Tag: M.W=200-300

Adding a certain compound to certain chemical reactions, such as: 552331-15-4, 1-(5-Bromo-2-fluorophenyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 552331-15-4, blongs to alcohols-buliding-blocks compound. COA of Formula: C8H8BrFO

To a stirred solution of 1 -(5 -bromo-2-fluorophenyl)ethanol 30-1 (1.2 g, 5.48 mmol) in DCM (15 ml) was added tribromophosphine (0.26 mL, 2.74 mmol). The reaction mixture was stirred at 0C for lh, and then diluted with DCM (50 mL). Then saturated NaHCO3 solution was added dropwise to the mixture, and the layers were separated. The organic layer was washed with saturated NaHCO3 solution (3OmL), brine (30 mL), and then dried over Na2SO4, and concentrated to give the crude product 30-2, which was used in the next step without purification.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,552331-15-4, its application will become more common.

Reference:
Patent; MERCK SHARP & DOHME CORP.; HAGMANN, William K.; NARGUND, Ravi P.; BLIZZARD, Timothy A.; JOSIEN, Hubert; BIJU, Purakkattle; PLUMMER, Christopher W.; DANG, Qun; LI, Bing; LIN, Linus S.; CUI, Mingxiang; HU, Bin; HAO, Jinlai; CHEN, Zhengxia; WO2014/19186; (2014); A1;,
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Reference of 1454-85-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1454-85-9, name is Heptadecan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

To an ice-cold solution of heptadecanol (2.0 g, 7.8 mmole) in methylenechloride (20 rut) and TEA (3 rat, 20 rumole) was added the abovesuspension of acid chloride (9.3 mmole) in nethylene chloride (20 mL). After stirring for 10 ninutes at ice bath tenperature, the ice?bath was removed and stirring continued at room temperature for 4 h. The reaction mixture was then washed with water (2 x 8 mL) followed bybrine (10 mL), dried over anhydrous sodium sulfate, filtered and concentrated. The crude residue was purified by column chromatography using 5percent methanol in methylene chloride to give the pure required compound 17 (1.1 g, 27percent) as a off white solid, m.p.llo?112¡ã C. ?H NHR (CDC13) 5 0.87 (t, d, .1=7.2 Hz, 3H), 1.24 (m, 28H), 1.40?1.51 (m, 4H),1.60?1.79 (m, 2H), 2.55 (s,3H), 2.75 (m, 3H), 2.85?3.06 (m, 4H),3.60?3.85 (m,3H), 4.03(t, d, J=7.2 Hz, 2H), 4.88 (m,1H), 4.94(m,lH); ESMS:507 (H+H)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1454-85-9, Heptadecan-1-ol.

Reference:
Patent; LIXTE BIOTECHNOLOGY, INC.; KOVACH, John, S.; JOHNSON, Francis; SAMUDRALA, Ramakrishna; GUPTA, Ramesh, C.; WO2015/73802; (2015); A1;,
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Electric Literature of 100751-63-1, Adding some certain compound to certain chemical reactions, such as: 100751-63-1, name is 6-Bromo-2-naphthylmethanol,molecular formula is C11H9BrO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 100751-63-1.

To a solution of (6-bromonaphtbalen-2-yl)methanol (0.7 g, 2.97 mmol) in dichloromethane (20mL) was added TBSCI (667 mg, 4.45 mmol) and imidazole (302 mg, 4.45 mmol). After theaddition, the reaction mixture was stirred at 25 C for 1 h. The reaction was then quenched by addition of saturated aqueous NI-l4Cl (20 mE) and extracted with ethyl acetate (3 x 30 mL). The combined organic layers were dried over Na2SO4 and concentrated under reduced pressure. The residue was purified by silica-gel chromatography (petroleum ether: ethyl acetate = 30: 1) togive the title compound (0.8 g, 77 % yield) as a colorless oil.

According to the analysis of related databases, 100751-63-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.; ALBRECHT, Brian, K.; COTE, Alexandre; GEHLING, Victor; HSIAO-WEI TSUI, Vickie; KIEFER, James, Richard, Jr.; LIANG, Jun; MAGNUSON, Steven; NASVESCHUK, Christopher, G.; PASTOR, Richard; ROMERO, F. Anthony; TAYLOR, Alexander, M.; ZHANG, Birong; (287 pag.)WO2016/112284; (2016); A1;,
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Application of 106-28-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.106-28-5, name is (2E,6E)-3,7,11-Trimethyldodeca-2,6,10-trien-1-ol, molecular formula is C15H26O, molecular weight is 222.37, as common compound, the synthetic route is as follows.

To a stirred mixture of (E,E)-farnesol 1 (0.50 g, 2.25 mmol) in non-dried DCM (50 mL) under nitrogen was added Dess-Martin periodinane (1.43 g, 3.40 mmol), and the resulting mixture stirred for 2 h 50 min. Saturated aqueous sodium bicarbonate solution (20 mL) was added dropwise, the mixture stirred 10 min, then extracted with DCM (3 x 25 mL). The organic layer was dried (MgSO4), and the solvent was removed in vacuo. The crude product was purified using flash chromatography (19:1 hexanes: ethyl acetate) to give the title product (0.495 g, 99%) as a clear colourless oil.

Statistics shows that 106-28-5 is playing an increasingly important role. we look forward to future research findings about (2E,6E)-3,7,11-Trimethyldodeca-2,6,10-trien-1-ol.

Reference:
Article; Duhamel, Nina; Martin, Damian; Larcher, Roberto; Fedrizzi, Bruno; Barker, David; Tetrahedron Letters; vol. 57; 40; (2016); p. 4496 – 4499;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 163119-16-2, name is 2,6-Di-tert-butyl-4-methylcyclohexanol. A new synthetic method of this compound is introduced below., Application In Synthesis of 2,6-Di-tert-butyl-4-methylcyclohexanol

Synthesis of malonic acid ethyl 2,6-di-tert-butyl-4-methylcyclohexyl ester (d) Trifluoroacetic anhydride (41 ml, 0.29 mol) was added, dropwise, to a solution of the above 2,6-di-tert-butyl-4-methylcyclohexanol (d) (50.2 g, 0.22 mol) in ethyl acetate (200 ml) at 0C, and then the above malonic acid ethyl ester monopotassium salt (b) (41.6 g) was added thereto, slowly. After stirring it at room temperature for 2 hours, 200 ml of water was added thereto, and then 33 g of sodium hydrogencarbonate was added, slowly, to neutralize the reaction mixture. The organic layer was separated, washed with water once, and then with brine once; then it was dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure, to obtain crude malonic acid ethyl 2,6-di-tert-butyl-4-methylcyclohexyl ester (d) (76 g). The thus obtained crude malonic acid ethyl 2,6-di-tert-butyl-4-methylcyclohexyl ester (d) was used directly in the next step without purification.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 163119-16-2, 2,6-Di-tert-butyl-4-methylcyclohexanol.

Reference:
Patent; FUJI PHOTO FILM CO., LTD.; EP720981; (1996); A1;,
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Application of 261723-32-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 261723-32-4, name is (3-Bromo-2-fluorophenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

Pyridinium chlorochromate (22.3 g, 103 mmol, 1.91 eq) was dissolved in DCM (140 mL) and 4 Molecular Sieves (22.3 g) were added to the solution. The reaction mixture was stirred for 30 minutes. A solution of benzyl alcohol 40 (11 g, 54 mmol, 1 eq) in DCM (140 mL) was added dropwise over the course of 5 min. The orange reaction mixture immediately turned dark brown upon addition of alcohol. After stirring for 30 min, the reaction mixture was diluted with 70% Hexane/EtOAc solution (250 mL) and filtered through a plug of silica gel (150 g). The silica gel was washed with Hexane/EtOAc (500 mL), and concentrated in vacuo to afford 9.8 g of aldehyde 41 as a white solid. Yield 70% over 2 steps.

According to the analysis of related databases, 261723-32-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Infinity Discovery, Inc.; US2008/114167; (2008); A1;,
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Reference of 163119-16-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 163119-16-2, name is 2,6-Di-tert-butyl-4-methylcyclohexanol, molecular formula is C15H30O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Cyanoacetic acid 46.8 g (0.55 mol), toluene 320ml was added to 2,6-di-tert-butyl-4-methylcyclohexanol 113 g (0.5 mol), subjected to stirring at room temperature, whereas, pyridine 43 .5g the (0.55mol) was dropped. Then, dropping acetic anhydride 112.3g (1.1mol), it was 15 hours heated and stirred at 60C. After completion of the reaction, the reaction solution, sodium hydrogen carbonate of 95g, poured slowly with stirring in an aqueous solution consisting of water 750ml. Then, extracted with ethyl acetate of 250ml, after concentrating the ethyl acetate layer, the methanol 400ml added to the residue, after being heated and dissolved at 60C , to precipitate a crystal was cooled to 0C It was. The crystals were filtered, washed with water, by performing the methanol wash, to afford intermediate 4 135g (92% yield).

According to the analysis of related databases, 163119-16-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; FUJIFILM CORPORATION; SASAKI, DAISUKE; (63 pag.)JP5908824; (2016); B2;,
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Reference of 24034-73-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 24034-73-9, name is (2E,6E,10E)-3,7,11,15-Tetramethylhexadeca-2,6,10,14-tetraen-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

The resulting 2E-conjugated ester 8 was reduced to the corresponding 2E-alcohol 9 by means of a lithium aluminum hydride (LAH) treatment, which was then converted into the corresponding 2E,6E,10E-geranylgeranyl bromide 10 by means of phosphorus tribromide (PBr3) treatment in ethyl ether (EE) or with Ph3P and CBr4 in acetonitrile (ACN) at 0C. Furthermore, the interaction of carbanion (derived from ethyl acetoacetate 5 and sodium ethoxide) with the bromide 10 at 0C afforded the desired 2E,6E,10E-geranylgeranyl ketoester 11, a precursor needed for 5E,9E,13E-geranylgeranyl acetone 1. The subsequent ester hydrolysis and decarboxylation of ketoester 11 using aq. 5N KOH at 80C yielded the requisite 5E,9E,13E-geranylgeranyl acetone 1. TLC Rf: 0.28 (5% Ethyl Acetate in Hexanes); LC Retention time: 16.68 min; MS (m/e): 313 [M – 18 + H]+, 331 [M H]+, 353 [M + K] .

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 24034-73-9, (2E,6E,10E)-3,7,11,15-Tetramethylhexadeca-2,6,10,14-tetraen-1-ol.

Reference:
Patent; COYOTE PHARMACEUTICALS, INC.; SERIZAWA, Hiroaki; ARGADE, Ankush; DATWANI, Akash; SPENCER, Natalie; PAN, Yonghua; ERMINI, Florian; WO2014/163643; (2014); A1;,
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Application of 1208434-90-5 , The common heterocyclic compound, 1208434-90-5, name is (2,6-Difluoro-3,5-dimethoxyphenyl)methanol, molecular formula is C9H10F2O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of (2,6-difluoro-3,5-dimethoxyphenyl)methanol (1.5g, 7.38mmol) in diethyl ether (20mL), and pyridine (0.029g, 0.3mmol), PBr3 (0.69mL, 7.38mmol) was added slowly over a period of 10 min. Reaction mass was stirred at 35 C for 3hr. Reaction mass was quenched with ice cold water and extracted with diethyl ether (3x25mL). The organic phase was washed with brine, dried over Na2S04, filtered and concentrated under vacuum. The residue was purified by silica gel column chromatography to afford the title compound (1.68g, yield: 85.2%). 1H-NMR (CDC13, 300MHz): 6.60 (t, 1H), 4.52 (s, 2H), 3.87 (s, 6H).

The synthetic route of 1208434-90-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; EISAI R & D MANAGEMENT CO., LTD.; REYNOLDS, Dominic; HAO, Ming-Hong; WANG, John; PRAJAPATI, Sundeep; SATOH, Takashi; SELVARAJ, Anand; (128 pag.)WO2016/164703; (2016); A1;,
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Synthetic Route of 517-21-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 517-21-5, name is Sodium 1,2-dihydroxyethane-1,2-disulfonate. A new synthetic method of this compound is introduced below.

Zinc powder (2.18 g, 33.4 mmol) was added to a mixture of 2-(benzo[1,2,5]thiadiazole-4-sulfonylamino)-4-cyano-benzoic acid methyl ester (1.25 g, 3.34 mmol) and ACOH (20 mL), and the resulting mixture was heated at 50 C. for 2 h with vigorous stirring. The mixture was filtered through a pad of diatomaceous earth, rinsed with methanol, and concentrated to a yellow solid. This material was dissolved in methanol (15 mL) and added to a mixture of glyoxal sodium bisulfite adduct (2.70 g, 10.0 mmol), AcOH (0.9 mL), NaOAc (0.27 g, 3.3 mmol), and H2O (4.5 mL). The reaction was allowed to proceed at reflux for 3 h. The resulting mixture was diluted with DCM and filtered through a pad of diatomaceous earth, rinsing with DCM. The filtrate was washed with H2O, dried over MgSO4, concentrated, and purified by flash chromatography (hexanes/EtOAc) to provide the title compound (0.28 g, 23%). TLC (silica, 50% EtOAc/hexanes): Rf=0.13. MS (ESI): mass calculated for C17H12N4O4S, 368.1; m/z found, 367 [M-H]-. HPLC (reverse phase): RT=8.72 min. 1H NMR (400 MHz, CDCl3): 11.42 (s, 1H), 8.96 (dd, J=4.4, 1.8 Hz, 2H), 8.63 (dd, J=7.4, 1.4 Hz, 1H), 8.36 (dd, J=8.5, 1.4 Hz, 1H), 8.16 (d, J=1.4 Hz, 1H), 7.97-7.90 (m, 2H), 7.20 (dd, J=8.2, 1.5 Hz, 1H), 3.94 (s, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,517-21-5, its application will become more common.

Reference:
Patent; Allison, Brett D.; Hack, Michael D.; Phuong, Victor K.; Rabinowitz, Michael H.; Rosen, Mark D.; US2005/38032; (2005); A1;,
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