Tag: M.W=200-250

Nakayama, Yumiko published the artcileEffect of whitening gel containing vitamins on skin conditions, Related Products of alcohols-buliding-blocks, the publication is Igaku to Yakugaku (2016), 73(7), 899-904, database is CAplus.

This paper presents exptl. results for the effect of whitening gel containing vitamins on skin conditions. A weighed amount of raw materials to obtain the whitening gel containing vitamins. Performing clin. test by evaluating melanin content, brightness, skin wrinkles, skin conditions, statistical anal., and adverse effects. A result which observed from the clin. anal. with improved safety, melanin content and skin brightness, capable of removing wrinkles on the corner of eyes, spots, and dullness, and avoiding toxic side effects.

Igaku to Yakugaku published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Tengfei published the artcilePhotoelectrochemical Decomposition of Lignin Model Compound on a BiVO₄ Photoanode, Formula: C15H16O3, the publication is ChemSusChem (2020), 13(14), 3622-3626, database is CAplus and MEDLINE.

The photoelectrochem. decomposition of lignin model compounds at a BiVO₄ photoanode is demonstrated with simulated sunlight and an applied bias of 2.0 V. These prototypical lignin model compounds are photoelectrochem. converted into the corresponding aryl aldehyde and phenol derivatives in a single step with conversion of up to ≈64% over 20 h. Control experiments suggest that vanadium sites are electrocatalytically active, which precludes the need for a redox mediator in solution This feature of the system is corroborated by a layer of V₂O₅ deposited on BiVO₄ serving to boost the conversion by 10%. Our methodol. capitalizes on the reactive power of sunlight to drive reactions that have only been studied previously by electrochem. or catalytic methods. The use of a BiVO₄ photoanode to drive lignin model decomposition therefore provides a new platform to extract valuable aromatic chem. feedstocks using solar energy, electricity and biomass as the only inputs.

ChemSusChem published new progress about 70110-65-5. 70110-65-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Alcohol,Ether,Benzene Compounds, name is 2-Phenoxy-1-phenylpropane-1,3-diol, and the molecular formula is C15H16O3, Formula: C15H16O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhou, Xiaoyuan published the artcileLignol Cleavage by Pd/C Under Mild Conditions and Without Hydrogen: A Role for Benzylic CH Activation?, COA of Formula: C15H16O3, the publication is ChemSusChem (2014), 7(6), 1623-1626, database is CAplus and MEDLINE.

The cleavage of CO bonds in lignin model compounds without hydrogen was developed using the com. available Pd/C. Hydrogen donor solvents are helpful for this reaction through transfer hydrogenation, but not necessary. A redox neutral process that utilizes the internal hydrogen source for the cleavage is also possible. An initial mechanistic study indicates that the β-benzylic-H atom in the substrate plays a critical role and that the present system undergoes a process different from previous reports.

ChemSusChem published new progress about 70110-65-5. 70110-65-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Alcohol,Ether,Benzene Compounds, name is 2-Phenoxy-1-phenylpropane-1,3-diol, and the molecular formula is C24H20Ge, COA of Formula: C15H16O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Nunez-Delicado, Estrella published the artcileHydroperoxidase Activity of Lipoxygenase in the Presence of Cyclodextrins, Application of 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol, the publication is Archives of Biochemistry and Biophysics (1999), 367(2), 274-280, database is CAplus and MEDLINE.

The oxidation of xenobiotics by the hydroperoxidase activity of lipoxygenase in the presence of cyclodextrins was studied. These produced an inhibitory effect on xenobiotics oxidation, based on their degree of hydrophobicity and the charge (isoproterenol < 4-methyl-catechol (4MC) < 4-tert-butylcatechol (TBC) < 4-tert-octylcatechol (TOC)). This inhibitory effect was due to the complexation of xenobiotics in the hydrophobic cavity of cyclodextrins. The complexation constant K_c was calculated by nonlinear regression of the inhibition curves obtained in the presence of cyclodextrins, and the values obtained were 400, 16,250, and 35,127 M^-1 for 4MC, TBC, and TOC, resp. The validity of these values was checked at different points of the Michaelis-Menten saturation curve, and a sigmoidal inhibition curve was obtained at the saturating concentration of the o-diphenol, TBC, with no change in the K_c value. This demonstrates the validity of the equations used to calculate K_c for the complete range of the Michaelis-Menten equation. (c) 1999 Academic Press.

Archives of Biochemistry and Biophysics published new progress about 1139-46-4. 1139-46-4 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol, and the molecular formula is C14H22O2, Application of 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hagen, Helen published the artcileAminoferrocene-Based Prodrugs Activated by Reactive Oxygen Species, COA of Formula: C14H21BO3, the publication is Journal of Medicinal Chemistry (2012), 55(2), 924-934, database is CAplus and MEDLINE.

Cancer cells generally generate higher amounts of reactive oxygen species than normal cells. On the basis of this difference, prodrugs have been developed (e.g., hydroxyferrocifen), which remain inactive in normal cells, but become activated in cancer cells. In this work we describe novel aminoferrocene-based prodrugs, which, in contrast to hydroxyferrocifen, after activation form not only quinone methides (QMs), but also catalysts (iron or ferrocenium ions). The released products act in a concerted fashion. In particular, QMs alkylate glutathione, thereby inhibiting the antioxidative system of the cell, whereas the iron species induce catalytic generation of hydroxyl radicals. Since the catalysts are formed as products of the activation reaction, it proceeds autocatalytically. The most potent prodrug described here is toxic toward cancer cells (human promyelocytic leukemia (HL-60), IC₅₀ = 9 μM, and human glioblastoma-astrocytoma (U373), IC₅₀ = 25 μM), but not toxic (up to 100 μM) toward representative nonmalignant cells (fibroblasts).

Journal of Medicinal Chemistry published new progress about 1370732-71-0. 1370732-71-0 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester, name is (3-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol, and the molecular formula is C14H21BO3, COA of Formula: C14H21BO3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Speckmeier, Elisabeth published the artcileART – An Amino Radical Transfer Strategy for C(sp²)-C(sp³) Coupling Reactions, Enabled by Dual Photo/Nickel Catalysis, Application of 2-(2,3-Dihydro-1H-inden-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, the publication is Journal of the American Chemical Society (2022), 144(22), 9997-10005, database is CAplus and MEDLINE.

Introducing the novel concept of amino radical transfer (ART) enabled the use of easily accessible and com. available alkyl boronic esters as cross coupling partners for aryl halides in dual photoredox/nickel catalysis mediated by visible light. Activation of otherwise photochem. innocent boronic esters by radicals generated from primary or secondary alkylamines gaves rise to an outstanding functional group tolerance in a mild, fast and air stable reaction. As shown in more than 50 examples including unprotected alcs., amines and carboxylic acids, ArR [Ar = 4-MeOC₆H₄, 4-MeC(O)HNC₆H₄, 3-pyridyl, etc.; R = cyclohexyl, 1-tert-butoxycarbonyl-4-piperidyl, Bn, etc.] this reaction allowed to quickly build up relevant scaffolds for organic synthesis and medicinal chem. In comparison with existing methods for C(sp²)-C(sp³) couplings an extraordinary generality could be realized via the ART concept, employing a single set of optimized reaction conditions. Due to its selectivity, the transformation could also be used for late-stage functionalization, as demonstrated with three exemplary syntheses of drug mols. Furthermore, the successful one-to-one scalability of this reaction up to gram scale without the necessity of any further precautions or flow systems was demonstrated.

Journal of the American Chemical Society published new progress about 608534-44-7. 608534-44-7 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic,Boronic acid and ester,Boronate Esters,Boronic Acids,Boronic acid and ester, name is 2-(2,3-Dihydro-1H-inden-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C18H10F3NO3S2, Application of 2-(2,3-Dihydro-1H-inden-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Brand, N. published the artcilePrimary mechanism in the degradation of 4-octylphenol photoinduced by Fe(III) in water-acetonitrile solution, Name: 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol, the publication is Journal of Photochemistry and Photobiology, A: Chemistry (2000), 135(2-3), 221-228, database is CAplus.

The degradation of 4-octylphenol (4-OP), a toxic and persistent product in the environment, photoinduced by Fe(III) was studied in water/acetonitrile solution (95/5 by volume). The initial rate of 4-OP degradation depends on the irradiation wavelength and on the initial concentration of Fe(OH)²⁺, the monomeric species present in our exptl. conditions. Several photoproducts were identified among them 4-(1,1,3,3-tetramethylbutyl)pyrocatechol. The formation of octylphenoxyl radical was observed by fast kinetics as a result of the quenching reaction between Fe(III) species in the excited state and 4-OP. For longer irradiation times, regeneration of the monomeric species, Fe(OH)²⁺, is suggested due to Fe(II) reoxidation by radicals.

Journal of Photochemistry and Photobiology, A: Chemistry published new progress about 1139-46-4. 1139-46-4 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol, and the molecular formula is C14H22O2, Name: 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yang, Xingye published the artcileOptical Control of CRAC Channels Using Photoswitchable Azopyrazoles, Computed Properties of 328-90-5, the publication is Journal of the American Chemical Society (2020), 142(20), 9460-9470, database is CAplus and MEDLINE.

The Ca²⁺ release-activated Ca²⁺ (CRAC) channels control many Ca²⁺-modulated physiol. processes in mammals. Hyperactivating CRAC channels are known to cause several human diseases, including Stormorken syndrome. Here, we show the design of azopyrazole-derived photoswitchable CRAC channel inhibitors (designated piCRACs), which enable optical inhibition of store-operated Ca²⁺ influx and downstream signaling. Moreover, piCRAC-1 has been applied in vivo to alleviate thrombocytopenia and hemorrhage in a zebrafish model of Stormorken syndrome in a light-dependent manner.

Journal of the American Chemical Society published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C26H45N5O7Si2, Computed Properties of 328-90-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cui, Tingting published the artcileAtomically Dispersed Pt-N₃C₁ Sites Enabling Efficient and Selective Electrocatalytic C-C Bond Cleavage in Lignin Models under Ambient Conditions, Product Details of C15H16O3, the publication is Journal of the American Chemical Society (2021), 143(25), 9429-9439, database is CAplus and MEDLINE.

Selective cleavage of C-C linkages is the key and a challenge for lignin degradation to harvest value-added aromatic compounds To this end, electrocatalytic oxidation presents a promising technique by virtue of mild reaction conditions and strong sustainability. However, the existing electrocatalysts (traditional bulk metal and metal oxides) for C-C bond oxidative cleavage suffer from poor selectivity and low product yields. We show for the first time that atomically dispersed Pt-N₃C₁ sites planted on nitrogen-doped carbon nanotubes (Pt₁/N-CNTs), constructed via a stepwise polymerization-carbonization-electrostatic adsorption strategy, are highly active and selective toward C_α-C_β bond cleavage in β-O-4 model compounds under ambient conditions. Pt₁/N-CNTs exhibits 99% substrate conversion with 81% yield of benzaldehyde, which is exceptional and unprecedented compared with previously reported electrocatalysts. Moreover, Pt₁/N-CNTs using only 0.41 weight % Pt achieved a much higher benzaldehyde yield than those of the state-of-the-art bulk Pt electrode (100 weight % Pt) and com. Pt/C catalyst (20 weight % Pt). Systematic exptl. investigation together with d. functional theory (DFT) calculation suggests that the superior performance of Pt₁/N-CNTs arises from the atomically dispersed Pt-N₃C₁ sites facilitating the formation of a key C_β radical intermediate, further inducing a radical/radical cross-coupling path to break the C_α-C_β bond. This work opens up opportunities in lignin valorization via a green and sustainable electrochem. route with ultralow noble metal usage.

Journal of the American Chemical Society published new progress about 70110-65-5. 70110-65-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Alcohol,Ether,Benzene Compounds, name is 2-Phenoxy-1-phenylpropane-1,3-diol, and the molecular formula is C15H16O3, Product Details of C15H16O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gupta, Sharad published the artcileSynthesis of structurally diverse bis-peptide oligomers, Category: alcohols-buliding-blocks, the publication is Journal of Organic Chemistry (2006), 71(23), 8691-8695, database is CAplus and MEDLINE.

The authors have developed second-generation monomers I (n = 1, 2) and improved conditions for rapidly and simultaneously closing multiple diketopiperazines on solid support. These new conditions involve either the microwave heating of a suspension of solid-supported amino-tetrafluoropropyl esters in acetic acid/triethylamine catalyst solution or continuous flow of catalyst solution through the resin, heated in a flow cell apparatus The authors demonstrate that monomers I and II can be combined with the new conditions easily to synthesize previously inaccessible hetero and homo spiro ladder oligomers III and IV.

Journal of Organic Chemistry published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts