Tag: M.W=200-250

Lin, Yu-Ya A. published the artcileOlefin Cross-Metathesis on Proteins: Investigation of Allylic Chalcogen Effects and Guiding Principles in Metathesis Partner Selection, Synthetic Route of 2595-07-5, the main research area is olefin cross metathesis protein allylic chalcogen.

Olefin metathesis has recently emerged as a viable reaction for chem. protein modification. The scope and limitations of olefin metathesis in bioconjugation, however, remain unclear. Herein the authors report an assessment of various factors that contribute to productive cross-metathesis on protein substrates. Sterics, substrate scope, and linker selection are all considered. It was discovered during this investigation that allyl chalcogenides generally enhance the rate of alkene metathesis reactions. Allyl selenides were exceptionally reactive olefin metathesis substrates, enabling a broad range of protein modifications not previously possible. The principles considered in this report are important not only for expanding the repertoire of bioconjugation but also for the application of olefin metathesis in general synthetic endeavors.

Journal of the American Chemical Society published new progress about Bacillus lentus. 2595-07-5 belongs to class alcohols-buliding-blocks, name is (2R,3R,4S,5R,6R)-2-(Allyloxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C9H16O6, Synthetic Route of 2595-07-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kurapati, Sathish Kumar published the artcilecis-Dioxomolybdenum(VI) complexes with unsymmetric linear tetradentate ligands: syntheses, structures and bromoperoxidase activities, SDS of cas: 92093-23-7, the main research area is dioxomolybdenum hydroxyethylamino substituted phenol complex preparation electrochem; aralkyl bromide preparation dioxomolybdenum hydroxyethylamino substituted phenol catalyst; oxidative bromination dioxomolybdenum hydroxyethylamino substituted phenol catalyst; crystal structure dioxomolybdenum hydroxyethylamino ethylamino methyl substituted phenol complex.

Reactions of [MoO2(acetylacetonate)2], 2-((2-(2-hydroxyethylamino)ethylamino)methyl)-4-R-phenols (H2Ln, n = 1 – 5 for R = H, Me, OMe, Cl and Br, resp.) and KOH in 1:1:2 mol ratio in methanol afford a series of complexes having the general formula cis-[MoO2(Ln)] (1-5) in 81-86% yields. The complexes have been characterized using elemental anal., spectroscopy (IR, UV-visible, and 1H NMR, 13C NMR and 13C-DEPT NMR) and electrochem. measurements. The mol. structures of 1-4 have been determined using single-crystal x-ray crystallog. In each of 1-4, the ONNO-donor 6,5,5-membered fused chelate rings forming (Ln)2- and the two mutually cis oxo groups assemble a distorted octahedral N2O4 coordination sphere around the metal center. In the crystal lattice, each of 1-4 forms a one-dimensional infinite chain structure via intermol. N-H···O hydrogen bonding interactions. In cyclic voltammograms, the diamagnetic complexes display an irreversible metal-centered reduction in the potential range -0.73 to -0.88 V (vs. Ag/AgCl). The physicochem. data are consistent with a very similar gross mol. structure for all of 1-5. All the complexes exhibit decent bromoperoxidase activities and are also able to effectively catalyze benzoin and methyl(phenyl)sulfide oxidation reactions.

Applied Organometallic Chemistry published new progress about Aralkyl bromides Role: SPN (Synthetic Preparation), PREP (Preparation). 92093-23-7 belongs to class alcohols-buliding-blocks, name is 1-(4-Bromophenyl)ethane-1,2-diol, and the molecular formula is C8H9BrO2, SDS of cas: 92093-23-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nishi, Nobuya published the artcileSynthesis of a Pentasaccharide Repeating Unit of Lipopolysaccharide Derived from Virulent E. coli O1 and Identification of a Glycotope Candidate of Avian Pathogenic E. coli O1, Recommanded Product: Benzyl (5-hydroxypentyl)carbamate, the main research area is bovine serum albumin oligosaccharide aminoglycoside; stereoselective glycosylation lipopolysaccharide synthesis BSA oligosaccharide aminoglycoside transition state; BSA glycoconjugate pentasaccharide oligosaccharide antigen vaccine antibody; Avian Pathogenic Escherichia coli lipopolysaccharide pentasaccharide repeating unit; avian pathogenic Escherichia coli; boron-mediated aglycon delivery; glycoconjugate; glycotope; β-rhamnoside.

Avian pathogenic Escherichia coli (APEC) is a common bacterial pathogen infecting chickens, resulting in economic losses to the poultry industry worldwide. In particular, APEC O1, one of the most common serotypes of APEC, is considered problematic due to its zoonotic potential. Therefore, many attempts have been made to develop an effective vaccine against APEC O1. In fact, the lipopolysaccharide (LPS) O-antigen of APEC O1 has been shown to be a potent antigen for inducing specific protective immune responses. However, the detailed structure of the O-antigen of APEC O1 is not clear. The present study demonstrates the first synthesis of a pentasaccharide repeating unit of LPS derived from virulent E. coli O1 and its conjugate with BSA. ELISA tests using the semi-synthetic glycoconjugate and the APEC O1 immune chicken serum revealed that the pentasaccharide is a glycotope candidate of APEC O1, with great potential as an antigen for vaccine development.

Angewandte Chemie, International Edition published new progress about Antibodies and Immunoglobulins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 87905-98-4 belongs to class alcohols-buliding-blocks, name is Benzyl (5-hydroxypentyl)carbamate, and the molecular formula is C13H19NO3, Recommanded Product: Benzyl (5-hydroxypentyl)carbamate.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bunthitsakda, Warunda published the artcileControlled rapid synthesis and in vivo immunomodulatory effects of LM α(1,6)mannan with an amine linker, Category: alcohols-buliding-blocks, the main research area is lipomannan synthesis controlled polymerization glycan conjugate adjuvant vaccine; Adjuvant; Controlled polymerization; Glycan conjugation; Lipomannan glycan; Rapid synthesis.

The synthetic lipomannan (LM) α(1,6)mannans, already equipped with an amine linker on the reducing end, are rapidly synthesized in a size-, regio-, and stereocontrolled reaction. The size of the mannans is regulated through the concentration of the linker, applied during the controlled ring-opening polymerization reaction. The versatile amine linker enables a variety of glycan conjugations. The synthetic α(1,6)mannans exert adjuvant activities for a real vaccine antigen, tetanus toxoid (TT) in vitro, as demonstrated by the increased secretion of proinflammatory cytokines TNF-α and IL-6 from the treated macrophages. A conjugation of synthetic α(1,6)mannan with TT can also enhance immune response to TT in vivo after immunization as shown by an increase in TNF-α, IFN-γ, and IL-2 production in splenocytes.

Carbohydrate Polymers published new progress about Conjugation (bond). 87905-98-4 belongs to class alcohols-buliding-blocks, name is Benzyl (5-hydroxypentyl)carbamate, and the molecular formula is C13H19NO3, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Arvand, Majid published the artcileElectrochemical study on the natural and chemical preservatives antibacterial effect against S. aureus PTCC 1112 and its determination at low levels, Computed Properties of 70445-33-9, the publication is Journal of the Iranian Chemical Society (2020), 17(1), 195-203, database is CAplus.

Pathogen microorganisms detection, such as Staphylococcus aureus (S. aureus), is so critical because it can be dangerous for public health. In this research, we have tried to introduce a simple and sensitive modified biosensor by multiwalled carbon nanotubes (MWCNTs) for S. aureus PTCC 1112 detection which was inoculated in PBS (pH 7.4). The pulsed amperometric detection (PAD) method showed that by increasing the concentration of S. aureus suspension, the related current will increase linearly in a dynamic range of 1.88 × 10⁷-3.00 × 10⁸ cfu mL^-1, with a detection limit of 4.85 × 10⁵ cfu mL^-1. The antibacterial effect of three herbal essential oils, tea, bergamot and lemon, and three common chem. cosmetic preservatives, euxyl (phenoxyethanol:ethylhexylglycerin), benzyl alc. and benzalib (alkyl benzyl di-Me ammonium chloride), was compared by electrochem. and biol. methods. The results based on disk diffusion agar method and PAD revealed that this biosensor can be used for comparing the effectiveness of natural and chem. preservatives to inhibit the growth of bacteria. By adding the essential oils into the S. aureus suspension in PBS, the related currents were largely decreased about 65.83% (green tea), 80.49% (bergamot) and 93.30% (lemon) that are in agreement with the inhibition zones of microbial test and comparable to chem. preservatives of euxyl (73.52%), benzyl alc. (90.65%) and benzalib (93.81%). It demonstrates the comparative antibacterial effect of these essential oils vs. chem. preservatives and the ability of MWCNTs/GCE to detect the presence or absence of S. aureus in a few minutes.

Journal of the Iranian Chemical Society published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Computed Properties of 70445-33-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ferrit, M. published the artcileEffects of long-chains of zwitterionic micelles on binding constants of triflusal and acetylsalicylic acid, Recommanded Product: 2-Hydroxy-4-(trifluoromethyl)benzoic acid, the publication is Colloids and Surfaces, A: Physicochemical and Engineering Aspects (2009), 345(1-3), 26-30, database is CAplus.

A spectrophotometric study of the reaction of the alk. hydrolysis of triflusal (TFL) and acetylsalicylic acid (ASA) in the presence of zwitterionic micelles was carried out, with the objective of determining the effects of the hydrophobic and electrostatic interactions on the micellar union of both drugs. A series of zwitterionic surfactants of alkyldimethylammonio propanesulfonate (SB3-n) was used: decyldimethylammonio propanesulfonate (SB3-10), tetradecyldimethylammonio propanesulfonate (SB3-14), hexadecyldimethylammonio propanesulfonate (SB3-16). This reaction is inhibited at higher surfactant concentrations The exptl. data has been processed according to the micellar pseudophase model. The values of the binding constants of both drugs in the micelle (K _S) determine the importance of the hydrophobic and electrostatic interactions in the micelle solubilization of both drugs.

Colloids and Surfaces, A: Physicochemical and Engineering Aspects published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Recommanded Product: 2-Hydroxy-4-(trifluoromethyl)benzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ferrit, Monica published the artcileThe study of the influence of surfactant charge on alkaline hydrolysis reactions of acetylsalicylic acid (ASA) and triflusal (TFL) using spectrophotometric methods, Application of 2-Hydroxy-4-(trifluoromethyl)benzoic acid, the publication is European Journal of Pharmaceutical Sciences (2007), 31(3-4), 211-220, database is CAplus and MEDLINE.

In this research, the effects of micellar systems on alk. hydrolysis reactions of acetylsalicylic acid (ASA) and triflusal (TFL) were found to be dependant upon the surfactant charge within the micelle. In cationic micelles, there is a catalytic effect at low concentrations of surfactant. However, this reaction is inhibited at higher surfactant concentrations In anionic micelles, a catalytic effect occurs, while in zwitterionic and non-ionic micelles there is an inhibitory effect. Such reactions are attributable to changes in reactants on the micellar surface, or to the fact that both reactants are found in different microenvironments. The pseudophase (PS) and ion-exchange (PPIE) models were found to be consistent with the exptl. result. Furthermore, the association constants for both drugs could be determined together with micellar rate constants in heterogeneous media.

European Journal of Pharmaceutical Sciences published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Application of 2-Hydroxy-4-(trifluoromethyl)benzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Palmer, Michael J. published the artcilePotent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series, Synthetic Route of 328-90-5, the publication is Journal of Medicinal Chemistry (2021), 64(9), 6085-6136, database is CAplus and MEDLINE.

Dihydroorotate dehydrogenase (DHODH) has been clin. validated as a target for the development of new antimalarials. Experience with clin. candidate triazolopyrimidine DSM265 (1) suggested that DHODH inhibitors have great potential for use in prophylaxis, which represents an unmet need in the malaria drug discovery portfolio for endemic countries, particularly in areas of high transmission in Africa. We describe a structure-based computationally driven lead optimization program of a pyrrole-based series of DHODH inhibitors, leading to the discovery of two candidates for potential advancement to preclin. development. These compounds have improved physicochem. properties over prior series frontrunners and they show no time-dependent CYP inhibition, characteristic of earlier compounds Frontrunners have potent antimalarial activity in vitro against blood and liver schizont stages and show good efficacy in Plasmodium falciparum SCID mouse models. They are equally active against P. falciparum and Plasmodium vivax field isolates and are selective for Plasmodium DHODHs vs. mammalian enzymes.

Journal of Medicinal Chemistry published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Synthetic Route of 328-90-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Saxena, A. K. published the artcileModelling the binding affinity of steroids to zebrafish sex hormone-binding globulin, Synthetic Route of 1139-46-4, the publication is SAR and QSAR in Environmental Research (2014), 25(5), 407-421, database is CAplus and MEDLINE.

The circulating endogenous steroids are transported in the bloodstream. These are bound to a highly specific sex hormone-binding globulin (SHBG) and in lower affinity to proteins such as the corticosteroid-binding protein and albumin in vertebrates, including fish. It is generally believed that the glycoprotein SHBG protects these steroids from rapid metabolic degradation and thus intervenes in its availability at the target tissues. Endocrine disrupters binding to SHBG affect the normal activity of natural steroids. Since xenobiotics are primarily released in the aquatic environment, there is a need to evaluate the binding affinity of xenosteroid mimics on fish SHBG, especially in zebrafish (Danio rerio), a small freshwater fish originating in India and widely employed in ecotoxicol., toxicol., and genetics. In this context, a zebrafish SHBG (zfSHBG) homol. model was developed using the human SHBG (hSHBG) receptor structure as template. It was shown that interactions with amino acids Ser-36, Asp-59 and Thr-54 were important for binding affinity. A ligand-based pharmacophore model was also developed for both zfSHBG and hSHBG inhibitors that differentiated binders from non-binders, but also demonstrated structural requirements for zfSHBG and hSHBG ligands. The study provides insights into the mechanism of action of endocrine disruptors in zebrafish as well as providing a useful tool for identifying anthropogenic compounds inhibiting zfSHBG.

SAR and QSAR in Environmental Research published new progress about 1139-46-4. 1139-46-4 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol, and the molecular formula is C14H22O2, Synthetic Route of 1139-46-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sutter, Marc published the artcile1,2,3-Trimethoxypropane and Glycerol Ethers as Biosource Solvents from Glycerol. Synthesis by Solvent-Free Phase-Transfer Catalysis and Utilization as an Alternative Solvent in Chemical Transformations, Quality Control of 70445-33-9, the publication is ChemCatChem (2013), 5(10), 2893-2904, database is CAplus.

1,2,3-Trimethoxypropane, 1-alkoxy-2,3-dimethoxypropane and 1-aryloxy-2,3-dimethoxypropane were prepared in good yields and selectivity by a solid-liquid phase-transfer catalysis in the presence of an inorganic base and an ammonium salt as a phase-transfer catalyst with no addnl. solvent. No heating was required and the synthesis of the target compounds was achieved easily under atm. pressure on a 150 g scale. For the preparation of 1,2,3-trimethoxypropane, the conversion of glycerol was complete and the selectivity for the expected glycerol tri-Me ether was above 95%. This product was used as a solvent in organic reactions such as a transesterification between glycerol and vegetable oil, organometallic reactions (Grignard- and Barbier-type reactions), carbon-carbon coupling reactions (Suzuki, Sonogashira, Heck) and in etherification reactions by dehydrogenative alkylation. The solvent showed interesting properties for the solubilization of polymers.

ChemCatChem published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C6H12Br2, Quality Control of 70445-33-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts