Tag: M.W=200-250

Qian, Ya-fang published the artcileDetermination of triflusal and its active metabolite 2-hydroxy-4-(trifluoromethyl)benzoic acid in human plasma by LC-MS, Category: alcohols-buliding-blocks, the publication is Yaowu Fenxi Zazhi (2014), 34(9), 1541-1548, database is CAplus.

A reliable liquid chromatog.-mass spectrometry (LC-MS) method for the determination of triflusal and its active metabolite 2-hydroxy-4-(trifluoromethyl)benzoic acid (HTB) in human plasma was developed. The stability of triflusal in human plasma was evaluated when formic acid of different concentrations was used as the esterase inhibitor. The plasma concentrations of triflusal and HTB were determined by LC-MS, resp. Separation of the analytes was achieved on a Hedera ODS-2 column, and MS determination was carried out in electrospray ionization mode. The stability of triflusal in human plasma was kept by adding 20 μL of 4% formic acid to an aliquot of 400 μL of plasma, and then triflusal was extracted with acetyl acetate. Triflusal was eluted with a mobile phase of acetonitrile (A)-5 mmol·L^-1 ammonium acetate solution containing 0.1 % acetic acid (B) using gradient elution (0-0.1 min, 20%A; 0.1-0.15 min, 20%A→30%A; 0.15-6 min, 30%A; 6-6.5 min, 30% A→100% A; 6.5-9.5 min, 100% A; 9.5-10 min, 100% A→20% A; 10-13.7 min, 20% A) at a flow rate of 0.4 mL·min^-1. The deprotonated ions were at m/z 247.0 and 150.0 for monitoring for triflusal and the internal standard (IS) paracetamol, resp. The protein precipitation method was used for HTB sample treatment. HTB in the treated samples was separated with a mobile phase of methanol-5 mmol·L^-1 ammonium acetate solution containing 3% formic acid (75:25) at a flow rate of 0.25 mL·min^-1. The deprotonated ions were at m/z 205.0 and 137.0 for monitoring for HTB and salicylic acid (IS) resp. The calibration ranges were 0.01-20.37 μg·mL^-1 and 0.7-159.9 μg·mL^-1 for triflusal and HTB, resp. As the lower limit of quantitation for triflusal (0.01 μg·mL^-1) was lower than that by the previous reported methods (0.03 μg·mL^-1), the elimination half-life of triflusal in human could be determined more accurately. The current method was successfully applied to determine the concentration levels of triflusal and HTB in human plasma. The methods can be used for determination of triflusal and HTB in human plasma in pharmacokinetics and bioequivalence studies.

Yaowu Fenxi Zazhi published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ge, Jie published the artcileEffect of food on the pharmacokinetics of triflusal and its major active metabolite, 2-hydroxy-4-trifluoromethyl benzoic acid, in healthy subjects, SDS of cas: 328-90-5, the publication is International Journal of Clinical Pharmacology and Therapeutics (2015), 53(3), 272-276, database is CAplus and MEDLINE.

Objective: The objective of this study was to evaluate the pharmacokinetic parameters of triflusal and its major active metabolite, 2-hydroxy-4-trifluoromethyl benzoic acid (HTB), following a single oral dose of 900 mg in healthy subjects under fed and fasting conditions. Methods: The study participants (n = 12) were randomized to receive one 900 mg triflusal capsule in a fasting condition (no food for 12 h) or a fed condition (after a high-fat meal); after a 2-wk washout period, participants received the same dose of triflusal capsule under the converse condition. Pharmacokinetic parameters were calculated using WinNonlin 6.2 software. Safety was evaluated through assessment of adverse events, standard laboratory evaluations, vital signs, and 12-lead electrocardiog. Results: The mean Cmax of triflusal and HTB were 13.96, 110.2 ug/mL for the fasting state and 9.546, 97.15 ug/mL for the fed state, resp. The AUC0-144 of triflusal and HTB were 19.66, 5,572 h × μg/mL for the fasting state and 22.20, 5,038 h × μg/mL for the fed state, the AUC0-∞ of triflusal and HTB were 19.79, 6,333 h × μg/mL for the fasting state and 22.44, 5,632 h × μg/mL for the fed state, resp. The results showed that Cmax and AUCs for triflusal were outside the bioequivalency (BE) interval after food intake, but there was no statistically significant change for HTB. Conclusion: High-fat food intake may affect the pharmacokinetics of triflusal capsule in healthy subjects.

International Journal of Clinical Pharmacology and Therapeutics published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, SDS of cas: 328-90-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lewinska, Agnieszka published the artcileTargeted hybrid nanocarriers as a system enhancing the skin structure, Safety of 3-((2-Ethylhexyl)oxy)propane-1,2-diol, the publication is Molecules (2021), 26(4), 1063, database is CAplus and MEDLINE.

The skin is constantly exposed to external and internal factors that disturb its function. In this work, two nanosystems-levan nanoparticles and a surfactin-stabilized nanoemulsion were preserved (tested for microbial growth) and characterized (size, polydispersity, Zeta potential, and stability). The nanosystems were introduced in the model formulations-cream, tonic, and gel, and confirmed by TEM. The anal. showed that nanoemulsion has a spherical morphol. and size 220- 300 nm, while levan nanoparticles had irregular shapes independently of the use of matrix and with particle size (130-260 nm). Addnl., we examined the antiradical effect of levan nanoparticles and nanoemulsion in the prototype of formulations by scavenging DPPH (2,2-diphenyl-1-picrylhydrazyl; EPR spectroscopy). The model cream with both nanosystems and the whole range of products with nanosystems were evaluated in vivo for hydration, elasticity, smoothness, wrinkles and vascular lesions, discoloration, resp. The cream improved skin condition in all tested parameters in at least 50% of volunteers. The use of more comprehensive care, addnl. consisting of a tonic and gel, reduced the previously existing skin discoloration to 10.42 ± 0.58%. The presented prototype formulations are promising in improving skin conditions.

Molecules published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Safety of 3-((2-Ethylhexyl)oxy)propane-1,2-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Draelos, Zoe Diana published the artcileThe effect of an anti-inflammatory botanical cleanser/night mask combination on facial redness reduction, SDS of cas: 70445-33-9, the publication is Journal of Drugs in Dermatology (2018), 17(6), 671-676, database is CAplus and MEDLINE.

Facial redness is a common difficult to control cosmetic problem representing various phases of rosacea. Using anti-inflammatory/antioxidant botanicals in moisturizer formulations is a possible approach to minimizing the erythema.This research utilized a common facial cleanser, but only applied the botanically based moisturizer to one half face to properly assess efficacy. 30 female subjects Filzpatrick skin types l-IV 30-55 years of age with mild to moderate chronic facial redness, defined as a redness score of 3-6 on a 10-point scale, were enrolled. By the end of week 4, statistically significant improvement was seen on the cleanser/mask treated side in scaling (P<0.001), flaking (P<0.001), tactile smoothness (P<0.001), textural smoothness (P<0.001), firmness (P<0.001), radiance (Pc0.001), luminosity (P<0.001), and overall appearance (P<0.001).Thus, cosmetic moisturizers may be useful in reducing facial redness.

Journal of Drugs in Dermatology published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, SDS of cas: 70445-33-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

James, Kenneth published the artcileThe synthesis of per-O-benzyl-α-D-galactosyl and -α-L-fucosyl bromides, Related Products of alcohols-buliding-blocks, the main research area is hexopyranosyl perbenzylated bromide; galactopyranosyl perbenzylated bromide; fucopyranosyl perbenzylated bromide; benzylated hexopyranosyl bromide.

The title galactosyl bromide was prepared by benzylation of allyl galactopyranoside, with PhCH2Br-NaH, isomerization of the allyl group with tert-BuOK-Me2SO to prop-1-enyl tetra-O-benzyl-β-D-galactopyranoside. Removal of the vinyl residue with HgO and reaction with p-O2NC6H4COCl gave the tetra-O-benzyl-1-O-p-nitrobenzoyl-D-galactopyranose (I). Treatment of I with HBr gave 80% of the α-bromide as an oil. The fucopyranosyl derivative was prepared similarly.

Australian Journal of Chemistry published new progress about hexopyranosyl perbenzylated bromide; galactopyranosyl perbenzylated bromide; fucopyranosyl perbenzylated bromide; benzylated hexopyranosyl bromide. 2595-07-5 belongs to class alcohols-buliding-blocks, name is (2R,3R,4S,5R,6R)-2-(Allyloxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C9H16O6, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Von Wettstein-Knowles, Penny published the artcile7-Oxopentadecan-2-ol esters – a new epicuticular wax lipid class, Recommanded Product: 5-Tridecanol, the main research area is oxopentadecanol ester barley epicuticular wax.

The alkan-1-ol and alkan-2-ol esters (primarily, C38-48 and C33-35, resp.) of barley epicuticular waxes are known to arise via 2 different biosynthetic pathways. A third type of ester (∼0.2% by weight of spike wax), previously unknown in these plant lipids, was identified. The esters were isolated via preparative TLC together with the longer chain primary alcs. From the effects of chem. treatments analyzed with the aid of TLC and gas chromatog. (GC), the presence of an oxo group in the alc. moiety was deduced. GC-mass spectrometry of the esters and their alc. moieties before and after NaBH4 treatment and of the fatty acid moieties resulted in the identification of at least 3 7-oxopentadecan-2-ol esters (C33, C35, and C37). 2,7-Dihydroxypentadecane was synthesized and its mass spectrum found to be identical to that of the reduced ester alc. moiety. A determination of the relative amounts of these esters in 10 different genotypes supports the contention that biosynthetically the pentadecan-2-ol esters are precursors of those containing an oxo group on C 7.

Carlsberg Research Communications published new progress about Barley. 58783-82-7 belongs to class alcohols-buliding-blocks, name is 5-Tridecanol, and the molecular formula is C13H28O, Recommanded Product: 5-Tridecanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rauter, Marion published the artcileSynthesis of benzyl β-D-galactopyranoside by transgalactosylation using a β-galactosidase produced by the over expression of the Kluyveromyces lactis LAC4 gene in Arxula adeninivorans, Related Products of alcohols-buliding-blocks, the main research area is benzyl beta galactopyranoside transgalactosylation galactosidase Kluyveromyces LAC4 Arxula.

The LAC4 gene of Kluyveromyces lactis encoding for β-galactosidase was overexpressed in the yeast Arxula adeninivorans to produce the enzyme, which can be used for the synthesis of β-D-galactosides. These compounds play a major role as precursors for the synthesis of glycolipids and glycoproteins in medicine or for the production of tensides. The Xplor2 transformation/expression platform was used because it enabled stable integration of the gene in the Arxula genome and the production of high levels of the enzyme. The recombinant β-galactosidase, fused with C-terminal His-tag region (Lac4-6hp), was purified by precipitation with ammonium sulfate and FPLC using hydroxylapatite. The enzyme exhibited optimal activity at 37 to 40°, pH 6.5 in 50 mM sodium acetate buffer. Activity was measured by the formation of p-nitrophenol at 405 nm from the hydrolyzed chromogenic substrate, p-nitrophenyl-β-D-gal. Biochem. characterization included the calculation of Km and apparent kcat values of the enzyme. The formation of benzyl β-D-gal by 0.1 U enzyme from A. adeninivorans with transgalactosylation was six times higher than that for the prokaryotic enzyme from E. coli. Moreover, the partially purified enzyme was used for the selective hydrolysis of allyl β-D-gal in a mixture of allyl β- and allyl α-D-gal, with 4 g l-1 being hydrolyzed within one day by 1 U ml-1. Thus, the recombinant β-galactosidase produced in A. adeninivorans is of potential interest for the enzymic synthesis of benzyl β-D-gal and other galactosides as well as the selective hydrolysis of anomeric mixtures and could be used to replace difficult chem. procedures.

Journal of Molecular Catalysis B: Enzymatic published new progress about Anomers. 2595-07-5 belongs to class alcohols-buliding-blocks, name is (2R,3R,4S,5R,6R)-2-(Allyloxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C9H16O6, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rossi, Marco published the artcileSeparation of O- and C-allyl glycoside anomeric mixtures by capillary electrophoresis and high-performance liquid chromatography, Related Products of alcohols-buliding-blocks, the main research area is allyl glycoside anomer capillary electrophoresis liquid chromatog.

Rapid and reliable methods for the anal. of O- and C-allyl galactopyranosides and glucopyranosides are presented, based on capillary zone electrophoresis (CZE) and micellar electrokinetic capillary chromatog. (MEKC). In MEKC, the formation of chromophoric and charged complexes between the saccharides and borate as well as the hydrophobic interactions with micelles jointly contributed to the selective separation and sensitive detection of all the investigated anomeric couples. Some non-purified synthesis mixtures of C-allyl glycosides were successfully characterized without pre-treatment. MEKC buffer conditions for which glycosides separation was successfully achieved were then exported and applied to reverse-phase liquid chromatog. (RP-HPLC), for the quant. isolation of each allyl glycoside anomer. Identification of the obtained anomeric products was performed by electrospray mass spectrometry and 13C NMR spectroscopy. Glycoside-solvent interactions driving the selective anomeric separation were shortly addressed and discussed on the basis of sugar derivatives structural differences.

Journal of Chromatography A published new progress about Anomers. 2595-07-5 belongs to class alcohols-buliding-blocks, name is (2R,3R,4S,5R,6R)-2-(Allyloxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C9H16O6, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mandal, Satadru Sekhar published the artcileNovel solutions for vaccines and diagnostics to combat brucellosis, Product Details of C13H19NO3, the main research area is vaccine Brucella A antigen polysaccharide tetanus toxoid brucellosis; diagnosis brucellosis Brucella synthetic M antigen polysaccharide.

Brucellosis is diagnosed by detection of antibodies in the blood of animals and humans that are specific for two carbohydrate antigens, termed A and M, which are present concurrently in a single cell wall O-polysaccharide. Animal brucellosis vaccines contain these antigenic determinants, and consequently infected and vaccinated animals cannot be differentiated as both groups produce A and M specific antibodies. We hypothesized that chem. synthesis of a pure A vaccine would offer unique identification of infected animals by a synthetic M diagnostic antigen that would not react with antibodies generated by this vaccine. Two forms of the A antigen, a hexasaccharide and a heptasaccharide conjugated to tetanus toxoid via reducing and nonreducing terminal sugars, were synthesized and used as lead vaccine candidates. Mouse antibody profiles to these immunogens showed that to avoid reaction with diagnostic M antigen it was essential to maximize the induction of anti-A antibodies that bind internal oligosaccharide sequences and minimize production of antibodies directed toward the terminal nonreducing monosaccharide. This objective was achieved by conjugation of Brucella O-polysaccharide to tetanus toxoid via its periodate oxidized terminal nonreducing monosaccharide, thereby destroying terminal epitopes and focusing the antibody response on internal A epitopes. This establishes the method to resolve the decades-long challenge of how to create effective brucellosis vaccines without compromising diagnosis of infected animals.

ACS Central Science published new progress about Animalia. 87905-98-4 belongs to class alcohols-buliding-blocks, name is Benzyl (5-hydroxypentyl)carbamate, and the molecular formula is C13H19NO3, Product Details of C13H19NO3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Serna, Sonia published the artcileConstruction of N-Glycan Microarrays by Using Modular Synthesis and On-Chip Nanoscale Enzymatic Glycosylation, Product Details of C13H19NO3, the main research area is construction glycan microarray modular synthesis chip nanoscale enzymic glycosylation.

An effective chemoenzymic strategy is reported that has allowed the construction, for the first time, of a focused microarray of synthetic N-glycans. Based on modular approaches, a variety of N-glycan core structures have been chem. synthesized and covalently immobilized on a glass surface. The printed structures were then enzymically diversified by the action of three different glycosyltransferases in nanodroplets placed on top of individual spots of the microarray by a printing robot. Conversion was followed by lectin binding specific for the terminal sugars. This enzymic extension of surface-bound ligands in nanodroplets reduces the amount of precious glycosyltransferases needed by seven orders of magnitude relative to reactions carried out in the solution phase. Moreover, only those ligands that have been shown to be substrates to a specific glycosyltransferase can be individually chosen for elongation on the array. The methodol. described here, combining focused modular synthesis and nanoscale on-chip enzymic elongation, could open the way for the much needed rapid construction of large synthetic glycan arrays.

Chemistry – A European Journal published new progress about Affinity. 87905-98-4 belongs to class alcohols-buliding-blocks, name is Benzyl (5-hydroxypentyl)carbamate, and the molecular formula is C13H19NO3, Product Details of C13H19NO3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts