Tag: M.W=200-250

Fukudome, Chiaki; Takisawa, Rihito; Nakano, Ryohei; Kusano, Miyako; Kobayashi, Makoto; Motoki, Ko; Nishimura, Kazusa; Nakazaki, Tetsuya published the artcile< Analysis of mechanism regulating high total soluble solid content in the parthenocarpic tomato fruit induced by pat-k gene>, Application of C6H10O8, the main research area is parthenocarpic tomato fruit soluble solid patk gene expression.

Total soluble solid (TSS) in tomatoes is an important trait that affects consumer’s preference. Previous studies have observed high TSS content in parthenocarpic tomato fruits induced by a parthenocarpic gene, pat-k. However, the mechanisms regulating high TSS content remain unknown. Hence, we have investigated the water content, metabolites involved with high TSS content, and gene expression related to starch synthesis in tomato fruits to elucidate the mechanism regulating high TSS content. We have found that independent of fruit water content, parthenocarpic fruits induced by pat-k had higher TSS content than pollinated fruits on Pat-k homozygous plants. Addnl., metabolome anal. of mature fruits has revealed that fructose influenced the difference in TSS content between pollinated fruits on Pat-k homozygous plants and the parthenocarpic fruits on pat-k homozygous plants. Furthermore, high performance liquid chromatog. (HPLC) anal. showed that not only fructose contents but also glucose contents were higher in the parthenocarpic fruits on pat-k homozygous plants than pollinated fruits on Pat-k homozygous plants, suggesting that increases in these sugar contents influenced the high TSS content in the pat-k-induced parthenocarpic fruits. We also have found that parthenocarpic fruits had high starch content and upregulated Sus4, which is involved in starch synthesis, during the early stages of fruit development. Since previous reports have suggested that high starch content during the early stages of fruit development attributed to high sugar content in mature tomato fruits, our results suggest that high accumulation of starch in young fruits could be involved with high TSS content in parthenocarpic fruits induced by pat-k.

Scientia Horticulturae (Amsterdam, Netherlands) published new progress about Anthesis. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Application of C6H10O8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Huang, Kang; Wang, Yuegang; Bai, Yang; Luo, Qiuyan; Lin, xuancai; Yang, Qiuyu; Wang, Shihao; Xin, hongjie published the artcile< Gut microbiota and metabolites in atrial fibrillation patients and their changes after catheter ablation>, Category: alcohols-buliding-blocks, the main research area is microbiota metabolite catheter ablation human atrial fibrillation; atrial fibrillation; gut metabolites; gut microbiota.

The gut microbiota has been shown to be associated with multiple cardiovascular diseases, but there is little research on the gut microbiota and atrial fibrillation (AF); thus, how the gut microbiota and metabolites change in AF patients after catheter ablation is unclear. In this study, we used 16S rRNA high-throughput sequencing and nontargeted metabolomic detection to conduct horizontal and longitudinal analyses of the gut microbiota and metabolites of AF patients. Compared with a control group, species richness and diversity increased significantly in AF patients. Among them, opportunistic pathogenic bacteria, such as Klebsiella, Haemophilus,Streptococcus, and Enterococcus, were significantly increased, and symbiotic bacteria, such as Agathobacter and Butyrivibrio, were significantly reduced. After catheter ablation, intestinal symbiotic bacteria (Lactobacillus, Agathobacter, Lachnospira, etc.) were increased in most AF patients, while pathogenic bacteria (Ruminococcus, etc.) were reduced. Moreover, in AF patients, caffeine, which was neg. correlated with Klebsiella, was downregulated, and estradiol and ascorbic acid, which were pos. correlated with Agathobacter, were also downregulated. After catheter ablation, citrulline, which was pos. correlated with Ralstonia and Lactobacillus, was increased. Oleanolic acid, which was neg. correlated with Ralstonia was downregulated. In conclusion, our results not only show overall changes in the gut microbiota and metabolites in AF patients but also indicate their changes in the short term after catheter ablation. These data will provide novel possibilities for the future clin. diagnosis and treatment of AF.

Microbiology Spectrum published new progress about Ablation (catheter). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Machado, Noelia D.; Fernandez, Mariana A.; Diaz, David Diaz published the artcile< Recent Strategies in Resveratrol Delivery Systems>, Electric Literature of 501-36-0 , the main research area is review resveratrol delivery system photostability; drug delivery systems; encapsulation; nutrition; pharmaceutics; resveratrol.

A review. Resveratrol, a natural polyphenolic stilbenoid widely found in grapes and wines, displays beneficial properties such as cardio-protective, antioxidant and anti-inflammatory activities. Trans-resveratrol (RSV) is the most bioactive and more abundant stereoisomer found in nature. Despite the pos. properties of RSV, there are various factors that limit its effectiveness, including low aqueous solubility, low oral bioavailability and chem. instability. During the last years, an increasing number of strategies such as nano and micro encapsulation have been developed in order to overcome these limitations and enhance the use of RSV in nutritional and pharmaceutical applications. This Review summarizes the advances and main properties of several RSV carriers and delivery systems reported during the last 5 years.

ChemPlusChem published new progress about Anti-inflammatory agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Electric Literature of 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fraga, Cesar G.; Croft, Kevin D.; Kennedy, David O.; Tomas-Barberan, Francisco A. published the artcile< The effects of polyphenols and other bioactives on human health>, Product Details of C14H12O3, the main research area is review polyphenols quercetin cerebral blood flow.

A review. Although deficiencies in polyphenol intake do not result in specific deficiency diseases, adequate intake of polyphenols could confer health benefits, especially with regard to chronic diseases. Tea, cocoa, fruits, and berries, as well as vegetables, are rich in polyphenols. Flavan-3-ols from cocoa have been found to be associated with a reduced risk of stroke, myocardial infarction, and diabetes, as well as improvements in lipids, endothelial-dependent blood flow and blood pressure, insulin resistance, and systemic inflammation. The flavonoid quercetin and the stilbene resveratrol have also been associated with cardiometabolic health. Although polyphenols have been associated with improved cerebral blood flow, evidence of an impact on cognition is more limited. The ability of dietary polyphenols to produce clin. effects may be due, at least in part, to a bi-directional relationship with the gut microbiota. Polyphenols can impact the composition of the gut microbiota (which are independently associated with health benefits), and gut bacteria metabolize polyphenols into bioactive compounds that produce clin. benefits. Another critical interaction is that of polyphenols with other phytochems., which could be relevant to interpreting the health parameter effects of polyphenols assayed as purified extracts, whole foods, or whole food extracts

Food & Function published new progress about Blood pressure Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Product Details of C14H12O3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Simental-Mendia, Luis E.; Guerrero-Romero, Fernando published the artcile< Effect of resveratrol supplementation on lipid profile in subjects with dyslipidemia: A randomized double-blind, placebo-controlled trial>, Synthetic Route of 501-36-0, the main research area is dyslipidemia lipid lowering agent resveratrol; Dyslipidemia; Lipid profile; Lipids; Randomized controlled trial; Resveratrol.

Objectives: The aim of this study was to explore the effect of resveratrol supplementation on lipid profile in individuals with dyslipidemia. Methods: Apparently healthy men and non-pregnant women 20 to 65 y of age with new diagnosis of dyslipidemia were enrolled in a randomized double-blind, placebo-controlled trial and randomly allocated to receive either resveratrol 100mg/d or placebo (sucrose 0.5 g/d) for 2 mo. Smoking, alc. intake, diabetes, acute or chronic renal or hepatic diseases, malignancy, cardiovascular disease, serum triacylglycerol levels ≥400mg/dL, low-d. lipoprotein cholesterol levels ≥190mg/dL, and consumption of lipid-lowering drugs or supplements containing resveratrol were exclusion criteria. Results: Seventy-one individuals with new diagnosis of dyslipidemia were enrolled and randomly allocated to the resveratrol (n = 35) or placebo groups (n = 36). At baseline, there were no significant differences between the study groups. After intervention period, individuals in the resveratrol group showed a significant decrease in total cholesterol (201.4 ± 34.4 vs. 220.6 ± 37.4, P = 0.04) and triacylglycerol (133.4 ± 55.3 vs. 166.7 ± 68.5, P = 0.04) concentrations compared with the placebo group, without significant statistical differences for high-d. lipoprotein cholesterol and low-d. lipoprotein cholesterol levels. Conclusion: The results suggest that resveratrol supplementation significantly reduces total cholesterol and triacylglycerol concentrations in individuals with dyslipidemia.

Nutrition (New York, NY, United States) published new progress about Dyslipidemia. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Synthetic Route of 501-36-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pourhanifeh, Mohammad H.; Shafabakhsh, Rana; Reiter, Russel J.; Asemi, Zatollah published the artcile< The Effect of Resveratrol on Neurodegenerative Disorders: Possible Protective Actions Against Autophagy, Apoptosis, Inflammation and Oxidative Stress>, HPLC of Formula: 501-36-0, the main research area is review resveratrol neurodegenerative disorder autophagy apoptosis inflammation oxidative stress; Parkinson’s disease; Resveratrol; apoptosis; autophagy; inflammation; oxidative stress..

A review. The prevalence of neurodegenerative disorders characterized by the loss of neuronal function is rapidly increasing. The pathogenesis of the majority of these diseases is not entirely clear, but current evidence has shown the possibility that autophagy, apoptosis, inflammation and oxidative stress are involved. The present review summarizes the therapeutic effects of resveratrol on neurodegenerative disorders, based on the especially mol. biol. of these diseases. The PubMed, Cochrane, Web of Science and Scopus databases were searched for studies published in English until March 30th, 2019 that contained data for the role of inflammation, oxidative stress, angiogenesis and apoptosis in the neurodegenerative disorders. There are also studies documenting the role of mol. processes in the progression of central nervous system diseases. Based on current evidence, resveratrol has potential properties that may reduce cell damage due to inflammation. This polyphenol affects cellular processes, including autophagy and the apoptosis cascade under stressful conditions. Current evidence supports the beneficial effects of resveratrol on the therapy of neurodegenerative disorders.

Current Pharmaceutical Design published new progress about Alzheimer disease. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, HPLC of Formula: 501-36-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

De Amicis, Francesca; Chimento, Adele; Montalto, Francesca Ida; Casaburi, Ivan; Sirianni, Rosa; Pezzi, Vincenzo published the artcile< Steroid receptor signallings as targets for resveratrol actions in breast and prostate cancer>, Category: alcohols-buliding-blocks, the main research area is review resveratrol anticancer agent signal transduction breast prostate cancer; Resveratrol; androgen receptor; breast cancer; oestrogen receptor; prostate cancer.

A review. Extensive research over the past 25 years in hormone-dependent cancers, such as breast cancer and prostate cancer, has identified the mol. mechanisms driven by steroid receptors, elucidating the interplay between genomic and non-genomic steroid receptors mechanism of action. Altogether, these mechanisms create the specific gene expression programs that contribute to endocrine therapy resistance and cancer progression. These findings, on the bidirectional mol. crosstalk between steroid and growth factor receptors pathways in endocrine resistance, suggest the use of multi-target inhibitors together with endocrine therapies, for treating resistant disease. In this review we will discuss the novel understanding on the chemopreventive and anti-cancer activities of Resveratrol (3,5,4′-trihydroxy-stilbene) (RSV), a phytoalexin found in grapes acting on a plethora of targets. We will highlight Resveratrol effect on steroid receptors signalling and its potential use in the treatment of hormone-dependent cancer. Understanding the mol. mechanisms by which the bioactive compound influences cancer cell behavior, by interfering with steroid receptors functional activity, will help to advance the design of combination strategies to increase the rate of complete and durable clin. response in patients.

International Journal of Molecular Sciences published new progress about Androgen receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rodighiero, S.; De Simoni, A.; Formenti, A. published the artcile< The voltage-dependent nonselective cation current in human red blood cells studied by means of whole-cell and nystatin-perforated patch-clamp techniques>, Synthetic Route of 35564-86-4, the main research area is cation current erythrocyte cell nystatin perforated patch clamp.

Human red blood cells (RBC) can be studied by means of whole-cell and nystatin-perforated patch-clamp techniques. In 85% of the whole-cell experiments (n=86) and 69% of the perforated-patch recordings (n=13), steps to pos. potentials, from a holding potential of 0 mV, induced a slow-activating non-inactivating persistent outward current which reverted at about 0 mV. The current activation phase fitted well with a two-component exponential curve. Half-maximal conductance was reached at about 42 mV. Na+ and K+ carried this current, which was not affected by 20 nM charybdotoxin or 20 mM TEA, but was reduced following a partial substitution of extracellular Cl- by tartrate. This current has characteristics similar to the single-channel currents already described in RBC and may be involved in the rapid adaptations of these cells in the circulation.

Biochimica et Biophysica Acta, Biomembranes published new progress about Bioelectric conductivity. 35564-86-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H18ClNO5, Synthetic Route of 35564-86-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ivanovic, Stefan; Mandrone, Manuela; Simic, Katarina; Ristic, Mirjana; Todosijevic, Marina; Mandic, Boris; Godevac, Dejan published the artcile< GC-MS-based metabolomics for the detection of adulteration in oregano samples>, Computed Properties of 87-73-0, the main research area is GCMS metabolomic detection adulteration oregano sample.

Oregano is one of the most used culinary herb and it is often adulterated with cheaper plants. In this study, GC-MS was used for identification and quantification of metabolites from 104 samples of oregano (Origanum vul-gare and O. onites) adulterated with olive (Olea europaea), venetian sumac (Cotinus coggygria) and myrtle (Myrtus communis) leaves, at five different concentration levels. The metabolomics profiles obtained after the two-step derivatization, involving methoxyamination and silanization, were subjected to multivariate data anal. to reveal markers of adulteration and to build the regression models on the basis of the oregano-to-adulterants mixing ratio. Orthogonal partial least squares enabled detection of oregano adulterations with olive, Venetian sumac and myrtle leaves. Sorbitol levels distinguished oregano samples adulterated with olive leaves, while shikimic and quinic acids were recognized as discrimination factor for adulteration of oregano with venetian sumac. Fructose and quinic acid levels correlated with oregano adulteration with myrtle. Orthogonal partial least squares discriminant anal. enabled dis-crimination of O. vulgare and O. onites samples, where catechollactate was found to be discriminating metabolite.

Journal of the Serbian Chemical Society published new progress about Adulterants. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Computed Properties of 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yongpisanphop, J. published the artcile< Searching for a plant species having a potent bioherbicide using in silico approach>, SDS of cas: 87-73-0, the main research area is Medicago bioherbicide L2 Aminoadipate aldisine weed control.

Toxic herbicide residue in the environment is one of the most important problems in the world, especially in the agricultural country. To solve this problem, an effectively new bioherbicide needs to be discovered urgently. This motivated to search the novel bioherbicide. In silico technique has been accepted as a promising tool to discover new active compounds Based on 2D structural similarity, 18 new natural compounds were obtained from the KNApSAcK database. Among the structural leads, 12 natural phyto-compounds were selected to calculate the lowest free energy of binding value using mol. docking. Comp_7 and Comp_10 showed the lowest free energy of binding -7.84 and -7.43 kcal/mol resp. which were similar to glyphosate (-8.49 kcal/mol). Based on the binding interaction using ProteinsPlus program, a natural phyto-compound (Comp_7: L-2-Aminoadipate) was identified as a potential bioherbicide. It could be found in Medicago sativa L. Significantly, this procedure becomes a high powerful tool to increase the probability to discover the new potent bioherbicide and identify the plant host species for weed control. Moreover, M. sativa should be extracted to test the property of weed control for further study.

Research Journal of Chemistry and Environment published new progress about Alfalfa. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, SDS of cas: 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts