Tag: M.W=200-250

Wang, Yinling published the artcileCeCl₃-promoted simultaneous photocatalytic cleavage and amination of Cα-Cβ bond in lignin model compounds and native lignin, Safety of 2-Phenoxy-1-phenylpropane-1,3-diol, the publication is CCS Chemistry (2020), 2(3), 107-117, database is CAplus.

It remains challenging to achieve valuable platform chems. from lignin because of its complicated polymeric structure and inherent inert chem. activities. So far, only a few examples have been reported for the selective cleavage of C-C bonds in lignin due to their intrinsic inertness and ubiquity. Here, we present a simple and com. available cerium(III) chloride (CeCl₃)-promoted photocatalytic depolymerization strategy to realize the simultaneous cleavage and amination of Cα-Cβ bond in a variety of lignin model compounds at room temperature This procedure does not require any pretreatments and breakdown of C-O bonds or loss of γ-CH₂OH group to generate aldehydes (up to 97%) and N-containing products (up to 95%) in good to excellent yields. Addnl., this CeCl₃-based photocatalyst system could maintain excellent catalytic performance even after 10 sequential cycles with new starting materials. Moreover, this approach realizes the precise control over the reaction via switching the external light stimuli on/off. Further, this method is effective for the depolymerization of real lignin, thus affording the corresponding cleavage and amination products of Cα-Cβ bonds.

CCS Chemistry published new progress about 70110-65-5. 70110-65-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Alcohol,Ether,Benzene Compounds, name is 2-Phenoxy-1-phenylpropane-1,3-diol, and the molecular formula is C18H12FN, Safety of 2-Phenoxy-1-phenylpropane-1,3-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wu, Jingjing published the artcilePhotoinduced Deaminative Borylation of Alkylamines, Application In Synthesis of 608534-44-7, the publication is Journal of the American Chemical Society (2018), 140(34), 10700-10704, database is CAplus and MEDLINE.

An operationally simple deaminative borylation reaction of primary alkylamines was developed. The formation of electron-donor-acceptor complexes between N-alkylpyridinium salts and bis(catecholato)diboron enables photoinduced single-electron transfer and fragmentation to C-centered radicals, which are subsequently borylated. The mild conditions allow a diverse range of readily available alkylamines to be efficiently converted into synthetically valuable alkylboronic esters under catalyst-free conditions.

Journal of the American Chemical Society published new progress about 608534-44-7. 608534-44-7 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic,Boronic acid and ester,Boronate Esters,Boronic Acids,Boronic acid and ester, name is 2-(2,3-Dihydro-1H-inden-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C14H14, Application In Synthesis of 608534-44-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Guo, Xiao-xia published the artcileNew highly phosphorescent heteroleptic tris-cyclometalated iridium(III) complexes: Synthesis and photophysical characterization, Product Details of C8H5F3O3, the publication is Guangpuxue Yu Guangpu Fenxi (2010), 30(1), 170-173, database is CAplus and MEDLINE.

New heteroleptic tris-cyclometalated iridium(III) complexes (ppy)₂Ir(LX) [ppy = 2-phenylpyridine, LX = Sal (salicylic acid), MSal (4-methylsalicylic acid), FSal (4-trifluoromethylsalicylic acid)] was synthesized and characterized. The mol. structure, photophys. properties and thermal stability were tested and analyzed. The results show that the absorption peaks were located around 270, 370, 450 and 484 nm resp. at room temperature The two former peaks at 270 and 370 nm should belong to ¹π^–π^* transition at ppy and transition from salicylic acid ligands to 2-phenylpyridine. The peaks around 450 and 484 nm can be assigned to the charge transfer transition from Ir to ligand (¹MLCT and ³MLCT) and ³π^–π^* transition resp. The PL emission peaks were located at 520, 522, and 510 nm, resp. The emission of (ppy)₂Ir(Sal) and (ppy)₂Ir(MSal) was mainly ascribed to the radiation transition of triple state ³MLCT, while the emission of (ppy)₂ Ir(FSal) was mainly from the radiation transition between Sal and ppy, partly from the radiation transition of single state ¹MLCT and triple state ³MLCT. The quantum efficiencies of these complexes were 0.37, 0.33 and 0.29 resp. The thermal decomposition temperature was from 306 to 328°C. (ppy)₂Ir(LX), being efficient phosphorescent materials with good thermal stability, can be used in organic electroluminescent devices.

Guangpuxue Yu Guangpu Fenxi published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Product Details of C8H5F3O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yu, Jian-ning published the artcileA new type of iridium (III) phenylpyrazole complexes: synthesis, photophysical characterization, Category: alcohols-buliding-blocks, the publication is Guangpuxue Yu Guangpu Fenxi (2010), 30(9), 2424-2427, database is CAplus and MEDLINE.

New heteroleptic iridium(III) complexes (ppz)₂Ir(LX), which consist of two cyclometalated ligands ppz(1-pheny-lpyrazole) together with an ancillary ligand LX (LX=2-(2′-hydroxylphenyl)benzothiazole (BTZ),2-(3′-methyl-2′-hydroxyl-phenyl) benzothiazole (3-MeBTZ), 2-(4′-methyl-2′-hydroxylphenyl)benzothiazole (4-MeBTZ) and 2-(4′-Trifluoromcthyl-2′-hydroxylphenyl)benzothiazole (4-tfmBTZ)), were synthesized and characterized. The mol. structures and photophys. properties were characterized and analyzed comparatively. The results show that the four complexes have basically similar UV-Vis absorption spectra, fluorescence excitation and emission spectra. Their maximum emission peaks are located at 583-615 nm, and accompanied by a lower intensity emission band around 400 nm. The weak emissions around 400 nm are ascribed to the radiation transition of single state excition from ancillary ligand BTZ perturbed by metallic ion, and light emission around long-wavelength to the radiation transition of ³MLCT of Ir(BTZ) fragment. While the triplet state ³MLCT of Ir(ppz)₂ fragment might be quenched at room temperature For all complexes, the excitations with maximum efficiency are located at 250-310 nm, which indicates that main contributor to light emitting is ligand-centered absorption(¹π-π^*) of ppz and BTZ rather than ³MLCT transitions, and thus provides a striking evidence that there is intersystem crossing from ¹π-π^* state to ³MLCT state in these complexes. Compared with Ir(ppz)₃, these complexes not only have stronger phosphorescence at room temperature but also their emission color can be tuned by modifying ancillary ligand.

Guangpuxue Yu Guangpu Fenxi published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C10H2F12NiO4, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Marzenell, Paul published the artcileAminoferrocene-Based Prodrugs and Their Effects on Human Normal and Cancer Cells as Well as Bacterial Cells, Product Details of C14H21BO3, the publication is Journal of Medicinal Chemistry (2013), 56(17), 6935-6944, database is CAplus and MEDLINE.

Aminoferrocene-based prodrugs are activated under cancer-specific conditions (high concentration of reactive oxygen species, ROS) with the formation of glutathione scavengers (p-quinone methide) and ROS-generating iron complexes. Herein, the authors explored three structural modifications of these prodrugs to improve their properties: (a) the attachment of a -COOH function to the ferrocene fragment leads to the improvement of water solubility and reactivity in vitro but also decreases cell-membrane permeability and biol. activity, (b) the alkylation of the N-benzyl residue does not show any significant affect, and (c) the attachment of the second arylboronic acid fragment improves the toxicity (IC₅₀) of the prodrugs toward human promyelocytic leukemia cells (HL-60) from 52 to 12 μM. Finally, the authors demonstrated that the prodrugs are active against primary chronic lymphocytic leukemia (CLL) cells, with the best compounds exhibiting an IC₅₀ value of 1.5 μM. The most active compounds were found to not affect mononuclear cells and representative bacterial cells.

Journal of Medicinal Chemistry published new progress about 1370732-71-0. 1370732-71-0 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester, name is (3-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol, and the molecular formula is C14H21BO3, Product Details of C14H21BO3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Qiao, Chunhua published the artcile5′-O-[(N-Acyl)sulfamoyl]adenosines as Antitubercular Agents that Inhibit MbtA: An Adenylation Enzyme Required for Siderophore Biosynthesis of the Mycobactins, SDS of cas: 328-90-5, the publication is Journal of Medicinal Chemistry (2007), 50(24), 6080-6094, database is CAplus and MEDLINE.

A study of the structure-activity relationships of 5′-O-[N-(salicyl)sulfamoyl]adenosine (6), a potent inhibitor of the bifunctional enzyme salicyl-AMP ligase (MbtA, encoded by the gene Rv2384) in Mycobacterium tuberculosis, is described, targeting the salicyl moiety. A systematic series of analogs was prepared exploring the importance of substitution at the C-2 position revealing that a hydroxy group is required for optimal activity. Examination of a series of substituted salicyl derivatives indicated that substitution at C-4 was tolerated. Consequently, a series of analogs at this position provided 4-fluoro derivative, which displayed an impressive MIC₉₉ of 0.098 μM against whole-cell M. tuberculosis under iron-limiting conditions. Examination of other heterocyclic, cycloalkyl, alkyl, and aminoacyl replacements of the salicyl moiety demonstrated that these nonconservative modifications were poorly tolerated, a result consistent with the fairly strict substrate specificities of related nonribosomal peptide synthetase adenylation enzymes.

Journal of Medicinal Chemistry published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, SDS of cas: 328-90-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gormemis, Ahmet E. published the artcileBenzofuroindole analogues as potent BK_Ca channel openers, Recommanded Product: 2-Hydroxy-4-(trifluoromethyl)benzoic acid, the publication is ChemBioChem (2005), 6(10), 1745-1748, database is CAplus and MEDLINE.

New, potent, large-conductance, calcium-activated potassium-channel (BK_Ca) openers that show calcium-independent activation in electrophysiol. evaluations have been designed through optimizing the structure of the benzofuroindole skeleton by comparison with a known BK_Ca-channel opener (BMS-204352). A series of substituted benzofuroindoles I (R¹ = H, Br; R² = H, CF₃, OCH₃, Cl; R³ = H, COOH, COOCH₃, Cl, OCH₃, CF₃; R⁴ = H, Cl, F; R⁵ = H, Cl, CF₃; R⁶ = H, Cl, F, CF₃) were prepared via sequence of reactions including as a key step either classical Fischer indole or microwave assisted cyclization of phenylhydrazones of benzofuranones. The BK_Ca-channel-opening activities of synthesized benzofuroindoles were studied. In particular, compound I (R¹ = R⁴ = R⁵ = H; R² = CF₃; R³ = COOH, R⁶ = Cl) showed the most potent and effective activity in an intracellular calcium-independent manner. These new potassium channel openers might find therapeutic use to treat neuronal damage and be applied to therapeutic intervention in stroke, asthma, hypertension, convulsion, and traumatic brain injury.

ChemBioChem published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Recommanded Product: 2-Hydroxy-4-(trifluoromethyl)benzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

da Cruz, Marcia G. A. published the artcileElectrochemical Depolymerization of Lignin in a Biomass-based Solvent, Product Details of C15H16O3, the publication is ChemSusChem (2022), 15(15), e202200718, database is CAplus and MEDLINE.

Breaking down lignin into smaller units is the key to generate high value-added products. Nevertheless, dissolving this complex plant polyphenol in an environment-friendly way is often a challenge. Levulinic acid, which is formed during the hydrothermal processing of lignocellulosic biomass, has been shown to efficiently dissolve lignin. Herein, levulinic acid was evaluated as a medium for the reductive electrochem. depolymerization of the lignin macromol. Copper was chosen as the electrocatalyst due to the economic feasibility and low activity towards the hydrogen evolution reaction. After depolymerization, high-resolution mass spectrometry and NMR spectroscopy revealed lignin-derived monomers and dimers. A predominance of aryl ether and phenolic groups was observed Depolymerized lignin was further evaluated as an anti-corrosion coating, revealing enhancements on the electrochem. stability of the metal. Via a simple depolymerization process of biomass waste in a biomass-based solvent, a straightforward approach to produce high value-added compounds or tailored biobased materials was demonstrated.

ChemSusChem published new progress about 70110-65-5. 70110-65-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Alcohol,Ether,Benzene Compounds, name is 2-Phenoxy-1-phenylpropane-1,3-diol, and the molecular formula is C15H16O3, Product Details of C15H16O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lin, Yi-Wen published the artcileGrowth of Pseudomonas sp. TX1 on a wide range of octylphenol polyethoxylate concentrations and the formation of dicarboxylated metabolites, Related Products of alcohols-buliding-blocks, the publication is Bioresource Technology (2010), 101(8), 2853-2859, database is CAplus and MEDLINE.

Pseudomonas sp. TX1, is able to use octylphenol polyethoxylates (OPEO_n, or Triton X-100; average n = 9.5) as a sole carbon source. It can grow on 0.05-20% of OPEO_n with a specific growth rate of 0.34-0.44 h^-1. High-performance liquid chromatog.-mass spectrometer anal. of OPEO_n degraded metabolites revealed that strain TX1 was able to shorten the ethoxylate chain and produce octylphenol (OP). Furthermore, formation of the short carboxylate metabolites, such as carboxyoctylphenol polyethoxylates (COPEO_n, n = 2, 3) and carboxyoctylphenol polyethoxycarboxylates (COPEC_n, n = 2, 3) began at the log stage, while octylphenol polyethoxycarboxylates (OPEC_n, n = 1-3) was formed at the stationary phase. All the short-ethoxylated metabolites, OPEO_n, OPEC_n, COPEO_n, and COPEC_n, accumulated when the cells were in the stationary phase. This study is the first to demonstrate the formation of COPEO_n and COPEC_n from OPEO_n by an aerobic bacterium.

Bioresource Technology published new progress about 1139-46-4. 1139-46-4 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol, and the molecular formula is C14H22O2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ihndris, Ray W. published the artcileEffect of promising insect repellents on plastics and paints, Related Products of alcohols-buliding-blocks, the publication is United States, Agricultural Research Service, [Report] ARS (1955), 27 pp., database is CAplus.

Action of 380 repellents on Lucite, cellulose acetate, and Vinylite after 48 h. of contact are tabulated (studies in 1946). Sixty-eight of the compounds did not change any of the plastics. Lucite was attacked by 261, cellulose acetate by 126, and Vinylite by 251. Only 99 compounds attacked all 3. Results of studies in 1953 are shown in a tabulation of effects on paint, Plexiglas, Vinylite, rayon, and Plastocel of 136 repellents which had not proved unsatisfactory since 1946 for some other reason. All but 2 compounds affected paint; one of them, octyl crotonate, affected only varnish and vinylite, and the other, 3,6,8-trimethyl-4-nonyne-3-6-diol affected only varnish. Vinylite was damaged by 107, Plexiglas by 58, rayon by 55, and Plasticel by 46. In other tests only 2 chems., 2-benzyloxynaphthalene and 2-iso-pentyloxynaphthalene, affected polyethylene, and they only slightly. Fourteen materials slightly stained nylon. In still other tests, Lucite and Plexiglas were found to differ slightly in their resistance to various agents.

United States, Agricultural Research Service, [Report] ARS published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts