Zhang, Datong’s team published research in Archives of Pharmacal Research in 33 | CAS: 438565-33-4

Archives of Pharmacal Research published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C8H14O4, Category: alcohols-buliding-blocks.

Zhang, Datong published the artcileSynthesis and preliminary antibacterial evaluation of 2-butyl succinate-based hydroxamate derivatives containing isoxazole rings, Category: alcohols-buliding-blocks, the publication is Archives of Pharmacal Research (2010), 33(6), 831-842, database is CAplus and MEDLINE.

Two series of novel 2-Bu succinate-based Hydroxamate derivatives containing isoxazole rings, e.g. I [R = H, i-Bu], were synthesized, characterized and evaluated for antibacterial activity. The synthesized compounds were found to exhibit weak to moderate inhibitory activity against Staphytlococcusaureu and Klebsiellar pneumonia in vitro. All the compounds synthesized were found to be more effective against Klebsiellar pneumonia compared to Staphytlococcus aureu.

Archives of Pharmacal Research published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C8H14O4, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Herbinski, Aurelien’s team published research in Chemistry – A European Journal in 28 | CAS: 70445-33-9

Chemistry – A European Journal published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Name: 3-((2-Ethylhexyl)oxy)propane-1,2-diol.

Herbinski, Aurelien published the artcileEco-conception of Highly Salt-Tolerant Alkyl Ether Carboxylate Hydrotropes with a Glyceryl Spacer, Name: 3-((2-Ethylhexyl)oxy)propane-1,2-diol, the publication is Chemistry – A European Journal (2022), 28(28), e202200274, database is CAplus and MEDLINE.

New alkyl ether carboxylates with a glyceryl spacer instead of ethylene glycol units had been synthesized using environmentally friendly methodol. A cascade synthesis of acetalization and hydrogenolysis was developed to obtain products containing an alkyl chain linked to a glycerol unit bearing a polar carboxylate head. These products were methylated by using tri-Me phosphate to observe the influence of a free or methoxylated alc. on the physicochem. properties. Finally, saponification gave the carboxylate anionic group of the new hydrotropes. Studying the amphiphilicity, the tolerance to sodium and calcium ions, and the solubilizing power of these bio-based ionic/nonionic hydrotropes has shown that they exhibited significantly improved application properties compared to similar petro-based hydrotropes.

Chemistry – A European Journal published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Name: 3-((2-Ethylhexyl)oxy)propane-1,2-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Rajendran, Ranjith kumar’s team published research in Bioresource Technology in 226 | CAS: 1139-46-4

Bioresource Technology published new progress about 1139-46-4. 1139-46-4 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol, and the molecular formula is C14H22O2, Related Products of alcohols-buliding-blocks.

Rajendran, Ranjith kumar published the artcileBiodegradation of the endocrine disrupter 4-tert-octylphenol by the yeast strain Candida rugopelliculosa RRKY5 via phenolic ring hydroxylation and alkyl chain oxidation pathways, Related Products of alcohols-buliding-blocks, the publication is Bioresource Technology (2017), 55-64, database is CAplus and MEDLINE.

4-(1,1,3,3-Tetramethylbutane)-phenol (4-tert-OP) is one of the most prevalent endocrine disrupting pollutants. Information about bioremediation of 4-tert-OP remains limited, and no study has been reported on the mechanism of 4-tert-OP degradation by yeasts. The yeast Candida rugopelliculosa RRKY5 was proved to be able to utilize 4-methylphenol, bisphenol A, 4-ethylphenol, 4-tert-butylphenol, 4-tert-OP, 4-tert-nonylphenol, isooctane, and phenol under aerobic conditions. The optimum conditions for 4-tert-OP degradation were 30°C, pH 5.0, and an initial 4-tert-OP concentration of 30 mg L-1; the maximum biodegradation rate constant was 0.107 d-1, equivalent to a min. half-life of 9.6 d. SEM revealed formation of arthroconidia when cells were grown in the presence of 4-tert-OP, whereas the cells remained in the budding form without 4-tert-OP. Identification of the 4-tert-OP degradation metabolites using liquid chromatog.-hybrid mass spectrometry revealed three different mechanisms via both branched alkyl side chain and aromatic ring cleavage pathways.

Bioresource Technology published new progress about 1139-46-4. 1139-46-4 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol, and the molecular formula is C14H22O2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Oh, Soo-Jin’s team published research in Molecular Pharmacology in 84 | CAS: 328-90-5

Molecular Pharmacology published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, HPLC of Formula: 328-90-5.

Oh, Soo-Jin published the artcileMONNA, a potent and selective blocker for transmembrane protein with unknown function 16/anoctamin-1, HPLC of Formula: 328-90-5, the publication is Molecular Pharmacology (2013), 84(5), 726-735, database is CAplus and MEDLINE.

Transmembrane protein with unknown function 16/anoctamin-1 (ANO1) is a protein widely expressed in mammalian tissues, and it has the properties of the classic calcium-activated chloride channel (CaCC). This protein has been implicated in numerous major physiol. functions. However, the lack of effective and selective blockers has hindered a detailed study of the physiol. functions of this channel. In this study, we have developed a potent and selective blocker for endogenous ANO1 in Xenopus laevis oocytes (xANO1) using a drug screening method we previously established. We have synthesized a number of anthranilic acid derivatives and have determined the correlation between biol. activity and the nature and position of substituents in these derived compounds A structure-activity relationship revealed novel chem. classes of xANO1 blockers. The derivatives contain a -NO2 group on position 5 of a naphthyl group-substituted anthranilic acid, and they fully blocked xANO1 chloride currents with an IC50 < 10 μM. The most potent blocker, N-((4-methoxy)-2-naphthyl)-5-nitroanthranilic acid (MONNA), had an IC50 of 0.08 μM for xANO1. Selectivity tests revealed that other chloride channels such as bestrophin-1, chloride channel protein 2, and cystic fibrosis transmembrane conductance regulator were not appreciably blocked by 10∼30 μM MONNA. The potent and selective blockers for ANO1 identified here should permit pharmacol. dissection of ANO1/CaCC function and serve as potential candidates for drug therapy of related diseases such as hypertension, cystic fibrosis, bronchitis, asthma, and hyperalgesia.

Molecular Pharmacology published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, HPLC of Formula: 328-90-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lee, Yunmi’s team published research in Journal of the American Chemical Society in 131 | CAS: 608534-44-7

Journal of the American Chemical Society published new progress about 608534-44-7. 608534-44-7 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic,Boronic acid and ester,Boronate Esters,Boronic Acids,Boronic acid and ester, name is 2-(2,3-Dihydro-1H-inden-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C15H21BO2, Recommanded Product: 2-(2,3-Dihydro-1H-inden-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane.

Lee, Yunmi published the artcileEfficient boron-copper additions to aryl-substituted alkenes promoted by NHC-based catalysts. Enantioselective Cu-catalyzed hydroboration reactions, Recommanded Product: 2-(2,3-Dihydro-1H-inden-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, the publication is Journal of the American Chemical Society (2009), 131(9), 3160-3161, database is CAplus and MEDLINE.

Efficient hydroboration of alkenes by bis-pinacoldiborane(4), B2pin2, catalyzed by NHC-copper(I) 2-imidazolylidene and 2-imidazolidinylidene complexes gave pinacol alkylboronic esters and the corresponding alcs. after oxidative deboration. Asym. hydroboration was achieved using chiral chloro[(4S,5S)-1,3-bis(2-methylphenyl)-4,5-diphenyl-2-imidazolylidene]copper catalyst. Reactions are promoted with 0.5-5 mol % of a readily available N-heterocyclic carbene (NHC) complex; the presence of MeOH promotes in situ protonation of the C-Cu bond and leads to efficient catalyst turnover, constituting a net Cu-catalyzed hydroboration process. Reactions proceed in >98:<2 site selectivity and furnish secondary organoborane isomers that complement those obtained through reactions of boron-hydride reagents or by Rh- or Ir-catalyzed hydroborations (benzylic secondary C-B bonds). Initial observations regarding processes catalyzed by chiral NHC complexes, delivering products in up to 99:1 enantiomeric ratio, are disclosed.

Journal of the American Chemical Society published new progress about 608534-44-7. 608534-44-7 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic,Boronic acid and ester,Boronate Esters,Boronic Acids,Boronic acid and ester, name is 2-(2,3-Dihydro-1H-inden-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C15H21BO2, Recommanded Product: 2-(2,3-Dihydro-1H-inden-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Pedersen, R. T.’s team published research in Chemico-Biological Interactions in 128 | CAS: 1139-46-4

Chemico-Biological Interactions published new progress about 1139-46-4. 1139-46-4 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol, and the molecular formula is C14H22O2, COA of Formula: C14H22O2.

Pedersen, R. T. published the artcileIdentification of novel metabolites of the xenoestrogen 4-tert-octylphenol in primary rat hepatocytes, COA of Formula: C14H22O2, the publication is Chemico-Biological Interactions (2000), 128(3), 189-209, database is CAplus and MEDLINE.

A number of environmental pollutants, including 4-tert-alkylphenols, can mimic the actions of endogenous steroids and have the potential to disrupt the endocrine function in humans and animals. The biotransformation of a 4-tert-alkylphenol in isolated rat hepatocytes was studied in order to determine the possible fate and activity of these xenoestrogens in higher vertebrates. Hepatocytes were incubated with 30 μM 4-(1′,1′,3′,3′-tetramethylbutyl)[U-14C]phenol (4-tert-octylphenol; t-OP) for up to 60 min. Radiolabeled metabolites were detected by radio-HPLC and the structures determined by gas chromatog.-mass spectrometry (GC-MS) anal. of the conjugated or aglycon products. After a 15 min incubation, over 97% of t-OP was metabolized to a complex mixture of metabolites. The initial metabolites formed were identified as products of hydroxylation of the aromatic ring to form catechols and methylated catechols, as well as glucuronide conjugates of the catechol metabolites or parent phenol. These products were further metabolized by hydroxylation of the alkyl chain followed by glucuronide conjugation of the alkoxy group. The conjugated metabolites of t-OP are unlikely to retain estrogen receptor activity; however t-OP is metabolized by some pathways that are similar to that of estrogen catabolism, namely by ortho-hydroxylation to form catechols, methylation by catechol O-methyltransferases and ring conjugation by uridine diphosphoglucuronosyl transferases. Further investigations are needed to determine whether 4-tert-alkylphenols can alter circulating sex steroid profiles by acting as substrates of enzymes determining estrogen metabolism and excretion.

Chemico-Biological Interactions published new progress about 1139-46-4. 1139-46-4 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol, and the molecular formula is C14H22O2, COA of Formula: C14H22O2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Beck, R.’s team published research in Physical Chemistry Chemical Physics in 3 | CAS: 70445-33-9

Physical Chemistry Chemical Physics published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Application of 3-((2-Ethylhexyl)oxy)propane-1,2-diol.

Beck, R. published the artcilePhase behaviour and physical properties of mixtures of calcium salts of α-sulfonated fatty acid methyl ester and a cosurfactant, Application of 3-((2-Ethylhexyl)oxy)propane-1,2-diol, the publication is Physical Chemistry Chemical Physics (2001), 3(24), 5438-5443, database is CAplus.

We have studied the phase behavior of mixtures of calcium salts of α-sulfonated fatty acid Me ester Ca(Cx-α-MES)2 and a monoglycerin ether as cosurfactant (EHG). The mol. interactions between the surfactant and the cosurfactant and the influence on the phase behavior have been studied systematically. With increasing cosurfactant concentration the micellar L1-phase shows a transition to an Lα-phase and an L3 sponge phase. The L3-phase is observed for the first time in a ternary phase diagram of a Ca-salt of a α-sulfonated fatty acid Me ester, the cosurfactant 2-ethylhexyl-monoglyceride and water. As for other ternary surfactant/cosurfactant systems, the L3-phase occurs with increasing cosurfactant/surfactant ratios after the Lα-phase. Some properties of the newly observed L3-phase are the same as for other known L3-phases. It is a low viscosity, optically isotropic fluid with a low flow birefringence. The time constants τ of the elec. birefringence results scale with τ ∼ Φ-3. Its conductivity is very much higher than the conductivity of the neighboring Lα-phase. However there are some marked differences from known normal L3-phases. The novel L3-phase is thermodynamically stable in spite of ionic charges on the bilayer. There is no two phase region between the Lα and the L3-phase in the system Ca(C14-αMES)2/EHG and the L3-phase is stable over a wide cosurfactant/surfactant ratio between one and two. In SANS measurements it shows a broad correlation peak that occurs at about the same position as the sharper peak in the Lα-phase. The structure of the L3-phase is demonstrated by FF-TEM micrographs.

Physical Chemistry Chemical Physics published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Application of 3-((2-Ethylhexyl)oxy)propane-1,2-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Luo, Feihua’s team published research in Tetrahedron Letters in 84 | CAS: 328-90-5

Tetrahedron Letters published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Application of 2-Hydroxy-4-(trifluoromethyl)benzoic acid.

Luo, Feihua published the artcilePalladium-catalyzed ortho-C-H hydroxylation of benzoic acids, Application of 2-Hydroxy-4-(trifluoromethyl)benzoic acid, the publication is Tetrahedron Letters (2021), 153434, database is CAplus.

A simple Pd(OAc)2 catalyzed ortho-hydroxylation of benzoic acids using TBHP as the sole oxidant was explored. This protocol featured relatively broad substrate scope and operational simplicity. The compatibility of ortho-substituted substrates was an effective complement to the previous ortho-hydroxylation reaction.

Tetrahedron Letters published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Application of 2-Hydroxy-4-(trifluoromethyl)benzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Duclos, Marie-Christine’s team published research in ChemSusChem in 11 | CAS: 70445-33-9

ChemSusChem published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Formula: C11H24O3.

Duclos, Marie-Christine published the artcileMethylation of Polyols with Trimethylphosphate in the Presence of a Lewis or Bronsted Acid Catalyst, Formula: C11H24O3, the publication is ChemSusChem (2018), 11(3), 547-551, database is CAplus and MEDLINE.

The alkylation of alcs. and polyols has been investigated with alkyl phosphates in the presence of a Lewis or Bronsted acid catalyst. The permethylation of polyols was developed under solvent-free conditions at 100 °C with either iron triflate or Aquivion PW98, affording the isolated products in yields between 52 and 95 %. The methodol. was also adjusted to carry out peralkylation with longer alkyl chains.

ChemSusChem published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Formula: C11H24O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Xuan’s team published research in Journal of Organic Chemistry in 83 | CAS: 70110-65-5

Journal of Organic Chemistry published new progress about 70110-65-5. 70110-65-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Alcohol,Ether,Benzene Compounds, name is 2-Phenoxy-1-phenylpropane-1,3-diol, and the molecular formula is C15H16O3, Recommanded Product: 2-Phenoxy-1-phenylpropane-1,3-diol.

Li, Xuan published the artcileBBr3-Assisted Preparation of Aromatic Alkyl Bromides from Lignin and Lignin Model Compounds, Recommanded Product: 2-Phenoxy-1-phenylpropane-1,3-diol, the publication is Journal of Organic Chemistry (2018), 83(18), 11019-11027, database is CAplus and MEDLINE.

For the first time, BBr3-assisted nucleophilic substitution was applied to a variety of β-O-4 and α-O-4 model compounds for the highly effective cleavage of different C-O bonds, including C-Oα-OH, Cβ-O/Cα-O and CMe-O bonds (<0.5 h and >99% conversion for most cases). Without any pretreatment, the substitution proceeds at room temperature in the absence of any catalyst, or additive, selectively affording phenols and important organic synthesis reagents, aromatic alkyl bromides, in high to excellent yields (up to 98%). Preliminary studies also highlight the prospect of this method for the effective cleavage of different types of C-O bonds in real lignin. A total 14 wt % yield of aromatic alkyl bromide, 4-(1,2-dibromo-3-hydroxypropyl)benzene-1,2-diol (10), has been obtained from an extracted lignin through this method.

Journal of Organic Chemistry published new progress about 70110-65-5. 70110-65-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Alcohol,Ether,Benzene Compounds, name is 2-Phenoxy-1-phenylpropane-1,3-diol, and the molecular formula is C15H16O3, Recommanded Product: 2-Phenoxy-1-phenylpropane-1,3-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts