Tag: M.W=150-200

Wan, Ruiying published the artcileConstruction of ion conducting channels by embedding hydrophilic oligomers in piperidine functionalized poly(2,6-dimethyl-1,4-phenylene oxide) membranes, SDS of cas: 6346-09-4, the publication is European Polymer Journal (2021), 110150, database is CAplus.

A suitable microphase separation morphol. has been demonstrated to be an efficient strategy to achieve high ionic conductivity with reasonable durability to anion exchange membranes (AEMs). Herein, hydrophilic oligomers of polyethylene glycols (PEGs) with different mol. weights were blended, sep., with poly(2,6-dimethyl-1,4-phenylene oxide) modified by 4,4-diethoxybutan-1-amine and 1-methylpiperidine (20PDM). The presence of hydrophilic PEGs facilitates the formation of the interconnected nano-channels in the AEMs for ion conduction according to the anal. results by both transmission electron microscopy (TEM) and small angle X-ray scattering (SAXS). The membrane containing 2 wt% PEGs with a mol. weight of 2 kDa reaches a hydroxide conductivity of 97.2 mS cm^-1 at 80°C, which is 25 mS cm^-1 higher than that the pristine 20PDM membrane possessing the same ion exchange capacity. A peak power d. of 328 mW cm^-2 is attained at 60°C by the proposed membrane based single fuel cell fueling with humidified H₂ and O₂ with 0.1 MPa of back pressure. The chem. structure, water uptake and swelling as well as resistance to hot alkali solutions of the prepared membranes were investigated.

European Polymer Journal published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C15H14Cl2S2, SDS of cas: 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Dehua published the artcileMicroporous Aluminophosphate ULM-6: Synthesis, NMR Assignment, and Its Transformation to AlPO₄-14 Molecular Sieve, Category: alcohols-buliding-blocks, the publication is Journal of Physical Chemistry C (2016), 120(22), 11854-11863, database is CAplus.

A pure fluorinated aluminophosphate [Al₈P₈O₃₂F₄·(C₃H₁₂N₂)₂(H₂O)₂] (ULM-6) was synthesized via an aminothermal strategy, in which triisopropanolamine (TIPA) was used as the solvent together with the addition of propyleneurea and HF. The ¹³C NMR spectrum demonstrates that 1,3-diaminopropane, the in situ decomposer of propyleneurea, is the real structure-directing agent (SDA) for ULM-6 crystals. The local Al, P, and F environments of the dehydrated ULM-6 were studied by 1-dimensional and 2-dimensional solid-state NMR spectroscopy. The spatial proximities are extracted from ¹⁹F{²⁷Al}, ¹⁹F{³¹P}, ²⁷Al{¹⁹F}, and ³¹P{¹⁹F} rotational-echo double resonance (REDOR) NMR experiments as well as ¹⁹F → ³¹P heteronuclear correlation (HETCOR) NMR and {³¹P}²⁷Al HMQC NMR experiments, allowing a full assignment of all the ¹⁹F, ²⁷Al, and ³¹P resonances to the corresponding crystallog. sites. Also, the structure of ULM-6 is closely related to that of AlPO₄-14. A combination of high-temperature powder XRD, thermal anal., and ¹⁹F NMR reveals that the removal of F atoms at higher temperature is crucial to the phase transformation of ULM-6 to AlPO₄-14. The calcined product shows high CO₂/CH₄ and CO₂/N₂ selectivity with ratios of 15.5 and 29.1 (101 kPa, 25°), resp.

Journal of Physical Chemistry C published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C38H24F4O4P2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hong, Fengying published the artcileN-terminal strategy (N1-N4) toward high performance liquid crystal materials, Application In Synthesis of 23351-09-9, the publication is Tetrahedron (2016), 72(10), 1285-1292, database is CAplus.

Liquid crystal materials have a variety of applications in many fields such as display techniques as well as photonics and optics. However, only few design principles have been disclosed on liquid crystal materials with different N-heterocycles as the terminal groups, which hinder the development of the heterocyclic liquid crystals. Here, a strategy of mol. design for N-heterocyclic liquid crystal materials is reported. On the basis of this strategy, a series of convenient N-heterocycles such as pyrrole, pyrazole, imidazole, 1,2,3-triazole, 1,2,4-triazole, 1,2,3,4-tetrazole were applied to synthesize the novel liquid crystals. Most of them have proved to exhibit good mesomorphic behaviors which make them excellent components in the mixture of the LCDs materials. The simple attachment of N-heterocyclic units to the liquid crystal mols. through a mild reaction condition will provide a good prospect for the design of N-heterocyclic liquid crystals.

Tetrahedron published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Application In Synthesis of 23351-09-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Nie, Ai Hua published the artcileDrug discovery based on the structure of FKBPs: design, synthesis and evaluation of L-1,4-thiazane-3-carboxylic acid derivatives as neuroimmunophilin ligands, Quality Control of 101-98-4, the publication is Chinese Chemical Letters (2005), 16(2), 163-166, database is CAplus.

Based on the structure of FK506, FKBP12 and calcineurin complex and the interactive characteristics of small mol. ligands with FK-506-binding proteins (FKBPs), a series of L-tetrahydro-1,4-thiazine-3-carboxylic acid derivatives I [X = O, R = PhCH₂NMeCH₂CH₂, PhCH:CHCH₂, 3-cyclohexylpropyl, 4-O₂NC₆H₄CH₂, etc.; X = NH, R = Me₂CHCH₂CH(CO₂Et), PhCH₂CH(CO₂CH₂Ph), etc.] was designed and synthesized as neuroimmunophilin ligands. The results of evaluation show that I [X = O; R = (PhCH₂OCH₂)₂CH] (N308) has a great promise as a candidate of neuroprotective and neuroregenerative agent.

Chinese Chemical Letters published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Quality Control of 101-98-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Nie, AiHua published the artcileDrug discovery based on the structure of FKBP12: Design, synthesis and evaluation of L-1,4-thiazane-3-carboxylic acid derivatives as neuroimmunophilin ligands, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol, the publication is Science in China, Series B: Chemistry (2007), 50(3), 405-417, database is CAplus.

By choosing neuroimmunophilin FKBP12 as a therapeutical target, the authors have attempted to discover a new structural drug for treating neurodegenerative disease. This drug should possess neurotrophic activity and not affect the immune system. Based on the crystal structure of FKBP12, FK506 and Calcineurin complex, small organic mols. were designed. These mols. were to have the ability of binding to FKBP12 in a virtual screening. By using a solution parallel synthetic method, these compounds were synthesized. The neuroprotective and neuroregenerative activities of these compounds were evaluated by binding assays, PC12 cells survival and neurite outgrowth model, chick dorsal root ganglion cultures (DRG) and 6-OHDA lesioned mice sympathetic nerve endings model. The evaluation results of these compounds showed that (2S)-2-[[[(3R)-4-(4-toluenesulfonyl)thiomorpholin-3-yl]carbonyl]amino]-4-methylpentanoic acid Et ester (N308) has great promise as a candidate for a neuroprotective and neuroregenerative agent.

Science in China, Series B: Chemistry published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Nie, Aihua published the artcileDrug discovery based on structure of FKBP52: design and synthesis of 2-azabicyclo[2.2.1]hept-5-ene-3-carboxylic acid derivatives and determination of their activity as neuroimmunophilin ligands, Synthetic Route of 101-98-4, the publication is Zhongguo Yaowu Huaxue Zazhi (2006), 16(6), 323-330, database is CAplus.

A method for the synthesis of the title compounds is reported here. One such 2-aza-bicyclo[2.2.1]hept-5-ene-3-carboxy derivatives were investigated for their activity as neuroimmunophilin ligands. SYBYL/Composer was used for homol. modeling the structure of domain 1 (D1) of FKBP52 (a member of the FK506-binding family of immunophilins). Based on the structure of FKBP52D1, CADD (computer-aided drug design) was employed to design and virtually screen such novel 2-azabicyclo[2.2.1]hept-5-ene-3-carboxy derivatives These compounds were synthesized by liquid-phase synthetic method. Cultured chick DRGs (dorsal root ganglion sensory neurons) was applied to evaluate neurotrophic activity of these target compounds Novel 2-azabicyclo[2.2.1]hept-5-ene-3-carboxy derivatives were designed based on the structure of FKBP52 and 21 target compounds were synthesized. In cultured chick DRGs, one compound produced potent neurotrophic effects and promoted neurite outgrowth in vitro.

Zhongguo Yaowu Huaxue Zazhi published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Synthetic Route of 101-98-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jin, Zhongmin published the artcileInterrogating cadmium and lead biosorption mechanisms by Simplicillium chinense via infrared spectroscopy, Product Details of C8H8O3, the publication is Environmental Pollution (Oxford, United Kingdom) (2020), 263(Part_A), 114419, database is CAplus and MEDLINE.

Fungi-associated phytoremediation is an environmentally friendly and cost-efficient approach to remove potential toxic elements (PTEs) from contaminated soils. Many fungal strains have been reported to possess PTE-biosorption behavior which benefits phytoremediation performance. Nevertheless, most studies are limited in rich or defined medium, far away from the real-world scenarios where nutrients are deficient. Understanding fungal PTE-biosorption performance and influential factors in soil environment can expand their application potential and is urgently needed. This study applied attenuated total reflection Fourier-transform IR (ATR-FTIR) coupled with phenotypic microarrays to study the biospectral alterations of a fungal strain Simplicillium chinense QD10 and explore the mechanisms of Cd and Pb biosorption. Both Cd and Pb were efficiently adsorbed by S. chinense QD10 cultivated with 48 different carbon sources and the biosorption efficiency achieved >90%. Accordingly, Pb and Cd biosorption by S. chinense QD10 followed discriminating mechanisms, specific adsorption on cell membrane for Cd and unspecific extracellular precipitation for Pb. This work lends new insights into the mechanisms of PTE-biosorption via IR spectrochem. tools, which provide more comprehensive clues for biosorption behavior with a nondestructive and high-throughput manner solving the traditional tech. barrier regarding the real-world scenarios.

Environmental Pollution (Oxford, United Kingdom) published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, Product Details of C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cui, Lei published the artcileData-driven prediction of the product formation in industrial 2-keto-L-gulonic acid fermentation, Related Products of alcohols-buliding-blocks, the publication is Computers & Chemical Engineering (2012), 386-391, database is CAplus.

Mixed culture fermentation of Bacillus megaterium and Gluconobacter oxydans is widely used to produce 2-keto-L-gulonic acid (2-KGA), a key precursor for L-ascorbic acid synthesis. For such mixed cultivation, kinetic modeling is difficult because the interactions between the two strains are not well known yet. In this paper, data-driven prediction of the product formation is presented for the purpose of better process monitoring. A rolling learning-prediction approach based on neural networks is practiced to predict 2-KGA formation. Techniques associated with the approach, such as the data pretreatment and the rolling learning-prediction mechanism, are given in more detail. The validation results by using the data from com. scale 2-KGA cultivation indicate that the prediction error is less than 5% in the later phase of fermentation and the reliable prediction time span is 8 h. The robustness of the prediction approach is further tested by adding extra noises to the process variables.

Computers & Chemical Engineering published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yan, Ying published the artcileStructured modeling and validation for 2-KGA mixed cultivation, Name: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, the publication is Shanghai Jiaotong Daxue Xuebao (2012), 46(11), 1723-1728, database is CAplus.

The mechanism of interaction between Ketogulonicigenium vulgare and Bacillus megaterium was investigated for 2-keto-L-gulonic acid (2-KGA) mixed culture. Based on the metabolic pathway anal. in K. vulgare, a macrokinetic model was constructed, where, a first-order closed-loop regulator model was introduced to describe the induction of the enzyme pool responsible for the growth of K. vulgare at the beginning of the cultivation. The model describes the balance of intracellular substance and energy flow rates. The key reaction rates such as the specific substrate consumption rate, the specific growth rate, the specific acetyl-CoA formation rate as well as the specific oxygen uptake rate are obtained with this model. The specific substrate consumption rate and the specific growth rate are then coupled into a bioreactor model such that the relationship between substrate feeding rate and state variables is set up. The exptl. validation results were presented.

Shanghai Jiaotong Daxue Xuebao published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C65H82N2O18S2, Name: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yuan, Ke published the artcileTranscriptional response of Mycobacterium sp. strain A1-PYR to multiple polycyclic aromatic hydrocarbon contaminations, Related Products of alcohols-buliding-blocks, the publication is Environmental Pollution (Oxford, United Kingdom) (2018), 243(Part_B), 824-832, database is CAplus and MEDLINE.

Cometabolism mechanisms of organic pollutants in environmental microbes have not been fully understood. In this study, a global anal. of Mycobacterium sp. strain A1-PYR transcriptomes on different PAH substrates (single or binary of pyrene (PYR) and phenanthrene (PHE)) was conducted. Comparative results demonstrated that expression levels of 23 PAH degradation enzymes were significantly higher in the binary substrate than in the PYR-only one. These enzymes constituted an integrated enzymic system to actualize all transformation steps of PYR, and most of their encoded genes formed a novel gene cascade in the genome of strain A1-PYR. The roles of different genotypes of enzymes in PYR cometabolism were also discriminated even though all of their gene sequences were presented in the genome of this strain. NidAB and PdoA2B2 instead of NidA3B3 served the initial oxidization of PAHs, and PcaL replaced PcaCD to catalyze the formation of 3-oxoadipate. Novel genes associated with PYR cometabolism was also predicted by the relationships between their transcription profiles and PYR removal. The results showed that ABC-type transporters probably played important roles in the transport of PAHs and their metabolites through cell membrane, and [4Fe-4S] ferredoxin might be essential for dioxygenases (NidAB and PdoA2B2) to achieve oxidative activities. This study provided mol. insight in that microbial degrader subtly cometabolized recalcitrant PAHs with relatively more degradable ones.

Environmental Pollution (Oxford, United Kingdom) published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C14H14, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts