Tag: M.W=200-250

Yang, Bo published the artcileVisible light-promoted dihydroxylation of styrenes with water and dioxygen, Category: alcohols-buliding-blocks, the main research area is visible light promoted dihydroxylation styrene water dioxygen; vicinal alc preparation.

An efficient visible light promoted metal-free dihydroxylation of styrenes with water and dioxygen was developed for the construction of vicinal alcs. The protocol was operationally simple with a broad substrate scope. The mechanistic studies demonstrated that one of the hydroxyl groups came from water and the other one came from mol. oxygen. Addnl., the β-alkyoxy alcs. could also be obtained using a similar strategy.

Chemical Communications (Cambridge, United Kingdom) published new progress about Dihydroxylation. 92093-23-7 belongs to class alcohols-buliding-blocks, name is 1-(4-Bromophenyl)ethane-1,2-diol, and the molecular formula is C8H9BrO2, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wu, Chia-Hui published the artcileSimple and Practical Real-Time Analysis of Solid-Phase Reactions by Thin-Layer Chromatography, Application In Synthesis of 87905-98-4, the main research area is glycoside solid phase preparation TLC reaction analysis; triazole solid phase preparation TLC reaction analysis; amino acid solid phase preparation TLC reaction analysis.

Solid-phase synthesis is a practical approach for simplifying the time-consuming and routine purification steps in the preparation of numerous naturally occurring mols.; however, studying such reactions is difficult due to the lack of a convenient monitoring method. By using thin-layer chromatog. in conjunction with a photolabile linker on a resin, we developed a convenient and simple method for monitoring solid-phase reactions in real time by thin-layer chromatog. This method provides a user-friendly protocol for examining reaction conditions for solid-state syntheses.

Synlett published new progress about Click chemistry. 87905-98-4 belongs to class alcohols-buliding-blocks, name is Benzyl (5-hydroxypentyl)carbamate, and the molecular formula is C13H19NO3, Application In Synthesis of 87905-98-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Abendrot, Michal published the artcileZinc(II) complexes of amino acids as new active ingredients for anti-acne dermatological preparations, Formula: C11H24O3, the publication is International Journal of Molecular Sciences (2021), 22(4), 1641, database is CAplus and MEDLINE.

Zinc compounds have a number of beneficial properties for the skin, including antimicrobial, sebostatic and demulcent activities. The aim of the study was to develop new anti-acne preparations containing zinc-amino acid complexes as active ingredients. Firstly, the cytotoxicity of the zinc complexes was evaluated against human skin fibroblasts (1BR.3.N cell line) and human epidermal keratinocyte cell lines, and their antimicrobial activity was determined against Cutibacterium acnes. Then, zinc complexes of glycine and histidine were selected to create original gel formulations. The stability (by measuring pH, d. and viscosity), microbiol. purity (referring to PN-EN ISO standards) and efficacy of the preservative system (according to Ph.Eur. 10 methodol.) for the preparations were evaluated. Skin tolerance was determined in a group of 25 healthy volunteers by the patch test. The preparations containing zinc(II) complexes with glycine and histidine as active substances can be topically used in the treatment of acne skin due to their high antibacterial activity against C. acnes and low cytotoxicity for the skin cells. Dermatol. recipes have been appropriately composed; no irritation or allergy was observed, and the preparations showed high microbiol. purity and physicochem. stability.

International Journal of Molecular Sciences published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Formula: C11H24O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Pospisil, J. published the artcileAntioxidants and stabilizers. XIII. Activity of phenolic antioxidants with large tertiary alkyl groups in lard and isopropyl oleate, Safety of 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol, the publication is Fette, Seifen, Anstrichmittel (1968), 70(6), 442-5, database is CAplus.

The activity of 5 types of phenolic antioxidants containing 1 or 2 OH groups and substituted by 1 or more large tert-alkyl groups with 4, 8, or 12 C atoms was tested with lard and iso-Pr oleate as substrates. The effectiveness of the antioxidants was dependent on several factors which affect their reaction with the ROO- radicals formed by the autoxidation of the fat. The antioxidants tested had a different effect on the 2 substrates. The best effect was with a 2,4,6-trisubstituted phenol and a 4-tert-alkylpyrocatechol acting on lard. 17 references.

Fette, Seifen, Anstrichmittel published new progress about 1139-46-4. 1139-46-4 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol, and the molecular formula is C14H22O2, Safety of 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Coupek, Jiri published the artcileGel chromatographic behavior of mononuclear aromatic hydrocarbons and phenols, Formula: C14H22O2, the publication is Journal of Chromatography (1974), 95(1), 103-12, database is CAplus.

The gel chromatog. behavior of aromatic hydrocarbons and phenols during elution with THF in columns packed with styrene-divinylbenzene copolymer was investigated. From the elution volumes of 27 aromatic hydrocarbons and 80 phenols, conclusions were drawn about the effects of the types and positions of substituents and of the numbers and positions of phenolic hydroxyl groups on the elution volumes of these compounds in the system under investigation. The effects of the size of the alkyl substituents and of their positions with respect to the hydroxyl group of phenols were determined, and the partial contributions of the alkyl and hydroxyl groups to the elution volumes were calculated Chromatog. results were used for the characterization of the solvatability of phenolic mols. with THF and as the basis of a discussion of problems of the steric hindrance of hydroxyl groups due to neighboring substituents.

Journal of Chromatography published new progress about 1139-46-4. 1139-46-4 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol, and the molecular formula is C14H22O2, Formula: C14H22O2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Nechitailo, N. A. published the artcileDihydric phenols as stabilizers for irradiated polypropylene, COA of Formula: C14H22O2, the publication is Plasticheskie Massy (1966), 37-41, database is CAplus.

Polypropylene (I) of mol. weight 390,000 after addition of 0.1 mmol of stabilizer/g. was irradiated with ⁶⁰Co γ-rays at an intensity of 1.0-1.5 megarads/h. in vacuo with a dose of 160 megarads or in air with a dose of 40 megarads. After irradiation, the fraction insoluble in o-xylene and intrinsic viscosity (in Decalin at 135°) of I were determined As stabilizers hydroquinone (II), 2-methylhydroquinone (III), 2-tert-butylhydroquinone (IV), 2-tert-octylhydroquinone (V), 2,5-di-tert-butylhydroquinone (VI), pyrocatechol (VII), 4-methylpyrocatechol (VIII), 4-tert-butylpyrocatechol (IX), 4-tert-octylcatechol (X), and 3,5-di-tert-butylpyrocatechol (XI) were used. The oxidation of I with air was determined by DTA and ir anal. γ-rays caused fission of chains and a decrease in mol. weight and softening temperature; simultaneously, crosslinking took place and an insoluble gel was formed. In the absence of air, no oxidation took place and only IX, X, and XI decreased the destruction of I; the amount of gel formed in I without stabilizers was 77.5%, and with II 68.0%, III 54.8%, IV 50.3%, V 43.7%, VI 67.0%, VII 40%, VIII 15.0%, IX 14.2%, X 71.0%, and XI 8.7%. Dihydric phenols shifted the temperature of the oxidation initiation to higher temperatures; the effect of alkyl derivatives of VII containing tert-Bu groups was especially strong. Oxidation of I irradiated in the presence of air was weakened by the addition of several phenols (no formation of a gel fraction, strong diminution of absorption by OH groups in the ir spectrum). The intrinsic viscosity of I irradiated in the presence of air was 0.13 for pure I (before irradiation 3.2), for II 0.11, III 0.23, IV 0.13, V 0.22, VI 0.13, VII 0.31, VIII 0.31, IX 0.20, X 0.11, and XI 0.17.

Plasticheskie Massy published new progress about 1139-46-4. 1139-46-4 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol, and the molecular formula is C14H22O2, COA of Formula: C14H22O2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Leal-Duaso, Alejandro published the artcileGlycerol as a source of designer solvents: physicochemical properties of low melting mixtures containing glycerol ethers and ammonium salts, Synthetic Route of 70445-33-9, the publication is Physical Chemistry Chemical Physics (2017), 19(41), 28302-28312, database is CAplus and MEDLINE.

In this work we report the preparation of mixtures of several alkyl glyceryl ethers, as hydrogen bond donor compounds, with two ammonium salts, choline chloride and N,N,N-triethyl-2,3-dihydroxypropan-1-aminium chloride. The stability of the mixtures at different molar ratios and temperatures has been evaluated in order to determine the formation of low melting mixtures Liquid and stable mixtures have been characterized and their physico-chem. properties such as d., viscosity, refractive index, conductivity and surface tension have been measured in the temperature range of 293.15 K to 343.15 K. Comparison of the mixtures prepared herein with the ones containing glycerol and choline chloride evidences the possibility of tuning the physico-chem. properties by changing the substitution pattern in the hydrogen bond donor compound or in the ammonium salt, thus broadening the scope of application of these mixtures

Physical Chemistry Chemical Physics published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Synthetic Route of 70445-33-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Molins-Molina, Oscar published the artcilePhotobinding of triflusal to human serum albumin investigated by fluorescence, proteomic analysis, and computational studies, Application In Synthesis of 328-90-5, the publication is Frontiers in Pharmacology (2019), Consuelo 1028, database is CAplus and MEDLINE.

Triflusal is a platelet antiaggregant employed for the treatment and prevention of thromboembolic diseases. After administration, it is biotransformed into its active metabolite, the 2-hydroxy-4-trifluoromethylbenzoic acid (HTB). We present here an investigation on HTB photobinding to human serum albumin (HSA), the most abundant protein in plasma, using an approach that combines fluorescence, MS/MS, and peptide fingerprint anal. as well as theor. calculations (docking and mol. dynamics simulation studies). The proteomic anal. of HTB/HSA photolyzates shows that HTB addition takes place at the e-amino groups of the Lys137, Lys199, Lys205, Lys351, Lys432, Lys525, Lys541 and Lys545 residues and involves replacement of the trifluoromethyl moiety of HTB with a new amide function. Only Lys199 is located in an internal pocket of the protein, and the remaining modified residues are placed in the external part. Docking and mol. dynamic simulation studies reveal that HTB supramol. binding to HSA occurs in the “V-cleft” region and that the process is assisted by the presence of Glu/Asp residues in the neighborhood of the external Lys, in agreement with the exptl. observed modifications. In principle, photobinding can occur with other trifluoroarom. compounds and may be responsible for the appearance of undesired photoallergic side effects.

Frontiers in Pharmacology published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Application In Synthesis of 328-90-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Nuin, Edurne published the artcilePhotosensitivity to triflusal: formation of a photoadduct with ubiquitin demonstrated by photophysical and proteomic techniques, Product Details of C8H5F3O3, the publication is Frontiers in Pharmacology (2016), 277/1-277/8, database is CAplus and MEDLINE.

Triflusal is a platelet aggregation inhibitor chem. related to acetylsalicylic acid, which is used for the prevention and/or treatment of vascular thromboembolisms, which acts as a prodrug. Actually, after oral administration it is absorbed primarily in the small intestine, binds to plasma proteins (99%) and is rapidly biotransformed in the liver into its deacetylated active metabolite 2-hydroxy-4-trifluoromethylbenzoic acid (HTB). In healthy humans, the half-life of triflusal is ca. 0.5 h, whereas for HTB it is ca. 35 h. From a pharmacol. point of view, it is interesting to note that HTB is itself highly active as a platelet anti-aggregant agent. Indeed, studies on the clin. profile of both drug and metabolite have shown no significant differences between them. It has been evidenced that HTB displays ability to induce photoallergy in humans. This phenomenon involves a cell-mediated immune response, which is initiated by covalent binding of a light-activated photosensitizer (or a species derived therefrom) to a protein. In this context, small proteins like ubiquitin could be appropriate models for investigating covalent binding by means of MS/MS and peptide fingerprint anal. In previous work, it was shown that HTB forms covalent photoadducts with isolated lysine. Interestingly, ubiquitin contains seven lysine residues that could be modified by a similar reaction. With this background, the aim of the present work is to explore adduct formation between the triflusal metabolite and ubiquitin as model protein upon sunlight irradiation, combining proteomic and photophys. (fluorescence and laser flash photolysis) techniques. Photophys. and proteomic anal. demonstrates monoadduct formation as the major outcome of the reaction. Interestingly, addition can take place at any of the ε-amino groups of the lysine residues of the protein and involves replacement of the trifluoromethyl moiety with a new amide function. This process can in principle occur with other trifluoroarom. compounds and may be responsible for the appearance of undesired photoallergic side effects.

Frontiers in Pharmacology published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Product Details of C8H5F3O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gasparic, Jiri published the artcileIdentification of organic compounds. XL. Chromatographic methods for analyzing mixtures of alkyl phenols, SDS of cas: 1139-46-4, the publication is Journal of Chromatography (1961), 408-17, database is CAplus.

cf. CA 55, 12157e. Mixtures of alkyl phenols (I) were obtained by alkylation of the phenols with isobutylene or diisobutylene. Monohydric I were separated and identified by paper chromatog. in solvent systems including HCONMe₂/C₆H₁₄ or paraffin oil/MeOH/H₂O. HCONH₂-impregnated paper and the solvent system C₆H₆/CHCl₃ are recommended for separating alkyl derivatives of pyrocatechols. For anal. purposes, the pyrocatechol derivatives can also be separated on polyamide powder columns with aqueous alc. as eluent. I and alkylcresols are also separated and identified by gas chromatog. on a nonpolar (silicone oil) and a polar (Polydiol 400 3,5-dinitrobenzoate) liquid phase. R_f values in 6 solvent systems and colors with o-chloro-p-nitroaniline (before and after spraying with O.1N NaOH) and diazotized sulfanilic acid are tabulated for PhOH and 25 I. R_f values are also tabulated for pyrocatechol and 4 alkylated derivatives in 3 solvent systems. Retention volumes are given for PhOH and 15 I.

Journal of Chromatography published new progress about 1139-46-4. 1139-46-4 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol, and the molecular formula is C14H22O2, SDS of cas: 1139-46-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts