Tag: M.W=200-300

Electric Literature of 575-03-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 575-03-1 as follows.

(1) to 10 ml containing 0.5mmol of 4 – trifluoromethyl -7 – hydroxy coumarin and 0.625mmol of triethylamine in tetrahydrofuran solution, slowly dropping 0.6mmol to methyl benzoyl chloride (dissolved in 5 ml of in tetrahydrofuran), to control the temperature 0 ¡ãC;(2) stirring ice 1h after, solution to return to room temperature, stirring overnight;(3) the reaction solution through the pressure reducing and removing the solvent, the solid residue is purified by silica gel chromatography, using ethyl acetate-hexane – (1:3 v/v) elute, shall be 131 mg white solid powdery pure product.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,575-03-1, its application will become more common.

Reference:
Patent; Da Lianli Technology Changshu Institute Co., Ltd.; Cui Jingnan; Feng Lei; (11 pag.)CN104592985; (2017); B;,
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Related Products of 5675-51-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5675-51-4, name is 1,12-Dodecanediol, molecular formula is C12H26O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 1 Preparation of 12-bromododecan-1-ol (3) 48% HBr in water (77 ml; 0.46 mol; 15 eq.) is added to a solution of 1,12-dodecan-ol (6.15 g; 30.4 mmol; 1 eq.) in cyclohexane (140 ml). The heterogeneous mixture is heated under reflux. After 6 h, the aqueous phase is extracted with ether (3*100 ml). The organic phases are combined, washed with a saturated solution of Na2CO3, dried on MgSO4, filtered and evaporated. The crude reaction product is purified by silica gel chromatography (eluent: hexane-AcOEt: 6-4) to yield 7.06 g of a white solid. Yield: 85% Empirical formula: C12H25BrO

According to the analysis of related databases, 5675-51-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Centre National de la Recherche Scientifique(CNRS); Universite de Luxembourg; US2010/48731; (2010); A1;,
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Related Products of 73978-41-3 ,Some common heterocyclic compound, 73978-41-3, molecular formula is C7H9ClN6O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Initially, the compound 6-bromomethyl-pteridine-2,4-diamine as shown inFormula XIIIH9N N N(XIII)was prepared by first suspending 2,4-diamino-6-(hydroxymethyl)pteridine hydrochloride(2.29 g, 10 mmol) in 100 ml glacial acetic acid, warming to reflux and then allowing tocool to ambient temperature. Hydrobromic acid and 30% AcOH solution (191 ml) wasthen added and the flask stoppered for 4 days. The reaction mixture was then poured into1200 ml dry diethyl ether with stirring. The product was allowed to settle and excesssolvent was removed by decantation. The product was collected, washed with additionalether, and dried for later use.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,73978-41-3, its application will become more common.

Reference:
Patent; SERENEX, INC.; WO2006/14706; (2006); A2;,
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Adding a certain compound to certain chemical reactions, such as: 20605-01-0, Diethyl 2,2-bis(hydroxymethyl)malonate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 20605-01-0, blongs to alcohols-buliding-blocks compound. Product Details of 20605-01-0

General procedure: A solution of diethyl 2,2-bis(hydroxymethyl) malonate(12 mmol), 1 (10 mmol) and sulfonated carbon(1.0 g) were heated to reflux in a mixture of N,N-dimethylformamide(10 mL) and cyclohexane (6 mL)under stirring for 3 h. After cooling to room temperature,the solution was filtered and the solvent was removed in vacuo, the residue was dissolved in EtOAc (15 mL),washed with saturated brine (10 mL ¡Á 2) and water(10 mL¡Á2), dried over anhydrous Na2SO4. The solventwas filtered and concentrated to give 2a-2d as colorless oil.

The synthetic route of 20605-01-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Yuan, Lin; Li, Zhong Yan; Zhang, Min; Yuan, Xian You; Zhu, Xiao Qing; Journal of Nanoscience and Nanotechnology; vol. 17; 3; (2017); p. 2201 – 2205;,
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Electric Literature of 1261524-75-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1261524-75-7, name is 3-Bromo-2-chlorobenzyl Alcohol, molecular formula is C7H6BrClO, molecular weight is 221.48, as common compound, the synthetic route is as follows.

Step D: 5-bromo-4-chloro-2-benzofuran-l(3H)-one: To a flask charged with (3-bromo-2- chlorophenyl)methanol (1.1 g, 4.8 mmol) and a stir bar was added thallium trifluoroacetate (2.9 g, 5.3 mmol) and TFA (6 mL). The mixture was allowed to stir at RT for 16 hours. The volatiles were removed under reduced pressure. The residue was pumped under high vacuum for 15 minutes before palladium (II) chloride (0.085 g, 0.48 mmol), magnesium oxide (0.39 g, 9.6 mmol), lithium chloride (0.20 g, 4.8 mmol), and ethanol (30 mL) were added. The mixture was stirred under an atmosphere of carbon mono-oxide until the reaction turned black. The reaction was diluted with DCM. The suspension was filtered through a pad of celite to remove the solids. The filtrate was adsorbed onto silica gel, and purified by MPLC to afford the title compound.

Statistics shows that 1261524-75-7 is playing an increasingly important role. we look forward to future research findings about 3-Bromo-2-chlorobenzyl Alcohol.

Reference:
Patent; MERCK SHARP & DOHME CORP.; TANG, Haifeng; PIO, Barbara; TEUMELSAN, Nardos; PASTERNAK, Alexander; DEJESUS, Reynalda; WO2013/62892; (2013); A1;,
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Application of 17773-10-3 ,Some common heterocyclic compound, 17773-10-3, molecular formula is C5H14INO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Intermediate 39 (150 mg, 0.15 mmol) was dissolved in DCM (4 ml) and hydroxyethyltrimethyl-ammonium iodide (173 mg, 0.75 mmol), EDC (86 mg, 0.45 mmol) and DMAP (55 mg, 0.45 mmol) were added. The mixture was stirred at RT for 7 h and water (4 ml) was added. The aqueous layer was separated and evaporated. Purification was achieved using HPLC system 3.Yield: 35 mg (16%)LC-MS (Method 1): Rt 6.78 min, m/z 585.80 [M2+]/2

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 17773-10-3, Choline Iodide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ARGENTA DISCOVERY LTD; WO2006/82412; (2006); A2;,
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Electric Literature of 20712-12-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 20712-12-3 as follows.

Step 2: Synthesis of 2-amino-5-bromobenzaldehyde A mixture of (2-amino-5-bromophenyl)methanol (10 g, 49.5 mmol) and Mn02 (25.8 g, 296.6 mmol) in CH2C12 (400 mL) was stuffed at RT overnight. LCMS showed the reaction was completed. The solid was filtered off, and the filtrate was concentrated to give the titlecompound as a light yellow solid (8 g, 8 1percent), which was directly used in next step without further purification. MS (ES+) C7H6BrNO requires: 199, found: 200, 202 [M + H].

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,20712-12-3, its application will become more common.

Reference:
Patent; BLUEPRINT MEDICINES; BIFULCO, Neil, Jr.; BROOIJMANS, Natasja; HODOUS, Brian, L.; KIM, Joseph, L.; MIDUTURU, Chandrasekhar, V.; WO2014/11900; (2014); A2;,
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Adding a certain compound to certain chemical reactions, such as: 722-92-9, 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 722-92-9, blongs to alcohols-buliding-blocks compound. COA of Formula: C9H7F6NO

2-(tert-Butoxycarbonyl)-5-(methylsulfonyl)isoindoline- 1 -carboxylic acid (4.40 g, 12.89 mmol) and 2-(4-aminophenyl)- 1,1,1,3,3,3 -hexafluoropropan-2-ol (3.34 g, 12.89 mmol)were combined in EtOAc (50 mL) to give a suspension, before the addition of triethylamine (5.39 mL, 38.67 mmol) gave a dark brown solution. The solution was chilled by stirring on an ice I water bath before the addition of T3P (50percent in EtOAc, 15.35 mL, 25.78 mmol) through a dropping funnel. The addition was controlled to ensure that the temperature did not exceed 5 ¡ãC. After one hour the reaction solution was washed withwater (2 x 5OmL). The combined water washes were extracted with EtOAc (5OmL). The combined organic extracts were washed with 0. 1M aq HC1 (2 x 5OmL) and brine (25mL) before being dried over MgSO4. Filtration and concentration in vacuo gave a residue, which was purified by flash chromatography eluting with 0 ? 60percent EtOAc in n-heptane to give the title compound (4.95 g, 66percent) as a solid.LCIMS: mlzrr 581 EM-H]-. ?H NMR (400 MHz, DMSO-d6, mixture of rotamers, 1.8*:1) 151.35*, 1.47 (s, 9H), 3.20, 3.21* (s, 3H), 4.69? 4.88 (m, 2H), 5.61*, 5.63 (s, 1H), 7.6?7.76 (m, 5H), 7.86?7.92 (m, 1H), 7.98, 8.01* (s, 1H), 8.63*, 8.65 (s, 1H), 10.75 (s, 1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,722-92-9, its application will become more common.

Reference:
Patent; ASTRAZENECA AB; LEVER, Sarah; NARJES, Frank; OLSSON, Roine, Ingemar; VON BERG, Stefan; (124 pag.)WO2018/229155; (2018); A1;,
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Reference of 7073-69-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.7073-69-0, name is 2-(2-Bromophenyl)propan-2-ol, molecular formula is C9H11BrO, molecular weight is 215.087, as common compound, the synthetic route is as follows.

In a 250 mL three-necked flask, 0.03 mol of dibenzofuran-3-amine, 0.04 mol of 2-(2-bromophenyl)propan-2-ol, and 150 mL of toluene were stirred and mixed under a nitrogen atmosphere.Then adding 0.05 mol of sodium t-butoxide, 0.0015 mol of Pd2 (dba) 3, 0.0015 mol of tri-tert-butylphosphine, heating to 115 C, refluxing reaction for 24 hours;Naturally cooled to room temperature, filtered, and the filtrate was subjected to vacuum distillation (-0.09 MPa, 85 C).Passing through a neutral silica gel column to give 2-(2-(dibenzofuran-3-ylamino)phenyl)propan-2-ol;

The chemical industry reduces the impact on the environment during synthesis 7073-69-0, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Jiangsu March Optoelectric Technology Co., Ltd.; Miao Kangjian; Zhang Zhaochao; Zhang Xiaoqing; Li Chong; (37 pag.)CN108203427; (2018); A;,
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Adding a certain compound to certain chemical reactions, such as: 23783-42-8, 2,5,8,11-Tetraoxatridecan-13-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 2,5,8,11-Tetraoxatridecan-13-ol, blongs to alcohols-buliding-blocks compound. Recommanded Product: 2,5,8,11-Tetraoxatridecan-13-ol

A method of synthesizing the silybin phenolic ether derivatives as shown in Formula I-d is as follows:1) Add 8.00 g (0.20 mol) NaOH, 80 ml water to a 250 ml three-necked flask.Stir to dissolve it evenly. 24.96 g (0.12 mol) of tetraethylene glycol monomethyl ether was added to 50 ml of THF to be uniformly dissolved, then added to the above-mentioned three-necked flask and uniformly mixed with the NaOH solution.The mixture was stirred in an ice bath at 0 55 C. and thoroughly deoxygenated with nitrogen. 22.88 g (0.12 mol) of p-toluenesulfonyl chloride and 40 ml of THF were mixed well, and then slowly added dropwise to the above three-necked flask. The dropping process kept the temperature of the reaction liquid. After exceeding 10C, the reaction was continued for 6 hours after completion of the dropwise addition to stop the reaction.The reaction solution was extracted three times with diethyl ether, and the ether extract was washed with water until neutral and then dried over anhydrous magnesium sulfate. After filtration and rotary evaporation, the ether was removed.This gave 40.83 g (yield: 94%) of the corresponding p-toluenesulfonate of formula III-b,

The synthetic route of 23783-42-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Chinese Academy Of Sciences Physics And Chemistry Technology Institute; Zhao Yuxia; He Ru; Wu Feipeng; (18 pag.)CN105037337; (2018); B;,
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