Tag: M.W=200-250

Kim, Seung-Woo published the artcileNeuroprotective effect of triflusal and its main metabolite, 2-hydroxy-4-trifluoromethylbenzoic acid (HTB), in the postischemic brain, Application In Synthesis of 328-90-5, the publication is Neuroscience Letters (2017), 59-64, database is CAplus and MEDLINE.

2-Hydroxy-4-trifluoromethylbenzoic acid (HTB) is a metabolite of triflusal (TF), and has been reported to exert anti-inflammatory effect. In this study, the authors investigated whether HTB has a neuroprotective effect against ischemic brain injuries. We showed that i.v. administration of HTB (5 mg/kg) 30 min before or 1, 3, or 6 h after middle cerebral artery occlusion (MCAO) reduced brain infarct to 10.4 ± 3.3%, 16.9 ± 2.3%, 22.2 ± 1.5% and 40.7 ± 7.5%, resp., of that of treatment-naive MCAO controls, and the therapeutic time window extended to 9 h after MCAO (40.7 ± 7.5%). Furthermore, HTB suppressed infarct formation, protected motor activities, and ameliorated neurol. deficits more effectively than by TF or salicylic acid (SA). HTB markedly suppressed microglial activation and proinflammatory cytokines expressions in the postischemic brain and in BV2 cells and suppressed LPS-induced nitrite production by inhibiting IkB degradation In addition, HTB suppressed NMDA-induced neuronal cell death more effectively than TF or SA in primary cortical neuron cultures. Together, these results indicate that HTB has multi-modal protective effects against ischemic brain damage that encompass anti-inflammatory, anti-excitotoxicity, and anti-Zn²⁺-toxicity effects.

Neuroscience Letters published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Application In Synthesis of 328-90-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Travassos, Ana Rita published the artcileNon-fragrance allergens in specific cosmetic products, Category: alcohols-buliding-blocks, the publication is Contact Dermatitis (2011), 65(5), 276-285, database is CAplus and MEDLINE.

Objectives. Reports about the nature of the ingredients responsible for allergic contact dermatitis caused by specific cosmetic products are scarce. Methods. Between Jan. 2000 and Dec. 2010, the specific cosmetic products having caused allergic contact dermatitis, as well as the individual allergenic cosmetic ingredients present in them, were recorded by use of a standardized form. Results. Among 11 different categories of cosmetic product, skin care products, followed by hair care and body-cleansing products, were most often involved. The presence of the allergenic ingredient(s) in a specific cosmetic product was confirmed according to the ingredient label in 959 of 1448 records. Six hundred and twenty-one of 959 concerned non-fragrance components, preservatives being responsible for 58% of them. Reactions to formaldehyde and formaldehyde-releasers were most often correlated with body-cleansing products, particularly 2-bromo-2-nitropropane-1,3-diol and skin care products. They were followed by the methylchloroisothiazolinone/methylisothiazolinone mixture, most frequently found as allergens in hair care and intimate hygiene products, and facial cleansers (in the last category together with diazolidinyl urea). Octocrylene was by far the most frequent (photo)allergen in sun care products. Conclusions. This study provides information on the presence and frequency of allergens in specific causal cosmetic products.

Contact Dermatitis published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C20H28B2O4S2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Robichaud, David J. published the artcileDetermining the effects of concerted elimination reactions in the pyrolysis of lignin using model compounds, Related Products of alcohols-buliding-blocks, the publication is Preprints of Symposia – American Chemical Society, Division of Fuel Chemistry (2012), 57(1), 174, database is CAplus.

Lignin pyrolysis occurs over a very broad temperature range at much higher temperatures compared with pyrolysis of the other two primary components of biomass (cellulose and hemicellulose). Due to the higher temperatures required to deconstruct the lignin polymer it promotes the formation of radicals that can lead to excessive char formation due to cross linking and forms more reactive products. It is therefore advantageous to discover new catalytic pathways that can disassemble lignin at lower temperatures, forming more stable products improving the yields of hydrocarbons, and generating less particulate material. This study investigated the thermochem. of the lignin linkage units using ab initio calculations on dimeric model compounds Quantum mech. electronic structure calculations were used to compare the energies of the competing decomposition pathways for the dimer compounds and to estimate the rates of the reactions. The theor. calculations indicated that concerted elimination pathways dominate over bond homolysis reactions under typical pyrolysis conditions. However, this does not mean that concerted elimination will be the dominant loss process for lignin. Bimol. radical chem. could very well dwarf the unimol. pathways investigated in this study. These concerted pathways tend to form stable, reasonably non-reactive products that would be more suited producing a fungible bio-oil for the production of liquid transportation fuels.

Preprints of Symposia – American Chemical Society, Division of Fuel Chemistry published new progress about 70110-65-5. 70110-65-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Alcohol,Ether,Benzene Compounds, name is 2-Phenoxy-1-phenylpropane-1,3-diol, and the molecular formula is C15H16O3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Robichaud, David J. published the artcileDetermining the effects of concerted elimination reactions in the pyrolysis of lignin using model compounds, COA of Formula: C15H16O3, the publication is Preprints of Symposia – American Chemical Society, Division of Fuel Chemistry (2012), 57(1), 1038, database is CAplus.

Lignin pyrolysis is a significant impediment in forming liquid fuel from biomass. Lignin pyrolyzes at a higher temperature than other biomass components (ie cellulose and hemicellulose) and tends to form radicals which lead to crosslinking and ultimately char formation. A primary step in advancing biomass-to-fuel technol. will be to discover mechanisms that can disassemble lignin at lower temperatures and depolymerize lignin into more stable products. We have studied the thermochem. of the various inter-linkage units found in lignin (β-O4, α-O4, β-β, β-O5, etc.) using electronic structure calculations at the M06-2x/6-311++G(d,p) on a series of dimer model compounds In addition to the usually-assumed bond homolysis reactions, we have studied a variety of concerted elimination pathways that will tend to produce closed-shell stable products. Such a bottom-up approach could aid in the targeted development of catalysts that produce more desirable products under less severe reactor conditions.

Preprints of Symposia – American Chemical Society, Division of Fuel Chemistry published new progress about 70110-65-5. 70110-65-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Alcohol,Ether,Benzene Compounds, name is 2-Phenoxy-1-phenylpropane-1,3-diol, and the molecular formula is C15H16O3, COA of Formula: C15H16O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jia, Kangle published the artcileThermal, light and pH triple stimulated changes in self-assembly of a novel small molecular weight amphiphile binary system, Application of 2-Hydroxy-4-(trifluoromethyl)benzoic acid, the publication is RSC Advances (2015), 5(1), 640-642, database is CAplus.

Novel multiple stimuli-responsive fluids based on an azobenzene-contained surfactant 1-[2-(4-decylphenylazo-phenoxy)-ethyl]-3-methylimidazolium bromide (C10AZOC2IMB) and a hydrotrope 4-(trifluoromethyl) salicylic acid (4FS) can be reversibly induced by temperature, light and pH from vesicles to wormlike micelles. UV-vis spectra, rheol. and cryo-TEM measurements were utilized to prove the self-assembly transitions.

RSC Advances published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Application of 2-Hydroxy-4-(trifluoromethyl)benzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chen, Xu published the artcileIron-Catalyzed, Markovnikov-Selective Hydroboration of Styrenes, Quality Control of 608534-44-7, the publication is Organic Letters (2017), 19(5), 969-971, database is CAplus and MEDLINE.

A highly Markovnikov-selective, iron-catalyzed hydroboration of styrenes is reported using available oxazolinylphenyl picolinamide as the ligand to afford the branched hydroboration products with up to >50/1 b/l. This reaction is operationally simple and could be carried out in gram scale.

Organic Letters published new progress about 608534-44-7. 608534-44-7 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic,Boronic acid and ester,Boronate Esters,Boronic Acids,Boronic acid and ester, name is 2-(2,3-Dihydro-1H-inden-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C15H21BO2, Quality Control of 608534-44-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Xu, Xiushang published the artcileSynthesis and characterization of dibenzo[hi,st]ovalene as a highly fluorescent polycyclic aromatic hydrocarbon and its π-extension to circumpyrene, Formula: C8H5F3O3, the publication is Yuki Gosei Kagaku Kyokaishi (2020), 78(11), 1094-1104, database is CAplus.

This account described the synthetic approaches to dibenzo[hi,st]ovalene (DBOV) as a novel PAH with a combination of armchair and zigzag edges and the elucidation of its unique optoelectronic and photophys. properties, such as strong red emission with a fluorescence quantum yield of up to 0.89 and stimulated emission. Furthermore, DBOV demonstrated the so-called fluorescence blinking that enables its application as a fluorophore in single-mol. localization microscopy, which is one of the modern superresoln. fluorescence microscopy methods. The self-assembly of a DBOV derivative bearing two 3,4,5-tris(dodecyloxy)phenyl groups was also investigated, showing the formation of helical columnar stacks. On the other hand, the regioselective bromination of DBOV was achieved, allowing the postsynthetic functionalization and modulation of the optoelectronic properties. Moreover, π-extension of the DBOV at the bay regions led to circumpyrene, the largest circumarene synthesized to date.

Yuki Gosei Kagaku Kyokaishi published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C6H5NO, Formula: C8H5F3O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Dawei published the artcileAn efficient solvent-free synthesis of isoxazolyl-1,4-dihydropyridines on solid support SiO₂ under microwave irradiation, Safety of 3-(2-Chlorophenyl)-5-isoxazolemethanol, the publication is Monatshefte fuer Chemie (2016), 147(9), 1605-1614, database is CAplus.

An efficient synthesis of 1,4-dihydropyridines was developed. 1,4-Dihydropyridines were synthesized starting from various 3-substituted isoxazolyl-5-carbaldehydes, Et acetoacetate, and ammonium acetate under microwave irradiation and solvent-free conditions (86-96 %), and were characterized by HRMS, FTIR, ¹H NMR, and ¹³C NMR spectroscopy. Solid support SiO₂ possesses favorable catalysis and dispersancy for the condensation reaction. The merits of the method included the environmental friendly reaction conditions, simple operation, extensive substrates, good yields and reuse of the SiO₂. Moreover, the crystal structure of compound di-Et 4-[3-(2-methoxyphenyl)isoxazol-5-yl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate in orthorhombic Pbca space group was presented.

Monatshefte fuer Chemie published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C6H6N2O, Safety of 3-(2-Chlorophenyl)-5-isoxazolemethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhong, Yuan-hui published the artcileMethods for synthesis of trifluoromethylsalicylic acid and its intermediate, HPLC of Formula: 328-90-5, the publication is Zhejiang Huagong (2014), 45(1), 7-10, database is CAplus.

A review. 4-(Trifluoromethyl) salicylic acid and m-trifluoromethylphenol are critical intermediate and raw material in the field of pesticide, medicine and others. This article summarizes the methods for synthesis of 4-(trifluoromethyl) salicylic acid, also mainly introduces the synthetic methods of m-trifluoromethylphenol, the synthetic material of 4-(trifluoromethyl) salicylic acid, including the diazotization and hydrolysis of trifluoromethylaniline, the hydroxylation, the trifluoromethylation, the catalytic hydrogenation, the oxidation of benzotrifluoride with hydrogen peroxide, and so on.

Zhejiang Huagong published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C12H25Br, HPLC of Formula: 328-90-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Palmer, Ian Arthur published the artcileNovel salicylic acid analogs induce a potent defense response in Arabidopsis, Application of 2-Hydroxy-4-(trifluoromethyl)benzoic acid, the publication is International Journal of Molecular Sciences (2019), 20(13), 3356, database is CAplus and MEDLINE.

The master regulator of salicylic acid (SA)-mediated plant defense, NPR1 (NONEXPRESSER OF PR GENES 1) and its paralogs NPR3 and NPR4, act as SA receptors. After the perception of a pathogen, plant cells produce SA in the chloroplast. In the presence of SA, NPR1 protein is reduced from oligomers to monomers, and translocated into the nucleus. Several of these analogs can induce SA-mediated defense and inhibit growth of Pseudomonas syringae in Arabidopsis. These analogs, when sprayed on Arabidopsis, can induce the accumulation of the master regulator of plant defense NPR1. In a yeast two-hybrid system, these analogs can strengthen the interactions among NPR proteins. We demonstrated that these analogs can induce the expression of the defense marker gene PR1. Furthermore, we hypothesized that these SA analogs could be potent tools against the citrus greening pathogen Candidatus liberibacter spp. In fact, our results suggest that the SA analogs we tested using Arabidopsis may also be effective for inducing a defense response in citrus. Several SA analogs consistently strengthened the interactions between citrus NPR1 and NPR3 proteins in a yeast two-hybrid system. In future assays, we plan to test whether these analogs avoid degradation by SA hydroxylases from plant pathogens. In future assays, we plan to test whether these analogs avoid degradation by SA hydroxylases from plant pathogens.

International Journal of Molecular Sciences published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Application of 2-Hydroxy-4-(trifluoromethyl)benzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts