤4H2O (0.800g, 0.647mmol) substituted NaMoO4¡¤2H2O, CoCl2¡¤6H2O was replaced by CuCl2¡¤2H2O (0.400g, 2.346mmol) and the stirring time was added to 45min. Blue block crystals were obtained after two weeks. Yield: ca. 45% (based on (NH4)6Mo7O24¡¤4H2O). Anal. calcd. (found %) for C22H70 Cu2Mo8N10O38 (2): C 13.36 (13.49), H 3.57 (3.75), N 7.08 (6.91), Cu 6.22 (6.43), Mo 38.95 (38.81). Notably, albeit CoCl2¡¤6H2O and Ho(NO3)3¡¤5H2O in the preparation of 1 and Ho(NO3)3¡¤5H2O in the preparation of 2 were used as the starting materials, they can’t be observed in the products. When they were moved away under similar conditions, 1 and 2 can’t be obtained, which suggest that there are the collaborative influences of them and other reaction ingredients during the formation of 1 and 2.

Statistics shows that 64431-96-5 is playing an increasingly important role. we look forward to future research findings about 2,2′-(Propane-1,3-diylbis(azanediyl))bis(2-(hydroxymethyl)propane-1,3-diol).

Reference:
Article; Li, Hailou; Shao, Bo; Li, Yanyan; Chen, Lijuan; Zhao, Junwei; Inorganic Chemistry Communications; vol. 61; (2015); p. 68 – 72;,
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Adding some certain compound to certain chemical reactions, such as: 575-03-1, name is 7-Hydroxy-4-(trifluoromethyl)coumarin, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 575-03-1. 575-03-1

General procedure: The appropriate bromoketone (6a-o) (1.7 mmol) and triethylamine (1.6 mmol) were added to as olution of either7-hydroxy-4-methyl-2H-chromen-2-one 4 (1.4 mmol)or 7-hydroxy-4-(trifluoromethyl)-2H-chromen-2-one 5 (1.4 mmol) in THF (20 mL). The mixture was stirred at room temperature for 24h, filtered and the solvent was evaporated under reduced pressure.The solid residue was purified by column chromatography eluting with DCM/MeOH 9:1 to afford (7a-n) and (8a-o).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 575-03-1.

Reference:
Article; Kandil, Sahar; Westwell, Andrew D.; Mcguigan, Christopher; Bioorganic and Medicinal Chemistry Letters; vol. 26; 8; (2016); p. 2000 – 2004;,
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13826-35-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 13826-35-2, name is (3-Phenoxyphenyl)methanol, molecular formula is C13H12O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To an oven-dried 20 cm3 test tube with a ground-in stopperequipped with a stir bar were added anthranilamide (1.0 mmol), benzyl alcohol (1.0 mmol), KOH (2.0 mmol),and 4 cm3 toluene. The test tube was put in an oil bath potpreheated at 90 C and the mixture was stirred for 20 h at90 C. After cooling to room temperature, the reactionmixture was added about 5 g silica gel and directly condensedon a rotator under vacuum. The resulting residualwas transferred to a silica gel chromatography column andeluted with a solution of petroleum ether and ethyl acetate[4/1 (v/v)] to give a white solid 2-phenyl-4(3H)-quinazolinone.For some products (3f, 3g, 3n, and 3t) onlysparingly soluble in ethyl acetate, the reaction mixtureswere condensed in vacuo on a rotary evaporator. Theresiduals were washed three times with water and oncewith ethyl acetate, and then dried in an infrared oven togive the desired products pure enough for NMR analysis.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 13826-35-2, (3-Phenoxyphenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Qiu, Dezhi; Wang, Yanyan; Lu, Dongming; Zhou, Lihong; Zeng, Qingle; Monatshefte fur Chemie; vol. 146; 8; (2015); p. 1343 – 1347;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 78573-45-2, name is 3-(3-(Trifluoromethyl)phenyl)propan-1-ol. This compound has unique chemical properties. The synthetic route is as follows. 78573-45-2

Step 3: Preparation of Compound III (i.e., 3-(3-trifluoromethylphenyl)propanal) To a solution of 10 g (48 mmol) of Compound VII, 76.6 mg of TEMPO (2,2,6,6-tetramethyl-1-piperidinyloxy free radical) and 234 mg of potassium bromide in 70 mL methylene chloride was added 220 mL (pH=9.5) of sodium hypochlorite solution over 20 minutes at 10-15 C. with stirring. After five minutes of additional stirring, the organic layer was separated. The aqueous layer was extracted twice with 40 mL of methylene chloride, and the collected organic layers were dried and evaporated to yield 10 g of crude Compound III as a yellowish liquid. Yield: 100%; purity (determined by GC): 90.3%, contains 8.25% of Compound NMR data (200 MHz, CDCl3, ppm): 2.81 (t, 2H), 3.00 (t, 21-1), 7.37-7.46 (m, 4H), 9.80 (s, 1H).

Statistics shows that 78573-45-2 is playing an increasingly important role. we look forward to future research findings about 3-(3-(Trifluoromethyl)phenyl)propan-1-ol.

Reference:
Patent; Medichem, S.A.; US2010/267988; (2010); A1;,
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517-21-5, Adding a certain compound to certain chemical reactions, such as: 517-21-5, Sodium 1,2-dihydroxyethane-1,2-disulfonate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 517-21-5, blongs to alcohols-buliding-blocks compound.

6-Methylquinoxaline; A solution of 3,4-diaminotoluene (Aldrich, 100 g, 0.82 mol) in 600 mL of hot water (temp. 70-75 C.) was added rapidly to a 60 C. slurry of glyoxal-sodium bisulfite adduct (Aldrich, 239.5 g, 0.9 mol, 1.1 eq) in 400 mL of water. The resulting dark-brown clear solution was heated at 60 C. for 1 hr, then 5 g (0.02 mol) of additional glyoxal adduct was added. The mixture was allowed to cool to r.t. and filtered through a paper filter. The filtrate was neutralized with 5 M aq. NaOH to pH 7.5-7.8 and then extracted with ether (4¡Á400 mL). The extract was dried over Na2SO4 and concentrated on a rotary evaporator to afford 92 g of brown oil which was distilled in vacuum (bp. 100-102 C. at 10 mm Hg; Cavagnol, J. C.; Wiselogle, F. Y. J. Am. Chem. Soc. 1947, 69, 795; 86 C. at 1 mm Hg). Yield 89 g (75%) as a pale-yellow oil.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,517-21-5, its application will become more common.

Reference:
Patent; Wyeth; US2005/282820; (2005); A1;,
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