Tag: M.W=200-300

Application of 2215-78-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2215-78-3, name is (4-Phenoxyphenyl)methanol, molecular formula is C13H12O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

2-benzylamino nicotinic acid (0.228 g) in 1,2-dichloroethane, 4-phenoxybenzyl alcohol (0.200 g), 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride (0. 230 g) and 4-dimethylaminopyridine (0.146 g) was added, the mixture was heated and stirred for 2 h at 80 C. After cooling to room temperature, added water and extracted with methylene chloride and extracted with further methylene chloride and the aqueous layer. The combined organic layers were dried over anhydrous sodium sulfate. And concentrated under reduced pressure, and the obtained residue is purified by silica gel column chromatography, compounds of the present invention described in Table 1 (No. 1), to give 0.246 g, an oil.

According to the analysis of related databases, 2215-78-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; AGRO-KANESHOCOMPANY LIMITED; AIZAWA, RYO; HONMA, ATSUKO; OKADA, ITARU; HATAMOTO, MASAHIRO; FUKUCHI, TOSHIKI; (12 pag.)JP2016/11277; (2016); A;,
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Related Products of 722-92-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 722-92-9, name is 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol, molecular formula is C9H7F6NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 2-(4-aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol (10.0 g, 38.6 mmol) in DMF (50 mL) was dropwise added a solution of sodium nitrite (2.8 g, 40.5 mmol) in water (15.5 mL) and a 6M solution of hydrochloric acid (19.3 mL, 115.7 mmol), while maintaining the reaction temperature at 0?5 C. The reaction mixture was stirred for 30 min, and then potassium iodide (6.4 g, 38.6 mmol) was added portionwise at 0?5 C. The resulting reaction mixture was stirred overnight at rt. The reaction mixture was extracted with EtOAc, and the combined organic layers were washed with saturated sodium thiosulphate and dried over Na2SO4. The solvent was evaporated in vacuo to obtain the crude, which was purified by flash chromatography on silica gel (?5% EtOAc/Hex) to obtain the title compound.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 722-92-9, 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol.

Reference:
Patent; The Scripps Research Institute; Kamenecka, Theodore Mark; Griffin, Patrick R.; Shin, Youseung; He, Yuanjun; Blayo, Anne-Laure; Lyda, Brent R.; Koenig, Marcel; Kumar, Naresh; Burris, Thomas; (119 pag.)US9586928; (2017); B2;,
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Electric Literature of 145691-59-4, Adding some certain compound to certain chemical reactions, such as: 145691-59-4, name is (3,5-Dibromophenyl)methanol,molecular formula is C7H6Br2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 145691-59-4.

The above benzyl alcohol (0.26 g, 1.0 mmol) and methyl (4-hydroxy-2-methylphenoxy)acetate (0.30 g, 1.5 mmol) and triphenylphosphine (0.50 g, 1.85 mmol) were dissolved in a mixture of anhydrous toluene (3-mL) and tetrahydrofuran (1 mL) and the mixture was cooled to 0¡ã C. Diisopropyl azodicarboxylate (0.22 g, 1.2 mmol) was added dropwise under nitrogen. The reaction mixture was stirred for 12 h at ambient temperature and the solvents were evaporated in vacuo. Column chromatography (silica gel Fluka 60, hexanes/ethyl acetate 98:2-90:10) gave methyl [4-(3,5-dibromo)benzyloxy]-2-methylphenoxy]acetate. Yield: 0.25 g (56percent). RF (SiO2, hexanes/ethyl acetate 8:2) 0.45. 1H NMR spectrum (300 MHz, CDCl3, deltaH): 7.61 (s, 1H); 7.48 (s, 2H); 6.80 (s, 1H); 6.67 (s, 2H); 4.92 (s, 2H); 4.60 (s, 2H); 3.80 (s, 3H); 2.28 (s, 3H).

According to the analysis of related databases, 145691-59-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Novo Nordisk A/S; US2009/209588; (2009); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 20017-67-8, name is 3,3-Diphenyl-1-propanol, the common compound, a new synthetic route is introduced below. Recommanded Product: 20017-67-8

EXAMPLE 29 9-(3,3-Diphenylpropoxy)-9H-indeno[1,2-b]pyrazine-2,3(1H, 4H)-dione A suspension of 9-hydroxy-9H-indeno[1,2-b]pyrazine-2,3(1H, 4H)-dione. 1H2 O (1.0 g, 4.26 mmol) in benzene (40 ml), 3,3-diphenyl-1-propanol (10 ml) and p-toluensulfonic acid (40 mg) was refluxed with water separation for 48 hours. The reaction mixture was evaporated in vacuo to dryness, the residue was suspended in ethanol (10 ml) and the precipitate was filtered off and washed with ethanol and dried to give 0.224 g (12.5%) of the title compound. M.p. 224-228 C. 1 H-NMR(DMSO-d6, delta): 2.14-2.32 (m, 2H), 3.0-3.22 (m, 2H), 4.13 (t, 1H), 5.22 (s, 1H), 7.0-7.5 (m, 14H), 12.12 (s, 1H), 12.26 (s, 1H). Analysis: Calculated for C26 H22 N2 O3.1/2H2 O: C, 74.45; H, 5.53; N, 6.68%. Found: C, 74.37; H, 5.58; N, 6.28%.

The synthetic route of 20017-67-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Faarup; Peter; Jakobsen; Palle; Jorgensen; Anker S.; Klitgaard; Henrik; US5468748; (1995); A;,
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64372-62-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 64372-62-9, name is 2-Chloro-5-(trifluoromethyl)benzyl alcohol. A new synthetic method of this compound is introduced below.

Step 5a. Palladium Catalyzed Suzuki Coupling-AllylPdCl Dimer Catalyst In a 250 ml flask equipped with a reflux condenser was placed 2-chloro-5-(trifluoromethyl)benzyl alcohol (10 g; 47.5 mmol), 4-fluoro-5-isopropyl-2-methoxyphenylboronic acid (10.81 g; 95 wt % purity, 48.4 mmol), acetonitrile (80 ml) and 3 M K2CO3 (42.7 ml, 128 mmol). The resulting biphasic solution was sparged with nitrogen for several minutes. [AllylPdCl]2 (0.043 g, 0.119 mmol) and PCy3.HBF4 (0.087 g, 0.237 mmol) were added under nitrogen flow, and the reaction mixture was warmed to 70 C. until HPLC showed the reaction was complete. [0046] The reaction mixture was then cooled to room temperature and the phases were separated. The organic layer was washed with 10% NaCl solution (50 ml). After phase separation, Darco KB-G activated carbon (2.0 g) was added to the organic layer, and the mixture was stirred for 1 hr at room temperature. The mixture was then filtered through a pad of Solka-Floc. The filtrate was assayed and was found to contain 15.5 g of product (95% yield). The filtrate was azeotropically dried with acetonitrile and concentrated to an oil under vacuum. The crude product was used in the next step without further treatment.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,64372-62-9, 2-Chloro-5-(trifluoromethyl)benzyl alcohol, and friends who are interested can also refer to it.

Reference:
Patent; Chung, Cheol K.; Humphey, Guy R.; Maligres, Peter E.; Wright, Timothy J.; US2014/303380; (2014); A1;,
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149104-89-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 149104-89-2, name is (4-Bromo-3-methylphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

[00157] Step 2: A solution of (4-bromo-3-methylphenyl)methanol (5.0 g, 24.87 mmol) and imidazole (5.1 g, 74.61 mmol) in THF (50 mL) was cooled to 0 ¡ãC and treated with chloro(triisopropyl)silane (7. 2 g, 7.9 mL, 37.30 mmol), then allowed to warm to room temperature and stirred for 16 h. The reaction mixture was diluted with water and DCM. The organic layer was washed with brine, dried over Na2S04, filtered, and concentrated in vacuo to yield (4-bromo-3-methylbenzyloxy)triisopropylsilane as a colorless oil, (8.8 g, 97percent yield). XH NMR (400 MHz, CDC13) delta 7.47 (d, J= 8.2 Hz, 1H), 7.21 (s, 1H), 7.04 (d, J= 8.1 Hz, 1H), 4.75 (s, 2H), 2.39 (s, 3H), 1.22 – 1.14 (m, 3H), 1.09 (d, J= 6.5 Hz, 18H).

Statistics shows that 149104-89-2 is playing an increasingly important role. we look forward to future research findings about (4-Bromo-3-methylphenyl)methanol.

Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; CHARRIER, Jean-Damien; BINCH, Haley, Marie; HURLEY, Dennis, James; CLEVELAND, Thomas; JOSHI, Pramod; FANNING, Lev Tyler, Dewey; PINDER, Joanne; O’DONNELL, Michael; VIRANI, Anisa, Nizarali; KNEGTEL, Ronald, Marcellus Alphonsus; DURRANT, Steven, John; YOUNG, Stephen, Clinton; PIERRE-HENRI; KAY, David; REAPER, Philip, Michael; WO2011/143426; (2011); A1;,
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61439-59-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 61439-59-6, name is 2-(4-(Benzyloxy)phenyl)ethanol, molecular formula is C15H16O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 3 d2-l-Benzyloxv-4-(2-methoxv-ethyl)-benzene-OH ^- ‘J ^-OCD3[00262] 2-(4-Benzyloxyphenyl)-ethanol (3.94 mmol) was added to a suspension of sodium hydride (11.3 mmol) in 9 mL of dry dimethylformamide at 0 C. d3-Methyl methanesulfonate (5.92 mmol) was added dropwise and the reaction mixture was stirred at ambient temperature overnight, quenched with water, and extracted with ethyl acetate. The combined organic layers were washed with brine, dried over sodium sulfate, and the solvent was removed under reduce pressure to afford the title compound as an oil. Yield: 90%. 1H- NMR (CDCl3): delta7.35-7.47 (m, 5H); 7.18 (d, J = 8.1 Hz, 2H); 6.94 (d, J= 8.1 Hz, 2H); 5.07 (s, 2H); 3.60 (t, J= 6.6 Hz, 2H); 2.86 (t, J= 6.6 Hz, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 61439-59-6, 2-(4-(Benzyloxy)phenyl)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; AUSPEX PHARMACEUTICALS, INC.; WO2007/139923; (2007); A1;,
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5391-88-8 ,Some common heterocyclic compound, 5391-88-8, molecular formula is C8H9BrO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: Bi(OTf)3 (1.0 mol%) was added to a solution of the appropriate secbenzylalcohol (1.0 equiv) and TMSN3 (1.2 equiv) in CH2Cl2 (4.0mL/mmol) at r.t. When the reaction was complete (TLC), the solventwas removed and the crude material was purified by column chromatography.

According to the analysis of related databases, 5391-88-8, the application of this compound in the production field has become more and more popular.

Reference:
Article; Tummatorn, Jumreang; Thongsornkleeb, Charnsak; Ruchirawat, Somsak; Thongaram, Phanida; Kaewmee, Benyapa; Synthesis; vol. 46; 11; (2015);,
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355-80-6, Adding a certain compound to certain chemical reactions, such as: 355-80-6, 2,2,3,3,4,4,5,5-Octafluoro-1-pentanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 355-80-6, blongs to alcohols-buliding-blocks compound.

General procedure: A solution of 2-chloro-1,3,2-dioxaphospholane 1 or 2 or 2-chloro-1,3,2-dioxaphosphinane 6 or 7 in 10 mL of hexane was added dropwise with stirring over a period of 2 h to a solution of 0.05 mol of polyfluoroalkanol 3 or 4 and 6.1 g (0.06 mol) of triethylamine in 80 mL of hexane, maintaining the temperature at -10 to -5C. Triethylamine hydrochloride separated from the solution as a white solid. The cooling bath was removed, and the mixture was stirred for 3 h at room temperature and left overnight. The precipitate was filtered off and washed with hexane (3*20 mL). The filtrate was combined with the washings, the solvent was distilled off under reduced pressure, and the residue was distilled in a vacuum.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,355-80-6, its application will become more common.

Reference:
Article; Gusarova; Verkhoturova; Arbuzova; Kazantseva; Albanov; Nalibaeva; Bishimbaeva; Apartsin; Kireeva; Trofimov; Russian Journal of General Chemistry; vol. 88; 4; (2018); p. 705 – 712; Zh. Obshch. Khim.; vol. 88; 4; (2018); p. 623 – 630,8;,
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1074-16-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1074-16-4, name is 2-(2-Bromophenyl)ethanol, the common compound, a new synthetic route is introduced below.

A solution of 2-bromophenethylalcohol (10 g, 50 mmol) in thionyl chloride (45 ml_) was treated with dimethylformamide (0.1 ml_) and heated to reflux for 6 hours. The reaction mixture was cooled to 00C, quenched by the addition of H2O (100 ml_), extracted with ethyl ether (250 ml_), dried (Na2SO4), and evaporated to provide 2- bromophenethylchloride (9.0 g, 82%) as a yellow oil:HPLC purity 99.2% at 210-370 nm, 10.4 minutes; Xterra RP18, 3.5u, 150 x 4.6 mm column, 1.2 mL/minutes, 85/15-5/95 (ammonium formate buffer pH = 3.5/ACN+MeOH) for 10 minutes, hold 4 minutes.

Statistics shows that 1074-16-4 is playing an increasingly important role. we look forward to future research findings about 2-(2-Bromophenyl)ethanol.

Reference:
Patent; WYETH; WO2008/73956; (2008); A2;,
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