Wang, Jie’s team published research in Youji Huaxue in 33 | CAS: 328-90-5

Youji Huaxue published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C16H20N2, HPLC of Formula: 328-90-5.

Wang, Jie published the artcilePreparation of N-aryl-salicylamide derivatives as antitumor agents, HPLC of Formula: 328-90-5, the publication is Youji Huaxue (2013), 33(5), 1026-1034, database is CAplus.

According to the scaffold hopping, a series of N-aryl-salicylamide derivatives, which have fragments of tyrosine kinase inhibitors lapatinib and neratinib were designed and synthesized. Their structures were identified by IR, 1H NMR, 13C NMR and MS techniques. The target compounds were tested for cytotoxic activity against four cancer cell lines, including A549, MCF-7, SGC-7901, Bel-7402, by Me thiazolyl tetrazolium (MTT) in vitro. All the compounds demonstrated certain antitumor abilities, and some of them were better than gefitinib.

Youji Huaxue published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C16H20N2, HPLC of Formula: 328-90-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhao, Qiuting’s team published research in Organometallics in 41 | CAS: 608534-44-7

Organometallics published new progress about 608534-44-7. 608534-44-7 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic,Boronic acid and ester,Boronate Esters,Boronic Acids,Boronic acid and ester, name is 2-(2,3-Dihydro-1H-inden-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C48H47FeP, Recommanded Product: 2-(2,3-Dihydro-1H-inden-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane.

Zhao, Qiuting published the artcileGroup 4 Metallocene Complexes Supported by a Redox-Active O,C-Chelating Ligand, Recommanded Product: 2-(2,3-Dihydro-1H-inden-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, the publication is Organometallics (2022), 41(12), 1488-1500, database is CAplus.

Group 4 metallocene complexes Cp2M[OC] (Cp = η5-C5H5; M = Ti (1) or Zr (2); [OC] = κ2-O,C-OC6H2-2-CPh2-4,6-tBu2) supported with a redox-active bidentate O,C-ligand were successfully synthesized through salt metathesis. X-ray crystallog. results showed that both complexes maintained similar bent metallocene coordination geometry. A close inspection of the structural parameters revealed a remarkably long Ti-C bond in 1, indicating concomitant intramol. charge transfer upon metathesis and coordination. The electronic structure of 1 was studied by EPR measurements, revealing the presence of a Ti(III) center and one [OC]•- radical anion. In contrast, the diamagnetic complex 2 was found to comprise a Zr(IV) center and an alkyl/aryloxo dianion. Divergent catalytic reactivity was observed for the two Group 4 derivatives in the reaction between alkenes and HBpin. Specifically, dehydrogenative boration products (i.e., vinyl boronate esters) were obtained exclusively in the presence of the Zr complex (18 examples, up to 90% yield), while the Ti compound selectively promoted the formation of alkyl boronate esters via hydroboration (19 examples, up to 99% yield).

Organometallics published new progress about 608534-44-7. 608534-44-7 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic,Boronic acid and ester,Boronate Esters,Boronic Acids,Boronic acid and ester, name is 2-(2,3-Dihydro-1H-inden-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C48H47FeP, Recommanded Product: 2-(2,3-Dihydro-1H-inden-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Radzki, Dominik’s team published research in International Journal of Environmental Research and Public Health in 19 | CAS: 70445-33-9

International Journal of Environmental Research and Public Health published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Quality Control of 70445-33-9.

Radzki, Dominik published the artcileA Fresh Look at Mouthwashes-What Is Inside and What Is It For?, Quality Control of 70445-33-9, the publication is International Journal of Environmental Research and Public Health (2022), 19(7), 3926, database is CAplus and MEDLINE.

Mouthwashes are a very popular addnl. oral hygiene element and there are plenty of individual products, whose compositions are in a state of flux. The aim of our study was to investigate the compositions of mouthwashes and their functions, as well as to discuss their effectiveness in preventing and curing oral diseases and side effects. We searched for mouthwashes available on the market in Poland. We identified 241 individual mouthwash products. The extraction of compositions was performed and functions of the ingredients were assessed. Then, anal. was performed. The evaluation revealed that there are plenty of ingredients, but a typical mouthwash is a water-glycerin mixture and consists of addnl. sweetener, surfactant, preservative, and some colorant and flavoring agent, as well as usually having two oral health substances, anticaries sodium fluoride and antimicrobial essential oils. The effectiveness or side effects of several substances of mouthwashes were thoroughly discussed. We recommend not multiplying individual mouthwash products and their ingredients beyond medical or pharmaceutical necessity, especially without scientific proof.

International Journal of Environmental Research and Public Health published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Quality Control of 70445-33-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kleinmans, Roman’s team published research in Chemical Science in 12 | CAS: 608534-44-7

Chemical Science published new progress about 608534-44-7. 608534-44-7 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic,Boronic acid and ester,Boronate Esters,Boronic Acids,Boronic acid and ester, name is 2-(2,3-Dihydro-1H-inden-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C15H21BO2, Safety of 2-(2,3-Dihydro-1H-inden-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane.

Kleinmans, Roman published the artcilePhotoredox-enabled 1,2-dialkylation of α-substituted acrylates via Ireland-Claisen rearrangement, Safety of 2-(2,3-Dihydro-1H-inden-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, the publication is Chemical Science (2021), 12(8), 2816-2822, database is CAplus and MEDLINE.

The 1,2-dialkylation of simple feedstock acrylates RC(=CH2)C(O)OR1 [R = H, Me, F, i-Pr, naphthalen-1-yl, etc.; R1 = prop-2-en-1-yl, 4-ethenyloxan-4-yl, 2-chloroprop-2-en-1-yl, 2-(4-oxocyclohexylidene)ethyl, etc.] for the synthesis of valuable tertiary carboxylic acids R2CH2C(R)(R3)C(O)OH [R2 = cyclohexyl, oxan-4-yl, 5-(2,5-dimethylphenoxy)-2-methylpentan-2-yl, etc.; R3 = prop-2-en-1-yl, 2-(oxan-4-ylidene)ethyl, 2-chloroprop-2-en-1-yl, etc.] by merging Giese-type radical addition with an Ireland-Claisen rearrangement have been reported. Key to success is the utilization of the reductive radical-polar crossover concept under photocatalytic reaction conditions to force the [3,3]-sigmatropic rearrangement after alkyl radical addition to allyl acrylates. Using readily available alkyl boronic acids as radical progenitors, this redox-neutral, transition-metal-free protocol allows the mild formation of two C(sp3)-C(sp3) bonds, thus providing rapid access to complex tertiary carboxylic acids in a single step. Moreover, this strategy enables the efficient synthesis of highly attractive α,α-dialkylated γ-amino butyric acids (GABAs) R4(CH2)2C(CH3)(CH2CH=CH2)C(O)OH [R4 = dibutylaminyl, morpholin-4-yl, 4-[2-(morpholin-4-yl)-2-oxoethyl]piperazin-1-yl, etc.] when α-silyl amines R4CH2Si(CH3)3 are used as radical precursors – a structural motif that was still inaccessible in related transformations. Depending on the nature of the radical precursors and their inherent oxidation potentials, either a photoredox-induced radical chain or a solely photoredox mechanism is proposed to be operative.

Chemical Science published new progress about 608534-44-7. 608534-44-7 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic,Boronic acid and ester,Boronate Esters,Boronic Acids,Boronic acid and ester, name is 2-(2,3-Dihydro-1H-inden-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C15H21BO2, Safety of 2-(2,3-Dihydro-1H-inden-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Fasano, Valerio’s team published research in Angewandte Chemie, International Edition in 59 | CAS: 608534-44-7

Angewandte Chemie, International Edition published new progress about 608534-44-7. 608534-44-7 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic,Boronic acid and ester,Boronate Esters,Boronic Acids,Boronic acid and ester, name is 2-(2,3-Dihydro-1H-inden-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C15H21BO2, Computed Properties of 608534-44-7.

Fasano, Valerio published the artcileDivergent, Stereospecific Mono- and Difluoromethylation of Boronic Esters, Computed Properties of 608534-44-7, the publication is Angewandte Chemie, International Edition (2020), 59(22), 8502-8506, database is CAplus and MEDLINE.

There is considerable interest in incorporating fluorine into agrochems. and pharmaceuticals to improve their biol. properties. While a number of methods have been reported for installing CH2F and CHF2 groups, they are mainly limited to radical reactions, which are invariably racemic. Herein, we report the divergent, stereospecific reaction of fluoroiodomethyllithium with boronic esters to give α-fluoro-boronic esters. These unique intermediates can be readily transformed into the corresponding mono- or difluoromethylated compounds through proto- or fluorodeboronation, resp. The use of the highly unstable fluoroiodomethyllithium was key to allowing rapid 1,2-migration over competing decomposition of the carbanion. DFT calculations informed and supported the exptl. findings. Thus, e.g., homologation of I with FCH2I/LDA → II (90%); protodeboronation using 4-tBu-catechol/TFA afforded III (90%).

Angewandte Chemie, International Edition published new progress about 608534-44-7. 608534-44-7 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic,Boronic acid and ester,Boronate Esters,Boronic Acids,Boronic acid and ester, name is 2-(2,3-Dihydro-1H-inden-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C15H21BO2, Computed Properties of 608534-44-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Dinkloh, A.’s team published research in Journal of the European Academy of Dermatology and Venereology in 29 | CAS: 70445-33-9

Journal of the European Academy of Dermatology and Venereology published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Quality Control of 70445-33-9.

Dinkloh, A. published the artcileContact sensitization in patients with suspected cosmetic intolerance: results of the IVDK 2006-2011, Quality Control of 70445-33-9, the publication is Journal of the European Academy of Dermatology and Venereology (2015), 29(6), 1071-1081, database is CAplus and MEDLINE.

Background : Ingredients of leave-on cosmetics and body care products may sensitize. However, not every case of cosmetic intolerance is due to contact sensitization. Objective : To describe the frequency of contact sensitization due to cosmetics in a large clinic population, and a possible particular allergen pattern. Methods : Retrospective anal. of data from the Information Network of Departments of Dermatol., 2006-2011. Results : Of 69 487 patients tested, ‘cosmetics, creams, sunscreens’ was the only suspected allergen source category in 10 124 patients (14.6%). A final diagnosis ‘allergic contact dermatitis’ was stated in 2658 of these patients (26.3%).Compared to a control group, there were significantly more reactions to fragrance mixes I and II, balsam of Peru, methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) and lanolin alcs. No special pattern of fragrance sensitization could be identified. Among the preservatives, MI was by far the leading allergen, while sensitization to other widely used compounds like parabens or phenoxyethanol was rare. Conclusions : True allergic reactions to cosmetic ingredients are rarer than generally assumed. Limitation of exposure to MI in leave-on cosmetics and body care products is urgently needed.

Journal of the European Academy of Dermatology and Venereology published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Quality Control of 70445-33-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Nakamura, Shohei’s team published research in Fragrance Journal in 45 | CAS: 70445-33-9

Fragrance Journal published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Application of 3-((2-Ethylhexyl)oxy)propane-1,2-diol.

Nakamura, Shohei published the artcileDevelopment and application of functional powder coated by perfluoropolyoxypropylene (PFPOP) derivative, Application of 3-((2-Ethylhexyl)oxy)propane-1,2-diol, the publication is Fragrance Journal (2017), 45(3), 38-41, database is CAplus.

For cosmetic ingredients, the surface treated clay powders are well used. Especially perfluoroalkyl derivatives are widely used for their water or sebum proof properties. We developed a novel perfluoropolyoxypropylene derivative and used as a surface treatment agent. Surface treated clay powders had much higher water and oil repellency and better smoothness. We confirmed its long lasting effect by applying it to powder foundation formulation with 30wt% surface treated powder.

Fragrance Journal published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Application of 3-((2-Ethylhexyl)oxy)propane-1,2-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gao, Fang’s team published research in ACS Catalysis in 6 | CAS: 70110-65-5

ACS Catalysis published new progress about 70110-65-5. 70110-65-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Alcohol,Ether,Benzene Compounds, name is 2-Phenoxy-1-phenylpropane-1,3-diol, and the molecular formula is C15H16O3, Name: 2-Phenoxy-1-phenylpropane-1,3-diol.

Gao, Fang published the artcileFragmentation of Lignin Samples with Commercial Pd/C under Ambient Pressure of Hydrogen, Name: 2-Phenoxy-1-phenylpropane-1,3-diol, the publication is ACS Catalysis (2016), 6(11), 7385-7392, database is CAplus.

We report the reagentless cleavage of prevalent β-O-4 linkages in lignin model compounds, as well as the cleavage of several types of organosolv lignins, catalyzed by com. available Pd/C. Such lignin fragmentation occurred without added reagent if the indigenous double bonds were reduced first or it occurred under conditions in which just 1 atm of hydrogen was added to the system to reduce C=C bonds of the original lignin sample in situ prior to fragmentation. A detailed view of the sites of cleavage of lignin samples from various sources was gained by HSQC NMR experiments Complex model compounds were prepared and shown to form simpler arenes and substituted phenols under catalytic conditions without added reagents. The hydrogen generated in situ from alc. functionalities provides the reductant for concomitant hydrogenolysis of C-O bonds in β aryl ethers. Decarbonylation of primary alcs. also occurred, and this process resulted in significant amounts of aromatic products containing substituents bearing one fewer carbon atom than the original linkages in lignin. The fragmentations of synthetic lignin and several organosolv lignins derived from Miscanthus giganteus and pine tree were conducted. Because the lignins contain alkenes that accept the hydrogen, two procedures involving reduction of the alkenes prior to C-O bond cleavage were developed. The first procedure involves reduction of the alkenes, followed by catalytic cleavage of C-O bonds after saturation of the C-C bonds; a second involves cleavage of lignin samples in the presence of 1 atm of hydrogen to saturate the alkenes before cleavage in situ. These protocols convert solid lignin to monomeric phenolic compounds with 20 mol % catalyst or to an oil (with 5 mol % Pd/C loading) having favorable viscosity parameters upon blending with a renewable organic solvent.

ACS Catalysis published new progress about 70110-65-5. 70110-65-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Alcohol,Ether,Benzene Compounds, name is 2-Phenoxy-1-phenylpropane-1,3-diol, and the molecular formula is C15H16O3, Name: 2-Phenoxy-1-phenylpropane-1,3-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shi, Jinguo’s team published research in Neurochemistry International in 148 | CAS: 328-90-5

Neurochemistry International published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C12H13F2N3O4S, Category: alcohols-buliding-blocks.

Shi, Jinguo published the artcileSynthesis and biological evaluation of 1,2,4-oxadiazole core derivatives as potential neuroprotectants against acute ischemic stroke, Category: alcohols-buliding-blocks, the publication is Neurochemistry International (2021), 105103, database is CAplus and MEDLINE.

Here, we report the synthesis and neuroprotective capacity of 27 compounds with a bisphenol hydroxyl-substituted 1,2,4-triazole core or 1,2,4-oxadiazole core for stroke therapy. In vitro studies of the neuroprotective effects of compounds 1-27 on sodium nitroprusside (SNP)-induced apoptosis in PC12 cells indicate that compound 24 is the most effective compound conferring potent protection against oxidative injury. Compound 24 inhibits reactive oxygen species (ROS) accumulation and restores the mitochondrial membrane potential (MMP). Moreover, further anal. of the mechanism showed that compound 24 activates the antioxidant defense system by promoting the nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) and increasing the expression of haem oxygenase 1 (HO-1). An in vivo study was performed in a rat model of transient focal cerebral ischemia generated by the intraluminal occlusion of the middle cerebral artery (MCAO). Compound 24 significantly reduced brain infarction and improved neurol. function. Overall, compound 24 potentially represents a promising compound for the treatment of stroke.

Neurochemistry International published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C12H13F2N3O4S, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shang, Yong-Jia’s team published research in Synthesis in | CAS: 438565-33-4

Synthesis published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C4H3Cl2N3, Product Details of C10H8ClNO2.

Shang, Yong-Jia published the artcileSynthesis of isoxazolines and isoxazoles using poly(ethylene glycol) as support, Product Details of C10H8ClNO2, the publication is Synthesis (2002), 1663-1668, database is CAplus.

A general method for the liquid-phase syntheses of isoxazoles and isoxazolines through a 1,3-dipolar cycloaddition is described. The poly(ethylene glycol) (PEG)-supported alkyne or alkene reacted with nitrile oxides generated in situ from aldoximes, followed by cleavage from the PEG, to give isoxazoles or isoxazolines in good yield and purity.

Synthesis published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C4H3Cl2N3, Product Details of C10H8ClNO2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts