Tag: M.W=200-250

Zhang, Yahui published the artcileSelective electrocatalytic hydroboration of aryl alkenes, Application In Synthesis of 608534-44-7, the publication is Green Chemistry (2021), 23(4), 1691-1699, database is CAplus.

Organoboron compounds are powerful precursors of value-added organic compounds in synthetic chem., and transition metal-catalyzed borylation has always been dominant. To avoid toxic reagents and costs associated with metal catalysts, simpler, more economical and effective approaches for delivering organoborons are highly desirable. Here, without the use of any metal catalysts, a CH₃CN-involved electrochem. borylation reaction is reported with alkenes and HBpin as substrates. The site-selectivity is realized to achieve mono- or di-functional borylation of an unsaturated bond by regulating the proportion of HBpin. In addition, the success of gram-scale experiments and versatile conversions confirms the potential applications of this strategy in industrial synthesis. The vital auxiliary role of N,N-diisopropylethylamine (DIEA) in the process of acetonitrile electrolysis is disclosed in the mechanism study. The proposed new strategy provides a generic platform for the discovery of addnl. challenging electrochem. systems for hydrogenation reactions.

Green Chemistry published new progress about 608534-44-7. 608534-44-7 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic,Boronic acid and ester,Boronate Esters,Boronic Acids,Boronic acid and ester, name is 2-(2,3-Dihydro-1H-inden-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C12H14O, Application In Synthesis of 608534-44-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shen, Chuansheng published the artcileOne-pot synthesis of (3-phenylisoxazol-5-yl)methanol derivatives under ultrasound, Quality Control of 438565-33-4, the publication is Letters in Organic Chemistry (2011), 8(4), 278-281, database is CAplus.

An ultrasonic-assisted, one-pot, efficient, convenient procedure for the synthesis of (3-phenylisoxazol-5-yl)methanol derivatives was developed. (3-Phenylisoxazol-5-yl)methanol derivatives with biol. and pharmaceutical property were synthesized in moderate to excellent yields. The synthetic methods possess the advantages of high yield, facile operation process and shorter reaction time, and so on.

Letters in Organic Chemistry published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C24H29N5O3, Quality Control of 438565-33-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Da-wei published the artcileUltrasonic-assisted synthesis of 1,4-disubstituted 1,2,3-triazoles via various terminal acetylenes and azide and their quorum sensing inhibition, Product Details of C10H8ClNO2, the publication is Ultrasonics Sonochemistry (2017), 343-353, database is CAplus and MEDLINE.

An efficient synthesis of 1,4-disubstituted 1,2,3-triazole derivatives I (R = C₆H₅, 2-ClC₆H₄, 3-O₂NC₆H₄, etc.) and II was studied. 1,4-Disubstituted 1,2,3-triazoles containing isoxazole and thymidine structures were synthesized in 84-96% yields starting from various terminal isoxazole ether alkynes and β-thymidine azide derivatives via a 1,3-dipolar cycloaddition using copper acetate, sodium ascorbate as the catalyst under ultrasonic assisted condition. Furthermore, the quorum sensing inhibitory activities of synthesized compounds were evaluated with Chromobacterium violaceum (C. Violaceum CV026) based on their inhibition of violacein production, with compound C₁₀-HSL as a pos. control. The compounds II (R = C₆H₅, 4-ClC₆H₄,and 4-C(CH₃)₃C₆H₄) exhibited considerable levels of inhibitory activity against violacein production, and IC₅₀ values were 217 +/- 19, 223 +/- 20 and 42.8 +/- 4.5 μM, resp., which highlighted the potential of these compounds as lead structures for further research towards the development of novel QS inhibitors.

Ultrasonics Sonochemistry published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C12H17NS2, Product Details of C10H8ClNO2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Da-Wei published the artcileEfficient solvent-free synthesis of bis(indolyl)methanes on SiO₂ solid support under microwave irradiation, HPLC of Formula: 438565-33-4, the publication is Chemical Papers (2015), 69(3), 470-478, database is CAplus.

An efficient synthesis of bis(indolyl)methanes I (R¹ = C₆H₅, 3-pyridinyl, 4-CH₃C₆H₄, etc.) was developed. Bis(indolyl)methanes were synthesized starting from various aromatic aldehydes with indole under microwave irradiation and solvent-free conditions (85-98%). Solid support SiO₂ was found to possess favorable catalytic and dispersancy parameters for the condensation reaction. Moreover, novel bis(indolyl)methanes containing an isoxazole ring II (R² = H, t-Bu, 4-Cl, etc.) were synthesized via this method in excellent yields (> 94%) using 3-substituted isoxazole-5-carbaldehydes and indole.

Chemical Papers published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C9H11NO4, HPLC of Formula: 438565-33-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Han, Yanfang published the artcileAsymmetric Retro-Claisen Reaction by Synergistic Chiral Primary Amine/Palladium Catalysis, Quality Control of 328-90-5, the publication is Organic Letters (2019), 21(18), 7258-7261, database is CAplus and MEDLINE.

We described herein a chiral primary amine/palladium catalyzed asym. retro-Claisen reaction of β-diketones with salicylic carbonates. A series of chiral α-alkylated ketones and macrolides were obtained with good yields and excellent enantioselectivities upon a sequence of decarboxylative benzylation, retro-Claisen cleavage, and enamine protonation. This strategy features broad substrate scope, mild conditions, as well as high atom economy with salicylic carbonates as the o-quinone methide precursors.

Organic Letters published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Quality Control of 328-90-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, M. published the artcilePharmacokinetics, safety and tolerability of triflusal and its main active metabolite HTB in healthy Chinese subjects, Related Products of alcohols-buliding-blocks, the publication is Drug Research (Stuttgart, Germany) (2014), 64(5), 263-268, 6 pp., database is CAplus and MEDLINE.

Objective: Triflusal presents comparable antiplatelet activity to aspirin while presenting a more favorable safety profile, and is used in the treatment of thrombosis. The study aimed to evaluate the pharmacokinetics and safety of triflusal and its major metabolite 2-(hydroxyl)-4-(trifluoromethyl)- benzoic acid (HTB) in healthy Chinese subjects. Methods: 30 healthy subjects were recruited in this randomized, single-center, and open-label, parallel, single ascending doses (300, 600, 900 mg) and multiple doses (600 mg, once daily for 7 days) study. Plasma samples were analyzed with a validated liquid chromatog. tandem mass spectrometry (LC/MS/MS) method. Safety was assessed by adverse events, ECG, laboratory testing, and vital signs. Results: Triflusal was safe and well tolerated. After single-dose administration, triflusal was rapidly absorbed with a mean Tmax of 0.55-0.92 h and a mean t1/2 kel of 0.35-0.65 h, HTB was absorbed with a mean Tmax of 2.35-3.03 h and a mean t1/2 kel of 52.5-65.57 h. Cmax and AUC for triflusal and HTB were approx. dose proportional over the 300-900 mg dose range. In the steady state, the accumulation index (R) indicated that the exposure of triflusal increased slightly with repeated dosing, and the exposure of HTB increased obviously. 3 Adverse events certainly related to the investigational drugs occurred in the multiple-dose phase. Conclusion: Following oral dosing under fasting condition, triflusal is promptly absorbed and rapidly depleted from the systemic circulation. HTB is quickly generated from triflusal and slowly eliminated. Triflusal accumulates slightly in the body. HTB plasma concentration builds up progressively toward steady-state.

Drug Research (Stuttgart, Germany) published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C12H21NO7, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Xu, Huanjun published the artcileReductive cleavage of inert aryl C-O bonds to produce arenes, COA of Formula: C15H16O3, the publication is Chemical Communications (Cambridge, United Kingdom) (2015), 51(61), 12212-12215, database is CAplus and MEDLINE.

Reductive cleavage of the aryl C-O bonds in various phenolic compounds and aryl ethers was achieved using LiAlH₄ combined with KOtBu and without any other catalysts or additives, solely producing arenes in high yields.

Chemical Communications (Cambridge, United Kingdom) published new progress about 70110-65-5. 70110-65-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Alcohol,Ether,Benzene Compounds, name is 2-Phenoxy-1-phenylpropane-1,3-diol, and the molecular formula is C11H10ClNO, COA of Formula: C15H16O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Yang-Hui published the artcilePd(II)-catalyzed hydroxylation of arenes with 1 atm of O₂ or air, Application In Synthesis of 328-90-5, the publication is Journal of the American Chemical Society (2009), 131(41), 14654-14655, database is CAplus and MEDLINE.

Pd(II)-catalyzed ortho-hydroxylation of variously substituted benzoic acids under 1 atm of O₂ or air is achieved under nonacidic conditions. Extensive labeling studies support a direct oxygenation of aryl C-H bonds with mol. oxygen.

Journal of the American Chemical Society published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C5H10O, Application In Synthesis of 328-90-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wu, Yanlin published the artcilePhotodegradation of 4-tert octylphenol in aqueous solution promoted by Fe(III), Related Products of alcohols-buliding-blocks, the publication is Environmental Science and Pollution Research (2013), 20(1), 3-9, database is CAplus and MEDLINE.

4-Tert-octylphenol (4-t-OP), a kind of endocrine-disrupting compounds, is widely distributed in natural water surroundings but can hardly be biodegraded. The advanced oxidation processes (AOPs) have been proved to be an efficient method to degrade 4-t-OP. The photodegradation of 4-t-OP in aqueous solution promoted by Fe(III) and the photooxidation mechanism were studied. The ferric perchlorate was added into the aqueous solution for the production of hydroxyl radical. The efficiency of mineralization was monitored by total organic carbon analyzer, and photooxidation products were determined by HPLC and liquid chromatog.-mass spectrometer. 4-t-OP (2.4 × 10^-5M) in aqueous solution was completely degraded after 45 min in the presence of Fe(III) (1.2 × 10^-3M) under UV irradiation (λ =365 nm). The optimal pH was 3.5. Higher Fe(III) concentration or lower initial 4-t-OP concentration led to increased photodegradation efficiency of 4-t-OP. The reaction was almost completely inhibited in the presence of 2-propanol. About 70% mineralization of the solution was obtained after 50 h. The photooxidation product was supposed to be 4-tert-octyl catechol. 4-t-OP in aqueous solution can be degraded in the presence of Fe(III) under the solar irradiation The photoinduced degradation is due to the reaction with hydroxyl radicals. It shows that the 4-t-OP is mineralized by the inducement of Fe(III) aquacomplexes, which exposes to solar light. Therefore, the results would provide useful information for the potential application of the AOPs to remove 4-t-OP in water surroundings.

Environmental Science and Pollution Research published new progress about 1139-46-4. 1139-46-4 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol, and the molecular formula is C25H23NO4, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wakita, Masahiro published the artcileSun protection by new vitamin C derivatives, Category: alcohols-buliding-blocks, the publication is Fragrance Journal (2021), 49(8), 36-41, database is CAplus.

Photoaging is caused by not only UV, but also blue light and near-IR rays. Reactive oxygen species (ROS) is generated inside our skin when the skin is exposed to these lights. As a result, wrinkles and sagging appear on the skin cause due to collagen and elastin reduced. Avoiding light exposure is the best solution against photoaging, but scavenging ROS is also important as the solution Generally, vitamin C is known as a cosmetic ingredient with strong antioxidant effect that eliminates ROS. However, it has problems of stability in itself and formulation. Therefore, author develops a highly stable vitamin C derivative 3-glyceryl ascorbate (3GA). It has a high stability in itself and formulation, in addition, author confirms its anti-photoaging effect improves wrinkles.

Fragrance Journal published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C12H16O3, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts