Tag: M.W=200-300

Related Products of 329218-12-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 329218-12-4, name is 3-Bromo-4-chlorobenzyl Alcohol. This compound has unique chemical properties. The synthetic route is as follows.

c. 3-Bromo-4-chloro-benzaldehyde To a solution of 3-bromo-4-chlorobenzyl alcohol (2.73 g, 12.34 mmol) in dichloromethane (75 mL) was added, at room temperature, pyridinium chlorochromate (2.66 g, 12.34 mmol). The reaction mixture was stirred at room temperature for 1 hr then filtered over celite. The solvent was removed under reduced pressure and the residue chromatographed on silica gel (10% ethyl acetate in hexane) to afford 2.52 g of 3-bromo-4-chloro-benzaldehyde (93% yield). 1H NMR (300 MHz; CDCl3) 1H NMR (300 MHz; CDCl3) 7.65 (d, J=8.1 Hz, 1H); 7.78 (dd, J1=8.4 Hz, J2=2.1 Hz, 1H); 8.12 (d, J=2.1 Hz, 1H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 329218-12-4, 3-Bromo-4-chlorobenzyl Alcohol.

Reference:
Patent; Maxia Pharmaceuticals, Inc.; US6515003; (2003); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 61439-59-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 61439-59-6, name is 2-(4-(Benzyloxy)phenyl)ethanol. A new synthetic method of this compound is introduced below.

To a mixture of 2-(4-benzyloxyphenyl)ethanol (1.19 g), triethylamine (700 mg), and ethyl acetate (30 ml), methanesulfonyl chloride (790 mg) was added dropwise at 0¡ãC, and the mixture was stirred at room temperature for two hours. The reaction mixture was washed with water, saturated aqueous sodium bicarbonate solution, 1 N hydrochloric acid, then, with saturated sodium chloride solution, and dried (MgSO4) and concentrated. To a mixture of the residue, ethyl (3-phenyl-1H-pyrazol-4-yl)acetate (1.0 g), and N, N-dimethylformamide (50 ml), sodium hydride (60percent, oily, 190 mg) was added at 0¡ãC, and the mixture was stirred at room temperature for one hour. The reaction mixture was poured into water, which was extracted with ethyl acetate. The ethyl acetate layer was washed with saturated aqueous sodium chloride solution, dried (MgSO4), and concentrated. The residue was subjected to silica gel column chromatography, and ethyl [1-[2-(4-benzyloxyphenyl)ethyl]-3-phenyl-1H-pyrazol-4-yl]acetate (0.45 g, yield: 24percent) was obtained as a colorless oily substance in the fraction eluted with diethyl ether-hexane (2:3, volume ratio). NMR(CDCl3) delta : 1.22(3H, t, J=7.0 Hz), 3.15(2H, t, J=7.4 Hz), 3.57(2H, s), 4.13(2H, q, J=7.0 Hz), 4.31(2H, t, J=7.4 Hz), 5.05(2H, s), 6.87-6.92(2H, m), 7.02-7.07(2H, m), 7.31-7.47(9H, m), 7.58-7.64(2H, m).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,61439-59-6, 2-(4-(Benzyloxy)phenyl)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; Takeda Chemical Industries, Ltd.; EP1228067; (2004); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 395-23-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 395-23-3, name is Phenyl(4-(trifluoromethyl)phenyl)methanol. A new synthetic method of this compound is introduced below.

Example 171: l-(4-Fluorophenyl)-3-(phenyl(4-(trifluoromethyl)phi methyl)ureaStep 1. Phenyl(4-(trifluoromethyl)phenyl)methanoneA solution of 4-(trifluoromethyl)benzhydrol (1.836 g, 7.3 mmol) in anhydrous DCM (65 mL) was treated with manganese(IV) oxide (<5 micron, activated) (5.7 g, 66 mmol). The resulting suspension was stirred at rt for 12 days. The catalyst was removed by filtration through a Celite brand filter agent pad. The filtrate was concentrated, and the resulting solid was dried under high vacuum to afford the title compound as a white solid. These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,395-23-3, its application will become more common. Reference:
Patent; AMGEN INC.; BROWN, James; CHEN, Jian J.; GORE, Vijay Keshav; HARRIED, Scott; HORNE, Daniel B.; KALLER, Matthew R.; LIU, Qingyian; MONENSCHEIN, Holger; NGUYEN, Thomas T.; NISHIMURA, Nobuko; ZHONG, Wenge; WO2012/177896; (2012); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 722-92-9, Adding some certain compound to certain chemical reactions, such as: 722-92-9, name is 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol,molecular formula is C9H7F6NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 722-92-9.

The product from step 1 (500 mg, 1.9 [MMOL)] and ethyl acetoacetate [(0. 27] mL, 2.1 [MMOL)] were combined and dissolved in methanol (10 mL) at ambient temperature. To this solution was added glacial acetic acid (0.13 mL, 2.1 [MMOL)] followed by sodium [CYANOBOROHYDRIDE] (194 mg, 3.1 [MMOL).] After stirring 18 h, the solution was [CONCENTRATED IN VACUO] and the resultant oil dissolved in ethyl acetate. The organics were washed with brine, dried over [MGS04,] and concentrated. Purification by reverse phase HPLC using a gradient elution of 60: 40 H20/TFA : CH3CN to 0: 100 H20/TFA : CH3CN at 254 nm afforded the title compound as a white solid (440 mg, [61 percent)] : mp = 103 [¡ãC.] H NMR [(CDC . S) 8] 7.43 (d, 2H), 6.64 (d, 2H), 4.07 (q, 2H), 3.90 (m, 1H), 3.43 (br s, 1 H), 2.58 (dd, 1 H), 2.41 (dd, [1 H),] 1.23 (d, 3H), 1.17 (t, 3H). MS (ES+) m/z 374 [(MH+).] [ANAL. CALC.] for C15H17NO3F6: C, 48.26 ; H, 4.59 ; N, 3.75. Found: C, 47.95 ; H, 4.45 ; N, 3.58.

According to the analysis of related databases, 722-92-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; PHARMACIA CORPORATION; WO2003/99769; (2003); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 23783-42-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 23783-42-8, name is 2,5,8,11-Tetraoxatridecan-13-ol. A new synthetic method of this compound is introduced below.

To a mixture of tetraethylene glycol monomethyl ether (3.00 g, 14.406 mmol) and soda (0.865 g, 21.6 mmol) diluted in THF (33 ml) and water (4 ml) cooled to 0 C., a solution of p-toluenesulfonic acid chloride (3.021 g, 15.8 mmol) in THF (4 ml) is slowly added. After 3 hours of stirring at 0 C., the mixture is poured into iced water (10 ml) and is diluted by dichloromethane. The aqueous phase is extracted with dichloromethane and the recombined organic phases are washed with water then with a NaCl-saturated solution, dried on MgSO4, filtered and concentrated under reduced pressure. The residue is purified by flash chromatography on a silica gel (petroleum ether/ethyl acetate 1/1 to 1/4) to yield 4.234 g (82%) of a colorless oil. deltaH (300 MHz, CDCl3) identical to the literature.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,23783-42-8, 2,5,8,11-Tetraoxatridecan-13-ol, and friends who are interested can also refer to it.

Reference:
Patent; Pierre Fabre Dermo-Cosmetique; US2008/267892; (2008); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 61439-59-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 61439-59-6, name is 2-(4-(Benzyloxy)phenyl)ethanol. A new synthetic method of this compound is introduced below.

To a mixture of 2-(4-benzyloxyphenyl)ethanol (1.19 g), triethylamine (700 mg), and ethyl acetate (30 ml), methanesulfonyl chloride (790 mg) was added dropwise at 0¡ãC, and the mixture was stirred at room temperature for two hours. The reaction mixture was washed with water, saturated aqueous sodium bicarbonate solution, 1 N hydrochloric acid, then, with saturated sodium chloride solution, and dried (MgSO4) and concentrated. To a mixture of the residue, ethyl (3-phenyl-1H-pyrazol-4-yl)acetate (1.0 g), and N, N-dimethylformamide (50 ml), sodium hydride (60percent, oily, 190 mg) was added at 0¡ãC, and the mixture was stirred at room temperature for one hour. The reaction mixture was poured into water, which was extracted with ethyl acetate. The ethyl acetate layer was washed with saturated aqueous sodium chloride solution, dried (MgSO4), and concentrated. The residue was subjected to silica gel column chromatography, and ethyl [1-[2-(4-benzyloxyphenyl)ethyl]-3-phenyl-1H-pyrazol-4-yl]acetate (0.45 g, yield: 24percent) was obtained as a colorless oily substance in the fraction eluted with diethyl ether-hexane (2:3, volume ratio). NMR(CDCl3) delta : 1.22(3H, t, J=7.0 Hz), 3.15(2H, t, J=7.4 Hz), 3.57(2H, s), 4.13(2H, q, J=7.0 Hz), 4.31(2H, t, J=7.4 Hz), 5.05(2H, s), 6.87-6.92(2H, m), 7.02-7.07(2H, m), 7.31-7.47(9H, m), 7.58-7.64(2H, m).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,61439-59-6, 2-(4-(Benzyloxy)phenyl)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; Takeda Chemical Industries, Ltd.; EP1228067; (2004); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 395-23-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 395-23-3, name is Phenyl(4-(trifluoromethyl)phenyl)methanol. A new synthetic method of this compound is introduced below.

Example 171: l-(4-Fluorophenyl)-3-(phenyl(4-(trifluoromethyl)phi methyl)ureaStep 1. Phenyl(4-(trifluoromethyl)phenyl)methanoneA solution of 4-(trifluoromethyl)benzhydrol (1.836 g, 7.3 mmol) in anhydrous DCM (65 mL) was treated with manganese(IV) oxide (<5 micron, activated) (5.7 g, 66 mmol). The resulting suspension was stirred at rt for 12 days. The catalyst was removed by filtration through a Celite brand filter agent pad. The filtrate was concentrated, and the resulting solid was dried under high vacuum to afford the title compound as a white solid. These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,395-23-3, its application will become more common. Reference:
Patent; AMGEN INC.; BROWN, James; CHEN, Jian J.; GORE, Vijay Keshav; HARRIED, Scott; HORNE, Daniel B.; KALLER, Matthew R.; LIU, Qingyian; MONENSCHEIN, Holger; NGUYEN, Thomas T.; NISHIMURA, Nobuko; ZHONG, Wenge; WO2012/177896; (2012); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 722-92-9, Adding some certain compound to certain chemical reactions, such as: 722-92-9, name is 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol,molecular formula is C9H7F6NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 722-92-9.

The product from step 1 (500 mg, 1.9 [MMOL)] and ethyl acetoacetate [(0. 27] mL, 2.1 [MMOL)] were combined and dissolved in methanol (10 mL) at ambient temperature. To this solution was added glacial acetic acid (0.13 mL, 2.1 [MMOL)] followed by sodium [CYANOBOROHYDRIDE] (194 mg, 3.1 [MMOL).] After stirring 18 h, the solution was [CONCENTRATED IN VACUO] and the resultant oil dissolved in ethyl acetate. The organics were washed with brine, dried over [MGS04,] and concentrated. Purification by reverse phase HPLC using a gradient elution of 60: 40 H20/TFA : CH3CN to 0: 100 H20/TFA : CH3CN at 254 nm afforded the title compound as a white solid (440 mg, [61 percent)] : mp = 103 [¡ãC.] H NMR [(CDC . S) 8] 7.43 (d, 2H), 6.64 (d, 2H), 4.07 (q, 2H), 3.90 (m, 1H), 3.43 (br s, 1 H), 2.58 (dd, 1 H), 2.41 (dd, [1 H),] 1.23 (d, 3H), 1.17 (t, 3H). MS (ES+) m/z 374 [(MH+).] [ANAL. CALC.] for C15H17NO3F6: C, 48.26 ; H, 4.59 ; N, 3.75. Found: C, 47.95 ; H, 4.45 ; N, 3.58.

According to the analysis of related databases, 722-92-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; PHARMACIA CORPORATION; WO2003/99769; (2003); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 23783-42-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 23783-42-8, name is 2,5,8,11-Tetraoxatridecan-13-ol. A new synthetic method of this compound is introduced below.

To a mixture of tetraethylene glycol monomethyl ether (3.00 g, 14.406 mmol) and soda (0.865 g, 21.6 mmol) diluted in THF (33 ml) and water (4 ml) cooled to 0 C., a solution of p-toluenesulfonic acid chloride (3.021 g, 15.8 mmol) in THF (4 ml) is slowly added. After 3 hours of stirring at 0 C., the mixture is poured into iced water (10 ml) and is diluted by dichloromethane. The aqueous phase is extracted with dichloromethane and the recombined organic phases are washed with water then with a NaCl-saturated solution, dried on MgSO4, filtered and concentrated under reduced pressure. The residue is purified by flash chromatography on a silica gel (petroleum ether/ethyl acetate 1/1 to 1/4) to yield 4.234 g (82%) of a colorless oil. deltaH (300 MHz, CDCl3) identical to the literature.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,23783-42-8, 2,5,8,11-Tetraoxatridecan-13-ol, and friends who are interested can also refer to it.

Reference:
Patent; Pierre Fabre Dermo-Cosmetique; US2008/267892; (2008); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 25392-41-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 25392-41-0, name is 4-(Chloromethyl)-7-hydroxy-2H-chromen-2-one. A new synthetic method of this compound is introduced below.

Coumarin 1 (1.77 g, 6.48 mmol) was suspended in 2 M NaOH(37 mL) and stirred at 80 C for 18 h. The resulting suspension was cooled to room temperature andacidified with concentrated hydrochloric acid to pH 1. The white precipitate was collected by vacuumfiltration and dried under reduced pressure (1.63 g, 99%); mp 154-156 C (lit. 156-157 C) [28]. H(500 MHz, DMSO-d6) 7.90 (1H, s, ArH), 7.86 (1H, s, ArH), 7.56 (1H, d, J = 8.0 Hz, ArH), 7.42 (1H, d,J = 8.25 Hz, ArH), 3.68 (2H, s, CH2). C (100 MHz, DMSO-d6) 172.2 (Cq), 155.4 (Cq), 144.8, 127.7 (Cq),126.2, 122.3, 117.3 (Cq), 114.9, 114.7 (Cq), 29.3 (CH2).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,25392-41-0, its application will become more common.

Reference:
Article; Duncan, Luke F.; Wang, Geqing; Ilyichova, Olga V.; Scanlon, Martin J.; Heras, Begona; Abbott, Belinda M.; Molecules; vol. 24; 20; (2019);,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts