Tag: M.W=200-250

Hou, Chih-Yao; Tain, You-Lin; Yu, Hong-Ren; Huang, Li-Tung published the artcile< The effects of resveratrol in the treatment of metabolic syndrome>, Electric Literature of 501-36-0, the main research area is resveratrol metabolic syndrome review; high-fat diet; metabolic syndrome; resveratrol; resveratrol derivatives.

A review. Resveratrol, also known as 3,5,4′-trihydroxystilbene, is a natural polyphenol that occurs as a phytoalexin. It is produced by plant sources such as grapes, apples, blueberries, plums, peanuts, and other oilseeds. This compound has a variety of effects on human health and diseases. This review summarizes the mounting evidence that resveratrol is helpful in treating metabolic syndrome and related disorders. Resveratrol can be provided either early as a reprogramming agent or later as part of treatment. A few of the main mechanisms underlying the beneficial effects of resveratrol on metabolic syndrome are outlined. This review also discusses the potential of resveratrol derivatives as a complementary or alternative medicine. In conclusion, resveratrol could be a useful regimen for the prevention and treatment of metabolic syndrome and its related conditions.

International Journal of Molecular Sciences published new progress about Cardiovascular disease. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Electric Literature of 501-36-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Haykal, Tony; Younes, Maria; El Khoury, Marianne; Ammoury, Carl; Tannous, Stephanie; Hodroj, Mohammad H.; Sarkis, Rita; Gasilova, Natalia; Menin, Laure; Rizk, Sandra published the artcile< The pro-apoptotic properties of a phytonutrient rich infusion of A. cherimola leaf extract on AML cells>, COA of Formula: C6H10O8, the main research area is Annona cherimola leaf extract proapoptotic phytonutrient acute myeloid leukemia; Acute Myeloid Leukemia; Annona cherimola tea infusion; Anti-oxidant; Apoptosis; Phytochemicals.

Annonaceae family has broad uses in herbal medicine for treatment of several diseases, whether through seeds′ or leaves′ extracts The present study investigates the antiproliferative and antitumor activity of Annona cherimola aqueous leaf (AAL) extract/infusion in acute myeloid leukemia (AML) cell lines in vitro. High-resolution LC-MS was first used to analyze the composition of the aqueous extract Cell proliferation assay, Annexin V staining, cell cycle anal., dual Annexin V/PI staining, cell death quantification by ELISA, ROS level detection and Western Blotting were then performed to elucidate the therapeutic effects of AAL extract The results obtained revealed a potent antioxidant activity of AAL extract Moreover, the extract exhibited dose- and time-dependent antiproliferative effects on AML cell lines by decreasing cell viability with an IC50 of 5.03% (volume/volume) at 24 h of treatment of KG-1 cells. This decrease in viability was accompanied with a significant increase in apoptotic cell death with cell cycle arrest and flipping of the phosphatidylserine from the inner to the outer leaflet of the cell membrane. The resp. overexpression and downregulation of proapoptotic proteins like cleaved caspase-8, cleaved PARP-1 and Bax and antiapoptotic proteins like Bcl-2 further validated the apoptotic pathway induced by AAL on AML cells. Finally, LC-MS revealed the presence of several compounds like fatty acids, terpenes, phenolics, cinnamic acids and flavonoids that could contribute to the antioxidant and anti-cancer effects of this herbal infusion. In addition to the generally known nutritional effects of the Annona cherimola fruit and leaves, the presented data validates the antioxidant and anti-cancerous effects of the leaf infusion on AML cell lines, proposing its potential therapeutic use against acute myeloid leukemia with future in vivo and clin. trials.

Biomedicine & Pharmacotherapy published new progress about Acute myeloid leukemia (cell lines). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, COA of Formula: C6H10O8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Erban, Alexander; Fehrle, Ines; Martinez-Seidel, Federico; Brigante, Federico; Mas, Agustin Lucini; Baroni, Veronica; Wunderlin, Daniel; Kopka, Joachim published the artcile< Discovery of food identity markers by metabolomics and machine learning technology>, Electric Literature of 87-73-0, the main research area is Salvia Linum Sesamum food processing marker metabolomics.

Verification of food authenticity establishes consumer trust in food ingredients and components of processed food. Next to genetic or protein markers, chems. are unique identifiers of food components. Non-targeted metabolomics is ideally suited to screen food markers when coupled to efficient data anal. This study explored feasibility of random forest (RF) machine learning, specifically its inherent feature extraction for non-targeted metabolic marker discovery. The distinction of chia, linseed, and sesame that have gained attention as “”superfoods”” served as test case. Chem. fractions of non-processed seeds and of wheat cookies with seed ingredients were profiled. RF technol. classified original seeds unambiguously but appeared overdesigned for material with unique secondary metabolites, like sesamol or rosmarinic acid in the Lamiaceae, chia. Most unique metabolites were diluted or lost during cookie production but RF technol. classified the presence of the seed ingredients in cookies with 6.7% overall error and revealed food processing markers, like 4-hydroxybenzaldehyde for chia and succinic acid monomethylester for linseed additions RF based feature extraction was adequate for difficult classifications but marker selection should not be without human supervision. Combination with alternative data anal. technologies is advised and further testing of a wide range of seeds and food processing methods.

Scientific Reports published new progress about Flax. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Electric Literature of 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yang, Minghui; Wei, Jinli; Huang, Ting; Lei, Luping; Shen, Chenguang; Lai, Jinzhi; Yang, Min; Liu, Lei; Yang, Yang; Liu, Guoshi; Liu, Yingxia published the artcile< Resveratrol inhibits the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in cultured Vero cells>, Synthetic Route of 501-36-0 , the main research area is resveratrol inhibition cultured Vero cell SARS CoV replication.

Resveratrol (3,4,5-trihydroxy-trans-stilbene, RES) is a phenolic compound produced by various members of spermatophytes such as grapes, mulberry, and peanuts. RES exhibits capacity to inhibit SARS-CoV-2 infection in the in-vitro cell culture. The results suggest a potential utility of RES as a novel therapy for COVID-19 infection.

Phytotherapy Research published new progress about Arachis hypogaea. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Synthetic Route of 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lasser, Elliott C.; Walters, Alton; Reuter, Stewart R.; Lang, Joseph published the artcile< Histamine release by contrast media>, HPLC of Formula: 35564-86-4, the main research area is histamine release contrast media; methylglucamines contrast media allergy.

Close arterial injections of x-ray contrast media into dogs increased plasma histamine (I) [51-45-6] levels in blood draining the liver or lungs. I levels were increased by injections of methylglucamine acetrizoate [22154-43-4], methylglucamine diatrizoate [131-49-7], or methylglucamine iodipamide [3521-84-4]. The Na salts of the contrast media showed much less histamine-releasing activity than the methylglucamine salts. Methylglucamine chloride [6284-40-8] also elevated plasma I. It is suggested that some allergic reactions to contrast media are mediated by I release.

Radiology (Oak Brook, IL, United States) published new progress about Allergy. 35564-86-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H18ClNO5, HPLC of Formula: 35564-86-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Alrafas, Haider Rasheed; Busbee, Philip B.; Nagarkatti, Mitzi; Nagarkatti, Prakash S. published the artcile< Resveratrol modulates the gut microbiota to prevent murine colitis development through induction of Tregs and suppression of Th17 cells>, Application of C14H12O3, the main research area is resveratrol regulatory T cell immune response gut microbiota colitis; 2,4,6-trinitrobenzenesulfonic acid; T helper cells; butyrate; fecal transfer; inflammation; short-chain fatty acid.

In the current study, we investigated if resveratrol, a polyphenol found in a variety of foods and beverages, would reverse microbial dysbiosis induced during colitis. Administration of resveratrol attenuated colonic inflammation and clin. symptoms in the murine model of 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis. Resveratrol treatment in mice with colitis led to an increase in CD4+FOXP3+ and CD4+IL-10+ T cells, and a decrease in CD4+IFN-γ+ and CD4+IL-17+ T cells. Anal. of cecal flush revealed that TNBS administration led to an increase in species such as Bacteroides acidifaciens, but decrease in species such as Ruminococcus gnavus and Akkermansia mucinphilia, as well as a decrease in SCFA i-butyric acid. Fecal transfer experiments confirmed the protective role of resveratrol-induced microbiota against colitis inasmuch as such recipient mice were more resistant to TNBS-colitis and exhibited polarization toward CD4+FOXP3+ T cells and decreases in CD4+IFN-γ+ and CD4+IL-17+ T cells. Collectively, these data demonstrate that resveratrol-mediated attenuation of colitis results from reversal of microbial dysbiosis induced during colitis and such microbiota protect the host from colonic inflammation by inducing Tregs while suppressing inflammatory Th1/Th17 cells.

Journal of Leukocyte Biology published new progress about 16S rRNA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Application of C14H12O3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cai, Zhiquan; Xie, Tao; Xu, Jin published the artcile< Source-sink manipulations differentially affect carbon and nitrogen dynamics, fruit metabolites and yield of Sacha Inchi plants>, Electric Literature of 87-73-0, the main research area is carbon source sink manipulation defoliation seed yield fruit Plukenetia; Fruitlet metabolites; Growth; Physiological traits; Plukenetia volubilis; Reproductive trait; Source–sink regulations.

Being a promising tropical woody oilseed crop, the evergreen and recurrent plants of Sacha Inchi (Plukenetia volubilis L.) has complex phenol. and source-sink interactions. Carbon source-sink manipulations with control and two treatments (reduce source, ca. 10% mature leaf pruning; reduce sink, 10% fruitlet thinning) were conducted on 2.5-yr-old field-grown P. volubilis plantation during the early-wet season in a seasonal tropical area. Leaf photosynthetic rate and specific leaf area largely remained unchanged in response to defoliation or defloration. Compared with control, higher N contents on average were observed in both remaining leaves and branches of the defoliated plants, suggesting that N-mobilization was mainly due to the enhanced N uptake from soil. Carbon, but not N, is a source-driven growth process of P. volubilis plants, as defoliation reduced the contents of non-structural carbohydrates (especially sugar) in branches, although temporally, whereas defloration increased available C reserve. The seasonal dynamic pattern of fruit ripening was altered by source-sink regulations. Total seed yield throughout the growing season, which depends on fruit set and retention (i.e., number of matured fruit) rather than individual fruit development (size), was slightly increased by defloration but was significantly decreased by defoliation. Compared with control, defloration did not enrich the KEGG pathway, but defoliation downregulated the TCA cycle and carbohydrate and lipid metabolisms in fruitlets after 24 days of the applications of source-sink manipulation. Carbohydrate reserves serve to buffer sink-source imbalances that may result from temporary adjustment in demand for assimilates (e.g., defloration) or shortfalls in carbon assimilation (e.g., defoliation). Defoliation is disadvantageous for the yield and also for carbohydrate and lipid accumulation in fruits of P. volubilis plants. Although more studies are needed, these results provide new insights to the further improvement in seed yield of the strong source-limited P. volubilis plants by source/sink manipulations.

BMC Plant Biology published new progress about Bioaccumulation. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Electric Literature of 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lasser, Elliott C.; Walters, Alton J.; Lang, Joseph H. published the artcile< Experimenatal basis for histamine release in contrast material reactions>, Application of C7H18ClNO5, the main research area is contrast media histamine release; methylglucamine histamine release.

Perfusion of the canine liver or lung with methylglucamine contrast media or with methylglucamine chloride [35564-86-4] increased plasma histamine [51-45-6] levels. The sodium salts of the contrast media were less effective than the methylglucamine salts, indicating an important role for the methylglucamine ion in histamine release. A threshold effect for contrast media-induced release of histamine was indicated, as well as a potentiating effect for sequential injections. Prolonged injection of a given quantity of contrast media resulted in greater histamine release than did rapid injections.

Radiology (Oak Brook, IL, United States) published new progress about Liver. 35564-86-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H18ClNO5, Application of C7H18ClNO5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Song, Zilan; Liu, Bo; Peng, Xia; Gu, Wangting; Sun, Yiming; Xing, Li; Xu, Yi; Geng, Meiyu; Ai, Jing; Zhang, Ao published the artcile< Design, Synthesis, and Pharmacological Evaluation of Biaryl-Containing PD-1/PD-L1 Interaction Inhibitors Bearing a Unique Difluoromethyleneoxy Linkage>, Related Products of 5505-63-5, the main research area is difluoromethyleneoxy linkage PD1 PDL1 interaction inhibitor anticancer.

Blockade of immune checkpoint PD-1/PD-L1 has been a promising anticancer strategy; however, clin. available PD-1/PD-L1 small-mol. inhibitors are lacking. In view of the high potency of compound 2 (BMS-1002), structural fine tuning of the methoxy linkage together with diverse modification in the solvent interaction region was conducted. A series of novel derivatives featuring a difluoromethyleneoxy linkage were designed. Compound 43 was identified as the most promising PD-1/PD-L1 inhibitor with an IC50 value of 10.2 nM in the HTRF assay. This compound is capable of promoting CD8+ T cell activation through inhibiting PD-1/PD-L1 cellular signaling. Moreover, in the Hepa1-6 syngeneic mouse model, administration of compound 43 at 1 mg/kg dosage promoted CD8+ T cell activation and delayed the tumor growth with good tolerance. Notably, the tumor in one mouse of the compound 43-treated group was completely regressed. These results indicate that compound 43 is a promising candidate worthy of further investigation.

Journal of Medicinal Chemistry published new progress about Antitumor agents. 5505-63-5 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H14ClNO5, Related Products of 5505-63-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Huang, Kang; Wang, Yuegang; Bai, Yang; Luo, Qiuyan; Lin, xuancai; Yang, Qiuyu; Wang, Shihao; Xin, hongjie published the artcile< Gut microbiota and metabolites in atrial fibrillation patients and their changes after catheter ablation>, Category: alcohols-buliding-blocks, the main research area is microbiota metabolite catheter ablation human atrial fibrillation; atrial fibrillation; gut metabolites; gut microbiota.

The gut microbiota has been shown to be associated with multiple cardiovascular diseases, but there is little research on the gut microbiota and atrial fibrillation (AF); thus, how the gut microbiota and metabolites change in AF patients after catheter ablation is unclear. In this study, we used 16S rRNA high-throughput sequencing and nontargeted metabolomic detection to conduct horizontal and longitudinal analyses of the gut microbiota and metabolites of AF patients. Compared with a control group, species richness and diversity increased significantly in AF patients. Among them, opportunistic pathogenic bacteria, such as Klebsiella, Haemophilus,Streptococcus, and Enterococcus, were significantly increased, and symbiotic bacteria, such as Agathobacter and Butyrivibrio, were significantly reduced. After catheter ablation, intestinal symbiotic bacteria (Lactobacillus, Agathobacter, Lachnospira, etc.) were increased in most AF patients, while pathogenic bacteria (Ruminococcus, etc.) were reduced. Moreover, in AF patients, caffeine, which was neg. correlated with Klebsiella, was downregulated, and estradiol and ascorbic acid, which were pos. correlated with Agathobacter, were also downregulated. After catheter ablation, citrulline, which was pos. correlated with Ralstonia and Lactobacillus, was increased. Oleanolic acid, which was neg. correlated with Ralstonia was downregulated. In conclusion, our results not only show overall changes in the gut microbiota and metabolites in AF patients but also indicate their changes in the short term after catheter ablation. These data will provide novel possibilities for the future clin. diagnosis and treatment of AF.

Microbiology Spectrum published new progress about Ablation (catheter). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts