Shibata, Kentaro’s team published research in Journal of the American Chemical Society in 144 | CAS: 328-90-5

Journal of the American Chemical Society published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C9H10O4, Product Details of C8H5F3O3.

Shibata, Kentaro published the artcileHomopolymer-block-Alternating Copolymers Composed of Acrylamide Units: Design of Transformable Divinyl Monomers and Sequence-Specific Thermoresponsive Properties, Product Details of C8H5F3O3, the publication is Journal of the American Chemical Society (2022), 144(22), 9959-9970, database is CAplus and MEDLINE.

In this work, we synthesized an acrylamide-based terpolymer that is a block copolymer composed of an AB alternating copolymer and a C homopolymer. The key to the unprecedented achievement is rational design of an acrylate-acrylamide divinyl monomer carrying CF3-substituted salicylic acid ester bonds (AAm-CF3) to realize the efficient and selective cyclopolymn. as well as the quant. transformation of the resultant cyclorepeating units. The selectivity in the cyclopolymn. and the pendant transformation ability were evaluated through reactivity ratios of the corresponding model monomers and quant. aminolysis reactions of the model compound The cyclopolymn. via the photoinduced electron transfer-reversible addition-fragmentation chain transfer (PET-RAFT) process with a macrochain-transfer agent and subsequent aminolysis reaction afforded the homopolymer-block-alternating copolymer. The sequence-controlled terpolymer exhibited a very unique thermal response behavior in water that was strikingly different from the corresponding sequence-uncontrolled terpolymers, such as homopolymer-block-statistical copolymers and all statistical terpolymers, despite the fact that the structure cannot be distinguished by 1H NMR.

Journal of the American Chemical Society published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C9H10O4, Product Details of C8H5F3O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lawan, Kunlayakorn’s team published research in Journal of Health Research in 23 | CAS: 70445-33-9

Journal of Health Research published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Related Products of alcohols-buliding-blocks.

Lawan, Kunlayakorn published the artcileAntimicrobial efficacy of caprylyl glycol and ethylhexylglycerine in emulsion, Related Products of alcohols-buliding-blocks, the publication is Journal of Health Research (2009), 23(1), 1-3, database is CAplus.

Antimicrobial efficacies of caprylyl glycol and ethylhexylglycerin in an emulsion were evaluated by USP24-NF19. The min. concentration of caprylyl glycol and ethylhexylglycerin inhibited Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Candida albicans within 1 day and Aspergillus niger within 28 days was 0.5% and 1.5%, resp. The 1:3 mixture ratio of the caprylyl glycol and ethylhexylglycerin was chosen for further steps on inhibitory effect towards those prohibited microbial in cosmetics by evaluation at the concentration of 0.5%, 1.0%, 1.5% and 2.0%, resp. It was found that the min. concentration inhibited S. aureus within 3 days, E. coli, P. aeruginosa and C. albicans within 1 day and A. niger within 28 days was 1.0%. This developed preservative system offers multifunctional cosmetic ingredients in addition to their emollient efficacies.

Journal of Health Research published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kozlowska, Justyna’s team published research in Cosmetics in 4 | CAS: 70445-33-9

Cosmetics published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Application In Synthesis of 70445-33-9.

Kozlowska, Justyna published the artcileEvaluation of sebostatic activity of Juniperus communis fruit oil and Pelargonium graveolens oil compared to niacinamide, Application In Synthesis of 70445-33-9, the publication is Cosmetics (2017), 4(3), 36/1-36/8, database is CAplus.

As a facial skin condition, oily skin causes cosmetic problems, such as large pores, shiny appearance, and the feeling of greasiness and heaviness. Furthermore, extensive sebum production leads to common skin disorders such as acne vulgaris or seborrheic dermatitis. This study investigated the efficacy of sebum control tonics containing Juniperus communis fruit oil, Pelargonium graveolens oil, or niacinamide. The effects of Juniperus communis fruit oil, Pelargonium graveolens oil, and niacinamide on sebum excretion rates were investigated using Sebumeter. Sebum measurements (SebumeterSM 815, Courage & Khazaka, Köln, Germany) were made on the skin surface in three places by applying the sebumeter probe to the forehead after 10, 60, and 120 min from application of the tonic. The results indicated that the application of the tonic maintained a lower sebum secretion 10 min and 60 min after the application of the cosmetic, compared to those before it. However, a visible sebum-reducing efficacy after 2 h was reported only for tonic containing 0.25% Pelargonium graveolens oil and for the tonic with the addition of 3% niacinamide. After 2 h, the values of sebum measurements were 44 ± 5.13 a.u. and 58 ± 9.07 a.u., resp. Our results show that the tonic with the addition of 0.25% Pelargonium graveolens oil is the most effective in reducing sebum production

Cosmetics published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Application In Synthesis of 70445-33-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Huang, Li’s team published research in Journal of Photochemistry and Photobiology, A: Chemistry in 251 | CAS: 1139-46-4

Journal of Photochemistry and Photobiology, A: Chemistry published new progress about 1139-46-4. 1139-46-4 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol, and the molecular formula is C14H22O2, Related Products of alcohols-buliding-blocks.

Huang, Li published the artcileDifferent photodegradation behavior of 4-tert-octylphenol under UV and VUV irradiation in aqueous solution, Related Products of alcohols-buliding-blocks, the publication is Journal of Photochemistry and Photobiology, A: Chemistry (2013), 69-77, database is CAplus.

Comparative study on 4-tert-octylphenol degradation under UV (253.7 nm) and VUV (combined 253.7 nm and 184.9 nm) radiation in aqueous solution was performed in laboratory scale(coating process) in this paper. Excitation light played the key role on 4-tert-octylphenol photodegradation 93.5% 4-tert-Octylphenol was decomposed after 20-min VUV radiation while only 49.5% degradation efficiency was achieved after 4-tert-octylphenol received UV radiation for the same irradiation time. Other factors influencing 4-tert-octylphenol degradation efficiency included solution pH, initial concentration and natural water constituents. Initial 4-tert-octylphenol concentration and pH exhibited different influence pattern on 4-tert-octylphenol degradation under UV and VUV radiation. 4-tert-Octylphenol photodegradation products were discerned by HPLC and GC-MS. 4-tert-octylcatechol was recognized as predominant photoproducts under both UV and VUV radiation. Trace amount of phenol was also detected when 4-tert-octylphenol was subjected to VUV radiation. Degradation of 4-tert-octylphenol upon UV radiation was, therefore, predicted to be initiated by the photoejection of an electron from excited 4-tert-octylphenol, whereas 4-tert-octylphenol photolysis upon VUV radiation may also involve the direct CC bond cleavage from excited 4-tert-octylphenol. No matter the excitation light wavelength, photopolymization process was found to occur at high initial 4-tert-octylphenol concentration Special attention should be paid to the photopolymerization phenomena during practical application of 4-tert-octylphenol photodegradation

Journal of Photochemistry and Photobiology, A: Chemistry published new progress about 1139-46-4. 1139-46-4 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol, and the molecular formula is C14H22O2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liao, Liping’s team published research in European Journal of Medicinal Chemistry in 190 | CAS: 328-90-5

European Journal of Medicinal Chemistry published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Recommanded Product: 2-Hydroxy-4-(trifluoromethyl)benzoic acid.

Liao, Liping published the artcileSynthesis and biological evaluation of 1,2,4-triazole derivatives as potential neuroprotectant against ischemic brain injury, Recommanded Product: 2-Hydroxy-4-(trifluoromethyl)benzoic acid, the publication is European Journal of Medicinal Chemistry (2020), 112114pp., database is CAplus and MEDLINE.

A series of 1,2,4-triazole derivatives I (R1 = H, OH; R2 = H, F, CF3, etc.; R3 = H, Me, F, CF3 ) was synthesized to investigate their neuroprotective effects and mechanisms of action. Some compounds noticeably protected PC12 cells from the cytotoxicity of H2O2 or sodium nitroprusside (SNP). Compound I (R1 = OH; R2 = OMe; R3 = H) was the most effective derivative Compound I (R1 = OH; R2 = OMe; R3 = H) chelated Fe (II) iron, scavenged reactive oxygen species (ROS), and restored the mitochondrial membrane potential (MMP). Moreover, it enhanced the activity of the antioxidant defense system by increasing the serum level of superoxide dismutase (SOD) and promoting the nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2). Compound I (R1 = OH; R2 = OMe; R3 = H) caused certain improvements in behavior, the cerebral infarction area, and serum levels of biochem. indicators (TNF-α, IL-1β, SOD and MDA) in a rat MCAO model. The LD (LD50) of compound I (R1 = OH; R2 = OMe; R3 = H) in mice receiving i.p. injections was greater than 400 mg/kg. Meanwhile, pharmacokinetic experiments revealed high bioavailability of this compound after both oral and i.v. administration (F = 60.76%, CL = 0.014 mg/kg/h) and a longer half-life (4.26 and 5.11 h after oral and i.v. administration, resp.). Based on these findings, compound I (R1 = OH; R2 = OMe; R3 = H) may be a promising neuroprotectant for the treatment of ischemic stroke.

European Journal of Medicinal Chemistry published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Recommanded Product: 2-Hydroxy-4-(trifluoromethyl)benzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hu, Yiping’s team published research in ChemistrySelect in 6 | CAS: 328-90-5

ChemistrySelect published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Formula: C8H5F3O3.

Hu, Yiping published the artcileDesign, Synthesis, Molecular Docking Studies of Deferasirox Derivatives of 1,2,4-Triazole as Potential Antimicrobial Agents, Formula: C8H5F3O3, the publication is ChemistrySelect (2021), 6(45), 12914-12920, database is CAplus.

A series of deferasirox derivatives of 1,2,4-triazole I (R1 = H, CF3; R2 = R3 = H, CF3, COOH, COOMe, COOEt) were designed and synthesized by the ring-opening rearrangement reaction of Ph hydrazine or its substituents and imines, some compounds are previously unknown. The antibacterial activities of all compounds against Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Candida albicans and Aspergillus niger were exptl. evaluated. Most of them exhibited potential antimicrobial activity and promising antifungal activity. Especially, I (R1 = CF3; R2 = COOEt; R3 = H) and I (R1 = CF3; R2 = H; R3 = COOEt) showed the best antimicrobial activity (MIC90 = 0.125-2.0μg/mL) against Staphylococcus aureus, Staphylococcus epidermidis and Escherichia coli, while compounds I (R1 = R2 = H; R3 = COOMe), I (R1 = CF3; R2 = COOMe; R3 = H) showed excellent antifungal activity (MIC90 = 0.5-2.0μg/mL). The mol. docking anal. further revealed that all the synthesized derivatives have shown potential binding affinities.

ChemistrySelect published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Formula: C8H5F3O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cho, Hea-Young’s team published research in Yakche Hakhoechi in 31 | CAS: 328-90-5

Yakche Hakhoechi published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, SDS of cas: 328-90-5.

Cho, Hea-Young published the artcileGastrointestinal and hepatic first-pass effects of triflusal in rats, SDS of cas: 328-90-5, the publication is Yakche Hakhoechi (2001), 31(4), 265-271, database is CAplus.

In order to elucidate the influence of intestinal and hepatic first-pass effect on the pharmacokinetics of triflusal, the biotransformation of triflusal in the gastrointestinal tract and liver was designed. Moreover, we tried to establish an HPLC method applicable for bioassay and available to pharmacokinetics, not only with the simultaneous determination of triflusal and its active metabolite, 2-hydroxy-4-trifluoromethyl benzoic acid (HTB), but also with improving sensitivity. After the administration of triflusal (10 mg/kg) and HTB (10 mg/kg) into femoral vein, portal vein (only triflusal) and oral route (only triflusal), pharmacokinetic parameters were investigated from the plasma concentration-time profiles of triflusal and HTB in rats. An HPLC method was developed for the simultaneous determination of triflusal and HTB in rat plasma, urine and bile. The HPLC anal. was carried out using a C18 column and acetonitrile-methanol-water (25:10:65, volume/volume/v) as the mobile phase and UV detection at 234 nm. Furosemide was used as the internal standard The calibration curves were linear over the concentration range 0.05-5.0 μg/mL for triflusal and 0.2-200.0 μg/mL for HTB with correlation coefficients greater than 0.999 and with intra-day or inter-day coefficients of variation not exceeding 10.0%. This assay procedure was applied to the study of metabolite pharmacokinetics of triflusal and HTB in rats. It was supposed that triflusal was almost metabolized in vivo because urinary and biliary excreted amounts of triflusal could be ignored as it was lower than 1.2 % of the administered dose. According to the gastrointestinal and hepatic biotransformation pathways of triflusal, it was found that triflusal was hydrolyzed by about 5 % in intestine and metabolized by about 53 % in liver, and that the bioavailability of triflusal after oral administration of triflusal was 0.44, and also that the fraction of total elimination rate of triflusal which formed HTB in liver (Fmi, %) was about 98%. These results showed that triflusal was almost metabolized in liver, and the total elimination of triflusal in the body was dependent to the formation rate of HTB from triflusal in liver.

Yakche Hakhoechi published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, SDS of cas: 328-90-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cho, Hea-Young’s team published research in Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences in 798 | CAS: 328-90-5

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, HPLC of Formula: 328-90-5.

Cho, Hea-Young published the artcileSimultaneous determination of triflusal and its major active metabolite, 2-hydroxy-4-trifluoromethyl benzoic acid, in rat and human plasma by high-performance liquid chromatography, HPLC of Formula: 328-90-5, the publication is Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences (2003), 798(2), 257-264, database is CAplus and MEDLINE.

A rapid, selective and sensitive HPLC method was developed and validated for the simultaneous determination of triflusal and its major active metabolite, 2-hydroxy-4-trifluoromethyl HOBz (HTB), in rat and human plasma. HPLC anal. was carried out using a 5-μm particle size, C18-bonded SiO2 column and MeCN-MeOH-H2O (25:10:65, volume/volume/v) as the mobile phase and UV detection at 234 nm. Furosemide was used as the internal standard The method involved extraction with an MeCN-CHCl3 mixture (60:40, volume/volume) and evaporation to dryness with N stream. The chromatograms showed good resolution and sensitivity and no interferences by plasma constituents. The mean absolute recovery for human plasma was 93.5 ± 4.2% for triflusal and 98.5 ± 3.1% for HTB. The lower limits of quantification of triflusal and HTB in human plasma were 20 and 100 ng/mL, resp. The calibration curves in human plasma were linear over the concentration range 0.02-5.0 μg/mL for triflusal and 0.1-200.0 μg/mL for HTB with correlation coefficients >0.999 and with inter- or intra-day coefficients of variation (CV) not exceeding 10.0%. This assay procedure was applied to the study of metabolite pharmacokinetics of triflusal and HTB in rat and human.

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, HPLC of Formula: 328-90-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yin, L.’s team published research in Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry in 50B | CAS: 438565-33-4

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C14H10O4S2, Recommanded Product: 3-(2-Chlorophenyl)-5-isoxazolemethanol.

Yin, L. published the artcileDesign, synthesis and antibacterial activity of novel N-formylhydroxylamine derivatives as PDF inhibitors, Recommanded Product: 3-(2-Chlorophenyl)-5-isoxazolemethanol, the publication is Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (2011), 50B(5), 695-703, database is CAplus.

N-formylhydroxylamines RC(NH2):COCH2NHCOCHBuCH2N(OH)CHO (R = substituted Ph) were synthesized through a multi-step protocol starting from H2C(CO2Et)2. The newly synthesized compounds were screened for antibacterial activity. All the compounds exhibited potent in-vitro inhibitory activity against S. aureus and weak activity against K. pneumoniae.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C14H10O4S2, Recommanded Product: 3-(2-Chlorophenyl)-5-isoxazolemethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Xi-Zhao’s team published research in Journal of the Chinese Chemical Society (Taipei, Taiwan) in 54 | CAS: 438565-33-4

Journal of the Chinese Chemical Society (Taipei, Taiwan) published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C4H7BrO2, Computed Properties of 438565-33-4.

Wang, Xi-Zhao published the artcileConcise synthesis and antimicrobial activities of new substituted 5-isoxazolpenicillins, Computed Properties of 438565-33-4, the publication is Journal of the Chinese Chemical Society (Taipei, Taiwan) (2007), 54(3), 643-652, database is CAplus.

The synthesis of a series of penicillin aryl-isoxazole derivatives, such as I [R = Ph, C6H4-4-F, -2-Cl, -4-Cl, -2-Br, -2-OMe, -4-OMe, -3-NO2, -4-NO2, -3-CF3, -4-CF3, C6H3-2,4-Cl2, -3,4-Cl2, C6H2-2,4,5-Cl3, -3,4,5-Cl3, pyridin-2-yl, pyridin-4-yl], were prepared via amidation reactions of the corresponding aryl-substituted isoxazolecarbonyl chlorides with 6-aminopenicillanic acid. Concise large-scale synthesis of the 3,5-disubstituted isoxazoles by 1,3-dipolar cycloaddition reactions of the intermediate aryloximes RCH:NOH with HCCCH2OH using CuSO4.5H2O as catalyst was also investigated. Some of the synthesized compounds were assayed for antimicrobial activities, showing satisfactory antimicrobial activities against Gram-neg. bacteria.

Journal of the Chinese Chemical Society (Taipei, Taiwan) published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C4H7BrO2, Computed Properties of 438565-33-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts