Tag: M.W=200-300

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 20017-67-8, name is 3,3-Diphenyl-1-propanol. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C15H16O

To a stirred solution of difluoroacetic acid (5.00 g, 52.1 mmol) and 3,3- diphenyl-l-propanol (11.4 ml, 57.3 mmol, 1.10 eq) in diethyl ether (100 ml) is added 4-dimethylaminopyridine (0.64 g, 5.21 mmol, 0. 01 eq) followed by diisopropylcarbodiimide (6.56 g, 52.1 mmol, 1.0 eq). The mixture is stirred at room temperature overnight. The precipitate is removed by vacuum filtration and washed with ether and the filtrate concentrated in vacuo. The residue is filtered through a plug of silica gel using 5% ether/hexanes eluent and the filtrate collected and concentrated. The resulting compound (14.40 g, 46.64 mmol) in xylenes (150 ml) is added Lawesson’s Reagent (24.1 g, 59.61 mmol). The reaction mixture is heated at reflux overnight and then cooled to room temperature. A precipitate formed which is removed by vacuum filtration and washed with ethyl acetate. The filtrate is passed through a plug of silica gel and eluted with 5% ether/hexanes and concentrated to give the title compound 3. 1H NMR (400 Mhz), CDCl3) 8 2.47, 4.07, 4. 24,5. 82,7. 23.

With the rapid development of chemical substances, we look forward to future research findings about 20017-67-8.

Reference:
Patent; PHARMACIA & UPJOHN COMPANY; WO2004/2479; (2004); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 17100-58-2, name is (4-Bromo-2-methylphenyl)methanol. A new synthetic method of this compound is introduced below., Computed Properties of C8H9BrO

Intermediate 16: r2-methvl-4-(4,4.5,5-tetramethyl-1 ,3,2-dioxaborolan-2-vl)phenyllmethanol; A solution of intermediate 15, (4-bromo-2-methylphenyl)methanol, (30 g, 150 mmol), bis(pinacolato)diboron (40 g, 156 mmol), Pd(dppf)CI2(N) (8 g, 10 mmol), and potassium acetate (44 g, 448 mmol) in 1 ,4-dioxane (600 ml.) was heated to reflux under N2 for 4 hours. After cooling, the reaction mixture was filtered, and the filtrate was concentrated in vacuo. Purification by flash chromatography (petroleum ether/ EtOAc: 5/1 ) gave the title compound [2- methyl-4-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2-yl)phenyl]methanol as a red oil (34 g, 90%yield). 1H NMR (400 MHz, DMSO-d6) J7.50-7.38 (m, 3H), 5.14 (t, 1 H), 4.51 (d, 2H), 2.22 (s, 3H), 1.28 (s, 12H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 17100-58-2, (4-Bromo-2-methylphenyl)methanol.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; BOUILLOT, Anne Marie Jeanne; DODIC, Nerina; GELLIBERT, Francoise Jeanne; MIRGUET, Olivier; WO2010/15652; (2010); A2;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 395-23-3, name is Phenyl(4-(trifluoromethyl)phenyl)methanol. A new synthetic method of this compound is introduced below., Application In Synthesis of Phenyl(4-(trifluoromethyl)phenyl)methanol

General procedure: A solution of 1,1-diarylmethanol, 1r-w (200mg, 0.80-1.08mmol) in dry CH2Cl2 (5mL) and TMSN3 (1.5equiv) were placed in a 25mL round-bottom flask fitted with guard tube. InBr3 (2mol%) was added to this reaction mixture. The contents were stirred at room temperature and the progress of reaction was monitored by TLC analyses. After stirring the contents for appropriate time period, the reaction was quenched with water. The product was extracted with CH2Cl2 (3¡Á15mL), washed with 10% Na2CO3 (20mL), water (20mL) and dried over anhydrous Na2SO4. The solvent was removed under reduced pressure to give brownish oil. Purification by flash chromatography afforded the products 2r-w.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 395-23-3, Phenyl(4-(trifluoromethyl)phenyl)methanol.

Reference:
Article; Kumar, Anil; Sharma, Ramesh K.; Singh, Tej V.; Venugopalan, Paloth; Tetrahedron; vol. 69; 50; (2013); p. 10724 – 10732;,
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Electric Literature of 756520-66-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 756520-66-8, name is 1-(2,6-Dichloro-3-fluorophenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

1-(2,6-Dichloro-3-fluorophenyl)ethan-1-ol 37 (24.00 g, 114.81 mmol) was dissolved in 300 mL of CH2ClCH2Cl. The solution was cooled to -5 C. To the solution was successively added Boc-L-proline (16.06 g, 74.63 mmol), EDCI (17.61 g, 91.85 mmol) and DMAP (1.68 g, 13.78 mmol). The resulting mixture was continued to stir overnight and diluted with 100 mL of water. The organic layer was collected, washed with brine, dried over anhydrous Na2SO4 and concentrated under vacuum. The crude product was purified by silica gel column chromatography (PE/EA 100:1-50:1, v/v) to afford (1S)-1-(2,6-dichloro-3-fluorophenyl)ethan-1-ol. (7.00 g, 58% yield). 1H NMR (400 MHz, CDCl3) delta 7.26 (dd, J = 4.8, 8.8 Hz, 1H), 7.02 (dd, J = 8.0, 8.8 Hz, 1H), 5.57 (q, J = 6.8 Hz, 1H), 2.86 (s, 1H), 1.64 (d, J = 6.8 Hz, 3H).

According to the analysis of related databases, 756520-66-8, the application of this compound in the production field has become more and more popular.

Reference:
Article; Zhang, Dengyou; Zhang, Xiaowei; Ai, Jing; Zhai, Yun; Liang, Zhongjie; Wang, Ying; Chen, Yi; Li, Chunpu; Zhao, Fei; Jiang, Hualiang; Geng, Meiyu; Luo, Cheng; Liu, Hong; Bioorganic and Medicinal Chemistry; vol. 21; 21; (2013); p. 6804 – 6820;,
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Electric Literature of 1334674-88-2 ,Some common heterocyclic compound, 1334674-88-2, molecular formula is C7H6BrN3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Step 3. 2-Bromo-5H-pyrrolo[2,3-b]pyrazine-7-carbaldehyde. To a suspension of (2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)methanol (127 g, 562 mmol) in acetone (2.5 L) was added dropwise Jones reagent (253 mL, 674 mol?2.67 M) below 10 C. After the addition, the resulting mixture was stirred at room temperature for 50 min, which time suspension became clean and then brown solid was precipitated. The three batches were combined for workup together. The reaction mixture was quenched with i-PrOH (60 mL) and filtered, the filter cake was washed with acetone (1 L¡Á2), the combined filtrate was evaporated to give 2-bromo-5H-pyrrolo[2,3-b]pyrazine-7-carbaldehyde (320 g, 84.4%) as a yellow solid. (A stock of Jones reagent (2.67 M) was prepared by carefully adding concentrated H2SO4 (184 mL) to CrO3 (213.6 g) then diluting to 800 mL with H2O.)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1334674-88-2, (2-Bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Thorarensen, Atli; Brown, Matthew Frank; Casimiro-Garcia, Agustin; Che, Ye; Coe, Jotham Wadsworth; Flanagan, Mark Edward; Gilbert, Adam Matthew; Hayward, Matthew Merrill; Langille, Jonathan David; Montgomery, Justin Ian; Telliez, Jean-Baptiste; Unwalla, Rayomand Jal; US2015/158864; (2015); A1;,
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Synthetic Route of 20017-67-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 20017-67-8, name is 3,3-Diphenyl-1-propanol. This compound has unique chemical properties. The synthetic route is as follows.

Step 1. Preparation of difluoroacetic acid, O-(3,3-diphenyl-propyl) ester. [0299] Dicyclohexylcarbodiimide (12.6 g, 62.4 mmol) is added portionwise with stirring to a solution of difluoroacetic acid (4.0 g, 4.0 mL, 62.4 mmol), 3,3-diphenyl-1-propanol (14.4 g, 13.8 mL, 68.4 mol) and 4-dimethylaminopyridine (732 mg, 6.2 mmol) in ethyl ether (180 mL) at 0-5 C. The reaction mixture is allowed to warm up to r.t., and stirred at r.t. overnight. The precipitated urea by-product is filtered off and washed with excess ethyl ether. The combined filtrates are evaporated under vacuum, and the residue is purified by silica gel flash chromatography (eluent: 5% ethyl ether in hexanes). White crystalline solid (17.3 g, 96%). HPLC Rt=7.2. MS (m/z): 291 [M+H]+.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 20017-67-8, 3,3-Diphenyl-1-propanol.

Reference:
Patent; Gordeev, Mikhail F.; Renslo, Adam; Luehr, Gary W.; Lam, Stuart; Westlund, Neil E.; Patel, Dinesh V.; US2003/232812; (2003); A1;,
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Adding a certain compound to certain chemical reactions, such as: 32328-03-3, Diethyl 3-hydroxyglutarate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 32328-03-3, blongs to alcohols-buliding-blocks compound. Safety of Diethyl 3-hydroxyglutarate

Sodium hydroxide (0.80 g, 20 mmol) was dissolved in water (10 mL), diethyl 3-hydroxyglutarate (0.95 g, 5.0 mmol) was added thereto, and the mixture was stirred at room temperature for 1 hour. Next, after cooling the reaction solution on ice,65% nitric acid was added in an equimolar amount to sodium hydroxide and stirred for 1 hour under ice cooling. to this, An aqueous solution (0.70 mL) containing silver nitrate (1.70 g, 10 mmol) was added dropwise and the mixture was further stirred for 1 hour. Thereafter, the precipitated white precipitate was collected by filtration.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,32328-03-3, its application will become more common.

Reference:
Patent; NOF CORPORATION; TAGAMI, YASUNOBU; MORISHITA, TAKEHIRO; MICHINISHI, JUNYA; (16 pag.)JP2015/107938; (2015); A;,
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Synthetic Route of 19936-14-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 19936-14-2, name is 1-(4-Bromophenyl)cyclobutanol. This compound has unique chemical properties. The synthetic route is as follows.

To a 50 mL two-neck flask were added 1-(4-bromophenyl)cyclobutanol (80 mg, 0.35 mmol), N-(1-((1-cyanocyclopropyl)carbamoyl)cyclohexyl)-6-(4,4,5,5 -tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran-2-carboxamide (168.0 mg, 0.35 mmol), Pd(dppf)Cl2¡¤CH2Cl2 (40 mg) and DMF (15 mL). To the mixture was added aqueous potassium carbonate (0.45 mL, 2 mol/L) under nitrogen protection. The resulting mixture was stirred at 90C for 3 h. To the reaction mixture was added saturated brine (50 mL), and the resulting mixture was extracted with ethyl acetate (50 mL*2). The combined organic layers were washed with saturated brine (40 mL*2), dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated in vacuo, and the residue was purified by silica-gel column chromatography (DCM:EtOAc=4:1, V/V) to give a white solid (80 mg, 50%). MS(ESI, pos.ion)m/z:498.2 (M+1); 1H NMR (600 MHz, CDCl3) delta 8.16 (s, 1H), 7.77 (d, J= 10.6 Hz, 2H), 7.67 (dd, J= 20.5, 8.3 Hz, 4H), 7.61 (d, J = 8.2 Hz, 1H), 7.54 (s, 1H), 6.61 (s, 1H), 2.69 – 2.61 (m, 2H), 2.45 (dt, J = 12.5, 9.5 Hz, 2H), 2.28 (d, J = 13.8 Hz, 2H), 2.15 – 1.98 (m, 5H), 1.82 – 1.72 (m, 4H), 1.55 (dt, J = 24.7, 9.6 Hz, 4H), 1.26 – 1.23 (m, 2H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 19936-14-2, 1-(4-Bromophenyl)cyclobutanol.

Reference:
Patent; Sunshine Lake Pharma Co., Ltd.; WANG, Xiaojun; ZHOU, Pingjian; YANG, Chuanwen; HUANG, Changwei; XIONG, Shaohui; ZHANG, Yingjun; ZHANG, Jiancun; (139 pag.)EP3342765; (2018); A1;,
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Related Products of 756520-66-8, Adding some certain compound to certain chemical reactions, such as: 756520-66-8, name is 1-(2,6-Dichloro-3-fluorophenyl)ethanol,molecular formula is C8H7Cl2FO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 756520-66-8.

1 -(2,6-dichloro-3- fluorophenyl)ethanol (5.2 g, 24.9 mmol), methanesulfonyl chloride (6.3 g, 55 mmol, 2.2 eq), and triethylamine (6.1 g) were stirred in 50 ml of DCM and 12 ml of DMF at room temperature overnight. Water and DCM were added, and the layers were separated. The aqueous layer was extracted with DCM. The combined organic layers were dried, evaporated and chromatographed (EtOAc/Hexanes 1 : 10) to give an oil, 5.11 g, in 71% yield.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 756520-66-8, 1-(2,6-Dichloro-3-fluorophenyl)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ARIAD PHARMACEUTICALS, INC.; QI, Jiwei; WANG, Yihan; LI, Feng; SHAKESPEARE, William, C.; KOHLMANN, Anna; DALGARNO, David, C.; ZHU, Xiaotian; WO2010/68292; (2010); A1;,
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Reference of 3344-77-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3344-77-2, name is 12-Bromododecan-1-ol, molecular formula is C12H25BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

(a) 2-(12-Bromododecyloxy)tetrahydropyran 12-Bromo-dodecan-1-ol (5.12 g, 19.3 mmol) was added to a vigorously stirred solution of dihydropyran (2.1 mL, 23.2 mmol) and Amberlyst HI5 (0.25 g, Aldrich D10,620-8) in hexane (100 mL). After 3 hours dihydropyran (2.1 mL) was added and the solution stirred for a further 15 hours. The mixture was then filtered, and the filtrate concentrated in vacuo and chromatographed graphed on silica gel, eluding with 2percent ethyl acetate in hexane to give the title compound, (a), 8.02 g (75percent), as an oil.

According to the analysis of related databases, 3344-77-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Warner-Lambert Company; US5073565; (1991); A;,
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