Tag: M.W=200-250

Green, Scott B.; Lanier, Robert J. Jr.; Carey, Shane M.; Morgan, David R.; Gracz, Hanna; Sherman, Julian; Rodriguez, Ana; D′Antonio, Edward L. published the artcile< Synthesis, biochemical, and biological evaluation of C2 linkage derivatives of amino sugars, inhibitors of glucokinase from Trypanosoma cruzi>, Category: alcohols-buliding-blocks, the main research area is glucosamine mannosamine galactosamine inhibitor glucokinase inhibitor parasite protozoan; amino sugar inhibitor glucokinase Trypanosoma cruzi glucosamine protozoan parasite; Amino sugars; Chagas’ disease; Glucokinase; Inhibitors; Neglected tropical diseases.

Eighteen amino sugar analogs were screened against Trypanosoma cruzi glucokinase (TcGlcK), a potential drug-target of the protozoan parasite in order to assess for viable enzyme inhibition. The analogs were divided into three amino sugar scaffolds that included D-glucosamine (D-GlcN), D-mannosamine (D-ManN), and D-galactosamine (D-GalN); moreover, all but one of these compounds were novel. TcGlcK is an important metabolic enzyme that has a role in producing G6P for glycolysis and the pentose phosphate pathway (PPP). The inhibition of these pathways via glucose kinases (i.e., glucokinase and hexokinase) appears to be a strategic approach for drug discovery. Glucose kinases phosphorylate D-glucose with co-substrate ATP to yield G6P and the formed G6P enters both pathways for catabolism. The compound screen revealed five on-target confirmed inhibitors that were all from the D-GlcN series, such as compounds 1, 2, 4, 5, and 6. Four of these compounds were strong TcGlcK inhibitors (1, 2, 4, and 6) since they were found to have micromolar inhibitory constant (Ki) values around 20 μM. Three of the on-target confirmed inhibitors amino sugars, e.g. I-III, revealed notable in vitro anti-T. cruzi activity with IC50 values being less than 50 μM. Compound 1 was benzoyl glucosamine (BENZ-GlcN), a known TcGlcK inhibitor that was the starting point for the design of the compounds in this study; in addition, TcGlcK – I inhibition properties were previously determined [D′Antonio, E. L. et al. (2015) Mol. Biochem. Parasitol. 204, 64-76]. As such, compounds II-III were further evaluated biochem., where formal Ki values were determined as well as their mode of TcGlcK inhibition. The Ki values determined for compounds II-III were 107 ± 4 μM and 15.2 ± 3.3 μM, resp., and both of these compounds exhibited the competitive inhibition mode.

Bioorganic & Medicinal Chemistry Letters published new progress about Drug discovery. 5505-63-5 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H14ClNO5, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Biswas, Manik Chandra; Bush, Bailey; Ford, Ericka published the artcile< Glucaric acid additives for the antiplasticization of fibers wet spun from cellulose acetate/acetic acid/water>, Application In Synthesis of 87-73-0, the main research area is cellulose acetate fiber glucaric acid spinning antiplasticization mech property; Antiplasticizer; Bio-based derivatives; Cellulose acetate; Glucarate salt; Glucaric acid; Spectroscopy; Strengthening; Structure-property relationship.

Cellulose acetate (CA) receives notable attention as an environmentally friendly, biodegradable polymer from renewable, low-cost resources. CA polymers are believed to have a critical role in shaping a greener and more circular textile economy. However, the mech. properties of CA fibers are among the lowest in terms of its tensile strength, poor wet strength, and low flexural strength. This study investigates the effect of biobased additives for antiplasticizing the mech. performance and structure of CA fibers. At up to 5% of CA, glucaric acid (GA) and its monoammonium salt were added to CA fibers. With 1.5% GA additive, tensile modulus improved by 155%, tensile strength by 55%, and CA flexibility according to knot to straight fiber tenacity ratios improved by 107% when compared to neat CA fibers. Based on the results, green small mol. antiplasticizers do exist, but their performance improvements are observed at low percentages of loading.

Carbohydrate Polymers published new progress about Acetate fibers Role: PEP (Physical, Engineering or Chemical Process), POF (Polymer in Formulation), PRP (Properties), PROC (Process), USES (Uses). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Application In Synthesis of 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Vestergaard, Martin; Ingmer, Hanne published the artcile< Antibacterial and antifungal properties of resveratrol>, Name: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol, the main research area is review resveratrol antibacterial antifungal property; ATP synthase inhibition; Antimicrobial; Antivirulence; Combination therapy; Resveratrol.

A review. Resveratrol is a naturally occurring polyphenolic antioxidant that has received massive attention for its potential health benefits, including anticarcinogenesis, anti-aging, and antimicrobial properties. The compound is well tolerated by humans and in recent years has been widely used as a nutraceutical. Its common use makes it interesting to investigate with respect to antimicrobial properties both as a single agent and in combination with conventional antibiotics. Resveratrol displays antimicrobial activity against a surprisingly wide range of bacterial, viral, and fungal species. At subinhibitory concentrations, resveratrol can alter bacterial expression of virulence traits leading to reduced toxin production, inhibition of biofilm formation, reduced motility, and interference with quorum sensing. In combination with conventional antibiotics, resveratrol enhances the activity of aminoglycosides against Staphylococcus aureus, whereas it antagonizes the lethal activity of fluoroquinolones against S. aureus and Escherichia coli. While the antimicrobial properties of the compound have been extensively studied in vitro, little is known about its efficacy in vivo. Nonetheless, following topical application resveratrol has alleviated acne lesions caused by the bacterium Propionibacterium acnes. There are currently no in vivo studies addressing its effect in combination with antibiotics, but recent research suggests that there may be a potential for enhancing the antimicrobial efficacy of certain existing antibiotic classes in combination with resveratrol. Given the difficulties associated with introducing new antimicrobial agents to the market, nutraceuticals such as resveratrol may prove to be interesting candidates when searching for solutions for the growing problem of antimicrobial resistance.

International Journal of Antimicrobial Agents published new progress about Antibacterial agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Name: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Xiaolei; Guo, Feng; Tian, Peng; Yu, Shuangen; Xue, Chun-Xu; Wang, Wei; Xiao, Jiaguang; Niu, Wentao published the artcile< Flammeovirga agarivorans sp. nov., an agar-digesting marine bacterium isolated from surface seawater>, Electric Literature of 87-73-0, the main research area is Flammeovirga agarivorans agar digesting marine bacterium surface seawater; Flammeovirga agarivorans sp. nov.; Luhuitou fringing reef; surface seawater.

A Gram-stain-neg., aerobic, gliding, reddish-orange-colored, rod-shaped strain, designated SR4T, was isolated from surface seawater sampled at Luhuitou fringing reef (South China Sea). Phylogenetic analyses based on the 16S rRNA gene, phylogenomic anal. of single-copy gene families and whole genome data affiliated it to the genus Flammeovirga. It was most closely related to Flammeovirga yaeyamensis NBRC 100898T (97.99% 16S rRNA gene similarity). The genome average nucleotide identity and DNA-DNA relatedness values between strain SR4T and its reference strains were less than 74.2 and 16.3%, resp. Growth occurred at 20-35° (optimum, 28°), pH 6.0-9.0 (optimum, pH 7.0) and in the presence of 1-6% (w/v) NaCl (optimum, 2-4%). The dominant fatty acids were C16 : 0, iso-C15 : 0 and C20 : 4 ω 6,9,12,15c. The polar lipid profile of strain SR4T comprised phosphatidylethanolamine, two glycolipids, two aminophospholipids and three unidentified lipids. The major respiratory quinone was MK-7. The DNA G + C content of strain SR4T was 34.20 mol%. On the basis of the polyphasic evidence, strain SR4T is proposed as representing a novel species of the genus Flammeovirga, for which the name Flammeovirga agarivorans sp. nov. is proposed. The type strain is SR4T (= KCTC 82075T = MCCC 1A17137T).

International Journal of Systematic and Evolutionary Microbiology published new progress about 16S rRNA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Electric Literature of 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kondo, Mizuho; Miyake, Jun-ichi; Tada, Kazuya; Kawatsuki, Nobuhiro published the artcile< Tuning photoluminescent wavelength of water-soluble oligothiophene/polymer complex film by proton bonding>, Reference of 660867-80-1, the main research area is thiophene oligomer pyridyl end group preparation photoluminescence photochromism protonation.

An oligothiophene derivative with pyridine end groups was prepared and the UV-visible absorption and photoluminescence of the compound were studied. Upon addition of aqueous polystyrenesulfonic acid solution, homogeneous complex films with protonated structure were observed Reversible color change in photoluminescence, in response to exposure of the protonated species to base solution was observed, which is due to reversible protonation of pyridyl end groups; this response can be applied to acid sensors.

Chemistry Letters published new progress about Luminescence. 660867-80-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H18BNO2, Reference of 660867-80-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Jian-Yuan; Huang, Hongbing published the artcile< Development of DNA-Compatible Suzuki-Miyaura Reaction in Aqueous Media>, SDS of cas: 660867-80-1, the main research area is DNA Suzuki Miyaura reaction aryl halide boronic acid.

DNA-encoded chem. libraries (DELs) are a cost-effective technol. for the discovery of novel chem. probes and drug candidates. A major limiting factor in assembling productive DELs is the availability of DNA-compatible chem. reactions in aqueous media. In an effort to increase the chem. accessibility and structural diversity of small mols. displayed by DELs, the authors developed a robust Suzuki-Miyaura reaction protocol that is compatible with the DNA structures. By employing a water-soluble Pd-precatalyst, the authors developed conditions that allow efficient coupling of DNA-linked aryl halides with a wide variety of boronic acids/esters including heteroaryl boronates.

Bioconjugate Chemistry published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent) (DNA-conjugate). 660867-80-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H18BNO2, SDS of cas: 660867-80-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Shaito, Abdullah; Posadino, Anna Maria; Younes, Nadin; Hasan, Hiba; Halabi, Sarah; Alhababi, Dalal; Al-Mohannadi, Anjud; Abdel-Rahman, Wael M.; Eid, Ali H.; Nasrallah, Gheyath K.; Pintus, Gianfranco published the artcile< Potential adverse effects of resveratrol a literature review>, Synthetic Route of 501-36-0 , the main research area is review resveratrol toxicity bioavailability stilbenoid; anticancer; antioxidant effects; biphasic; oxidative DNA damage; pro-oxidant effects; reactive oxygen species (ROS); resveratrol.

A review. Due to its health benefits, resveratrol (RE) is one of the most researched natural polyphenols. Resveratrol’s health benefits were first highlighted in the early 1990s in the French paradox study, which opened extensive research activity into this compound Ever since, several pharmacol. activities including antioxidant, anti-aging, anti-inflammatory, anti-cancerous, anti-diabetic, cardioprotective, and neuroprotective properties, were attributed to RE. However, results from the available human clin. trials were controversial concerning the protective effects of RE against diseases and their sequelae. The reason for these conflicting findings is varied but differences in the characteristics of the enrolled patients, RE doses used, and duration of RE supplementation were proposed, at least in part, as possible causes. In particular, the optimal RE dosage capable of maximizing its health benefits without raising toxicity issues remains an area of extensive research. In this context, while there is a consistent body of literature on the protective effects of RE against diseases, there are relatively few reports investigating its possible toxicity. Indeed, toxicity and adverse effects were reported following consumption of RE; therefore, extensive future studies on the long-term effects, as well as the in vivo adverse effects, of RE supplementation in humans are needed. Furthermore, data on the interactions of RE when combined with other therapies are still lacking, as well as results related to its absorption and bioavailability in the human body. In this review, we collect and summarize the available literature about RE toxicity and side effects. In this process, we analyze in vitro and in vivo studies that have addressed this stilbenoid. These studies suggest that RE still has an unexplored side. Finally, we discuss the new delivery methods that are being employed to overcome the low bioavailability of RE.

International Journal of Molecular Sciences published new progress about Bioavailability. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Synthetic Route of 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Moggia, Giulia; Kenis, Thomas; Daems, Nick; Breugelmans, Tom published the artcile< Electrochemical Oxidation of D-Glucose in Alkaline Medium: Impact of Oxidation Potential and Chemical Side Reactions on the Selectivity to D-Gluconic and D-Glucaric Acid>, Application In Synthesis of 87-73-0, the main research area is glucose electrochem oxidation chem side reaction gluconic glucaric acid.

The electrocatalytic oxidation of D-glucose was studied in alk. medium on copper, platinum, and gold electrodes with particular emphasis on the synthesis of a high value-added product: glucaric acid. An initial ranking of the three different materials, with respect to their electrochem. activity towards glucose oxidation, was performed utilizing cyclic voltammetry. To determine which functional group can react on which metal, cyclic voltammetry experiments were performed in three different solutions containing 0.04 M gluconic acid, glucuronic acid, or glucaric acid in 0.1 M aqueous NaOH. The observations drawn based on these initial experiments were then verified by analyzing the product solutions (obtained after prolonged electrolysis experiments) with HPLC anal. The oxidation of glucose on copper at high potentials leads predominantly to C-C cleavage products, mainly formic acid, with a selectivity of 54.2%; whereas, at lower potentials, the oxidation of the aldehyde group on C1 and of the hydroxymethyl group on C6 produces moderate yields of gluconic and glucaric acid. On platinum, the oxidation of the aldehyde group on C1 is the most relevant process; therefore, the selectivity towards gluconic acid obtained is as high as 78.4%. Nevertheless, at lower potentials, a higher selectivity to glucaric acid (12.6%) and a lower selectivity to gluconic acid (68.0%) are the result of a more effective oxidation of also the hydroxymethyl group on C6. Gold is the most active and selective electrocatalyst of the ones examined in this work. On gold, at lower potentials, the oxidation of the aldehyde group on C1 produces 86.6% of selectivity to gluconic acid while, at higher potentials, the oxidation of the hydroxymethyl group on C6 also takes place, promoting the further oxidation to glucaric acid (13.5% of selectivity is reached after 65 h of reaction at 5°C, with a residual gluconic acid equal to 65.8%). The demonstrated dependence of the selectivity on the oxidation potential suggests new future perspectives for the electrocatalytic oxidation of D-glucose to D-glucaric acid on bare metal electrodes. Moreover, the low selectivity of this process, very often claimed in literature, has been ascribed here for the first time to two chem. processes, which are in competition with the electrochem. one and both consume the reactant and promote the formation of undesired side-products.

ChemElectroChem published new progress about Electric current-potential relationship. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Application In Synthesis of 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mohseni, Roohollah; ArabSadeghabadi, Zahra; Ziamajidi, Nasrin; Abbasalipourkabir, Roghayeh; RezaeiFarimani, Azam published the artcile< Oral Administration of Resveratrol-Loaded Solid Lipid Nanoparticle Improves Insulin Resistance Through Targeting Expression of SNARE Proteins in Adipose and Muscle Tissue in Rats with Type 2 Diabetes>, Computed Properties of 501-36-0 , the main research area is resveratrol solid lipid nanoparticle insulin SNARE expression diabetes rat; Insulin resistance; Nanoparticles; Resveratrol; SNARE proteins.

In the current study, we developed resveratrol (RES)-loaded solid lipid nanoparticle (SLN-RES) in order to improve insulin resistance through the upregulation of SNARE protein complex in rats with type 2 diabetes. The SLN-RES characteristics include the following: the average size of 248 nm, the zeta potential of – 16.5 mV, and 79.9% RES entrapment efficiency. The release profile of SLN-RES showed an initial burst followed by a sustained release in natural condition. IR spectroscopy results revealed good incorporation of RES into core SLN. Spherical nanoparticle with less aggregation was observed under electronic microscopic examination Oral administration of SLN-RES prevented weight loss and showed better hypoglycemic effect than RES. Serum oxidative stress status was restored to the normal level by SLN-RES. Furthermore, expression of synaptosomal-associated protein 23 (Snap23), syntaxin-4 (Stx4), and vesicle-associated membrane protein 2 (Vamp2) as the major elements of SNARE protein complex were reduced by SLN-RES more significantly than RES treatment in muscle tissue. However, SLN-RES has a similar effect to RES treatment in adipose tissue. Taken together, our results revealed SLN-RES could be a modern and interestingly therapeutic approach for the improvement of insulin resistance through targeting the expression of Snap23, Stx4, and Vamp2 in adipose and muscle tissues.

Nanoscale Research Letters published new progress about Adipose tissue. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Computed Properties of 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Haydl, Alexander M.; Hartwig, John F. published the artcile< Palladium-Catalyzed Methylation of Aryl, Heteroaryl, and Vinyl Boronate Esters>, Application In Synthesis of 660867-80-1, the main research area is palladium catalyzed methylation aryl heteroaryl boronate ester iodomethane; methylated arene heterocycle preparation palladium catalyzed methylation.

A method for the direct methylation of aryl, heteroaryl, and vinyl boronate esters is reported, involving the reaction of iodomethane with aryl-, heteroaryl-, and vinylboronate esters catalyzed by palladium and PtBu2Me. This transformation occurs with a remarkably broad scope and is suitable for late-stage derivatization of biol. active compounds via the boronate esters. The unique capabilities of this method are demonstrated by combining carbon-boron bond-forming reactions with palladium-catalyzed methylation in a tandem transformation.

Organic Letters published new progress about Aromatic hydrocarbons Role: SPN (Synthetic Preparation), PREP (Preparation) (methylated). 660867-80-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H18BNO2, Application In Synthesis of 660867-80-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts