Ryba, O.’s team published research in Collection of Czechoslovak Chemical Communications in 30 | CAS: 1139-46-4

Collection of Czechoslovak Chemical Communications published new progress about 1139-46-4. 1139-46-4 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol, and the molecular formula is C14H22O2, Related Products of alcohols-buliding-blocks.

Ryba, O. published the artcileAntioxidants and stabilizers. VII. Influence of structure on polarographic half-wave potentials of alkylated pyrocatechols, Related Products of alcohols-buliding-blocks, the publication is Collection of Czechoslovak Chemical Communications (1965), 30(7), 2157-63, database is CAplus.

cf. CA 63, 10648b. The influence of substituents in various positions in pyrocatechol on E1/2 values was discussed in terms of polar, mesomeric, and steric effects of these groups. The pyrocatechol derivatives yielded best developed polarographic waves in acetate buffers, the dependence of E1/2 on pH being the same for all substances studied: E1/2 = E0 – 0.059 pH at 25°. The E0 values were determined with an accuracy of ±2 mv. and tabulated. The logarithmic analysis of the waves indicates a reversible 2-electron oxidation 20 references.

Collection of Czechoslovak Chemical Communications published new progress about 1139-46-4. 1139-46-4 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol, and the molecular formula is C14H22O2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Rastogi, Supriya’s team published research in Journal of the American Academy of Dermatology in 79 | CAS: 70445-33-9

Journal of the American Academy of Dermatology published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, COA of Formula: C11H24O3.

Rastogi, Supriya published the artcileAllergic contact dermatitis to personal care products and topical medications in adults with atopic dermatitis, COA of Formula: C11H24O3, the publication is Journal of the American Academy of Dermatology (2018), 79(6), 1028-1033.e6, database is CAplus and MEDLINE.

Atopic dermatitis (AD) is associated with skin-barrier disruption, immune dysregulation, and application of emollients and topical medications that might predispose a person toward developing allergic contact dermatitis. To determine the predictors of allergic contact dermatitis and relevant allergens in AD. A retrospective chart review was performed for 502 adults (age ≥18 years) who were patch tested to an expanded allergen series during 2014-2017. Overall, 108 (21.5%) had current AD and 109 (21.7%) had past AD. Patients with and without current AD had similar proportions of any pos. (+, ++, or +++ 80 [74.1%] vs 254 [64.5%], resp., chi-squared P = .06); strong-pos. (++ and +++ 34 [31.5%] vs 102 [25.9%], resp., P = .25); and irritant (56 [51.9%] vs 188 [47.7%], resp., P = .45) patch-test reactions. AD patients had significantly higher rates of pos. reactions to ingredients in their personal care products and topical medications, including fragrance mix II (P = .04), lanolin (P = .03), bacitracin (P = .04), cinnamal (P = .02), budesonide (P = .01), tixocortol (P = .02), and chlorhexidine (P = .001); relevance was established in >90% of these reactions. Polysensitization occurred more commonly in patients with AD than without (35 [32.4%] vs 75 [19.0%]; P = .01). Study was performed at a single center. AD patients had more pos. patch-test reactions to ingredients in their personal care products, topical steroids, and antibiotics.

Journal of the American Academy of Dermatology published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, COA of Formula: C11H24O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bleehen, S. S.’s team published research in Journal of Investigative Dermatology in 50 | CAS: 1139-46-4

Journal of Investigative Dermatology published new progress about 1139-46-4. 1139-46-4 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol, and the molecular formula is C14H22O2, Computed Properties of 1139-46-4.

Bleehen, S. S. published the artcileDepigmentation of skin with 4-sisopropylcatechol, mercaptoamines, and other compounds, Computed Properties of 1139-46-4, the publication is Journal of Investigative Dermatology (1968), 50(2), 103-17, database is CAplus and MEDLINE.

Thirty-three compounds including thiols, mercaptoamines, catechol, catechol derivatives, and quinones were tested for their depigmenting potency and irritant effect on the skin of guinea pigs. These compounds, in concentrations ranging from 1 to 10%, were applied topically to the epilated skin of the back and the unepilated skin of the ear of black guinea pigs; 4-isopropylcatechol (4-IPC) was the most potent depigmenting agent, and the depigmentation occurred only in the treated areas. When used in low concentrations (1-3%), 4-IPC did not irritate the skin. Evidence obtained by light and electron microscopy indicated that 4-IPC markedly reduced the population of the melanocytes in the epidermis. The few remaining melanocytes were rendered degenerative, and those found had only a few melanized melanosomes. Cutaneous depigmentation by 4-IPC apparently results from a selective action on melanocytes; they are either destroyed or inactivated.

Journal of Investigative Dermatology published new progress about 1139-46-4. 1139-46-4 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol, and the molecular formula is C14H22O2, Computed Properties of 1139-46-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Marko, Monika’s team published research in Journal of Dermatological Treatment in 33 | CAS: 70445-33-9

Journal of Dermatological Treatment published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Application In Synthesis of 70445-33-9.

Marko, Monika published the artcileReal-life efficiency and safety comparison study of emollient ointment based on glycerophosphoinositol (GPI) salt of choline and other emollient products in patients with atopic dermatitis, Application In Synthesis of 70445-33-9, the publication is Journal of Dermatological Treatment (2022), 33(2), 999-1010, database is CAplus and MEDLINE.

Introduction The aim of this study was to investigate the effectiveness and safety of emollient preparations in comparison with the emollient ointment containing glycerophosphoinositol salt of choline in patients with atopic dermatitis (AD). Methods In a ‘real-life’ study, 300 patients with moderate AD were age-stratified and divided into two groups: patients applying GPI emollient and the comparator. We evaluated the effectiveness of AD treatment using: Eczema Area and Severity Index (EASI), Three Item Severity (TIS), Visual Analog Scale (VAS) and Four-Item Itch Questionnaire. Results The GPI emollient was superior in reduction AD symptoms in children: VAS (-2.58 ± 0.25), TIS (-2.22 ± 0.22), EASI (-15.27 ± 1.77), and adults: VAS (-2.42 ± 0.19), TIS (-2.22 ± 0.17), EASI (-13.22 ± 1.53), as compared to the other emollient in children: VAS (-0.67 ± 0.19), TIS (0.47 ± 0.19), EASI (-3.71 ± 1.01) and adults: VAS (-0.86 ± 0.09), TIS (0.77 ± 0.09), EASI (-2.95 ± 0.46), p < .001. Similar results were observed in Four Item Itch Questionnaire. Conclusion Both emollients showed good safety and tolerance profile and reduced AD symptoms. The GPI emollient seems to be more slightly effective in reducing AD symptoms as compared to the other com. available emollient.

Journal of Dermatological Treatment published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Application In Synthesis of 70445-33-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hoang, Giang T.’s team published research in Journal of Organic Chemistry in 79 | CAS: 328-90-5

Journal of Organic Chemistry published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Computed Properties of 328-90-5.

Hoang, Giang T. published the artcileIntramolecular Oxyacylation of Alkenes Using a Hydroxyl Directing Group, Computed Properties of 328-90-5, the publication is Journal of Organic Chemistry (2014), 79(23), 11383-11394, database is CAplus and MEDLINE.

Alkene oxyacylation is a new strategy for the preparation of β-oxygenated ketones. Now, with Ir catalysis and low-cost salicylate esters, alkene oxyacylation can be promoted by simple and versatile hydroxyl directing groups. This paper discusses catalyst optimization, substituent effects, mechanistic experiments, and the challenges associated with asym. catalysis. Crossover experiments point to several key steps of the mechanism being reversible, including the most likely enantiodetermining steps. The oxyacylation products are also prone to racemization without catalyst when heated alone; however, crossover is not observed without catalyst. These observations account for the low levels of enantioinduction in alkene oxyacylation. The versatility of the hydroxyl directing group is highlighted by demonstrating further transformations of the products.

Journal of Organic Chemistry published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Computed Properties of 328-90-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ricciardi, Maria’s team published research in ChemSusChem in 11 | CAS: 70445-33-9

ChemSusChem published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Name: 3-((2-Ethylhexyl)oxy)propane-1,2-diol.

Ricciardi, Maria published the artcileFirst Attempt of Glycidol-to-Monoalkyl Glyceryl Ethers Conversion by Acid Heterogeneous Catalysis: Synthesis and Simplified Sustainability Assessment, Name: 3-((2-Ethylhexyl)oxy)propane-1,2-diol, the publication is ChemSusChem (2018), 11(11), 1829-1837, database is CAplus and MEDLINE.

The selective preparation of monoalkylglyceryl ethers (MAGEs) is a task for researchers owing to their broad range of applications. In this work, green feedstocks such as glycidol and alcs. were used to prepare MAGEs under mild reaction conditions (80 °C, 3 h, 0.5 mol % catalyst) in the presence of acid heterogeneous catalysts. Nafion shows the best performances in terms of conversion and selectivity to MAGES and also high stability. A comparison of the environmental performances with the most consolidated pathway from glycerol has shown that the usage of glycidol (recovered as a value-added product from Epicerol process) and Nafion leads to a lower impact on ecosystems. In addition, results achieved from a simplified socio-economic anal. show that the innovative route here proposed has potential (at the laboratory scale) of enhancing potential gains and of reducing the social implications resulting from externalities associated with environmental impacts (e.g., CO2 equivalents).

ChemSusChem published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Name: 3-((2-Ethylhexyl)oxy)propane-1,2-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Pan, Bendu’s team published research in Organic Chemistry Frontiers in 8 | CAS: 328-90-5

Organic Chemistry Frontiers published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Related Products of alcohols-buliding-blocks.

Pan, Bendu published the artcileIridium-catalyzed intramolecular asymmetric allylic etherification of salicylic acid derivatives with chiral-bridged biphenyl phosphoramidite ligands, Related Products of alcohols-buliding-blocks, the publication is Organic Chemistry Frontiers (2021), 8(16), 4514-4519, database is CAplus.

Iridium-catalyzed intramol. asym. allylic etherification of salicylic acid derivatives was successfully realized for the first time. By using chiral-bridged biphenyl phosphoramidite ligand, a class of novel chiral 1,4-benzoxazepinones I [R1 = H, 6-Me, 9-MeO, 8-F; R2 = Bn, 4-MeOC6H4CH2] was prepared conveniently with good to excellent yields (up to 99%) and high enantioselectivities (up to 99% ee). The effect of different substituents on the enantioselectivity was also discussed. Compared with BINOL or biphenol-derived counterparts, catalysis with ligand had obvious advantages in terms of catalytic activity and enantioselectivity. Mild conditions and a wide substrate scope demonstrated the practicability of this method. It was also found that the configuration of the product was directly related to the configuration of the alkene substrate and the E-substrate is more suitable for this reaction to obtain better enantioselectivity.

Organic Chemistry Frontiers published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Fukuda, K.’s team published research in Colloids and Surfaces, B: Biointerfaces in 20 | CAS: 70445-33-9

Colloids and Surfaces, B: Biointerfaces published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Quality Control of 70445-33-9.

Fukuda, K. published the artcileMicroemulsion formed by alkyl polyglucoside and an alkyl glycerol ether with weakly charged films, Quality Control of 70445-33-9, the publication is Colloids and Surfaces, B: Biointerfaces (2001), 20(2), 129-135, database is CAplus and MEDLINE.

We have studied the effects on phase equilibrium of a nonionic surfactant mixture-water-oil system when replacing small amount of surfactant mols. by ionic surfactant, sodium dodecyl sulfate (SDS). The nonionic surfactant system contains dodecyl-β-D-maltoside (C12AG2) and isooctyl glyceryl ether (i-C8GE) as cosurfactant, water and cyclohexane at constant water to oil ratio of 60/40 (weight/weight). Adding a small amount of SDS has large impact on the phase behavior. Clear liquid crystalline phase and upper microemulsion phase are added to the phase sequence at high i-C8GE/(C12AG2+i-C8GE) ratio. We also compare the phase equilibrium of pure dodecyl maltoside system with polyglucosides mixture system.

Colloids and Surfaces, B: Biointerfaces published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Quality Control of 70445-33-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Campbell, Curt B.’s team published research in Industrial & Engineering Chemistry Research in 29 | CAS: 1139-46-4

Industrial & Engineering Chemistry Research published new progress about 1139-46-4. 1139-46-4 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol, and the molecular formula is C14H22O2, HPLC of Formula: 1139-46-4.

Campbell, Curt B. published the artcileAmberlyst-15-catalyzed alkylation of phenolics with branched alkenes. Rearrangement of tert-alkylphenols and catechols to sec-alkyl isomers, HPLC of Formula: 1139-46-4, the publication is Industrial & Engineering Chemistry Research (1990), 29(4), 642-7, database is CAplus.

Alkylation of PhOH or catechol with olefins capable of forming tert-alkylcarbonium ions, catalyzed by Amberlyst 15, gave the corresponding tert-alkylphenols at 25-130°, with higher temperatures favoring the para isomer. Alkylations at 140-150° unexpectedly gave sec-alkylphenols, with both ortho and para isomers being formed in almost equal amounts The driving force of the reaction appeared to be the low stability of the tert-alkylphenols, leading to reversibility of the alkylation reaction. The rearrangement of tert-alkylphenols to sec-alkylphenols was favored when the tert-alkyl substituent was C>4.

Industrial & Engineering Chemistry Research published new progress about 1139-46-4. 1139-46-4 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol, and the molecular formula is C14H22O2, HPLC of Formula: 1139-46-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Katane, Masumi’s team published research in Journal of Medicinal Chemistry in 56 | CAS: 328-90-5

Journal of Medicinal Chemistry published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Recommanded Product: 2-Hydroxy-4-(trifluoromethyl)benzoic acid.

Katane, Masumi published the artcileIdentification of Novel d-Amino Acid Oxidase Inhibitors by in Silico Screening and Their Functional Characterization in Vitro, Recommanded Product: 2-Hydroxy-4-(trifluoromethyl)benzoic acid, the publication is Journal of Medicinal Chemistry (2013), 56(5), 1894-1907, database is CAplus and MEDLINE.

D-Amino acid oxidase (DAO) is a degradative enzyme that is stereospecific for d-amino acids, including d-serine and d-alanine, which are potential coagonists of the N-methyl-d-aspartate (NMDA) receptor. Dysfunction of NMDA receptor-mediated neurotransmission has been implicated in the onset of various mental disorders such as schizophrenia. Hence, a DAO inhibitor that augments the brain levels of d-serine and/or d-alanine and thereby activates NMDA receptor function is expected to be an antipsychotic drug, for instance, in the treatment of schizophrenia. In the search for potent DAO inhibitor(s), a large number of compounds were screened in silico, and several compounds were estimated as candidates. These compounds were then characterized and evaluated as novel DAO inhibitors in vitro. The results reported in this study indicate that some of these compounds are possible lead compounds for the development of a clin. useful DAO inhibitor and have the potential to serve as active site probes to elucidate the structure-function relationships of DAO.

Journal of Medicinal Chemistry published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Recommanded Product: 2-Hydroxy-4-(trifluoromethyl)benzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts