Tag: M.W=200-300

Electric Literature of 6642-34-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6642-34-8, name is (6-Bromobenzo[d][1,3]dioxol-5-yl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: In an oven dried Schlenk tube, were added alcohol 1 (100.0mg, 0.31-0.53mmol), ethyl acrylate [155.1-265.3mg, (i.e., 1.55-2.65 mmol)], and Cs2CO3 [303.0-518.0mg, (i.e., 0.93-1.59mmol)] followed by the addition of toluene (2mL) at rt under nitrogen atmosphere. The resulted reaction mixture was stirred at 50C in an oil bath for 48h. After the completion of Michael addition (monitored by TLC) and to the cooled reaction mixture at rt, were added Pd(OAc)2 (6.9-11.9mg, 10mol%) and PPh3 (16.3-27.8mg, 20mol%) under nitrogen atmosphere. The reaction mixture was then heated at 80C in an oil bath for 24h. Once after formation intermolecular Heck coupling product, (monitored by TLC) and then to the cooled reaction mixture at rt, was added DMF (3mL) and heated to 120C, in an oil bath for 12h (monitored by TLC). The reaction mixture at rt was quenched by the addition of aqueous NH4Cl and extracted with DCM (3¡Á15mL). The organic layers were washed with saturated NaCl solution, dried (Na2SO4), and filtered. Evaporation of the solvent under reduced pressure and purification of the crude material by silica gel column chromatography (petroleum ether/ethyl acetate) furnished the lactenones 5 (40-48%).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 6642-34-8, (6-Bromobenzo[d][1,3]dioxol-5-yl)methanol.

Reference:
Article; Reddy, A. Gopi Krishna; Krishna; Satyanarayana; Tetrahedron; vol. 69; 47; (2013); p. 10098 – 10107;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.109240-30-4, name is 1-(4-Bromophenyl)cyclopropanol, molecular formula is C9H9BrO, molecular weight is 213.0712, as common compound, the synthetic route is as follows.HPLC of Formula: C9H9BrO

1-(4-bromophenyl)cyclopropanol (250 mg, 1.17 mmol), potassium acetate (177 mg, 1.8 mmol), Bis(Pinacolato)Diboron (449 mg, 1.77 mmol), and Dichloro 1,1-bis(diphenylphosphino)ferrocene palladium(II) dichloromethane (44 mg, 0.06 mmol) were added to a flask and system was placed under argon. Reagents were taken up in dioxane (10 mL) and system was again evacuated and placed under argon. Mixture was heated at 100 C. for 17 hours. After cooling to room temperature, mixture was filtered over celite, washing with ethyl acetate. Filtrate was concentrated under reduced pressure and resulting residue was purified via silica gel column chromatography (0-50% ethyl acetate in hexanes) to yield 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclopropanol 7.63.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,109240-30-4, 1-(4-Bromophenyl)cyclopropanol, and friends who are interested can also refer to it.

Reference:
Patent; Gilead Scientific Systems, Inc.; Cory, Kevin S; Doo, Jimin; Farrand, Julie; Guerrero, Juan A; Katana, Ashley A; Cato, Daryl; Laisaweed, Scott I; Lee, Jiayao; Lingco, John O; Nicolaus, May; Notte, Gregory; Phyen, Hyeoung-Jung; Sangy, Michael; Sumit, Arun C; Adam J, Surayyah; Stephens, Cork L; Venkatraman, Chandrasekar; Watkins, William J; Yang, Jong Yu; Jabloki, Jeff; Jifel, Shiela; Ro, Jennifer; Lee, Sung H; Jao, Chung Dong; Grove, Jeffery; Su, Jianjun; Blomgren, Peter; Mitchell, Scott A; Shyung, Jin Ming; Chandrasekar, Jayaraman; (460 pag.)KR2016/37198; (2016); A;,
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Synthetic Route of 145691-59-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 145691-59-4, name is (3,5-Dibromophenyl)methanol. A new synthetic method of this compound is introduced below.

tert-Butyldimethylsilyl 3,5-dibromobenzyl ether. A mixture of 3,5-dibromobenzyl alcohol (9.77 g, 36.74 mmol), tert-butyldimethylchlorosilane (6.80 g, 45.1 mmol) and imidazole (6.08 g, 89.3 mmol) in DMF (100 mL) was stirred under argon over night. The reaction mixture was diluted with ether, washed with water three times, dried over magnesium sulfate, and concentrated under vacuum to provide the title compound. 1H NMR (400 MHz, CDCl3) delta 7.58 (s, 1H), 7.39 (s, 2H), 4.62 (s, 2H), 0.95 (s, 9H), 0.05 (s, 6H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,145691-59-4, (3,5-Dibromophenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; Payne, Linda S.; Tran, Lekhanh O.; Zhuang, Linghang H.; Young, Steven D.; Egbertson, Melissa S.; Wai, John S.; Embrey, Mark W.; Fisher, Thorsten E.; Guare, James P.; Langford, H. Marie; Melamed, Jeffrey Y.; Clark, David L.; US2003/229079; (2003); A1;,
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Related Products of 13826-35-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 13826-35-2, name is (3-Phenoxyphenyl)methanol. A new synthetic method of this compound is introduced below.

General procedure: All the reactions were carried out in a multi-reactor (Carousel 12 station, RADLEYS). Typically, 0.5 mmol morpholine (43 mg), 1.0 mmol benzyl alcohol (108 mg), 50 mg Au/HT (1.9 mol % Au), and 5 mL o-xylene were added to a 40 mL glass vessel. Then, the reaction mixture was stirred (310 rpm) at 90 C under argon. After 24 h, it was cooled down to room temperature. ?20 mL ethyl acetate was added to dissolve the reaction mixture and filtrated with celite to remove the solids. Then the ethyl acetate and solvent were removed under vacuum and a yellow liquid was obtained. It was further purified using column chromatography (ethyl acetate / petroleum ether = 2/3, v/v; Silica Gel: 200-300 mesh; Rf = 0.17) to obtain the pure product as a white solid.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,13826-35-2, (3-Phenoxyphenyl)methanol, and friends who are interested can also refer to it.

Reference:
Article; Zhu, Jiangling; Zhang, Yan; Shi, Feng; Deng, Youquan; Tetrahedron Letters; vol. 53; 25; (2012); p. 3178 – 3180;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 64431-96-5, name is 2,2′-(Propane-1,3-diylbis(azanediyl))bis(2-(hydroxymethyl)propane-1,3-diol). This compound has unique chemical properties. The synthetic route is as follows. Product Details of 64431-96-5

1 was prepared by the self-assembly approach: Na2MoO4¡¤2H2O (1.400g, 6.394mmol) and H6bthmap (0.414g, 1.466mmol) were dissolved in water (30mL, 1665mmol) at room temperature, and then the pH was adjusted to 4.0 with 6mol¡¤L-1 HCl. CoCl2¡¤6H2O (0.237g, 0.996mmol) and Ho(NO3)3¡¤5H2O (0.250g, 0.591mmol) were added, and then the pH was adjusted to 4.0 again with 6mol¡¤L-1 HCl. The reaction solution was stirred at ambient temperature for 30min, kept in the 70C water bath for 30min, filtered and evaporated at room temperature. Colorless block crystals were obtained after three weeks. Yield: ca. 42% (based on Na2MoO4¡¤2H2O). Anal. calcd. (found %) for C22H58Mo8N4Na2O40 (1): C 14.42 (14.63), H 3.19 (3.36), N 3.06 (2.95), Na 2.70 (2.51), Mo 41.74 (41.89). The synthetic method of 2 is similar to that of 1 except that (NH4)6Mo7O24¡¤4H2O (0.800g, 0.647mmol) substituted NaMoO4¡¤2H2O, CoCl2¡¤6H2O was replaced by CuCl2¡¤2H2O (0.400g, 2.346mmol) and the stirring time was added to 45min. Blue block crystals were obtained after two weeks. Yield: ca. 45% (based on (NH4)6Mo7O24¡¤4H2O). Anal. calcd. (found %) for C22H70 Cu2Mo8N10O38 (2): C 13.36 (13.49), H 3.57 (3.75), N 7.08 (6.91), Cu 6.22 (6.43), Mo 38.95 (38.81). Notably, albeit CoCl2¡¤6H2O and Ho(NO3)3¡¤5H2O in the preparation of 1 and Ho(NO3)3¡¤5H2O in the preparation of 2 were used as the starting materials, they can’t be observed in the products. When they were moved away under similar conditions, 1 and 2 can’t be obtained, which suggest that there are the collaborative influences of them and other reaction ingredients during the formation of 1 and 2.

With the rapid development of chemical substances, we look forward to future research findings about 64431-96-5.

Reference:
Article; Li, Hailou; Shao, Bo; Li, Yanyan; Chen, Lijuan; Zhao, Junwei; Inorganic Chemistry Communications; vol. 61; (2015); p. 68 – 72;,
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Synthetic Route of 80866-82-6 ,Some common heterocyclic compound, 80866-82-6, molecular formula is C8H9BrO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

3-(2-Oxo-2,3-dihydro-benzoimidazol-l-yl)-hexanoic acid ethyl ester (96.7 mg, 0.35 mmol), prepared as described above, (5-bromo-2-methoxy-phenyl)-methanol (152 mg, 0.7 mmol) and trrphenylphosphene (183.6, 0.7 mmol) were combined m a reaction vial and THF (1 iriL) was added. The mixture was stirred until complete solution was attained, then cooled to O0C, and diisopropylazodicarboxylate (0.136 mL, 0.7 mmol) was added dropwise. The reaction mixture was agitated at room temperature overnight, diluted with THF (2 mL) then treated directly with the Amberlyst resin (3 g, 4 mmol). This reaction mixture was agitated overnight and the resin was then filtered and washed with DMF (2 x 3 mL) and several portions of methanol. The product was eluted by treating the resin with a 20% solution of formic acid in methanol (5 mL) and washing with methanol (3 mL). The combined eluant and final wash was evaporated to provide the title compound (154 mg, 99%). LCMS (ESMS): m/z 447/9 (M+H+).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 80866-82-6, 5-Bromo-2-methoxybenzyl alcohol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG; WO2008/147697; (2008); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 457889-46-2, name is (4′-(Trifluoromethyl)-[1,1′-biphenyl]-4-yl)methanol, the common compound, a new synthetic route is introduced below. Application In Synthesis of (4′-(Trifluoromethyl)-[1,1′-biphenyl]-4-yl)methanol

Example 11A 4-Chloromethyl-4′-trifluoromethylbiphenyl A solution of 5.00 g (19.8 mmol) of (4′-trifluoromethylbiphenyl-4-yl)methanol in 40 ml of chloroform is mixed with 2.89 ml (39.7 mmol) of thionyl chloride dissolved in 10 ml of chloroform, and the mixture is stirred at room temperature over 12 hours. After reaction is complete, the reaction mixture is concentrated to dryness, and the residue is taken up ethyl acetate and washed with saturated sodium carbonate solution. The organic phase is subsequently separated off, dried over sodium sulfate and concentrated after filtration. The resulting crude product is purified by flash chromatography on silica gel 60 (mobile phase: cyclohexane/ethyl acetate 9:1). 5.26 g (19.4 mmol, 98% of theory) of the title compound are obtained. 1H-NMR (300 MHz, DMSO-d6, delta/ppm): 4.83 (s, 2H), 7.58 (d, 2H), 7.78 (d, 2H), 7.91 (d, 2H), 7.82 (d, 2H). MS (E1): 270 (M+).

The synthetic route of 457889-46-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Bartel, Stephan; Hahn, Michael; Moradi, Wahed Ahmed; Becker, Eva-Maria; Roelle, Thomas; Stasch, Johannes-Peter; Schlemmer, Karl-Heinz; Wunder, Frank; Knorr, Andreas; US2009/291993; (2009); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.63012-03-3, name is (3-Chlorophenyl)(phenyl)methanol, molecular formula is C13H11ClO, molecular weight is 218.68, as common compound, the synthetic route is as follows.category: alcohols-buliding-blocks

General procedure: To a solution of thiol 1 (0.5 mmol) in anhyd CH2Cl2 (2 mL) was added diaryl carbinol 2 (0.6 mmol) and BF3*OEt2 (5 mol% solution in CH2Cl2; 1 mL). The reaction mixture was stirred vigorously for <1 min. After completion of the reaction as checked by TLC, the solvent was removed under reduced pressure, and the residue was subjected to silica gel column chromatography by using 5-10% EtOAc in hexanes to afford the desired symmetrical and unsymmetrical diarylmethyl thioether in good to quantitative yield. At the same time, in my other blogs, there are other synthetic methods of this type of compound,63012-03-3, (3-Chlorophenyl)(phenyl)methanol, and friends who are interested can also refer to it. Reference:
Article; Singh, Pallavi; Peddinti, Rama Krishna; Synthesis; vol. 49; 16; (2017); p. 3633 – 3642;,
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Electric Literature of 1454-85-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1454-85-9, name is Heptadecan-1-ol. A new synthetic method of this compound is introduced below.

General procedure: Alcohol (1.0 eq.) and sodium hydride (60percent in mineral oil, 2.8 eq.) were introduced in dimethoxyethane (10 mL). The solution was refluxed up to the end of H2 emission. Then, a solution of (2,2-dimethyl-1,3-dioxolan-4-yl)methyl 4-methylbenzenesulfonate (1.4 eq.) in ethane-1,2-diol was added and the mixture was refluxed for 48 h. After cooling to room temperature, the solution was poured into water. The organic layer was extracted with diethyl ether and dried over Na2SO4. The solvents were removed under vacuum and the desired product was obtained after a purification by flash chromatography in chloroform. The advancement of the purification was followed by TLC in chloroform/acetone (90:10).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1454-85-9, its application will become more common.

Reference:
Article; Pinault, Michelle; Guimaraes, Cyrille; Couthon, Helene; Thibonnet, Jerome; Fontaine, Delphine; Chantome, Aurelie; Chevalier, Stephan; Besson, Pierre; Jaffres, Paul-Alain; Vandier, Christophe; Marine Drugs; vol. 16; 4; (2018);,
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Application of 83647-43-2, Adding some certain compound to certain chemical reactions, such as: 83647-43-2, name is (3-Bromo-2-methylphenyl)methanol,molecular formula is C8H9BrO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 83647-43-2.

Intermediate 22-1Preparation of 3-(3-bromo-2-methylbenzylidene)indolin-2-one Step 1 A mixture of (3-bromo-2-methylphenyl)methanol (prepared according to the procedures reported in US Pat. Appl. 2006/0173183, 500 mg, 2.49 mmol) in THF (20 mL) was stirred at rt and treated with 1,1,1-tris(acetyloxy)-1,1-dihydro-1,2-benziodoxol-3-(1H)-one (Dess-Martin periodinane, 1.58 g, 3.73 mmol). After 2 h, the mixture was diluted with ether (ca. 100 mL) and washed with 5% aqueous sodium bisulfite, NaHCO3 (aq) and brine, dried and concentrated. The residue was purified by column chromatography (eluting with a gradient from hexane to 55:45 hexane-EtOAc) to provide 3-bromo-2-methylbenzaldehyde as a colorless oil (343 mg, 70%). 1H NMR (400 MHz, chloroform-d) delta 10.26 (1H, s), 7.78 (2H, ddd, J=9.7, 8.0, 1.2 Hz), 7.20-7.27 (1H, m), 2.75 (3H, s).

According to the analysis of related databases, 83647-43-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Bristol-Myers Squibb Company; US2010/160303; (2010); A1;,
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