Tag: M.W=200-250

Kluczyk, Alicja published the artcileArgireline: Needle-Free Botox as Analytical Challenge, Computed Properties of 70445-33-9, the publication is Chemistry & Biodiversity (2021), 18(3), e2000992, database is CAplus and MEDLINE.

Argireline-containing cosmetics attract public interest due to their confirmed reduction of facial wrinkles. Argireline is a peptide that works by inhibiting the release of neurotransmitters in the neuromuscular junction, producing a botox-like effect. Therefore, it is used as a safe needle-free alternative to botox treatment. In this work we investigated the presence of Argireline in cosmetic creams and sera by application of reversed phase liquid chromatog. and tandem mass spectrometry (RP-HPLC/MS and MS/MS). The anal. revealed the presence of argireline and its oxidized form in several different cosmetics. The methionine residue in Argireline sequence was indicated as oxidation point according to neutral loss MS studies. The developed sample preparation strategy minimizes and monitors methionine oxidation, bringing to our attention the question of impact of ingredients on the stability of cosmetic product.

Chemistry & Biodiversity published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Computed Properties of 70445-33-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yong, Jianping published the artcileSynthesis of Isoxazole Moiety Containing Thieno[2,3-d]pyrimidine Derivatives and Preliminarily in vitro Anticancer Activity (Part II), Name: 3-(2-Chlorophenyl)-5-isoxazolemethanol, the publication is Anti-Cancer Agents in Medicinal Chemistry (2015), 15(9), 1148-1155, database is CAplus and MEDLINE.

New structures of isoxazole-moiety-containing thieno[2,3-d]pyrimidine derivatives I (R¹ = Me, Ph; R² = H, Me; R³ = H, Ph; R⁴ = H, 4-Me, 4-MeO, etc.) were synthesized for the first time and their in vitro anticancer activity against lung cancer A549, colorectal HCT116 and breast cancer MCF-7 cell lines was preliminarily evaluated using the MTT method. Most of the compounds exhibited good to excellent anticancer activity. In particular, I (R¹ = Me; R², R³ = H; R⁴ = Br), I (R¹, R³ = Ph; R² = H; R⁴ = 4-MeO) and I (R¹, R³ = Ph; R² = H; R⁴ = 4-Br) exhibited a broad spectrum and more potent anticancer activity against A549, HCT116 and MCF-7 cell lines, which can be regarded as the promising anticancer drug-candidates.

Anti-Cancer Agents in Medicinal Chemistry published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C14H10O4S2, Name: 3-(2-Chlorophenyl)-5-isoxazolemethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yong, Jianping published the artcileSynthesis of isoxazole moiety containing ferrocene derivatives and preliminarily in vitro anticancer activity, Related Products of alcohols-buliding-blocks, the publication is MedChemComm (2014), 5(7), 968-972, database is CAplus.

Seven isoxazole-ring-containing ferrocene derivatives were synthesized and characterized by ¹H NMR, ¹³C NMR, ESI-MS. Subsequently, their in vitro anticancer activity against A549, HCT116, and MCF-7 cell lines was preliminarily evaluated using the MTT method. Among them, ferrocenecarboxylic acid 3-(2-chlorophenyl)isoxazol-5-ylmethyl ester (3d) exhibited wide spectrum anticancer activity and is the most potent among the isoxazole-ring-containing ferrocene derivatives Compound 3d is more active against A549 and HCT116 cell lines (IC₅₀s: 0.747 and 3.65 nM, resp.) than the reference drug gefitinib (IC₅₀s: 17.90 and 21.55 μM, resp.). 3D can be seen as the best candidate for development of anticancer drugs.

MedChemComm published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C14H10O4S2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yong, Jianping published the artcileSynthesis and Biological Evaluation of Quinazoline Derivatives as Potential Anticancer Agents (II), Quality Control of 438565-33-4, the publication is Anti-Cancer Agents in Medicinal Chemistry (2015), 15(10), 1326-1332, database is CAplus and MEDLINE.

Under the guidance of our previous work, we synthesized 21 new structures of quinazolines (3a∼3u) and evaluated their in vitro anticancer activity against A549, HCT116 and MCF-7 cell lines using the MTT method. Most compounds showed good to excellent anticancer activity. In particular, 3o (regarded as erlotinib analogs) has marked anticancer activity against A549, HCT116 and MCF-7 cell lines (IC50s: 4.26, 3.92 and 0.14 M, resp.) as compared with the standard anticancer drug gefitinib (IC50s: 17.9, 21.55 and 20.68 M, resp.), and which can be regarded as the best candidate for development of anticancer drugs.

Anti-Cancer Agents in Medicinal Chemistry published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C14H10O4S2, Quality Control of 438565-33-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yong, Jian-Ping published the artcilePotential Anticancer Agents. I. Synthesis of Isoxazole Moiety Containing Quinazoline Derivatives and Preliminarily in vitro Anticancer Activity, Recommanded Product: 3-(2-Chlorophenyl)-5-isoxazolemethanol, the publication is Anti-Cancer Agents in Medicinal Chemistry (2015), 15(1), 131-136, database is CAplus and MEDLINE.

14 New structures of isoxazole-moiety-containing quinazoline derivatives(3a∼3n) were synthesized for the first time and characterized by IR, 1H NMR, 13C NMR, ESI-MS. Subsequently, their in vitro anticancer activity against A549, HCT116 and MCF-7 cell lines was preliminarily evaluated using the MTT method. Among them, most compounds showed good to excellent anticancer activity, especially 3d, 3i, 3k and 3m exhibited the more potent anticancer activity against A549, HCT116 and MCF-7 cell lines, which can be regarded as the promising drug candidates for development of anticancer drugs.

Anti-Cancer Agents in Medicinal Chemistry published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C14H10O4S2, Recommanded Product: 3-(2-Chlorophenyl)-5-isoxazolemethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Xiaokang published the artcileDiscovery of nitazoxanide-based derivatives as autophagy activators for the treatment of Alzheimer’s disease, SDS of cas: 328-90-5, the publication is Acta Pharmaceutica Sinica B (2020), 10(4), 646-666, database is CAplus and MEDLINE.

The efficacy and discovery of new chem. entities, two series of NTZ-based derivatives I [R¹ = H, SMe, SO₂Me, etc.; R² = 2-OH, 3-OH, 4-OH, 2-OAc] and II [R³ = Me, cyclohexyl, 2-MeC₆H₄, etc.] were designed, synthesized and evaluated as autophagy activator against AD. All compounds I and II were screened by the inhibition of phosphorylation of p70S6K, which was the direct substrate of mammalian target of rapamycin (mTOR) and its phosphorylation level could reflect the mTOR-dependent autophagy level. Among these analogs, compound II [R³ = 3-OAc] exhibited excellent potency in promoting β-amyloid (Aβ) clearance, inhibiting tau phosphorylation, as well as stimulating autophagy both in vitro and in vivo. Compound II [R³ = 3-OAc] could effectively improved the memory and cognitive impairments in APP/PS1 transgenic AD model mice. These results demonstrated that II [R³ = 3-OAc] was a potential candidate for the treatment of AD.

Acta Pharmaceutica Sinica B published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, SDS of cas: 328-90-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Wen published the artcileElectrochemically driven cross-electrophile coupling of alkyl halides, Product Details of C15H21BO2, the publication is Nature (London, United Kingdom) (2022), 604(7905), 292-297, database is CAplus and MEDLINE.

Here, electrochem. were used to achieve the differential activation of alkyl halides e.g., 2-(2-bromopropan-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (I) by exploiting their disparate electronic and steric properties. Specifically, the selective cathodic reduction of a more substituted alkyl halide (I) gives rise to a carbanion, which undergoes preferential coupling with a less substituted alkyl halide via bimol. nucleophilic substitution to forge a new carbon-carbon bond. This protocol enables efficient cross-electrophile coupling of a variety of functionalized and unactivated alkyl electrophiles in the absence of a transition metal catalyst, and shows improved chemoselectivity compared with existing methods.

Nature (London, United Kingdom) published new progress about 608534-44-7. 608534-44-7 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic,Boronic acid and ester,Boronate Esters,Boronic Acids,Boronic acid and ester, name is 2-(2,3-Dihydro-1H-inden-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C10H10O2, Product Details of C15H21BO2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Fernandez-Real, Jose-Manuel published the artcileSalicylates increase insulin secretion in healthy obese subjects, HPLC of Formula: 328-90-5, the publication is Journal of Clinical Endocrinology and Metabolism (2008), 93(7), 2523-2530, database is CAplus and MEDLINE.

Context: Conflicting results on the effects of salicylates on glucose tolerance in subjects with normal glucose tolerance or type 2 diabetes have been reported. Objective: The objective of the study was to investigate the effects of a salicylate derivative (triflusal) on insulin sensitivity and insulin secretion. Design, Setting, and Participants: This was a double-blind, randomized, crossover study with three treatment periods corresponding to two dose levels of triflusal and placebo in healthy obese subjects. Main Outcome Measures: Insulin sensitivity and insulin secretion, evaluated through frequently sampled iv glucose tolerance test that was performed after each treatment period, were measured. Insulin secretion was also evaluated in vitro in mice and human islets of Langerhans. Results: The administration of triflusal led to decreased fasting serum glucose concentration in the study subjects. Insulin sensitivity did not significantly change after each treatment period. Insulin secretion, however, significantly increased in a dose-dependent fashion after each triflusal treatment period. The administration of 800 μM of the main triflusal metabolite to whole mice islets of Langerhans led to a sustained increase in intracellular calcium concentration level. This was followed by a significantly increase in insulin secretion. In human islets, 200 μM of 2-hydroxy-4-trifluoromethylbenzoic acid was sufficient to increase insulin release. Conclusions: The administration of a salicylate compound led to lowering of serum glucose concentration We suggest that this effect was mediated through increased insulin secretion induced by salicylate directly on the β-cell.

Journal of Clinical Endocrinology and Metabolism published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, HPLC of Formula: 328-90-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Mondejar-Lopez, Maria published the artcileBiogenic Silver Nanoparticles from Iris tuberosa as Potential Preservative in Cosmetic Products, Related Products of alcohols-buliding-blocks, the publication is Molecules (2021), 26(15), 4696, database is CAplus and MEDLINE.

Biogenic-silver nanoparticles emerge as new nanosilver platforms that allow us to obtain silver nanoparticles via “green chem.”. In our study, biogenic-silver nanoparticles were obtained from Iris tuberosa leaf extract Nanoparticles were characterized by a UV-vis spectroscopy, dynamical light scattering technique. The transmission electron microscope revealed spheric and irregular nanoparticles with 5 to 50 nm in diameter Antimicrobial properties were evaluated against typical microbial contaminants found in cosmetic products, showing high antimicrobial properties. Furthermore, natural moisturizing cream was formulated with biogenic-silver nanoparticles to evaluate the preservative efficiency through a challenge test, indicating its promising use as preservative in cosmetics.

Molecules published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Argemi, Anna published the artcileSpectroscopic and chromatographic characterization of triflusal delivery systems prepared by using supercritical impregnation technologies, Application In Synthesis of 328-90-5, the publication is Journal of Pharmaceutical and Biomedical Analysis (2008), 46(3), 456-462, database is CAplus and MEDLINE.

This study describes the development and evaluation of an anal. method for the characterization of triflusal (2-acetoxy-4-(trifluoromethyl) benzoic acid) dispersed in sustained delivery systems prepared using supercritical fluid impregnation technol. Characterization assays comprised the determination of the percentage of triflusal and its degradation product impregnated in polymeric supports and further monitoring of the releases of the 2 drug components over time in physiol. conditions. Preliminary delivery profiles were monitored spectrophotometrically using a continuous-flow system. In this case, no selective wavelength for discriminating between triflusal and metabolite was found so that measurements at 225 nm provided overall profiles corresponding to the 2 compounds For a more accurate study, a chromatog. method was developed for monitoring the evolution of the concentration of the 2 components independently. Triflusal and metabolite were separated in a C₁₈ column and 25 mM acetic acid/acetate (pH 5.0) + methanol (40/60 volume/volume) mobile phase. Several triflusal-polymer samples were prepared under different exptl. conditions and release features were evaluated. Excellent delivery systems were obtained with poly(methyl)methacrylate beads treated at 40°C and 190 bar for 48 h using supercritical carbon dioxide as a solvent. These samples showed a constant sustained release of drug for several weeks.

Journal of Pharmaceutical and Biomedical Analysis published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Application In Synthesis of 328-90-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts